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The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease
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“Clinical trials have demonstrated the efficacy of NAD + precursors in the chemoprevention of non-melanoma skin cancer 126 , in reversing insulin resistance in prediabetic women 127 , and in reducing neuroinflammation in patients with Parkinson 's disease 128 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [128]
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“| | Human | Oral NR in Parkinson disease patients (Phase 1 trial) | Clinical improvement, reduced inflammatory cytokines in serum and cerebrospinal fluid | 128 |”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [128]
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Cites
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MDS clinical diagnostic criteria for Parkinson’s disease
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NAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697
Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.043 · Cited by 448
Brown, K. D., Maqsood, S., Huang, J.-Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.003 · Cited by 277
Conze, D., Brenner, C., & Kruger, C. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46120-z · Cited by 210
NAD+ biosynthesis, aging, and disease
Johnson, S., & Imai, S. (2018) · F1000Research · doi:10.12688/f1000research.12120.1 · Cited by 178
Multivariate data analysis for neuroimaging data: overview and application to Alzheimer’s disease
Initiative, T. A. D. N., Habeck, C., & Stern, Y. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9093-0 · Cited by 127
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BackgroundPayne, T., Appleby, M., Buckley, E., van Gelder, L. M. A., Mullish, B. H., Sassani, M., Dunning, M. J., Hernandez, D., Scholz, S. W., McNeill, A., et al. (2023) · Movement Disorders · doi:10.1002/mds.29450 · Cited by 76
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Metadata
- Authors
- Brakedal, B., Dölle, C., Riemer, F., Ma, Y., Nido, G. S., Skeie, G. O., Craven, A. R., Schwarzlmüller, T., Brekke, N., Diab, J., Sverkeli, L., Skjeie, V., Varhaug, K., Tysnes, O.-B., Peng, S., Haugarvoll, K., Ziegler, M., Grüner, R., Eidelberg, D., & Tzoulis, C.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 34
- Issue
- 3
- Pages
- 396-407.e6
- ISSN
- 1550-4131
- Cited by
- 323
- References
- 10
- Language
- en
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- The paper
- Brakedal, B., Dölle, C., Riemer, F., Ma, Y., Nido, G. S., Skeie, G. O., Craven, A. R., Schwarzlmüller, T., Brekke, N., Diab, J., Sverkeli, L., Skjeie, V., Varhaug, K., Tysnes, O.-B., Peng, S., Haugarvoll, K., Ziegler, M., Grüner, R., Eidelberg, D., & Tzoulis, C. (2022). The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metabolism. https://doi.org/10.1016/j.cmet.2022.02.001