Autophagy and Tumor Metabolism

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

The emerging hallmarks of cancer metabolism

Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 1× · see citing works

Autophagy: process and functionPreprint

Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 3,967 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923 · see citing works

Understanding the Intersections between Metabolism and Cancer Biology

Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,316 · see citing works

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

The machinery of macroautophagy

Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083 · see citing works

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,013 · see citing works

Autophagy and Metabolism

Rabinowitz, J. D., & White, E. (2010) · Science · doi:10.1126/science.1193497 · Cited by 1,982 · see citing works

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works

Pancreatic cancers require autophagy for tumor growth

Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes & Development · doi:10.1101/gad.2016111 · Cited by 1,498 · see citing works

Targeting cancer metabolism: a therapeutic window opens

Heiden, M. G. V. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3504 · Cited by 1,409 · see citing works

Targeting mitochondria metabolism for cancer therapy

Weinberg, S. E., & Chandel, N. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1712 · Cited by 1,385 · see citing works

Autophagy-deficient mice develop multiple liver tumors

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011) · Genes & Development · doi:10.1101/gad.2016211 · Cited by 1,342 · cited 1× · see citing works

The role for autophagy in cancer

White, E. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73941 · Cited by 1,332 · see citing works

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Guo, J. Y., Chen, H.-Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemons, J. M. S., Karantza, V., et al. (2011) · Genes & Development · doi:10.1101/gad.2016311 · Cited by 1,323 · see citing works

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo‐San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490784 · Cited by 1,182 · see citing works

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., et al. (2016) · Nature · doi:10.1038/nature19084 · Cited by 1,122 · see citing works

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

Amaravadi, R. K., Lippincott‐Schwartz, J., Yin, X., Weiss, W. A., Takebe, N., Timmer, W. C., DiPaola, R. S., Lotze, M. T., & White, E. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2634 · Cited by 899 · see citing works

Recent insights into the function of autophagy in cancerPreprint

Amaravadi, R. K., Kimmelman, A. C., & White, E. (2016) · Genes & Development · doi:10.1101/gad.287524.116 · Cited by 810 · see citing works

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature · doi:10.1038/nature14587 · Cited by 799 · see citing works

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

Khaminets, A., Behl, C., & Đikić, I. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.010 · Cited by 716 · see citing works

p53 status determines the role of autophagy in pancreatic tumour development

Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature · doi:10.1038/nature12865 · Cited by 713 · see citing works

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Ando, J., Iwadate, M., Yamamoto, M. P., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201102031 · Cited by 602 · see citing works

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

Guo, J. Y., Karsli-Uzunbas, G., Mathew, R., Aisner, S. C., Kamphorst, J. J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., et al. (2013) · Genes & Development · doi:10.1101/gad.219642.113 · Cited by 589 · see citing works

The dynamic nature of autophagy in cancerPreprint

Kimmelman, A. C. (2011) · Genes & Development · doi:10.1101/gad.17558811 · Cited by 587 · see citing works

Autophagy is required for glucose homeostasis and lung tumor maintenance

Karsli-Uzunbas, G., Guo, J. Y., Price, S., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0363 · Cited by 560 · see citing works

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

Mijaljica, D., Prescott, M., & Devenish, R. J. (2011) · Autophagy · doi:10.4161/auto.7.7.14733 · Cited by 547 · see citing works

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

Yang, A., Rajeshkumar, N. V., Wang, X., Yabuuchi, S., Alexander, B. M., Chu, G. C., Von Hoff, D. D., Maitra, A., & Kimmelman, A. C. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0362 · Cited by 486 · see citing works

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

Lock, R., Roy, S., Kenific, C. M., Su, J. S., Salas, E., Ronen, S. M., & Debnath, J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0500 · Cited by 467 · see citing works

Microenvironmental autophagy promotes tumour growth

Katheder, N. S., Khezri, R., O’Farrell, F., Schultz, S. W., Jain, A., Rahman, M. M., Schink, K. O., Theodossiou, T. A., Johansen, T., Juhász, G., et al. (2017) · Nature · doi:10.1038/nature20815 · Cited by 452 · see citing works

A dual role for autophagy in a murine model of lung cancer

Rao, S., Tortola, L., Perlot, T., Wirnsberger, G., Novatchkova, M., Nitsch, R., Sykacek, P., Frank, L., Schramek, D., Komnenovic, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms4056 · Cited by 444 · see citing works

Does Autophagy Contribute To Cell Death?

Debnath, J., Baehrecke, E. H., & Kroemer, G. (2005) · Autophagy · doi:10.4161/auto.1.2.1738 · Cited by 444 · see citing works

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of <i>Braf</i> V600E–Driven Lung Tumors

Strohecker, A. M., Guo, J. Y., Karsli-Uzunbas, G., Price, S. M., Chen, G. J., Mathew, R., McMahon, M., & White, E. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0397 · Cited by 435 · see citing works

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesisPreprint

Wei, H., Wei, S., Gan, B., Xu, P., Zou, W., & Guan, J. (2011) · Genes & Development · doi:10.1101/gad.2051011 · Cited by 402 · see citing works

Autophagy and cancer therapy

Maycotte, P., & Thorburn, A. M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14627 · Cited by 394 · see citing works

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

Wolpin, B. M., Rubinson, D. A., Wang, X., Chan, J. A.-W., Cleary, J. M., Enzinger, P. C., Fuchs, C. S., McCleary, N. J., Meyerhardt, J. A., Ng, K., et al. (2014) · The Oncologist · doi:10.1634/theoncologist.2014-0086 · Cited by 374 · see citing works

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cellsPreprint

Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Nostrand, S. C. V., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D., & White, E. (2016) · Genes & Development · doi:10.1101/gad.283416.116 · Cited by 373 · see citing works

Digesting the Expanding Mechanisms of Autophagy

Ktistakis, N. T., & Tooze, S. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.03.006 · Cited by 369 · see citing works

Autophagy and p53Preprint

White, E. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026120 · Cited by 322 · see citing works

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

Valencia, T., Kim, J. Y., Abu-Baker, S., Moscat-Pardos, J., Ahn, C. S., Reina-Campos, M., Duran, A., Castilla, E. A., Metallo, C. M., Diaz-Meco, M. T., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.004 · Cited by 304 · see citing works

Targeting the lysosome in cancer

Piao, S., & Amaravadi, R. K. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12953 · Cited by 303 · see citing works

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

Klionsky, D. J., Baehrecke, E. H., Brumell, J. H., Chu, C. T., Codogno, P., Cuervo, A. M., Debnath, J., Deretic, V. P., Elazar, Z., Eskelinen, E., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.17661 · Cited by 293 · see citing works

Emerging strategies to effectively target autophagy in cancer

Rebecca, V. W., & Amaravadi, R. K. (2015) · Oncogene · doi:10.1038/onc.2015.99 · Cited by 283 · see citing works

Autophagy and Cancer Therapy

Thorburn, A. M., Thamm, D. H., & Gustafson, D. L. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.091850 · Cited by 281 · see citing works

TOR-dependent control of autophagy: biting the hand that feeds

Neufeld, T. P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.005 · Cited by 261 · see citing works

Hydroxychloroquine concentration–response relationships in patients with rheumatoid arthritis

Münster, T., Gibbs, J. P., Shen, D. D., Baethge, B. A., Botstein, G. R., Caldwell, J. R., Dietz, F., Ettlinger, R. E., Golden, H. E., Lindsley, H. B., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10307 · Cited by 250 · see citing works

Targeting autophagy during cancer therapy to improve clinical outcomes

Levy, J. M. M., & Thorburn, A. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.009 · Cited by 238 · see citing works

Safety and biologic response of pre-operative autophagy inhibition in combination with gemcitabine in patients with pancreatic adenocarcinoma

Boone, B. A., Bahary, N., Zureikat, A. H., Moser, A. J., Normolle, D. P., Wu, W.-C., Singhi, A. D., Bao, P., Bartlett, D. L., Liotta, L. A., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4566-4 · Cited by 234 · see citing works

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

Endo, S., Nakata, K., Ohuchida, K., Takesue, S., Nakayama, H., Abe, T., Koikawa, K., Okumura, T., Sada, M., Horioka, K., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.010 · Cited by 228 · see citing works

The Mechanism and Physiological Function of Macroautophagy

Klionsky, D. J., & Codogno, P. (2013) · Journal of Innate Immunity · doi:10.1159/000351979 · Cited by 221 · see citing works

<i>Atg7</i> Overcomes Senescence and Promotes Growth of <i>Braf</i> V600E-Driven Melanoma

Xie, X., Koh, J. Y., Price, S., White, E., & Mehnert, J. M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1473 · Cited by 208 · see citing works

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

Mancias, J. D., & Kimmelman, A. C. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.027 · Cited by 196 · see citing works

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

Laddha, S. V., Ganesan, S., Chan, C. S., & White, E. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0614 · Cited by 195 · see citing works

Chaperone-Mediated Autophagy

Bejarano, E., & Cuervo, A. M. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-102js · Cited by 193 · see citing works

Autophagy, Metabolism, and CancerPreprint

Guo, J. Y., & White, E. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030981 · Cited by 182 · see citing works

Chaperone‐mediated autophagy in health and disease

Kon, M., & Cuervo, A. M. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.025 · Cited by 134 · see citing works

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2 -Associated Hereditary Breast Cancer

Huo, Y., Cai, H., Teplova, I., Bowman-Colin, C., Chen, G., Price, S. M., Barnard, N., Ganesan, S., Karantza, V., White, E., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0011 · Cited by 132 · see citing works

Atg7 cooperates with Pten loss to drive prostate cancer tumor growthPreprint

Santanam, U., Banach-Petrosky, W. A., Abate-Shen, C. T., Shen, M. M., White, E., & DiPaola, R. S. (2016) · Genes & Development · doi:10.1101/gad.274134.115 · Cited by 115 · see citing works

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

Karvela, M., Baquero, P., Kuntz, E. M., Mukhopadhyay, A., Mitchell, R., Allan, E. K., Chan, E. Y. W., Kranc, K. R., Calabretta, B., Salomoni, P., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1162359 · Cited by 113 · see citing works

Suppression of autophagy impedes glioblastoma development and induces senescence

Gammoh, N., Dudley-Fraser, J., Puente, C., Syred, H. M., Kang, H. H., Ozawa, T., Lam, D., Acosta, J. C., Finch, A. J., Holland, E. C., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1190053 · Cited by 112 · see citing works

Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status

Yang, A., & Kimmelman, A. C. (2014) · Autophagy · doi:10.4161/auto.29961 · Cited by 102 · see citing works

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents.

Wang, C., Hu, Q.-D., & Shen, H.-M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.028 · Cited by 97 · see citing works

Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor

Chaudhri, V. K., Salzler, G. G., Dick, S. A., Buckman, M. S., Sordella, R., Karoly, E. D., Mohney, R. P., Stiles, B. M., Elemento, O., Altorki, N. K., et al. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0437-t · Cited by 88 · see citing works

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers

Strohecker, A. M., & White, E. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0196 · Cited by 83 · see citing works

The Evolving, Multifaceted Roles of Autophagy in Cancer

Liu, J., & Debnath, J. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.01.005 · Cited by 80 · see citing works

Concentration-effect relationship of hydroxychloroquine in rheumatoid arthritis--a cross sectional study.

Tett, S. E., Day, R. O., & Cutler, D. J. (1993) · PubMed · Cited by 59 · see citing works

Novel Therapeutic Targets of Tumor Metabolism

Kishton, R. J., & Rathmell, J. C. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000099 · Cited by 48 · see citing works

Revisiting autophagy addiction of tumor cells

Nyfeler, B., & Eng, C. H. (2016) · Autophagy · doi:10.1080/15548627.2016.1170265 · Cited by 48 · see citing works

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

Lashinger, L. M., O’Flanagan, C. H., Dunlap, S. M., Rasmussen, A. J., Sweeney, S., Guo, J. Y., Lodi, A., Tiziani, S., White, E., & Hursting, S. D. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0158-4 · Cited by 46 · see citing works

Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature

Maes, H., Kuchnio, A., Carmeliet, P., & Agostinis, P. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.970097 · Cited by 33 · see citing works

Mouse Models Address Key Concerns Regarding Autophagy Inhibition in Cancer Therapy

Amaravadi, R. K., & Debnath, J. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0618 · Cited by 25 · see citing works

Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells' survival and growth revealing a new strategy for Hodgkin lymphoma treatment

Birkenmeier, K., Moll, K., Newrzela, S., Hartmann, S., Dröse, S., & Hansmann, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10300 · Cited by 22 · see citing works

Emerging approaches to target tumor metabolism

Ross, S. J., & Critchlow, S. E. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.07.001 · Cited by 21 · see citing works

Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?

Lebovitz, C. B., DeVorkin, L., Bosc, D., Rothe, K., Singh, J., Bally, M. B., Jiang, X., Young, R. N., Lum, J. J., & Gorski, S. M. (2015) · Autophagy · doi:10.1080/15548627.2015.1078962 · Cited by 20 · see citing works

Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832 · see citing works

Mechanism and medical implications of mammalian autophagy

Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771 · see citing works

Nrf2-Keap1 signaling in oxidative and reductive stress

Bellezza, I., Giambanco, I., Minelli, A., & Donato, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.02.010 · Cited by 2,093 · see citing works

NRF2 and the Hallmarks of Cancer

Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672 · see citing works

Autophagy in major human diseases

Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585 · see citing works

Lysosomes as dynamic regulators of cell and organismal homeostasis

Ballabio, A., & Bonifacino, J. S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0185-4 · Cited by 1,469 · see citing works

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272 · see citing works

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Gao, W., Wang, Y., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,069 · see citing works

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940 · see citing works

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Amaravadi, R. K., Kimmelman, A. C., & Debnath, J. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0292 · Cited by 928 · see citing works

Targeting autophagy in cancer

Onorati, A., Dyczynski, M., Ojha, R., & Amaravadi, R. K. (2018) · Cancer · doi:10.1002/cncr.31335 · Cited by 851 · see citing works

Molecular mechanisms of cell death in neurological diseases

Moujalled, D., Strasser, A., & Liddell, J. R. (2021) · Cell Death &amp; Differentiation · doi:10.1038/s41418-021-00814-y · Cited by 749 · see citing works

Meta-hallmarks of aging and cancer

López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works

Embracing cancer complexity: Hallmarks of systemic disease

Swanton, C., Bernard, E., Abbosh, C., André, F., Auwerx, J. H., Balmain, A., Bar‐Sagi, D., Bernards, R., Bullman, S., DeGregori, J. V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.009 · Cited by 555 · see citing works

Nucleotide metabolism: a pan-cancer metabolic dependency

Mullen, N. J., & Singh, P. K. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00557-7 · Cited by 475 · see citing works

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

Qin, C., Yang, G., Yang, J., Ren, B., Wang, H., Chen, G., Zhao, F., You, L., Wang, W., & Zhao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01169-7 · Cited by 415 · see citing works

Autophagy in tumour immunity and therapy

Xia, H., Green, D. R., & Zou, W. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00344-2 · Cited by 411 · see citing works

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

Nazio, F., Bordi, M., Cianfanelli, V., Locatelli, F., & Cecconi, F. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0292-y · Cited by 391 · see citing works

Autophagy as a molecular target for cancer treatment

Kocatürk, N. M., Akkoç, Y., Kığ, C., Bayraktar, O., Gözüaçık, D., & Kutlu, Ö. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.04.011 · Cited by 388 · see citing works

Autophagy and disease: unanswered questions

Yang, Y., & Klionsky, D. J. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-019-0480-9 · Cited by 369 · see citing works

The molecular biology of pancreatic adenocarcinoma: Translational challenges and clinical perspectives

Wang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369 · see citing works

Autophagy sustains pancreatic cancer growth through both cell-autonomous and nonautonomous mechanisms

Yang, A., Herter-Sprie, G., Zhang, H., Lin, E. Y., Biancur, D., Wang, X., Deng, J., Hai, J., Yang, S., Wong, K.-K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0952 · Cited by 349 · see citing works

Autophagy, cancer stem cells and drug resistance

Smith, A. G., & Macleod, K. F. (2018) · The Journal of Pathology · doi:10.1002/path.5222 · Cited by 364 · see citing works

KRAS mutation in pancreatic cancer

Luo, J. (2021) · Seminars in Oncology · doi:10.1053/j.seminoncol.2021.02.003 · Cited by 360 · see citing works

Autophagy maintains tumour growth through circulating arginine

Poillet-Perez, L., Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. S., Su, X., Maganti, A., Jiang, C., Lu, W., et al. (2018) · Nature · doi:10.1038/s41586-018-0697-7 · Cited by 363 · see citing works

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

Cunha, L. D., Yang, M., Carter, R., Guy, C., Harris, L., Crawford, J. C., Quarato, G., Boada-Romero, E., Kalkavan, H., Johnson, M. D. L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.061 · Cited by 334 · see citing works

Metabolic Codependencies in the Tumor Microenvironment

Dey, P., Kimmelman, A. C., & DePinho, R. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1211 · Cited by 342 · see citing works

Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches

Liu, F., Chen, J., Li, K., Li, H., Zhu, Y., Zhai, Y., Lu, B., Fan, Y., Liu, Z., Chen, X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02046-3 · Cited by 352 · see citing works

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Fendt, S., Frezza, C., & Erez, A. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0844 · Cited by 320 · see citing works

Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

Settembre, C., & Perera, R. M. (2023) · Nature reviews. Molecular cell biology · doi:10.1038/s41580-023-00676-x · Cited by 269 · see citing works

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

Lahiri, V., Hawkins, W. D., & Klionsky, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.003 · Cited by 286 · see citing works

Role of tumor and host autophagy in cancer metabolismPreprint

Poillet-Perez, L., & White, E. (2019) · Genes & Development · doi:10.1101/gad.325514.119 · Cited by 269 · see citing works

TGF-β signaling in the tumor metabolic microenvironment and targeted therapies

Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262 · see citing works

Hallmarks of cancer—Then and now, and beyond

Hanahan, D. (2026) · Cell · doi:10.1016/j.cell.2025.12.049 · Cited by 262 · see citing works

Mitophagy in Cancer: A Tale of Adaptation

Vara‐Pérez, M., Felipe‐Abrio, B., & Agostinis, P. (2019) · Cells · doi:10.3390/cells8050493 · Cited by 256 · see citing works

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

Danzi, F., Pacchiana, R., Mafficini, A., Scupoli, M. T., Scarpa, A., Donadelli, M., & Fiore, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01380-0 · Cited by 252 · see citing works

Autophagy in bone homeostasis and the onset of osteoporosis

Yin, X., Zhou, C., Li, J., Liu, R., Shi, B., Yuan, Q., & Zou, S. (2019) · Bone Research · doi:10.1038/s41413-019-0058-7 · Cited by 235 · see citing works

p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer

Sánchez‐Martín, P., Saito, T., & Komatsu, M. (2018) · FEBS Journal · doi:10.1111/febs.14712 · Cited by 242 · see citing works

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Jia, M., Xiao, Y., Sun, W., Zhou, Q., Chang, C., Gong, W., Feng, J., Xie, L., Zhan, R., Mo, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg4993 · Cited by 251 · see citing works

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

Kerk, S. A., Papagiannakopoulos, T. Y., Shah, Y. M., & Lyssiotis, C. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00375-9 · Cited by 238 · see citing works

Targeting autophagy in disease: established and new strategies

Koçak, M., Erdi, S. E., Jorba, G., Maestro, I., Farrés, J., Kirkin, V., Martı́nez, A., & Pleß, O. (2021) · Autophagy · doi:10.1080/15548627.2021.1936359 · Cited by 229 · see citing works

Nutrient scavenging in cancer

Finicle, B. T., Jayashankar, V., & Edinger, A. L. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0048-x · Cited by 231 · see citing works

Role of AMPK in autophagy

Wang, S., Li, H., Yuan, M., Fan, H., & Cai, Z. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1015500 · Cited by 229 · see citing works

The multifaceted role of autophagy in cancer

Russell, R. C., & Guan, K. (2022) · The EMBO Journal · doi:10.15252/embj.2021110031 · Cited by 229 · see citing works

Functions of autophagy in the tumor microenvironment and cancer metastasis

Mowers, E. E., Sharifi, M. N., & Macleod, K. F. (2018) · FEBS Journal · doi:10.1111/febs.14388 · Cited by 221 · see citing works

Autophagy as a modulator of cell death machinery

Noguchi, M., Hirata, N., Tanaka, T., Suizu, F., Nakajima, H., & Chiorini, J. A. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2724-5 · Cited by 215 · see citing works

Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer

Petroni, G., Cantley, L. C., Santambrogio, L., Formenti, S. C., & Galluzzi, L. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00579-w · Cited by 215 · see citing works

Dietary Approaches to Cancer Therapy

Tajan, M., & Vousden, K. H. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.04.005 · Cited by 208 · see citing works

Macropinocytosis confers resistance to therapies targeting cancer anabolism

Jayashankar, V., & Edinger, A. L. (2020) · Nature Communications · doi:10.1038/s41467-020-14928-3 · Cited by 200 · see citing works

Mechanisms and context underlying the role of autophagy in cancer metastasis

Dower, C. M., Wills, C. A., Frisch, S. M., & Wang, H. (2018) · Autophagy · doi:10.1080/15548627.2018.1450020 · Cited by 195 · see citing works

Metabolism in tumor microenvironment: Implications for cancer immunotherapy

Shi, R., Tang, Y., & Miao, H. (2020) · MedComm · doi:10.1002/mco2.6 · Cited by 198 · see citing works

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S. W., Gu, Y., Zbinden, M., Burge, M. R., Timmins, G. S., Hallows, K. R., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.028 · Cited by 194 · see citing works

Autophagy: A novel mechanism of chemoresistance in cancers

Li, X., Zhou, Y., Li, Y., Yang, L., Ma, Y., Peng, X., Yang, S., Liu, J., & Li, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109415 · Cited by 195 · see citing works

Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

Shu, F., Han, X., Li, Q.-N., Ren, X., Liu, Z., Hu, B., Wang, H., Wang, H., & Jiang, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01300-8 · Cited by 194 · see citing works

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

Lin, J., Xia, L., Liang, J., Han, Y., Wang, H., Oyang, L., Tan, S., Tian, Y., Rao, S., Chen, X., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1214-z · Cited by 191 · see citing works

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

Gremke, N., Polo, P., Dort, A., Schneikert, J., Elmshäuser, S., Brehm, C., Klingmüller, U., Schmitt, A., Reinhardt, H., Timofeev, O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18504-7 · Cited by 164 · see citing works

Harnessing metabolic dependencies in pancreatic cancers

Encarnación-Rosado, J., & Kimmelman, A. C. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00431-7 · Cited by 180 · see citing works

Autophagy and intermittent fasting: the connection for cancer therapy?

Antunes, F., Erustes, A. G., Costa, A. J., Nascimento, A. C., Bincoletto, C., Ureshino, R. P., Pereira, G. J. S., & Smaili, S. S. (2018) · Clinics · doi:10.6061/clinics/2018/e814s · Cited by 165 · see citing works

Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites

Bosc, C., Broin, N., Fanjul, M., Saland, E., Farge, T., Courdy, C., Batut, A., Masoud, R., Larrue, C., Skuli, S. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17882-2 · Cited by 161 · see citing works

Intermittent fasting in the prevention and treatment of cancer

Clifton, K., Ma, C. X., Fontana, L., & Peterson, L. L. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21694 · Cited by 160 · see citing works

Emancipating Target‐Functionalized Carbon Dots from Autophagy Vesicles for a Novel Visualized Tumor Therapy

Li, J., Yang, S., Deng, Y., Chai, P., Yang, Y., He, X., Xie, X., Kang, Z., Ding, G., Zhou, H., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201800881 · Cited by 156 · see citing works

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., Franco, W., Scarcelli, G., Polacheck, W. J., Roque, D. M., et al. (2021) · Cancers · doi:10.3390/cancers13174318 · Cited by 154 · see citing works

Poly(N‐isopropylacrylamide) and Its Copolymers: A Review on Recent Advances in the Areas of Sensing and Biosensing

Das, A., Babu, A., Chakraborty, S., Guyse, J. F. R. V., Hoogenboom, R., & Maji, S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402432 · Cited by 151 · see citing works

PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression

Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J., Duran, A., Nakanishi, Y., Nakanishi, N., L’Hermitte, A., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.018 · Cited by 126 · see citing works

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

Liao, M., Qin, R., Huang, W., Zhu, H.-P., Peng, F., Han, B., & Liu, B. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01260-0 · Cited by 144 · see citing works

KRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer

Pupo, E., Avanzato, D., Middonti, E., Bussolino, F., & Lanzetti, L. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00848 · Cited by 144 · see citing works

In Situ Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy via Autophagy Regulation Strategy

Chen, M., Yang, D., Sun, Y. H., Liu, T., Wang, W., Fu, J., Wang, Q., Bai, X., Quan, G., Pan, X., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c10396 · Cited by 141 · see citing works

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Li, M., Chiang, Y., Lyssiotis, C. A., Teater, M. R., Hong, J. Y., Shen, H., Wang, L., Hu, J., Jing, H., Chen, Z., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.002 · Cited by 141 · see citing works

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis

Sharma, G., Guardia, C. M. A., Roy, A., Vassilev, A. P., Sarić, A., Griner, L. N., Marugán, J., Ferrer, M., Bonifacino, J. S., & Depamphilis, M. (2019) · Autophagy · doi:10.1080/15548627.2019.1586257 · Cited by 131 · see citing works

Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity

White, E., Lattime, E. C., & Guo, J. Y. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.05.003 · Cited by 136 · see citing works

The biological underpinnings of therapeutic resistance in pancreatic cancerPreprint

Beatty, G. L., Werba, G., Lyssiotis, C. A., & Simeone, D. M. (2021) · Genes & Development · doi:10.1101/gad.348523.121 · Cited by 133 · see citing works

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Lee, C.-S., Lee, L. C., Yuan, T. L., Chakka, S., Fellmann, C., Lowe, S. W., Caplen, N. J., McCormick, F., & Luo, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817494116 · Cited by 126 · see citing works

New insights on sorafenib resistance in liver cancer with correlation of individualized therapy

Zhang, C., Wei-Qi, J., & Jin, D. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188382 · Cited by 130 · see citing works

Recent insights into the biology of pancreatic cancer

Yao, W., Maitra, A., & Ying, H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102655 · Cited by 125 · see citing works

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

Ashrafizadeh, M., Mohammadinejad, R., Tavakol, S., Ahmadi, Z., Roomiani, S., & Katebi, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28740 · Cited by 121 · see citing works

NF-κB Signalling in Glioblastoma

Soubannier, V., & Stifani, S. (2017) · Biomedicines · doi:10.3390/biomedicines5020029 · Cited by 120 · see citing works

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

Thomas, H. E., Zhang, Y., Stefely, J. A., Veiga, S. R., Thomas, G., Kozma, S. C., & Mercer, C. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.101 · Cited by 121 · see citing works

MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma

Fu, X., Shi, Y., Zhou, J., Peng, Y., Liu, W., Shi, G., Gao, Q., Wang, X., Song, K., Fan, J., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.012 · Cited by 118 · see citing works

Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

Yu, S., Zhang, C., & Xie, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188461 · Cited by 117 · see citing works

Autophagy and Hallmarks of Cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N. G., Feng, H., Hu, B., & Cheng, S. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018027913 · Cited by 116 · see citing works

ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3

Poole, L. P., Bock-Hughes, A., Berardi, D. E., & Macleod, K. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-00170-4 · Cited by 112 · see citing works

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway

Liang, Y., Hou, L., Li, L., Li, L., Zhu, L., Wang, Y., Huang, X. Y., Hou, Y., Zhu, D., Zou, H., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1035-8 · Cited by 110 · see citing works

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang, Y., Whaley‐Connell, A. T., Sowers, J. R., & Ren, J. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.004 · Cited by 109 · see citing works

Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response

Poillet-Perez, L., Sharp, D. W., Yang, Y., Laddha, S. V., Ibrahim, M., Bommareddy, P. K., Hu, Z. S., Vieth, J. A., Haas, M., Bosenberg, M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00110-7 · Cited by 109 · see citing works

Role of autophagy in aging: The good, the bad, and the ugly

TABIBZADEH, S. S. (2022) · Aging Cell · doi:10.1111/acel.13753 · Cited by 103 · see citing works

The physiological roles of autophagy in the mammalian life cycle

Wang, L., Ye, X., & Zhao, T. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12464 · Cited by 103 · see citing works

Autophagy in Cancer: Regulation by Small Molecules

Limpert, A. S., Lambert, L. J., Bakas, N. A., Bata, N., Brun, S. N., Shaw, R. J., & Cosford, N. D. P. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.004 · Cited by 104 · see citing works

CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas

Gao, L., Dou, Z., Ren, W., Li, S., Liang, K. X., & Zhi, K. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1971-9 · Cited by 102 · see citing works

Lipid Metabolism and Cancer

Cheng, H., Wang, M., Su, J., Li, Y., Jiao, L., Chu, J., Wan, X., Cao, Y., & Li, Q. (2022) · Life · doi:10.3390/life12060784 · Cited by 105 · see citing works

Combinatorial strategies to target RAS-driven cancers

Perurena, N., Situ, L., & Cichowski, K. M. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00679-6 · Cited by 104 · see citing works

Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning

Xiao, W., Xiong, Z., Xiong, W., Yuan, C., Xiao, H., Ruan, H., Song, Z., Wang, C., Bao, L., Cao, Q., et al. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12607 · Cited by 101 · see citing works

Lysosomes and Cancer Progression: A Malignant Liaison

Machado, E., Annunziata, I., van de Vlekkert, D., Grosveld, G., & d'Azzo, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642494 · Cited by 92 · see citing works

Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment

Gong, C., Hu, C., Gu, F., Xia, Q., Yao, C., Zhang, L., Qiang, L., Gao, S., & Gao, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.042 · Cited by 99 · see citing works

TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer

Zhou, C., Liang, Y., Zhou, L., Yan, Y., Liu, N., Zhang, R., Huang, Y., Wang, M., Tang, Y., Ali, D. W., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1826689 · Cited by 95 · see citing works

The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions

Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2021) · Cancers · doi:10.3390/cancers13215557 · Cited by 99 · see citing works

Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells

Liang, P., Jiang, B., Li, Y., Liu, Z., Zhang, P., Zhang, M., Huang, X., & Xiao, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1194-5 · Cited by 97 · see citing works

Nrf2 Modulation in Breast Cancer

Ghareghomi, S., Habibi-Rezaei, M., Arese, M., Saso, L., & Moosavi‐Movahedi, A. A. (2022) · Biomedicines · doi:10.3390/biomedicines10102668 · Cited by 97 · see citing works

Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins

Pechincha, C., Groessl, S., Kalis, R., de Almeida, M., Zanotti, A., Wittmann, M., Schneider, M., de Campos, R. P., Rieser, S., Brandstetter, M., et al. (2022) · Science · doi:10.1126/science.abn5637 · Cited by 93 · see citing works

TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells

He, R., Wang, M., Zhao, C., Shen, M., Yu, Y., He, L., Zhao, Y., Chen, H., Shi, X., Zhou, M., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1343-4 · Cited by 95 · see citing works

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes &amp; Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91 · see citing works

Unraveling autophagy-metabolism crosstalk in cancer: Molecular insights and therapeutic strategies

Wang, H., Yang, Q., Lu, Y., Du, C., Wang, W., & Zhang, L. (2026) · Theranostics · doi:10.7150/thno.132362 · Cited by 2 · see citing works

Tumor cell metabolism and autophagy as therapeutic targets

Poojary, S. S., & Singh, M. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00003-1 · Cited by 1 · see citing works

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

Mathew, R., & White, E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.008 · Cited by 235 · see citing works

Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by

Mathew, R., & White, E. (2015)

Unfolding the role of autophagy in the cancer metabolism

Pandey, A., Yadav, P., & Shukla, S. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101158 · Cited by 29 · see citing works