The Significance of Circadian Organization for Longevity in the Golden Hamster

Hurd, Mark W.; Ralph, Martin R.

doi:10.1177/074873098129000255

Cited by 275Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsSleep and Work-Related Fatigue

The Significance of Circadian Organization for Longevity in the Golden Hamster

Hurd, Mark W., Ralph, Martin R.·1998·Journal of Biological Rhythms

DOI 10.1177/074873098129000255

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Abstract

While functional roles for biological clocks have been demonstrated in organisms throughout phylogeny, the adaptive advantages of circadian organization per se are largely matters of conjecture. It is generally accepted, though without direct experimental evidence, that organisms derive primary benefits from the temporal organization of their physiology and behavior, as well as from the anticipation of daily changes in their environment and their own fluctuating physiological requirements. However, the consequences of circadian dysfunction that might demonstrate a primary adaptive advantage and explain the natural origins and apparent ubiquity of circadian systems have not been documented. The authors report that longevity in hamsters is decreased with a noninvasive disruption of rhythmicity and is increased in older animals given suprachiasmatic implants that restore higher amplitude rhythms. The results substantiate the importance of the temporal organization of physiology and behavior provided by the circadian clock to the health and longevity of an organism.

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Cardiomyopathy was observed in hamsters whose internal circadian clock period did not match the external 24-hour light cycle (i.e., 20-hour period due to the tau mutation).
“Cardiomyopathy was observed in hamsters whose internal circadian clock period did not match the external 24-hour light cycle (i.e., 20-hour period due to the tau mutation) (61,144).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [144]

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Evaluating the Adaptive Fitness of Circadian Clocks and their Evolution
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Authors: Hurd, M. W., & Ralph, M. R.
Affiliations: University of Houston (US)
University of Toronto (CA)
ORCID: Hurd, Mark W.
Ralph, Martin R.
Venue: Journal of Biological Rhythms
Publisher: SAGE Publications
Published: 1998-10
Volume: 13
Issue: 5
Pages: 430-436
ISSN: 0748-7304 (ISSN-L)
1552-4531
DOI: 10.1177/074873098129000255
OpenAlex: W1975982492
Cited by: 275
References: 33
Citations by year: 2026: 7 · 2025: 2 · 2024: 17 · 2023: 18 · 2022: 9 · 2021: 14 · 2020: 20 · 2019: 15 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 18 · 2014: 10 · 2013: 15 · 2012: 10
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Biological Rhythms (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Natural Sciences
National Institute on Aging
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian clock, longevity, golden hamster, suprachiasmatic nucleus, circadian rhythm disruption, aging
MeSH terms: Aging, Animals, Circadian Rhythm, Environment, Cricetinae, Longevity, Mesocricetus, Motor Activity, Suprachiasmatic Nucleus, Fetal Tissue Transplantation

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The Significance of Circadian Organization for Longevity in the Golden Hamster

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