One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,727

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313

Association of serum folate with prevalence of non-alcoholic fatty liver disease among adults (NHANES 2011–2018)

Yao, B., Lu, X., Xu, L., & Jiang, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1141156 · Cited by 20

Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency

Azad, F. M., Struys, E. A., Wingert, V., Hannibal, L., Mills, K., Jansen, J. H., Longley, D. B., Stunnenberg, H. G., & Atlasi, Y. (2023) · Science Advances · doi:10.1126/sciadv.adg7997 · Cited by 20

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

Novák, L., Treitli, S. C., Pyrih, J., Hałakuc, P., Pipaliya, S. V., Vacek, V., Brzoň, O., Soukal, P., Eme, L., Dacks, J. B., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1011050 · Cited by 19

A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool

Tenney, L., Pham, V. N., Brewer, T. F., & Chang, C. J. (2024) · Chemical Science · doi:10.1039/d4sc01183j · Cited by 20

Robotic automation of a UHPLC/MS-MS method profiling one-carbon metabolites, amino acids, and precursors in plasma

Andraos, S., Goy, M., Albert, B. B., Kussmann, M., Thorstensen, E. B., & O'Sullivan, J. M. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2019.113558 · Cited by 20

Epigenetic memory: gene writer, eraser and homocysteine

Tyagi, S. C., Stanišić, D., & Singh, M. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03895-4 · Cited by 20

Targeting the Metabolic Adaptation of Metastatic Cancer

Tarragó‐Celada, J., & Cascante, M. (2021) · Cancers · doi:10.3390/cancers13071641 · Cited by 19

Systems‐level transcriptional regulation of Caenorhabditis elegans metabolism

Nanda, S., Jacques, M., Wang, W., Myers, C. L., Yilmaz, L. S., & Walhout, A. J. M. (2023) · Molecular Systems Biology · doi:10.15252/msb.202211443 · Cited by 17

Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase

Stadhouders, L. E. M., Smith, J. A. B., Gabriel, B. M., Verbrugge, S. A. J., Hammersen, T. D., Kolijn, D., Vogel, I. S. P., Mohamed, A. D., de Wit, G. M. J., Offringa, C., et al. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113820 · Cited by 19

FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction

Chen, Z., Xu, J., Fang, K., Jiang, H., Leng, Z., Wu, H., Zhang, Z., Wang, Z., Li, Z., Sun, M., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02016-8 · Cited by 20

Microbial contribution to metabolic niche formation varies across the respiratory tract

Wong, K. K., Wu, B. G., Chung, M. C., Li, Q., Darawshy, F., Tsay, J.-C. J., Holub, M., Barnett, C. R., Kwok, B., Kugler, M. C., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.06.002 · Cited by 21

The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance

de Souza, A. P., Marinho, V., & Marques, M. R. (2025) · Epigenomes · doi:10.3390/epigenomes9030023 · Cited by 21

Low protein diet and methyl-donor supplements modify testicular physiology in mice

Morgan, H. L., Ampong, I., Eid, N. S., Rouillon, C., Griffiths, H. R., & Watkins, A. J. (2020) · Reproduction · doi:10.1530/rep-19-0435 · Cited by 26

Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice

Uebanso, T., Yoshimoto, A., Aizawa, S., Nakamura, M., Masuda, R., Shimohata, T., Mawatari, K., & Takahashi, A. (2020) · Nutrients · doi:10.3390/nu12030736 · Cited by 22

Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells

Rizzo, A., Satta, A., Garrone, G., Cavalleri, A., Napoli, A., Raspagliesi, F., Figini, M., Cecco, L. D., Iorio, E., Tomassetti, A., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01794-6 · Cited by 19

ARDS metabolic fingerprints: characterization, benchmarking, and potential mechanistic interpretation

Metwaly, S., Côté, A., Donnelly, S. J., Banoei, M. M., Lee, C. H., Andonegui, G., Yipp, B. G., Vogel, H. J., Fiehn, O., & Winston, B. W. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00077.2021 · Cited by 19

Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

Monti, M. M., Guiducci, G., Paone, A., Rinaldo, S., Giardina, G., Liberati, F. R., Cutruzzolà, F., & Tartaglia, G. G. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.05.019 · Cited by 20

Folic Acid-Coated Nanochitosan Ameliorated the Growth Performance, Hematological Parameters, Antioxidant Status, and Immune Responses of Rainbow Trout (Oncorhynchus mykiss)

Roudsari, S. F., Islami, H. R., Mousavi, S. A., & Mehrgan, M. S. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.647722 · Cited by 19

Brain on food: The neuroepigenetics of nutrition

Vaziri, A., & Dus, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105099 · Cited by 24

Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer

Glenny, E. M., Coleman, M. F., Giles, E. D., Wellberg, E. A., & Hursting, S. D. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120420-032437 · Cited by 18

Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts

Okada, M., Suzuki, S., Togashi, K., Sugai, A., Yamamoto, M., & Kitanaka, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111633 · Cited by 19

Blue Light Alters the Composition of the Jejunal Microbiota and Promotes the Development of the Small Intestine by Reducing Oxidative Stress

Zhang, Y., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2022) · Antioxidants · doi:10.3390/antiox11020274 · Cited by 19

Imbalances in TCA, Short Fatty Acids and One-Carbon Metabolisms as Important Features of Homeostatic Disruption Evidenced by a Multi-Omics Integrative Approach of LPS-Induced Chronic Inflammation in Male Wistar Rats

Hernández-Baixauli, J., Abasolo-Zabalo, N., Palacios-Jordan, H., Foguet‐Romero, E., Suñol, D., Galofré, M., Caimari, A., Baselga‐Escudero, L., Bas-Prior, J. M. D., & Mulero, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052563 · Cited by 19

Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk

Gu, I., Gregory, E., Atwood, C., Lee, S., & Song, Y. H. (2022) · Nutrients · doi:10.3390/nu14091722 · Cited by 20

The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance

Jersin, R. Å., Jonassen, L. R., & Dankel, S. N. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.974338 · Cited by 19

Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid in maternal plasma: a randomised trial of pregnant women in Canada

Cochrane, K. M., Elango, R., Devlin, A. M., Mayer, C., Hutcheon, J. A., & Karakochuk, C. D. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001733 · Cited by 19

Flavin‐containing monooxygenase (FMO): Beyond xenobiotics

Bhat, A., Carranza, F. R., Tuckowski, A. M., & Leiser, S. F. (2024) · BioEssays · doi:10.1002/bies.202400029 · Cited by 21

Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology

Sharma, S. A., Oladejo, S. O., & Kuang, Z. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.04.016 · Cited by 19

Targeting purine metabolism-related enzymes for therapeutic intervention: A review from molecular mechanism to therapeutic breakthrough

Wu, D., Yang, S., Yuan, C., Zhang, K., Tan, J., Guan, K., Zeng, H., & Huang, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136828 · Cited by 21

Urinary Metabolomics around Parturition Identifies Metabolite Alterations in Dairy Cows Affected Postpartum by Lameness: Preliminary Study

Zhang, G., Dervishi, E., Zwierzchowski, G., Mandal, R., Wishart, D. S., & Ametaj, B. N. (2020) · Dairy · doi:10.3390/dairy1010002 · Cited by 19

Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity

Farris, J. D., Calhoun, B., Alam†, M. S., Lee, S. W., & Haldar, K. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007871 · Cited by 19

Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer

Colloca, A., Balestrieri, A., Anastasio, C., Balestrieri, M. L., & D’Onofrio, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063212 · Cited by 19

Exploiting metabolic vulnerabilities in cancer: From mechanisms to therapeutic opportunities

Xue, Z.-R., Xin, Y.-Y., & Jin, W. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218067 · Cited by 21

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

Nengroo, M. A., Klein, A. T., Carr, H. S., Vidal-Cruchez, O., Sahu, U., McGrail, D. J., Sahni, N., Thompson, N. B., Faull, P. A., Gao, P., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.10.002 · Cited by 20

Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

Papadopoli, D. J., Ma, E. H., Roy, D. G., Russo, M. D. S. T., Bridon, G., Avizonis, D. Z., Jones, R. G., & St‐Pierre, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-64460-z · Cited by 20

A Metabolomics Analysis of Circulating Carotenoids and Breast Cancer Risk

Peng, C., Zeleznik, O. A., Shutta, K. H., ROSNER, B. A., Kraft, P., Clish, C. B., Stampfer, M. J., Willett, W. C., Tamimi, R. M., & Eliassen, A. H. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0837 · Cited by 18

Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress

Gansemer, E. R., & Rutkowski, D. T. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.858142 · Cited by 20

Knockdown of MTHFD2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through the ERK signaling pathway

Wu, S., Cai, W., Shi, Z., Ming, X., Yang, X., Zhou, Y., Chen, X., & Yang, M. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.05.007 · Cited by 18

Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

McGinnis, C. D., Jennings, E. Q., Harris, P. S., Galligan, J. J., & Fritz, K. S. (2022) · Cells · doi:10.3390/cells11132045 · Cited by 18

Metabolomics and integrated network pharmacology analysis reveal that ginkgolides act as potential active anticancer components by regulating one-carbon metabolism

Zhou, J., Qian, M., Li, C., Zhou, W., Yao, L., Chen, Y., & Abliz, Z. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115609 · Cited by 18

SHMT2 Induces Stemness and Progression of Head and Neck Cancer

Jin, Y., Jung, S., Lim, M. A., Oh, C., Piao, Y., Kim, H. J., Nguyena, Q., Kang, Y. E., Chang, J. W., Won, H.-R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179714 · Cited by 18

Biocatalytic One-Carbon Transfer – A Review

Müller, M., Germer, P., & Andexer, J. N. (2022) · Synthesis · doi:10.1055/s-0040-1719884 · Cited by 17

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

Godbole, A. A., Gopalan, S., Nguyen, T.-K., Munden, A. L., Lui, D. S., Fanelli, M. J., Vo, P., Lewis, C. A., Spinelli, J. B., Fazzio, T. G., et al. (2023) · eLife · doi:10.7554/elife.79511 · Cited by 16

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer

Bassal, M. A. (2023) · Biomolecules · doi:10.3390/biom13060944 · Cited by 19

HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression

Yang, Y., Zhang, M., Zhao, Y., Deng, T., Zhou, X. Y., Qian, H., Wang, M., Zhang, C., Huo, Z., Mao, Z., et al. (2023) · Cancer Science · doi:10.1111/cas.15982 · Cited by 19

Mitochondrial metabolism as a dynamic regulatory hub to malignant transformation and anti-cancer drug resistance

Tomar, M. S., Kumar, A., & Shrivastava, A. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149382 · Cited by 20

Nitrous oxide abuse direct measurement for diagnosis and follow-up: update on kinetics and impact on metabolic pathways

Lucas, A., Noyce, A. J., Gernez, É., El-Khoury, J. M., Garçon, G., Cavalier, E., Anthérieu, S., & Grzych, G. (2024) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-1252 · Cited by 18

The central role of mitochondrial metabolism in hepatic steatosis

Win, S., Than, T. A., Kaplowitz, N., Wong, N., Arya, A., Win, Z. T., Win, S. H., Phyu, E., Kuemerle, C., Suh, J., et al. (2024) · Exploration of Digestive Diseases · doi:10.37349/edd.2024.00039 · Cited by 18

A Transfer Hydrogenation Approach to Activity-Based Sensing of Formate in Living Cells

Crossley, S. W. M., Tenney, L., Pham, V. N., Xie, X., Zhao, M., & Chang, C. J. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c09735 · Cited by 17

Perspectives on folate with special reference to epigenetics and neural tube defects

Gurugubelli, K. R., & Ballambattu, V. B. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108576 · Cited by 23

A defined diet for pre-adult Drosophila melanogaster

Martelli, F., Quig, A., Mele, S., Lin, J., Fulton, T. L., Wansbrough, M., Barlow, C. K., Schittenhelm, R. B., Johnson, T. K., & Piper, M. D. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-57681-z · Cited by 18

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models

Ruszkowski, M., Sekula, B., Ruszkowska, A., Contestabile, R., Nogués, I., Angelaccio, S., Szczepaniak, A., & Dauter, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-56043-4 · Cited by 23

Responses of a Newly Evolved Auxotroph of Chlamydomonas to B 12 Deprivation

Bunbury, F., Helliwell, K. E., Mehrshahi, P., Davey, M. P., Salmon, D. L., Holzer, A., Smirnoff, N., & Smith, A. G. (2020) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.01375 · Cited by 18

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice

Sowton, A. P., Padmanabhan, N., Tunster, S. J., McNally, B. D., Murgia, A., Yusuf, A., Griffin, J. L., Murray, A. J., & Watson, E. D. (2020) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2020.100580 · Cited by 18

Folate pathways mediating the effects of ethanol in tumorigenesis

Sharma, J., & Krupenko, S. A. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109091 · Cited by 18

Expression Changes in Epigenetic Gene Pathways Associated With One‐Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non‐Typical Neurodevelopment

Zhu, Y., Mordaunt, C. E., Durbin-Johnson, B. P., Caudill, M. A., Malysheva, O., Miller, J. W., Green, R., James, S. J., Melnyk, S. B., Fallin, M. D., et al. (2020) · Autism Research · doi:10.1002/aur.2428 · Cited by 22

Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines

Kiss, E., Forika, G., Mohácsi, R., Németh, Z., Krenács, T., & Dank, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073598 · Cited by 18

Gene Expression Profiling of Tricarboxylic Acid Cycle and One Carbon Metabolism Related Genes for Prognostic Risk Signature of Colon Carcinoma

Zhang, Z., Zhu, H., Li, Q., Gao, W., Zang, D., Su, W., Yang, R., & Zhong, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.647152 · Cited by 18

Research progress and perspective in metabolism and metabolomics of psoriasis

Lian, N., Shi, L., Hao, Z., & Chen, M. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001242 · Cited by 18

Nutritional vitamin B12 regulates RAS/MAPK-mediated cell fate decisions through one-carbon metabolism

Laranjeira, A. C., Berger, S., Kohlbrenner, T., Greter, N. R., & Hajnal, A. (2024) · Nature Communications · doi:10.1038/s41467-024-52556-3 · Cited by 19

Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases

Zhang, M., Wei, J., He, C., Sui, L., Jiao, C., Zhu, X., & Pan, X. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00669-4 · Cited by 20

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification

Mao, Z., Liú, W., Zou, R., Sun, L., Huang, S., Wu, L., Chen, L., Wu, J., Lu, S., Song, Z., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02157-3 · Cited by 19

Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

Meliton, A. Y., Shin, K. W. D., Çetin-Atalay, R., Atalay, V., Tian, Y., Szafran, J. C. H., Cho, T., Sun, K. A., Woods, P. S., Shamaa, O. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64320-2 · Cited by 18

Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure

Jawaid, S., Strainic, J. P., Kim, J., Ford, M. R., Thrane, L., Karunamuni, G. H., Sheehan, M. M., Chowdhury, A., Gillespie, C. A., Rollins, A. M., et al. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14511 · Cited by 17

Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease

Rosenberger, F. A., Tang, J. X., Sergeant, K., Moedas, M. F., Zierz, C. M., Moore, D., Smith, C., Lewis, D., Guha, N., Hopton, S., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac002 · Cited by 17

Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia

Montanaro, A., Kitara, S., Cerretani, E., Marchesini, M., Rompietti, C., Pagliaro, L., Gherli, A., Su, A. H., Minchillo, M. L., Caputi, M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05002-5 · Cited by 17

Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism

Peng, M.-Z., Shao, Y., Li, X., Zhang, K., Cai, Y.-N., Lin, Y., Jiang, M., Liu, Z., Su, X., Zhang, W., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04404-0 · Cited by 17

Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine

Haws, S. A., Miller, L. J., Luz, D. R. L., Kuznetsov, V. I., Trievel, R. C., Crăciun, G., & Denu, J. M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104938 · Cited by 17

Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil

Li, C., Teng, P., Sun, S., Cui, K., Yao, S., Fei, B., Ling, F., & Huang, Z. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105090 · Cited by 17

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Nayeen, M. J., Katinas, J. M., Magdum, T., Shah, K., Wong-Roushar, J., O’Connor, C. E., Fifer, A. N., Wallace-Povirk, A., Hou, Z., Matherly, L. H., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00763 · Cited by 17

Molecular pathways and nutrigenomic review of insulin resistance development in gestational diabetes mellitus

Guevara‐Ramírez, P., Paz‐Cruz, E., Cadena-Ullauri, S., Ruiz‐Pozo, V. A., Tamayo‐Trujillo, R., Felix, M. L., Simancas‐Racines, D., & Zambrano, A. K. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1228703 · Cited by 21

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis

Maynard, A. G., Pohl, N. K., Mueller, A., Petrova, B., Wong, A. Y. L., Wang, P., Culhane, A. J., Brook, J. R., Hirsch, L. M., Hoang, N., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj9479 · Cited by 17

Quiescence enables unrestricted cell fate in naive embryonic stem cells

Khoa, L. T. P., Yang, W., Shan, M., Zhang, L., Mao, F., Zhou, B. O., Li, Q., Malcore, R. M., Harris, C. E., Zhao, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46121-1 · Cited by 17

Choline metabolism reprogramming mediates an immunosuppressive microenvironment in non-small cell lung cancer (NSCLC) by promoting tumor-associated macrophage functional polarization and endothelial cell proliferation

Xiao, B., Li, G., Gulizeba, H., Liu, H., Sima, X., Zhou, T., & Huang, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05242-3 · Cited by 19

Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease

Yu, Y., & Martins, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126302 · Cited by 18

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

Flickinger, K. M., Wilson, K. M., Rossiter, N. J., Hunger, A. L., Vishwasrao, P., Lee, T. D., Fritz, C. M., Richards, R. M., Hall, M. D., & Cantor, J. R. (2024) · Science Advances · doi:10.1126/sciadv.adq3591 · Cited by 18

Weanling Offspring of Dams Maintained on Serine‐Deficient Diet Are Vulnerable to Oxidative Stress

He, L., Zhang, H., & Zhou, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8026496 · Cited by 17

Differential Responses to Dietary Protein and Carbohydrate Ratio on Gut Microbiome in Obese vs. Lean Cats

Li, Q., & Pan, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.591462 · Cited by 21

Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows

Palombo, V., Alharthi, A. S., Batistel, F., Parys, C., Guyader, J., Trevisi, E., D’Andrea, M., & Loor, J. J. (2021) · BMC Genomics · doi:10.1186/s12864-021-07538-w · Cited by 16

Folate dose and form during pregnancy may program maternal and fetal health and disease risk

Pannia, E., Hammoud, R., Simonian, R., Kubant, R., & Anderson, G. H. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac025 · Cited by 17

Metabolomic signatures associated with cold adaptation and seasonal acclimation of Drosophila : profiling of 43 species

Moos, M., Overgaard, J., Hůla, P., Byrge, C. G., Šmilauer, P., Nedvěd, O., & Košťál, V. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.250076 · Cited by 15

One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999–2002

Bozack, A. K., Khodasevich, D., Nwanaji‐Enwerem, J. C., Gladish, N., Shen, H., Daredia, S., Gamble, M. V., Needham, B. L., Rehkopf, D. H., & Cárdenas, A. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.05.029 · Cited by 17

Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes

Li, X., Yang, J., Pu, Q., Peng, X., Xu, L., & Liu, S. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3714-2 · Cited by 16

Tying the knot in the tetrahydrofolate (THF) riboswitch: A molecular basis for gene regulation

Wilt, H. M., Yu, P., Tan, K., Wang, Y., & Stagno, J. R. (2021) · Journal of Structural Biology · doi:10.1016/j.jsb.2021.107703 · Cited by 16

A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

Lee, J., Chen, X., Wang, Y., Nishimura, T., Li, M., Ishikawa, S., Daikoku, T., Kawai, J., Tojo, A., & Gotoh, N. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.11.001 · Cited by 16

Cluster analysis and profiling of airway fluid metabolites in pediatric acute hypoxemic respiratory failure

Grunwell, J. R., Rad, M. G., Stephenson, S. T., Mohammad, A. F., Opolka, C., Fitzpatrick, A. M., & Kamaleswaran, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-02354-4 · Cited by 15

Earlier or delayed seasonal broodstock spawning changes nutritional status and metabolic programming of growth for next-generation Atlantic salmon

Skjærven, K. H., Mommens, M., Adam, A., Saito, T., Oveland, E., & Espe, M. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738187 · Cited by 17

A Dietary Antioxidant Formulation Ameliorates DNA Damage Caused by γ-Irradiation in Normal Human Bronchial Epithelial Cells In Vitro

Merlin, J. P. J., Mathavarajah, S., Dellaire, G., Murphy, K., & Rupasinghe, H. P. V. (2022) · Antioxidants · doi:10.3390/antiox11071407 · Cited by 16

Toxicoepigenetics and Environmental Health: Challenges and Opportunities

Svoboda, L. K., Perera, B. P. U., Morgan, R. K., Polemi, K. M., Pan, J., & Dolinoy, D. C. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00445 · Cited by 17

para -Aminobenzoic Acid Biosynthesis Is Required for Listeria monocytogenes Growth and Pathogenesis

Zhang, Y., Anaya-Sanchez, A., & Portnoy, D. A. (2022) · Infection and Immunity · doi:10.1128/iai.00207-22 · Cited by 20

Periconceptional biomarkers for maternal obesity: a systematic review

Hojeij, B., Rousian, M., Sinclair, K. D., Dinnyés, A., Steegers‐Theunissen, R. P. M., & Schoenmakers, S. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09762-5 · Cited by 17

The associations of dietary folate and serum folate with lipid profiles: findings from the national health and nutrition examination survey 2011–2016

Feng, Y., Chen, X., Pan, Y., & Yang, Y. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01793-4 · Cited by 16

Concentrations of vitamin B12 and folate in maternal serum and fetal fluids, metabolite interrelationships, and hepatic transcript abundance of key folate and methionine cycle genes: the impacts of maternal nutrition during the first 50 d of gestation

Syring, J. G., Crouse, M. S., Neville, T. L. L., Ward, A. K. K., Dahlen, C. R., Reynolds, L. P., Borowicz, P. P. P., McLean, K. J., Neville, B. W., & Caton, J. S. S. (2023) · Journal of Animal Science · doi:10.1093/jas/skad139 · Cited by 16

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment

Lechner, L., Opitz, R., Silver, M. J., Krabusch, P., Prentice, A. M., Field, M. S., Stachelscheid, H., Leitão, E., Schröder, C., Vallone, V. B. F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg1659 · Cited by 16

Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease

Li, Y., Wang, M., Liu, X., Rong, J., Miller, P. E., Joehanes, R., Huan, T., Guo, X., Rotter, J. I., Smith, J. A., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03149-2 · Cited by 16

One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon

Saito, T., Espe, M., Vikeså, V., Bock, C., Thomsen, T. H., Adam, A., Fernandes, J. M. O., & Skjærven, K. H. (2024) · Epigenetics · doi:10.1080/15592294.2024.2318517 · Cited by 16

Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila

Pilesi, E., Tesoriere, G., Ferriero, A., Mascolo, E., Liguori, F., Argirò, L., Angioli, C., Tramonti, A., Contestabile, R., Volonté, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06787-3 · Cited by 16

Separation of reproductive decline from lifespan extension during methionine restriction

Wei, F., Liu, S., Liu, J., Sun, Y., Allen, A. E., Reid, M. A., & Locasale, J. W. (2024) · Nature Aging · doi:10.1038/s43587-024-00674-4 · Cited by 16

Serine-Glycine-One-Carbon Metabolism: The Hidden Achilles Heel of MYCN-Amplified Neuroblastoma?

Rodriguez‐Garcia, A., & Arsenian‐Henriksson, M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1816 · Cited by 16

Metabolomics analysis of plasma and adipose tissue samples from mice orally administered with polydextrose and correlations with cecal microbiota

Saarinen, M., Kärkkäinen, O. K., Hanhineva, K., Tiihonen, K., Hibberd, A. A., Mäkelä, K. A., Raza, G. S., Herzig, K., & Anglenius, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-78484-y · Cited by 16

Chapter 1 Folate‐Mediated One‐Carbon Metabolism

Fox, J. T., & Stover, P. J. (2008) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)00401-9 · Cited by 402

Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and BeyondPreprint

Lim, E. W., & Metallo, C. M. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041533 · Cited by 5

Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes

Appling, D. R. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.12.1916088 · Cited by 350

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

Dekhne, A. S., Hou, Z., Gangjee, A., & Matherly, L. H. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0423 · Cited by 80

One-carbon metabolism in cancer cells: a critical review based on a core model of central metabolism

Mazat, J. (2021) · Biochemical Society Transactions · doi:10.1042/bst20190008 · Cited by 16