One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,727

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Seim, G. L., John, S. V., Arp, N. L., Fang, Z., Pagliarini, D. J., & Fan, J. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01153-w · Cited by 39

Abnormal methylation caused by folic acid deficiency in neural tube defects

Cao, R., Xie, J., & Zhang, L. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0504 · Cited by 39

Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon

Espe, M., Adam, A., Saito, T., & Skjærven, K. H. (2023) · Aquaculture Nutrition · doi:10.1155/2023/5706177 · Cited by 39

Choline metabolism and its implications in cancer

Yao, N., Li, W., Xu, G., Duan, N., Yu, G., & Qu, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1234887 · Cited by 44

Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5′-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows

Zhou, Y., Zhou, Z., Batistel, F., Martínez-Cortés, I., Pate, R. T., Luchini, D. N., & Loor, J. J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-14236 · Cited by 39

Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase

Zheng, Y., Ramsamooj, S., Li, Q., Johnson, J. L., Yaron, T. M., Sharra, K., & Cantley, L. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-40950-7 · Cited by 39

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O., & Reynolds, K. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.030 · Cited by 37

mTOR complex 2 is an integrator of cancer metabolism and epigenetics

Masui, K., Harachi, M., Cavenee, W. K., Mischel, P. S., & Shibata, N. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.03.001 · Cited by 39

Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis

Indika, N.-L. R., Deutz, N. E. P., ENGELEN, M. P. K. J., Peiris, H., Wijetunge, S., & Perera, R. (2021) · Biochimie · doi:10.1016/j.biochi.2021.02.018 · Cited by 40

Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

Anderson, D. E., Cui, J., Ye, Q., Huang, B., Tan, Y., Jiang, C., Zu, W., Gong, J., Liu, W., Kim, S. Y., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104759118 · Cited by 39

Metabolic modeling of host–microbe interactions for therapeutics in colorectal cancer

Bhalla, P., Rengaswamy, R., Karunagaran, D., Suraishkumar, G. K., & Sahoo, S. (2022) · npj Systems Biology and Applications · doi:10.1038/s41540-021-00210-9 · Cited by 41

Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups

Hirabayashi, T., Kawaguchi, M., Harada, S., Mouri, M., Takamiya, R., Miki, Y., Sato, H., Taketomi, Y., Yokoyama, K., Kobayashi, T., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2022.111940 · Cited by 43

Social networking at the microbiome-host interface

Lamont, R. J., Hajishengallis, G., & Koo, H. (2023) · Infection and Immunity · doi:10.1128/iai.00124-23 · Cited by 39

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Ramos, L., Henriksson, M., Helleday, T., & Green, A. C. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1290 · Cited by 38

5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis

Kim, J., Ryu, G., Seo, J., Go, M., Kim, G., Yi, S., Kim, S., Lee, H., Lee, J., Kim, H. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45174-6 · Cited by 43

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

Zhang, T., Fu, W., Zhang, H., Li, J., Xing, B., Cai, Y. A., Zhang, M., Liu, X., Qi, C., Qian, L., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01540-6 · Cited by 40

N-Alkyl-α-amino acids in Nature and their biocatalytic preparation

Hyslop, J. F., Lovelock, S. L., Watson, A. J. B., Sutton, P. W., & Roiban, G. (2019) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.01.006 · Cited by 38

Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism

Bhatia, M., Thakur, J., Suyal, S., O’Niel, R. A., Chakraborty, R., Pradhan, S., Sharma, M., Sengupta, S., Laxman, S., Masakapalli, S. K., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015129 · Cited by 38

MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine

Tong, D., Zhang, J., Wang, X., Li, Q., Liu, L., Lu, A., Guo, B., Yang, J., Ni, L., Qin, H., et al. (2020) · Oncogenesis · doi:10.1038/s41389-020-00281-z · Cited by 38

Betaine host–guest complexation with a calixarene receptor: enhanced in vitro anticancer effect

Fahmy, S. A., Ponte, F., Fawzy, I. M., Sicilia, E., & Azzazy, H. M. E.-S. (2021) · RSC Advances · doi:10.1039/d1ra04614d · Cited by 39

Metabolic reprogramming of the tumor immune microenvironment in ovarian cancer: A novel orientation for immunotherapy

Lin, Y., Zhou, X., Ni, Y., Zhao, X., & Liang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1030831 · Cited by 38

Ferroptosis: A new insight for treatment of acute kidney injury

Li, S., Wang, R., Wang, Y., Liu, Y., Qiao, Y., Li, P., Chen, J., Pan, S., Feng, Q., Liu, Z., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065867 · Cited by 40

Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis

Steinz, M. M., Ezdoglian, A. A., Khodadust, F., Molthoff, C. F. M., Srinivasarao, M., Low, P. S., Zwezerijnen, G. J. C., Yaqub, M. M., Beaino, W., Windhorst, A. D., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.819163 · Cited by 37

Metabolic signatures of pregnancy-induced cardiac growth

Fulghum, K., Smith, J. B., Chariker, J. H., Garrett, L. F., Brittian, K. R., Lorkiewicz, P. K., McNally, L. A., Uchida, S., Jones, S. P., Hill, B. G., et al. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00105.2022 · Cited by 37

The evolution of folate supplementation – from one size for all to personalized, precision, poly-paths

He, Q., & Li, J. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0087 · Cited by 37

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties

Tramonti, A., Nardella, C., di Salvo, M. L., Barile, A., Cutruzzolà, F., & Contestabile, R. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b01074 · Cited by 37

Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut–Liver Connection

Kim, S. H., Lee, W., Kwon, D., Lee, S., Son, S. W., Seo, M., Kim, K., Lee, Y., Kim, S., & Jung, Y. (2020) · Cells · doi:10.3390/cells9020341 · Cited by 37

Strengths and Weaknesses of Cell Synchronization Protocols Based on Inhibition of DNA Synthesis

Ligasová, A., & Koberna, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910759 · Cited by 34

Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity

Pileggi, C. A., Blondin, D. P., Hooks, B. G., Parmar, G., Alecu, I., Patten, D. A., Cuillerier, A., O’Dwyer, C., Thrush, A. B., Fullerton, M. D., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104192 · Cited by 37

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Makino, Y., Oe, C., Iwama, K., Suzuki, S., Nishiyama, A., Hasegawa, K., Okuda, H., Hirata, K., Ueno, M., Kawaji, K., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03555-x · Cited by 36

Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S‐adenosylmethionine, and related diseases: A review†

Monné, M., Marobbio, C. M. T., Agrimi, G., Palmieri, L., & Palmieri, F. (2022) · IUBMB Life · doi:10.1002/iub.2658 · Cited by 34

Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations, and Experiences

Holzapfel, C., Waldenberger, M., Lorkowski, S., Daniel, H., & the Working Group “Personalized Nutrition” of the German Nutrition Society (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200077 · Cited by 38

The methionine cycle and its cancer implications

Tassinari, V., Jia, W. P., Chen, W., Candi, E., & Melino, G. (2024) · Oncogene · doi:10.1038/s41388-024-03122-0 · Cited by 37

Folate deficiency induces mitotic aberrations and chromosomal instability by compromising the spindle assembly checkpoint in cultured human colon cells

Guo, X., Ni, J., Zhu, Y., Zhou, T., Ma, X., Xue, J., & Wang, X. (2017) · Mutagenesis · doi:10.1093/mutage/gex030 · Cited by 36

Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer

Nilsson, R., Nicolaidou, V., & Koufaris, C. (2019) · Gene · doi:10.1016/j.gene.2019.144032 · Cited by 36

One carbon metabolism in human lung cancer

Yao, S., Peng, L., Elakad, O., Küffer, S., Hinterthaner, M., Danner, B. C., von Hammerstein-Equord, A. F., Ströbel, P., & Bohnenberger, H. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1039 · Cited by 35

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., Bertolino, P., Cesta, C. E., Liu, X., Korbutt, G. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23673-0 · Cited by 36

Variably methylated retrotransposons are refractory to a range of environmental perturbations

Bertozzi, T. M., Becker, J. L., Blake, G. E. T., Bansal, A., Nguyen, D. K., Fernandez‐Twinn, D. S., Ozanne, S. E., Bartolomei, M. S., Simmons, R. A., Watson, E. D., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00898-9 · Cited by 38

Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

Jennings, E. Q., Fritz, K. S., & Galligan, J. J. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101053 · Cited by 38

Perspective: Developing a Nutrient-Based Framework for Protein Quality

Forester, S. M., Jennings-Dobbs, E. M., Sathar, S. A., & Layman, D. K. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.06.004 · Cited by 36

Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells

Lü, J., Liang, Y., Meng, H., Zhang, A., Zhao, J., & Zhang, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728783 · Cited by 34

Gene therapy for mitochondrial disorders

Keshavan, N., Minczuk, M. A., Viscomi, C. F., & Rahman, S. (2024) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12699 · Cited by 39

SLC25A48 controls mitochondrial choline import and metabolism

Verkerke, A. R. P., Shi, X., Li, M., Higuchi, Y., Yamamuro, T., Katoh, D., Nishida, H., Auger, C., Abe, I., Gerszten, R. E., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.010 · Cited by 41

One-Carbon Metabolism: Biological Players in Epithelial Ovarian Cancer

Rizzo, A., Napoli, A., Roggiani, F., Tomassetti, A., Bagnoli, M., & Mezzanzanica, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072092 · Cited by 36

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Alptekin, A., Ye, B., Yu, Y., Poole, C. J., van Riggelen, J., Zha, Y., & Ding, H. (2019) · Oncogene · doi:10.1038/s41388-019-0967-3 · Cited by 35

Glycolate combats massive oxidative stress by restoring redox potential in Caenorhabditis elegans

Diez, V., Traikov, S., Schmeißer, K., Adhikari, A. K. D., & Kurzchalia, T. V. (2021) · Communications Biology · doi:10.1038/s42003-021-01669-2 · Cited by 34

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

O’Connor, C. E., Wallace-Povirk, A., Ning, C., Frühauf, J., Tong, N., Gangjee, A., Matherly, L. H., & Hou, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-85818-x · Cited by 35

Active mitochondrial respiration in cancer: a target for the drug

Bedi, M., Ray, M., & Ghosh, A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04281-4 · Cited by 34

Human blood metabolites and lacunar stroke: A Mendelian randomization study

Guo, M., Hao, X.-Y., Tian, J., Wang, Y., Li, J., Fan, Y., Shi, J., Ma, D., Li, S., Zuo, C., et al. (2022) · International Journal of Stroke · doi:10.1177/17474930221140792 · Cited by 38

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids

Rodrigues, D., Coyle, L., Füzi, B., Ferreira, S., Jo, H., Herpers, B., Chung, S., Fisher, C., Kleinjans, J. C. S., Jennen, D. G. J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031286 · Cited by 35

Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan

Chen, S., Miki, T., Fukunaga, A., Eguchi, M., Kochi, T., Nanri, A., Kabe, I., & Mizoue, T. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.06.039 · Cited by 36

The direct targets of metformin in diabetes and beyond

Yao, L., Wang, L., Zhang, R., Soukas, A. A., & Wu, L. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.017 · Cited by 40

Nutrient availability shapes methionine metabolism in p16/ MTAP -deleted cells

Sanderson, S. M., Mikhael, P. G., Ramesh, V., Dai, Z., & Locasale, J. W. (2019) · Science Advances · doi:10.1126/sciadv.aav7769 · Cited by 36

DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism

Maresca, A., Dotto, V. D., Capristo, M., Scimonelli, E., Tagliavini, F., Morandi, L., Tropeano, C. V., Caporali, L., Mohamed, S., Roberti, M., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa014 · Cited by 34

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism

Santoro, V., Kovalenko, I., Vriens, K., Christen, S., Bernthaler, A., Haegebarth, A., Fendt, S., & Christian, S. (2020) · Oncotarget · doi:10.18632/oncotarget.27486 · Cited by 36

Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?

Psara, E., Pentieva, K. D., Ward, M., & McNulty, H. (2020) · Biochimie · doi:10.1016/j.biochi.2020.03.016 · Cited by 35

Circles of Life: linking metabolic and epigenetic cycles to immunity

Lio, C. J., & Huang, S. C. (2020) · Immunology · doi:10.1111/imm.13207 · Cited by 36

Stereoselective metabolomic and lipidomic responses of lettuce (Lactuca sativa L.) exposing to chiral triazole fungicide tebuconazole

Zhao, L., Zhang, Y., Wang, L., Liu, X., Zhang, J., & He, Z. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131209 · Cited by 34

Mitochondrial [ 2Fe‐2S ] ferredoxins: new functions for old dogs

Schulz, V., Freibert, S., Boß, L., Mühlenhoff, U., Stehling, O., & Lill, R. (2022) · FEBS Letters · doi:10.1002/1873-3468.14546 · Cited by 34

SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis

Li, Y., Bie, J., Zhao, L., Song, C., Zhang, T., Li, M., Yang, C., & Luo, J. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01185-2 · Cited by 33

A comprehensive review on signaling attributes of serine and serine metabolism in health and disease

Wu, D., Zhang, K., Khan, F. A., Pandupuspitasari, N. S., Guan, K., Sun, F., & Huang, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129607 · Cited by 35

Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders

Schiuma, G., Lara, D., Clement, J. P., Narducci, M., & Rizzo, R. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0375 · Cited by 34

Mitochondria: An overview of their origin, genome, architecture, and dynamics

Moura, J. P., Oliveira, P. J., & Urbano, A. M. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167803 · Cited by 45

Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning

He, L., Bao, J., Yang, Y., Dong, S., Zhang, L., Qi, Y., & Zhang, J. Z. H. (2019) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.9b00370 · Cited by 33

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2

Tramonti, A., Cuyàs, E., Encinar, J. A., Pietzke, M., Paone, A., Verdura, S., Arbusà, A., Martı́n-Castillo, B., Giardina, G., Joven, J., et al. (2021) · Cancers · doi:10.3390/cancers13164009 · Cited by 31

Mitochondrial metabolism in macrophages

Nassef, M. Z., Hanke, J. E., & Hiller, K. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00126.2021 · Cited by 32

Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

Piquereau, J., Boitard, S. E., Ventura‐Clapier, R., & Mericskay, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010030 · Cited by 32

Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID

Hayden, M. R., & Tyagi, S. (2021) · Medicina · doi:10.3390/medicina58010016 · Cited by 35

Recent Trends in Folic Acid (Vitamin B9) Encapsulation, Controlled Release, and Mathematical Modelling

Premjit, Y., Pandey, S., & Mitra, J. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2077361 · Cited by 33

Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

Mayneris‐Perxachs, J., Arnoriaga‐Rodríguez, M., Garre‐Olmo, J., Puig, J., Ramos, R., Trelis, M., Burokas, A., Coll, C., Zapata-Tona, C., Pedraza, S., et al. (2022) · The ISME Journal · doi:10.1038/s41396-022-01262-3 · Cited by 35

Isocoumarin derivatives from the endophytic fungus, Pestalotiopsis sp.

Song, R.-Y., Wang, X., Yin, G.-P., Liu, R., Kong, L., & Yang, M. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.08.012 · Cited by 33

Metabolic modulation of transcription: The role of one-carbon metabolism

Lin, J.-M. G., Kourtis, S., Ghose, R., Lorente, N. P., Kubicek, S., & Sdelci, S. (2022) · Cell chemical biology · doi:10.1016/j.chembiol.2022.11.009 · Cited by 36

Metabolomic biomarkers in liquid biopsy: accurate cancer diagnosis and prognosis monitoring

Wang, W., Zhen, S., Yu, P., Wang, L., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1331215 · Cited by 35

Biological, dietetic and pharmacological properties of vitamin B9

Siatka, T., Máťuš, M., Moravcová, M., Harčárová, P., Lomozová, Z., Matoušová, K., Suwanvecho, C., Krčmová, L. K., & Mladěnka, P. (2025) · npj Science of Food · doi:10.1038/s41538-025-00396-w · Cited by 44

Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH

Yu, X., Huang, C., Evers, M. J. W., Liu, J., Ting, H. J., Zhang, S., Chong, S. Y., Tan, M. S., Wang, S., Sayed, N., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx2681 · Cited by 35

The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release

Cao, H., Gao, M., Zhou, H., & Skolnick, J. (2018) · Communications Biology · doi:10.1038/s42003-018-0236-y · Cited by 32

Impact of Metabolic Pathways and Epigenetics on Neural Stem Cells

Fawal, M.-A., & Davy, A. (2018) · Epigenetics Insights · doi:10.1177/2516865718820946 · Cited by 31

Towards a Multivariate Biomarker-Based Diagnosis of Autism Spectrum Disorder: Review and Discussion of Recent Advancements

Vargason, T., Grivas, G., Hollowood-Jones, K., & Hahn, J. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100803 · Cited by 34

Stable COX17 Downregulation Leads to Alterations in Mitochondrial Ultrastructure, Decreased Copper Content and Impaired Cytochrome c Oxidase Biogenesis in HEK293 Cells

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Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

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