One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,727

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313

Activity-Based Sensing Methods for Monitoring the Reactive Carbon Species Carbon Monoxide and Formaldehyde in Living Systems

Ohata, J., Bruemmer, K. J., & Chang, C. J. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00386 · Cited by 135

Amino acids in the regulation of aging and aging-related diseases

Canfield, C.-A. E., & Bradshaw, P. C. (2019) · Translational Medicine of Aging · doi:10.1016/j.tma.2019.09.001 · Cited by 138

Regulation of and challenges in targeting NAD+ metabolism

Migaud, M. E., Ziegler, M., & Baur, J. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00752-w · Cited by 142

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks

Anderson, A. J., Jackson, T. D., Stroud, D. A., & Stojanovski, D. (2019) · Open Biology · doi:10.1098/rsob.190126 · Cited by 138

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

García‐Cañaveras, J. C., Lancho, O., Ducker, G. S., Ghergurovich, J. M., Xu, X., da Silva-Diz, V., Minuzzo, S. A., Indraccolo, S., Kim, H., Herranz, D., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0845-6 · Cited by 129

Role of mitochondria in liver metabolic health and diseases

Morio, B., Panthu, B., Bassot, A., & Rieusset, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102336 · Cited by 136

Reprogramming of serine, glycine and one-carbon metabolism in cancer

Li, A. M., & Ye, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165841 · Cited by 127

Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

Yang, C., Zhang, J., Liao, M., Yang, Y., Wang, Y., Yuan, Y., & Ouyang, L. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.006 · Cited by 126

Serine catabolism generates liver NADPH and supports hepatic lipogenesis

Zhang, Z., TeSlaa, T. A., Xu, X., Zeng, X., Yang, L., Xing, G., Tesz, G. J., Clasquin, M. F., & Rabinowitz, J. D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00487-4 · Cited by 130

Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid

Aparicio‐Trejo, O. E., Reyes-Fermín, L. M., Briones‐Herrera, A., Tapia, E., León‐Contreras, J. C., Hernández‐Pando, R., Sánchez‐Lozada, L. G., & Pedraza‐Chaverrí, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.005 · Cited by 125

Metabolomics and Lipidomics of Ischemic Stroke

Au, A. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.02.002 · Cited by 121

The complexity of the serine glycine one-carbon pathway in cancer

Reina‐Campos, M., Díaz-Meco, M. T., & Moscat, J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201907022 · Cited by 125

Calculation of ATP production rates using the Seahorse XF Analyzer

Desousa, B. R., Kim, K. K. O., Jones, A. E., Ball, A. B., Hsieh, W. Y., Swain, P. M., Morrow, D., Brownstein, A. J., Ferrick, D. A., Shirihai, O. S., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256380 · Cited by 135

Increased formate overflow is a hallmark of oxidative cancer

Meiser, J., Schuster, A. M., Pietzke, M., Voorde, J. V., Athineos, D., Oizel, K., Burgos-Barragan, G., Wit, N., Dhayade, S., Morton, J. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03777-w · Cited by 119

Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil

Montrose, D. C., Saha, S., Foronda, M., McNally, E. M., Chen, J. B., Zhou, X. K., Ha, T., Krumsiek, J., Büyüközkan, M., Verma, A., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1541 · Cited by 116

Folate metabolism: a re-emerging therapeutic target in haematological cancers

Zarou, M. M., Vázquez, A., & Helgason, G. V. (2021) · Leukemia · doi:10.1038/s41375-021-01189-2 · Cited by 120

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Mihajlovic, M., & Vinken, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063315 · Cited by 132

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Calvani, R., Picca, A., Marini, F., Biancolillo, A., Gervasoni, J., Persichilli, S., Primiano, A., Coelho‐Júnior, H. J., Bossola, M., Urbani, A., et al. (2018) · Nutrients · doi:10.3390/nu10111691 · Cited by 117

Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans

Mayneris‐Perxachs, J., Castells‐Nobau, A., Arnoriaga‐Rodríguez, M., Garre‐Olmo, J., Puig, J., Ramos, R., Martinez‐Hernández, F., Burokas, A., Coll, C., Moreno‐Navarrete, J. M., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.01.013 · Cited by 120

Cell cycle regulation of folate‐mediated one‐carbon metabolism

Lan, X., Field, M. S., & Stover, P. J. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1426 · Cited by 113

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Sullivan, M. R., Darnell, A. M., Reilly, M. F., Kunchok, T., Joesch-Cohen, L. M., Rosenberg, D. W., Ali, A., Rees, M. G., Roth, J. A., Lewis, C. A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00486-5 · Cited by 120

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

D’Alessandro, A., Kasmi, K. C. E., Plecitá‐Hlavatá, L., Ježek, P., Li, M., Zhang, H., Gupte, S. A., & Stenmark, K. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7217 · Cited by 111

Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis

Ling, H., Li, M., Yang, C., Sun, S., Zhang, W., Zhao, L., Xu, N., Zhang, J., Shen, Y., Zhang, X., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keac069 · Cited by 111

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Lionaki, E., Ploumi, C., & Tavernarakis, N. (2022) · Cells · doi:10.3390/cells11020214 · Cited by 110

Symposium review: One-carbon metabolism and methyl donor nutrition in the dairy cow

McFadden, J. W., Girard, C. L., Tao, S., Zhou, Z., Bernard, J. K., Duplessis, M., & White, H. M. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17319 · Cited by 109

l-Serine links metabolism with neurotransmission

Maugard, M., Vigneron, P.-A., Bolaños, J. P., & Bonvento, G. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101896 · Cited by 106

Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z., Park, E. J., Choi, J.-H., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3541 · Cited by 108

Beyond the Warburg effect: How do cancer cells regulate one-carbon metabolism?

Rosenzweig, A., Blenis, J., & Gomes, A. P. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00090 · Cited by 107

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention

Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110

More than a metabolic enzyme: MTHFD2 as a novel target for anticancer therapy?

Zhu, Z., & Leung, G. K. K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00658 · Cited by 106

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer

Li, K., Wu, J., Qin, B., Fan, Z.-M., Tang, Q., Lu, W., Zhang, H., Xing, F., Meng, M., Zou, S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0257-1 · Cited by 107

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Leung, K., Pai, Y. J., Chen, Q., Santos, C., Calvani, E., Sudiwala, S., Savery, D., Ralser, M., Gross, S. S., Copp, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.072 · Cited by 102

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Zheng, Y., Lin, T.-Y., Lee, G., Paddock, M. N., Momb, J., Cheng, Z., Li, Q., Fei, D. L., Stein, B. D., Ramsamooj, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.041 · Cited by 106

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

Kasai, S., Yamazaki, H., Tanji, K., Engler, M. J., Matsumiya, T., & Itoh, K. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-37 · Cited by 107

The nutritional requirements of Caenorhabditis elegans

Zečić, A., Dhondt, I., & Braeckman, B. P. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0637-7 · Cited by 111

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

Pranzini, E., Pardella, E., Muccillo, L., Leo, A., Nesi, I., Santi, A., Parri, M., Zhang, T., Uribe, A. H., Lottini, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111233 · Cited by 106

Regulatory mechanisms of one-carbon metabolism enzymes

Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105457 · Cited by 103

Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity

Bozack, A. K., Saxena, R., & Gamble, M. V. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051757 · Cited by 105

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

Mahajan, A., Sapehia, D., Thakur, S., Mohanraj, P. S., Bagga, R., & Kaur, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-54070-9 · Cited by 103

Distinct RNA N- demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates

Toh, J. D. W., Crossley, S. W. M., Bruemmer, K. J., Ge, E. J., He, D., Iovan, D. A., & Chang, C. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007349117 · Cited by 103

Critical role of the CD44 low CD62L low CD8 + T cell subset in restoring antitumor immunity in aged mice

Nakajima, Y., Chamoto, K., Oura, T., & Honjo, T. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103730118 · Cited by 103

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, N., Gustafsson, N., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S. R., Green, A. C., Vallin, K. S. A., Sarno, A., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00331-y · Cited by 104

Cancer Plasticity: The Role of mRNA Translation

Lee, L. J., Papadopoli, D. J., Jewer, M., Rincon, S. V. D., Topisirović, I., Lawrence, M. G., & Postovit, L.-M. M. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.09.005 · Cited by 104

Functional and Pathological Roles of AHCY

Vizán, P., Croce, L. D., & Aranda, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.654344 · Cited by 99

Inverse data-driven modeling and multiomics analysis reveals Phgdh as a metabolic checkpoint of macrophage polarization and proliferation

Wilson, J. L., Nägele, T., Linke, M., Demel, F., Fritsch, S. D., Mayr, H. K., Cai, Z., Katholnig, K., Sun, X., Fragner, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.011 · Cited by 97

Metabolic Footprints and Molecular Subtypes in Breast Cancer

Cappelletti, V., Iorio, E., Miodini, P., Silvestri, M., Dugo, M., & Daidone, M. G. (2017) · Disease Markers · doi:10.1155/2017/7687851 · Cited by 99

A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs

Liu, X., Mei, W., Padmanaban, V., Alwaseem, H., Molina, H., Passarelli, M. C., Tavora, B., & Tavazoie, S. F. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.008 · Cited by 99

Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer

Zeng, J., Wu, W. K. K., Wang, H., & Li, X. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104352 · Cited by 96

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 99

Metabolism and epigenetics at the heart of T cell function

Soriano‐Baguet, L., & Brenner, D. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.01.002 · Cited by 97

S-adenosyl- l -homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Greco, C. M., Cervantes, M., Fustin, J., Ito, K., Ceglia, N., Samad, M., Shi, J., Koronowski, K. B., Forné, I., Ranjit, S., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5629 · Cited by 95

Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side

Chao, J. R., Knight, K., Engel, A. L., Jankowski, C. S. R., Wang, Y., Manson, M. A., Gu, H., Djukovic, D., Raftery, D., Hurley, J. B., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.788422 · Cited by 93

The toxic side of one-carbon metabolism and epigenetics

Morellato, A. E., Umansky, C., & Pontel, L. B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101850 · Cited by 95

Epigenetic regulation of energy metabolism in obesity

Gao, W. Q., Liu, J.-L., Lü, X., & Yang, Q. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab043 · Cited by 100

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages

Sui, B., Ding, T., Wan, X., Chen, Y., Zhang, X., Cui, Y., Pan, J., Li, L., & Liu, X. (2024) · Exploration · doi:10.1002/exp.20230149 · Cited by 98

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Phelps, C. M., Willis, N. B., Duan, T., Lee, A. H., Zhang, Y., Rodriguez J, D. M., Pandey, S. P., Laughlin, C. R., Rosen, A. B. I., McPherson, A. C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.018 · Cited by 91

Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review

Ke, C., Pan, C., Zhang, Y., Zhu, X., & Zhang, Y. (2019) · Metabolomics · doi:10.1007/s11306-019-1615-1 · Cited by 91

Stool microRNA profiles reflect different dietary and gut microbiome patterns in healthy individuals

Tarallo, S., Ferrero, G., Filippis, F. D., Francavilla, A., Pasolli, E., Panero, V., Cordero, F., Segata, N., Grioni, S., Pensa, R. G., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325168 · Cited by 94

Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review

Fardous, A. M., & Heydari, A. R. (2023) · Nutrients · doi:10.3390/nu15214699 · Cited by 95

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Reich, S., Nguyen, C. D. L., Has, C., Steltgens, S., Soni, H., Coman, C., Freyberg, M., Bichler, A., Seifert, N., Conrad, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16747-y · Cited by 90

The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

Rossoni, A. W., Price, D. C., Seger, M., Lyska, D., Lammers, P. J., Bhattacharya, D., & Weber, A. P. M. (2019) · eLife · doi:10.7554/elife.45017 · Cited by 86

Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

Koju, N., Qin, Z., & Sheng, R. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00838-7 · Cited by 97

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

Haws, S. A., Yu, D., Ye, C., Wille, C. K., Nguyen, L. C., Krautkramer, K. A., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Liu, W. H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.004 · Cited by 94

Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

Szigeti, K. A., Kalmár, A., Galamb, O., Valcz, G., Barták, B. K., Nagy, Z. B., Zsigrai, S., Felletár, I., Patai, Á. V., Micsík, T., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-09659-1 · Cited by 89

Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics

Chicco, A. J., Le, C. H., Gnaiger, E., Dreyer, H. C., Muyskens, J. B., D’Alessandro, A., Nemkov, T. G., Hocker, A. D., Prenni, J. E., Wolfe, L. M., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000470 · Cited by 88

Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon

Gurwara, S., Ajami, N. J., Jang, A., Hessel, F. C., Chen, L., Plew, S., Wang, Z., Graham, D. Y., Hair, C. D., White, D. L., et al. (2019) · Nutrients · doi:10.3390/nu11030613 · Cited by 91

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Pramono, A. A., Rather, G. M., Herman, H., Lestari, K., & Bertino, J. R. (2020) · Biomolecules · doi:10.3390/biom10030358 · Cited by 88

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

Parkhitko, A. A., Filine, E., Mohr, S. E., Moskalev, A., & Perrimon, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101188 · Cited by 91

Recent trends in the application of nanoparticles in cancer therapy: The involvement of oxidative stress

Sanati, M., Afshari, A. R., Kesharwani, P., Sukhorukov, V. N., & Sahebkar, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.035 · Cited by 95

SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

Tête, A., Debizet, K., Imler, J., Tomkiewicz, C., Blanc, É., Barouki, R., Coumoul, X., & Bortoli, S. (2023) · Environment International · doi:10.1016/j.envint.2023.108219 · Cited by 95

Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism

Pham, V. N., Bruemmer, K. J., Toh, J. D. W., Ge, E. J., Tenney, L., Ward, C. C., Dingler, F. A., Millington, C. L., García-Prieto, C. A., Pulos-Holmes, M. C., et al. (2023) · Science · doi:10.1126/science.abp9201 · Cited by 88

The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure

Badolia, R., Ramadurai, D. K. A., Abel, E. D., Ferrin, P. C., Taleb, I., Shankar, T. S., Krokidi, A. T., Navankasattusas, S., McKellar, S. H., Yin, M. T., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044452 · Cited by 87

Mitochondrial Function in Muscle Stem Cell Fates

Bhattacharya, D., & Scimè, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00480 · Cited by 95

The Intersection of Purine and Mitochondrial Metabolism in Cancer

Vitto, H. D., Arachchige, D., Richardson, B. C., & French, J. B. (2021) · Cells · doi:10.3390/cells10102603 · Cited by 89

Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection

Bekdash, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032346 · Cited by 96

Targeting extracellular nutrient dependencies of cancer cells

García‐Bermúdez, J., Williams, R. T., Guarecuco, R., & Birsoy, K. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.011 · Cited by 93

Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

Li, F., Liu, P., Mi, W., Li, L., Anderson, N. M., Lesner, N. P., Burrows, M., Plesset, J. B., Majer, A. D., Wang, G., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00671-3 · Cited by 92

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

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