The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

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Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

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Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart

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Are Hippocampal Hypoperfusion and ATP Depletion Prime Movers in the Genesis of Alzheimer’s Disease? A Review of Recent Pertinent Observations from Molecular Biology

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Research and prospect of peptides for use in obesity treatment (Review)

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Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA

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MOTS-c regulates pancreatic alpha and beta cell functions in vitro

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Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

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It's a small, small world: unravelling the role and evolution of small RNAs in organelle and endosymbiont genomes.

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Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells

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Analysis of human mitochondrial genome co-occurrence networks of Asian population at varying altitudes

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Mitochondrial disorders as a mechanism for the development of obese Sarcopenia

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Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure

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The ‘non-conventional’ peptidome: A new layer in plant regulatory mechanisms

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MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats

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Role of MOTS-c in the regulation of bone metabolism

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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease

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Protocol for the assessment of human T cell activation by real-time metabolic flux analysis

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The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation

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Mitochondrial Signaling and Neurodegeneration

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Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses

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Profiling Analysis Reveals the Potential Contribution of Peptides to Human Adipocyte Differentiation

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Human milk derived peptide AOPDM1 attenuates obesity by restricting adipogenic differentiation through MAPK signalling

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Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4+ effector memory T cells

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The specific mitochondrial unfolded protein response in fast- and slow-twitch muscles of high-fat diet-induced insulin-resistant rats

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Effect of Humanin and MOTS-c on ameliorating reproductive damage induced by prepubertal cyclophosphamide chemotherapy in male mice

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Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane

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Are Mitochondria a Potential Target for Treating β-Thalassemia?

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Crosstalk Between Skeletal Muscle and Proximal Connective Tissues in Lipid Dysregulation in Obesity and Type 2 Diabetes

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Chasing the Ghost Proteome in the Dark Matter

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Micropeptides Identified from Human Genomes

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MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake—A Preliminary Study

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Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases

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Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair

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Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications

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sOCP: a framework predicting smORF coding potential based on TIS and in-frame features and effectively applied in the human genome

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Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia

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Mitochondrial-Derived Peptides: Implication in the Therapy of Neurodegenerative Diseases

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Mitochondrial Transplantation Therapy: A Novel Approach in the Era of Organelle-Centered Regenerative Medicine

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Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases

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Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain

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Our current understanding of the biological impact of endometrial cancer mtDNA genome mutations and their potential use as a biomarker

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A comparative analysis of mitochondrial ORFs provides new insights on expansion of mitochondrial genome size in Arcidae

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Expanding the Coding Potential of Vertebrate Mitochondrial Genomes: Lesson Learned from the Atlantic Cod

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Mitochondrial Biology and Medicine

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Effects of MOTS-c on the mitochondrial function of cells harboring 3243 A to G mutant mitochondrial DNA

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Avaliação do Nível de Fluxo Coronário com MOTS-C em Pacientes com IAMCSST Submetidos à ICP Primária

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MOTS-c in type 2 diabetes mellitus: From risk factors to cardiac complications and potential treatment

Fang, T., Han, J., Taberner, A. J., & Pham, T. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124009 · Cited by 6

Muscle-Targeted Nanocomposite Therapy Alleviates Age-Related Sarcopenia via Antioxidant and Metabolic Reprogramming

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Thyroid hormones, mitochondria, aging, and cancer

Glinsky, G. V., Hercbergs, A. A., & Davis, P. J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682089 · Cited by 8

MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner

Gudiksen, A., Hansen, C. C., der Stede, T. V., Daugaard, A. H., Schmidt, J. H., Ringholm, S., Merimi, M., Al-Obaidi, F. R., Kristoffersen, A. T., Zole, E., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.002 · Cited by 6

MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria

Zhang, Z., Chen, D., Du, K., Huang, Y., Li, X., Li, Q., & Lv, X. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.06.002 · Cited by 6

Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis

Xu, L., Tang, X., Yang, L., Chang, M., Xu, Y., Chen, Q., Chen, L., Liu, S., & Jiang, J. (2024) · Molecular Pain · doi:10.1177/17448069241252654 · Cited by 7

Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study

Kamiński, K., Blatkiewicz, M., Szyszka, M., Olechnowicz, A., Komarowska, H., Klimont, A., Wierzbicki, T., Karczewski, M., Ruchała, M., & Ruciński, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168721 · Cited by 6

In‐silico identification of putatively functional intergenic small open reading frames in the cucumber genome and their predicted response to biotic and abiotic stresses

Ahmad, E. M., Abdelsamad, A., El‐Shabrawi, H. M., El-Awady, M. A. M., Aly, M. A. M., & El‐Soda, M. (2024) · Plant Cell & Environment · doi:10.1111/pce.15104 · Cited by 6

MOTS-c relieves hepatocellular carcinoma resistance to TRAIL-induced apoptosis under hypoxic conditions by activating MEF2A

Shen, H., Nie, J., Wang, X., Li, G., Zhao, L., Jin, Y., & Jin, L. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114354 · Cited by 6

Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs

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Current Perspectives on Functional Involvement of Micropeptides in Virus–Host Interactions

Sun, H., Gu, R., Tang, T., Rai, K. R., & Chen, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083651 · Cited by 6

Expression Profile of Mouse Gm20594, Nuclear-Encoded Humanin-Like Gene

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Kcnma1 is involved in mitochondrial homeostasis in diabetes‐related skeletal muscle atrophy

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Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats

Öztürk, D. A., Erden, Y., & Tekin, S. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137722 · Cited by 6

African-origin Mitochondrial DNA Variants as a Contributing Factor to Susceptibilities for Diabetes and Age-related Diseases

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Using Human iPSC-Derived Neurons to Uncover Activity-Dependent Non-Coding RNAs

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Associations of Mitochondrial Variants With Lipidomic Traits in a Chinese Cohort With Coronary Artery Disease

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Humanin, MOTS-c and physical exercise: A new perspective

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Identification of Microproteins in Hep3B Cells at Different Cell Cycle Stages

Li, B., Zhang, Z., & Wan, C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00926 · Cited by 6

The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension

Sidorenko, D. A., Lvova, I. D., Tyganov, S. A., Shenkman, B. S., & Sharlo, K. A. (2025) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-025-09700-3 · Cited by 5

MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction

Ozkaya, D. Y., Haymana, C., Demirci, İ., Duman, U. G., Küpçük, E., Koç, G. E., Taşçı, İ., & Sonmez, Y. A. (2025) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2025-0063 · Cited by 5

Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects

Saracaloğlu, A., Mete, A. Ö., Ucar, D. F., Demiryürek, Ş., Erbağcı, E., & Demiryürek, A. T. (2023) · Current Protein and Peptide Science · doi:10.2174/1389203724666230217101202 · Cited by 5

An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats

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