One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,727

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654

The multifaceted contributions of mitochondria to cellular metabolism

Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935

Gut microbial metabolites as multi-kingdom intermediates

Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398

Targeting cancer metabolism in the era of precision oncology

Stine, Z. E., Schug, Z. T., Salvino, J. M., & Dang, C. V. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00339-6 · Cited by 1,189

Metabolic regulation of cell growth and proliferation

Zhu, J., & Thompson, C. B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0123-5 · Cited by 1,154

Circadian physiology of metabolism

Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092

Epigenetics in Human Obesity and Type 2 Diabetes

Ling, C., & Rönn, T. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.009 · Cited by 1,006

Amino acids in cancer

Lieu, E. L., Nguyen, T. A., Rhyne, S., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0375-3 · Cited by 847

The expanding world of tRNA modifications and their disease relevance

Suzuki, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00342-0 · Cited by 733

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836

ESPEN micronutrient guideline

Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 641

NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications

Ju, H., Lin, J., Tian, T., Xie, D., & Xu, R. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00326-0 · Cited by 607

Astrocyte-neuron metabolic cooperation shapes brain activity

Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sanderson, S. M., Gao, X., Dai, Z., & Locasale, J. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0187-8 · Cited by 601

The effect of HIF on metabolism and immunity

Taylor, C. T., & Scholz, C. C. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00587-8 · Cited by 517

One-carbon metabolism in cancer

Newman, A. C., & Maddocks, O. D. K. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.118 · Cited by 525

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

Melber, A., & Haynes, C. M. (2018) · Cell Research · doi:10.1038/cr.2018.16 · Cited by 498

Mitochondrial diseases: the contribution of organelle stress responses to pathology

Suomalainen, A., & Battersby, B. J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.66 · Cited by 505

Mitochondria at the crossroads of health and disease

Suomalainen, A., & Nunnari, J. M. (2024) · Cell · doi:10.1016/j.cell.2024.04.037 · Cited by 528

Vitamin B 12 , folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation

Froese, D. S., Fowler, B., & Baumgartner, M. R. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12009 · Cited by 479

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

Mardinoğlu, A., Wu, H., Björnson, E., Zhang, C., Hakkarainen, A., Räsänen, S., Lee, S., Mancina, R. M., Bergentall, M., Pietiläinen, K. H., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.005 · Cited by 465

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

Chen, L., Zhang, Z., Hoshino, A., Zheng, H. D., Morley, M. P., Arany, Z. P., & Rabinowitz, J. D. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0043-x · Cited by 426

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development

Clare, C., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2018) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020518-115206 · Cited by 423

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 425

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

Alves, A., Bassot, A., Bulteau, A., Pirola, L., & Morio, B. (2019) · Nutrients · doi:10.3390/nu11061356 · Cited by 385

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine

Cortese-Krott, M. M., Koning, A. M., Kuhnle, G., Nagy, P., Bianco, C. L., Pasch, A., Wink, D. A., Fukuto, J. M., Jackson, A. A., van Goor, H., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7083 · Cited by 371

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

Matilainen, O., Quirós, P. M., & Auwerx, J. H. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.02.004 · Cited by 376

Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research

de Souza, L. P., Alseekh, S., Scossa, F., & Fernie, A. R. (2021) · Nature Methods · doi:10.1038/s41592-021-01116-4 · Cited by 381

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

Burgos-Barragan, G., Wit, N., Meiser, J., Dingler, F. A., Pietzke, M., Mulderrig, L., Pontel, L. B., Rosado, I. V., Brewer, T. F., Cordell, R. L., et al. (2017) · Nature · doi:10.1038/nature23481 · Cited by 359

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Yang, L., Chu, Z., Liu, M., Zou, Q., Li, J., Liu, Q., Wang, Y., Wang, T., Xiang, J., & Wang, B. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01453-1 · Cited by 383

Glucose Metabolism in Cardiac Hypertrophy and Heart Failure

Tran, D. H., & Wang, Z. V. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012673 · Cited by 336

Targeting mitochondrial metabolism for precision medicine in cancer

Sainero‐Alcolado, L., Liaño-Pons, J., Ruiz-Pérez, M. V., & Arsenian‐Henriksson, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01022-y · Cited by 338

Metabolic orchestration of the wound healing response

Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 323

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Pareek, V., Tian, H., Winograd, N., & Benkovic, S. J. (2020) · Science · doi:10.1126/science.aaz6465 · Cited by 316

The Concept of Folic Acid in Health and Disease

Shulpekova, Y. O., Nechaev, V. M., Kardasheva, S. S., Sedova, A., Курбатова, А. А., Леонидовна, Б. Е., Kopylov, A. T., Malsagova, K. A., Dlamini, J. C., & Ivashkin, V. T. (2021) · Molecules · doi:10.3390/molecules26123731 · Cited by 302

Mitochondrial translation requires folate-dependent tRNA methylation

Morscher, R. J., Ducker, G. S., Li, H., Mayer, J., Gitai, Z., Sperl, W., & Rabinowitz, J. D. (2018) · Nature · doi:10.1038/nature25460 · Cited by 281

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Villa, E., Ali, E. S., Sahu, U., & Ben‐Sahra, I. (2019) · Cancers · doi:10.3390/cancers11050688 · Cited by 289

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

Kumar, S., & Lombard, D. B. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1458071 · Cited by 273

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

Kühl, I., Miranda, M., Atanassov, I., Kuznetsova, I., Hinze, Y., Mourier, A., Filipovska, A., & Larsson, N. (2017) · eLife · doi:10.7554/elife.30952 · Cited by 261

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

Ducker, G. S., Ghergurovich, J. M., Mainolfi, N., Suri, V., Jeong, S. K., Hsin-Jung Li, S., Friedman, A., Manfredi, M. G., Gitai, Z., Kim, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706617114 · Cited by 261

Metabolite exchange between mammalian organs quantified in pigs

Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza, C., Hwang, H. Y., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.002 · Cited by 256

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

Gao, X., Lee, K., Reid, M. A., Sanderson, S. M., Qiu, C., Li, S., Liu, J., & Locasale, J. W. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.017 · Cited by 256

Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

Bajracharya, R., Song, J. G., Patil, B. R., Lee, S. H., Noh, H.-M., Kim, D.-H., Kim, G.-L., Seo, S.-H., Park, J., Jeong, S. H., et al. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2089296 · Cited by 265

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

Kory, N., Wyant, G. A., Prakash, G., de Bos, J. U., Bottanelli, F., Pacold, M. E., Chan, S. H., Lewis, C. A., Wang, T., Keys, H. R., et al. (2018) · Science · doi:10.1126/science.aat9528 · Cited by 246

Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome

Mahmoud, A. M., & Ali, M. M. (2019) · Nutrients · doi:10.3390/nu11030608 · Cited by 256

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

Kurniawan, H., Franchina, D. G., Guerra, L., Bonetti, L., Soriano‐Baguet, L., Grusdat, M., Schlicker, L., Hunewald, O. E., Dostert, C., Merz, M. P., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.004 · Cited by 249

PERK is a critical metabolic hub for immunosuppressive function in macrophages

Raines, L. N., Zhao, H., Wang, Y., Chen, H.-Y., Gallart‐Ayala, H., Hsueh, P., Cao, W., Koh, Y., Almonte-Loya, A., Liu, P.-S., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01145-x · Cited by 245

Toward a better understanding of folate metabolism in health and disease

Zheng, Y., & Cantley, L. C. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181965 · Cited by 246

Formate metabolism in health and disease

Pietzke, M., Meiser, J., & Vazquez, A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.05.012 · Cited by 218

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

Doxtader, K. A., Wang, P., Scarborough, A. M., Seo, D., Conrad, N. K., & Nam, Y. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.025 · Cited by 223

Serine, glycine and one‑carbon metabolism in cancer (Review)

Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5158 · Cited by 227

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

Sugiura, A., Andrejeva, G., Voss, K., Heintzman, D. R., Xu, X., Madden, M. Z., Ye, X., Beier, K. L., Chowdhury, N. U., Wolf, M. M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.011 · Cited by 223

Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity

Yan, Y., Huang, L., Liu, Y., Yi, M., Chu, Q., Jiao, D., & Wu, K. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01322-3 · Cited by 226

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

Chen, P.-H., Cai, L., Huffman, K. E., Yang, C., Kim, J., Faubert, B., Boroughs, L. K., Ko, B., Sudderth, J., McMillan, E. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.028 · Cited by 209

The Diverse Functions of Non-Essential Amino Acids in Cancer

Choi, B.-H., & Coloff, J. L. (2019) · Cancers · doi:10.3390/cancers11050675 · Cited by 213

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

Cao, J. Y., Poddar, A., Magtanong, L., Lumb, J. H., Mileur, T. R., Reid, M. A., Dovey, C. M., Wang, J., Locasale, J. W., Stone, E. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.043 · Cited by 212

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 220

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

Minton, D. R., Nam, M., McLaughlin, D. J., Shin, J., Bayraktar, E. C., Alvarez, S., Sviderskiy, V. O., Papagiannakopoulos, T. Y., Sabatini, D. M., Birsoy, K., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.024 · Cited by 192

Moonlighting functions of metabolic enzymes and metabolites in cancer

Pan, C., Li, B., & Simon, M. C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.031 · Cited by 198

Role of mitochondrial alterations in human cancer progression and cancer immunity

Wang, S., Tseng, L., & Lee, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00956-w · Cited by 225

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

Ju, H., Lu, Y., Chen, D.-L., Zuo, Z.-X., Liu, Z., Wu, Q.-N., Mo, H., Wang, Z., Wang, D., Pu, H., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy160 · Cited by 190

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Wang, L. W., Shen, H., Nobre, L., Ersing, I., Paulo, J. A., Trudeau, S., Wang, Z., Smith, N. A., Ma, Y., Reinstadler, B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.003 · Cited by 190

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Wei, Z., Song, J., Wang, G., Cui, X., Zheng, J., Tang, Y., Chen, X., Li, J., Cui, L., Liu, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06812-y · Cited by 189

mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

Villa, E., Sahu, U., O’Hara, B. P., Ali, E. S., Helmin, K. A., Asara, J. M., Gao, P., Singer, B. D., & Ben‐Sahra, I. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.009 · Cited by 194

In defence of ferroptosis

Alves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 212

Associations of Serum Folate and Vitamin B 12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Liu, Y., Geng, T., Wan, Z., Lu, Q., Zhang, X., Qiu, Z., Lin, L., Zhu, K., Liu, L., Pan, A., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.46124 · Cited by 187

Emerging roles for folate receptor FOLR1 in signaling and cancer

Nawaz, F. Z., & Kipreos, E. T. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.12.003 · Cited by 184

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

Shang, M., Yang, H., Yang, R., Chen, T., Fu, Y., Li, Y., Fang, X.-L., Zhang, K., Jianju, Z., Li, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22173-5 · Cited by 186

Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

Ying, M., You, D., Zhu, X., Cai, L., Zeng, S., & Hu, X. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102065 · Cited by 186

Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework

Galmés, S., Serra, F. A., & Palou, A. (2020) · Nutrients · doi:10.3390/nu12092738 · Cited by 179

Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

Taymaz‐Nikerel, H., Karabekmez, M. E., Eraslan, S., & Kırdar, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-31939-9 · Cited by 175

Serine and Functional Metabolites in Cancer

Newman, A. C., & Maddocks, O. D. K. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.001 · Cited by 168

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C.-T., Qi, Y., Wang, Y.-C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y.-R., Oh, M. E., Sheng, X., Tang, Y., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0178-4 · Cited by 164

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

Luo, A. S., Leach, S. T., Barrès, R., Hesson, L. B., Grimm, M., & Simar, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00417 · Cited by 173

Human de novo purine biosynthesis

Pareek, V., Pedley, A. M., & Benkovic, S. J. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1832438 · Cited by 161

Targeting Metabolic–Redox Circuits for Cancer Therapy

Wang, K., Jiang, J., Lei, Y., Zhou, S., Wei, Y., & Huang, C. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.01.001 · Cited by 162

Glutathione and its precursors in cancer

Asantewaa, G., & Harris, I. S. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.03.001 · Cited by 160

Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation

Diehl, F. F., Lewis, C. A., Fiske, B. P., & Vander Heiden, M. G. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0108-x · Cited by 159

Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

Asano, K., Suzuki, T., Saito, A., Wei, F., Ikeuchi, Y., Numata, T., Tanaka, R., YAMANE, Y., Yamamoto, T., Goto, T., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky068 · Cited by 159

PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

Moreno‐Fernandez, M. E., Giles, D. A., Oates, J. R., Chan, C. C., Damen, M. S. M. A., Doll, J., Stankiewicz, T. E., Chen, X., Chetal, K., Karns, R. A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.018 · Cited by 163

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

Liu, S., Fu, S., Wang, G., Cao, Y., Li, L., Li, X., Yang, J. J., Li, N., Shan, Y., Cao, Y., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.013 · Cited by 159

Tumour metabolism and its unique properties in prostate adenocarcinoma

Bader, D. A., & McGuire, S. E. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-0288-x · Cited by 162

Ancillary Activity: Beyond Core Metabolism in Immune Cells

Puleston, D. J., Villa, M., & Pearce, E. L. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.019 · Cited by 150

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

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