One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,727

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313

MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

Augert, A., Mathsyaraja, H., Ibrahim, A. H., Freie, B. W., Geuenich, M., Cheng, P.-F., Alibeckoff, S. P., Wu, N., Hiatt, J. B., Basom, R., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.04.016 · Cited by 80

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD–Driven Acute Myeloid Leukemia

Bjelosevic, S., Gruber, E., Newbold, A., Shembrey, C., Devlin, J. R., Hogg, S. J., Kats, L. M., Todorovski, I., Fan, Z., Abrehart, T. C., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0738 · Cited by 79

Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD

Ghrayeb, A., Finney, A. C., Agranovich, B., Peled, D., Anand, S. K., McKinney, M. P., Sarji, M., Yang, D., Weissman, N., Drucker, S., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.013 · Cited by 77

Predictive Metabolomic Signatures for Safety Assessment of Metal Oxide Nanoparticles

Cui, L., Wang, X., Sun, B., Xia, T., & Hu, S. (2019) · ACS Nano · doi:10.1021/acsnano.9b05793 · Cited by 76

The Purinosome: A Case Study for a Mammalian Metabolon

Pedley, A. M., Pareek, V., & Benkovic, S. J. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-105728 · Cited by 81

Methionine metabolism controls the B cell EBV epigenome and viral latency

Guo, R., Liang, J. H., Zhang, Y., Lutchenkov, M., Li, Z., Wang, Y., Trujillo-Alonso, V., Puri, R., Giulino-Roth, L. G., & Gewurz, B. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.008 · Cited by 76

Microplastics drive microbial assembly, their interactions, and metagenomic functions in two soils with distinct pH and heavy metal availability

Meng, J., Li, W., Diao, C., Li, Z., Zhao, J., Haider, G., Zhang, H., Xu, J., Hu, M., Shan, S., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131973 · Cited by 75

Sulfur metabolism and its contribution to malignancy

Ward, N. P., & DeNicola, G. M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.05.001 · Cited by 74

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Hernández-Baixauli, J., Quesada‐Vázquez, S., Mariné-Casadó, R., Cardoso, K. G., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Baselga‐Escudero, L. (2020) · Nutrients · doi:10.3390/nu12030806 · Cited by 74

The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

Xiu, Y., & Field, M. S. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa153 · Cited by 75

The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

Werge, M. P., McCann, A., Galsgaard, E. D., Holst, D., Bugge, A. K., Albrechtsen, N. J. W., & Gluud, L. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051081 · Cited by 78

Molecular features driving cellular complexity of human brain evolution

Caglayan, E., Ayhan, F., Liu, Y., Vollmer, R. M., Oh, E., Sherwood, C. C., Preuss, T. M., Yi, S. V., & Konopka, G. (2023) · Nature · doi:10.1038/s41586-023-06338-4 · Cited by 68

Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring

Skjærven, K. H., Jakt, L. M., Fernandes, J. M. O., Dahl, J. A., Adam, A., Klughammer, J., Bock, C., & Espe, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21211-5 · Cited by 78

Serine Supports IL-1β Production in Macrophages Through mTOR Signaling

Chen, S., Xia, Y., He, F., Fu, J., Xin, Z., Deng, B., He, L., Zhou, X., & Ren, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01866 · Cited by 73

SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer

Sniegowski, T., Korać, K., Bhutia, Y. D., & Ganapathy, V. (2021) · Pharmaceuticals · doi:10.3390/ph14030216 · Cited by 73

Methionine synthase supports tumour tetrahydrofolate pools

Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R.-P., Wang, L., & Rabinowitz, J. D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00465-w · Cited by 86

Mitochondrial metabolism in neural stem cells and implications for neurodevelopmental and neurodegenerative diseases

Garone, C., Giorgio, F. D., & Carli, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05041-w · Cited by 80

Signaling Pathways Regulating Redox Balance in Cancer Metabolism

Santis, M. C. D., Porporato, P. E., Martini, M., & Morandi, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00126 · Cited by 77

Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice

Feng, H., Zhang, S., Wan, J. M., Gui, L., Ruan, M., Li, N., Zhang, H., Liu, Z., & Wang, H. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.07.086 · Cited by 72

Network-based metabolic characterization of renal cell carcinoma

Pandey, N., Lanke, V., & Vinod, P. K. U. (2020) · Scientific Reports · doi:10.1038/s41598-020-62853-8 · Cited by 71

Mitochondrial dynamics in cancer stem cells

Sessions, D. T., & Kashatus, D. F. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03773-2 · Cited by 75

Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection

Fabbrizi, E., Fiorentino, F., Carafa, V., Altucci, L., Mai, A., & Rotili, D. (2023) · Cells · doi:10.3390/cells12060852 · Cited by 77

Dietary restriction of amino acids for Cancer therapy

Kang, J. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00439-x · Cited by 77

Large‐scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival

Vantaku, V., Donepudi, S. R., Piyarathna, D. W. B., Amara, C. S., Ambati, C. R., Tang, W., Putluri, V., Chandrashekar, D. S., Varambally, S., Terris, M. K., et al. (2019) · Cancer · doi:10.1002/cncr.31890 · Cited by 75

Deregulated transcription factors in cancer cell metabolisms and reprogramming

Kant, R., Manne, R., Anas, M., Penugurti, V., Chen, T., Pan, B., Hsu, C.-C., & Lin, H. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.10.001 · Cited by 76

Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?

Krautkramer, K. A., Rey, F. E., & Denu, J. M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.761577 · Cited by 70

Metabolomic profiling of human lung tumor tissues – nucleotide metabolism as a candidate for therapeutic interventions and biomarkers

Moreno, P., Jiménez‐Jiménez, C., Garrido‐Rodríguez, M., Calderón-Santiago, M., Molina, S., Lara‐Chica, M., Priego‐Capote, F., Salvatierra, Á., Muñóz, E., & Calzado, M. A. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12369 · Cited by 71

Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid

Aparicio‐Trejo, O. E., Avila-Rojas, S. H., Tapia, E., Rojas‐Morales, P., León‐Contreras, J. C., Martínez‐Klimova, E., Hernández‐Pando, R., Sánchez‐Lozada, L. G., & Pedraza‐Chaverrí, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.016 · Cited by 70

Alterations in Gastric Microbial Communities Are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study

Gunathilake, M. N., Lee, J., Choi, I. J., Kim, Y., Kim, J., Yoon, J. K., Sul, W. J., & Kim, J. (2020) · Cancers · doi:10.3390/cancers12092619 · Cited by 73

Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential

Zhao, L. N., Björklund, M., Caldez, M. J., Zheng, J., & Kaldis, P. (2021) · Oncogene · doi:10.1038/s41388-021-01695-8 · Cited by 70

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy

Perea‐Gil, I., Seeger, T., Bruyneel, A. A. N., Termglinchan, V., Monte, E., Lim, E. W., Vadgama, N., Furihata, T., Gavidia, A. A., Ataam, J. A., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac305 · Cited by 71

Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

Giese, G. E., Walker, M. D., Ponomarova, O., Zhang, H., Li, X., Minevich, G., & Walhout, A. J. M. (2020) · eLife · doi:10.7554/elife.60259 · Cited by 69

Role of tyrosine phosphorylation in modulating cancer cell metabolism

Taddei, M. L., Pardella, E., Pranzini, E., Raugei, G., & Paoli, P. D. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188442 · Cited by 70

Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5

Fiorentino, F., Castiello, C., Mai, A., & Rotili, D. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00687 · Cited by 70

Metabolic adaptations in prostate cancer

Pujana-Vaquerizo, M., Bozal‐Basterra, L., & Carracedo, A. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02762-z · Cited by 73

Bacterial folate biosynthesis and colorectal cancer risk: more than just a gut feeling

Kok, D. E. G., Steegenga, W. T., Smid, E. J., Zoetendal, E. G., Ulrich, C. M., & Kampman, E. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1522499 · Cited by 70

Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis

Dong, W., Keibler, M. A., & Stephanopoulos, G. N. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.02.002 · Cited by 69

Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells

Lucas, S., Chen, G., Aras, S., & Wang, J. (2018) · Life Science Alliance · doi:10.26508/lsa.201800036 · Cited by 65

Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

Desplats, P., Gutierrez, A. M., Antonelli, M. C., & Frasch, M. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.013 · Cited by 74

Sources and Sinks of Serine in Nutrition, Health, and Disease

Handzlik, M. K., & Metallo, C. M. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061021-022648 · Cited by 75

Metabolomic Profiling of Human Spermatozoa in Idiopathic Asthenozoospermia Patients Using Gas Chromatography-Mass Spectrometry

Zhao, K., Zhang, J., Xu, Z., Xu, Y., Xu, A., Chen, W., Miao, C., Liu, S., Wang, Z., & Jia, R. (2018) · BioMed Research International · doi:10.1155/2018/8327506 · Cited by 67

Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

Lee, W. D., Pirona, A. C., Sarvin, B. A., Stern, A., Nevo‐Dinur, K., Besser, E., Sarvin, N., Lagziel, S., Mukha, D., Raz, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.002 · Cited by 67

Glycine homeostasis requires reverse SHMT flux

McBride, M. J., Hunter, C. J., Zhang, Z., TeSlaa, T. A., Xu, X., Ducker, G. S., & Rabinowitz, J. D. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.001 · Cited by 71

A reliable LC-MS/MS method for the quantification of natural amino acids in mouse plasma: Method validation and application to a study on amino acid dynamics during hepatocellular carcinoma progression

Liu, Z., Tu, M., Zhang, C., Jilek, J. L., Zhang, Q.-Y., & Yu, A. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2019.05.039 · Cited by 67

Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins

Janssen, J. J. E., Grefte, S., Keijer, J., & de Boer, V. C. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00078 · Cited by 70

Structural basis of antifolate recognition and transport by PCFT

Parker, J. L., Deme, J. C., Kuteyi, G., Wu, Z., Huo, J., Goldman, I. D., Owens, R. J., Biggin, P. C., Lea, S. M., & Newstead, S. L. (2021) · Nature · doi:10.1038/s41586-021-03579-z · Cited by 66

Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

Zheng, Y., Le, Z., Qin, Z., Guo, Y., Wang, S., Xue, M., Shen, K.-Y., Hu, B., Wang, X., Wang, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112666 · Cited by 67

Cellular and organismal function of choline metabolism

Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 71

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Shin, M., Momb, J., & Appling, D. R. (2017) · Cancer & Metabolism · doi:10.1186/s40170-017-0173-0 · Cited by 66

An evolutionarily conserved C4HC3-type E3 ligase regulates plant broad-spectrum resistance against pathogens

Fu, S., Wang, K., Ma, T., Liang, Y., Ma, Z., Wu, J., Xu, Y., & Zhou, X. (2022) · The Plant Cell · doi:10.1093/plcell/koac055 · Cited by 65

Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration

Sobral, A. F., Cunha, A., Silva, V., Gil-Martins, E., Silva, R. V. D. S., & Barbosa, D. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179339 · Cited by 75

Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1

Lin, K., Wei, L., Wang, R., Li, L., Song, S., Wang, F., He, M., Pu, W., Wang, J., Wazir, J., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.017 · Cited by 65

A bacterial route for folic acid supplementation

Maynard, C., Cummins, I., Green, J. M., & Weinkove, D. (2018) · BMC Biology · doi:10.1186/s12915-018-0534-3 · Cited by 64

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Miousse, I. R., Pathak, R., Garg, S., Skinner, C. M., Melnyk, S., Pavliv, O., Hendrickson, H. P., Landes, R. D., Lumen, A., Tackett, A. J., et al. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0576-0 · Cited by 64

Taxonomic and Functional Differences in Cervical Microbiome Associated with Cervical Cancer Development

Tango, C. N., Seo, S., Kwon, M., Lee, D.-O., Chang, H. K., & Kim, M. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-66607-4 · Cited by 64

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation

Albrecht, L. V., Bui, M. H., & Robertis, E. M. D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820161116 · Cited by 63

DNA methylation defects in spermatozoa of male partners from couples experiencing recurrent pregnancy loss

Khambata, K., Raut, S., Deshpande, S., Mohan, S., Sonawane, S., Gaonkar, R., Ansari, Z., Datar, M., Bansal, V., Patil, A. D., et al. (2020) · Human Reproduction · doi:10.1093/humrep/deaa278 · Cited by 63

The crosstalk between metabolism and translation

Biffo, S., Ruggero, D., & Santoro, M. M. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.022 · Cited by 66

Formate rescues neural tube defects caused by mutations in Slc25a32

Kim, J., Lei, Y., Guo, J., Kim, S., Wlodarczyk, B. J., Cabrera, R. M., Lin, Y. L., Nilsson, T., Zhang, T., Ren, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800138115 · Cited by 63

Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota

Hu, J., Lesseur, C., Yu, M., Manservisi, F., Panzacchi, S., Mandrioli, D., Belpoggi, F., Chen, J., & Petrick, L. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-82552-2 · Cited by 59

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis

Zeng, Y., Zhang, J., Xu, M., Chen, F., Zi, R., Yue, J., Zhang, Y., Chen, N., & Chin, Y. E. (2021) · Journal of Cancer · doi:10.7150/jca.60170 · Cited by 62

The Warburg effect on radioresistance: Survival beyond growth

Kang, H., Kim, B., Park, J., Youn, H., & Youn, B. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188988 · Cited by 67

Glioma cells require one-carbon metabolism to survive glutamine starvation

Tanaka, K., Sasayama, T., Nagashima, H., Irino, Y., Takahashi, M., Izumi, Y., Uno, T., Satoh, N., Kitta, A., Kyotani, K., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01114-1 · Cited by 59

The Role of Amino Acids in Endothelial Biology and Function

Li, M., Wu, Y., & Ye, L. (2022) · Cells · doi:10.3390/cells11081372 · Cited by 65

Cycling back to folate metabolism in cancer

Lee, Y., Vousden, K. H., & Hennequart, M. (2024) · Nature Cancer · doi:10.1038/s43018-024-00739-8 · Cited by 68

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

Padrón-Barthe, L., Villalba‐Orero, M., Gómez-Salinero, J. M., Acín‐Pérez, R., Cogliati, S., López-Olañeta, M. M., Ortiz-Sánchez, P., Bonzón‐Kulichenko, E., Vázquez, J., García‐Pavía, P., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.067 · Cited by 59

Personalized Nutrition: Translating the Science of NutriGenomics Into Practice: Proceedings From the 2018 American College of Nutrition Meeting

Aruoma, O. I., Hausman-Cohen, S., Pizano, J. M., Schmidt, M. A., Minich, D. M., Joffe, Y. T., Brandhorst, S., Evans, S. J., & Brady, D. M. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1582980 · Cited by 61

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

Wan, X., Wang, C., Huang, Z., Zhou, D., Xiang, S., Qi, Q., Chen, X., Arbely, E., Liu, C.-Y., Du, P., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-02825-y · Cited by 60

Formate Induces a Metabolic Switch in Nucleotide and Energy Metabolism

Oizel, K., Tait-Mulder, J., Fernández-de-Cossio-Díaz, J., Pietzke, M., Brunton, H., Lilla, S., Dhayade, S., Athineos, D., Blanco, G. R., Sumpton, D. P., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-020-2523-z · Cited by 57

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Grilo, L. F., Tocantins, C., Diniz, M. S., Gomes, R. M., Oliveira, P. J., Matafome, P. N., & Pereira, S. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13625 · Cited by 67

Cytosolic and mitochondrial NADPH fluxes are independently regulated

Niu, X., Stancliffe, E., Gelman, S. J., Wang, L., Schwaiger-Haber, M., Rowles, J. L., Shriver, L. P., & Patti, G. J. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01283-9 · Cited by 59

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Rowe, J. H., Elia, I., Shahid, O., Gaudiano, E. F., Sifnugel, N. E., Johnson, S., Reynolds, A. G., Fung, M. E., Joshi, S., LaFleur, M. W., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1301 · Cited by 59

The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells

Tanabe, A., & Sahara, H. (2020) · Cancers · doi:10.3390/cancers12102780 · Cited by 61

Facile preparation of an electrochemical aptasensor based on Au NPs/graphene sponge for detection of homocysteine

Wen, X., Zhao, X., Peng, B.-F., Yuan, K., Li, X., Zhu, L., & Lü, H.-L. (2021) · Applied Surface Science · doi:10.1016/j.apsusc.2021.149735 · Cited by 59

The serine–glycine–one-carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development

Rosa‐Téllez, S., Alcántara‐Enguídanos, A., Martínez-Seidel, F., Casatejada‐Anchel, R., Saeheng, S., Bailes, C., Erban, A., Medeiros, D. B., Alepuz, P. M., Matus, J. T., et al. (2023) · The Plant Cell · doi:10.1093/plcell/koad256 · Cited by 61

Novel Pyrrolo[3,2- d ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

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Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin

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