Role of divalent metals in infectious disease susceptibility and outcome

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Nutritional immunity: transition metals at the pathogen–host interface

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Macrophage defense mechanisms against intracellular bacteria

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Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial

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A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

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Iron homeostasis in host defence and inflammation

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Hepcidin and the iron-infection axis

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Nutritional immunity beyond iron: a role for manganese and zinc

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New roles for bacterial siderophores in metal transport and tolerance

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Mechanisms of mammalian iron homeostasis

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Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

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Iron availability and infection

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Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence

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Transition Metals and Virulence in Bacteria

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A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality

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High Risk of HIV-Related Mortality Is Associated With Selenium Deficiency

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The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

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Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients

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Nutritional Immunity: Host's Attempt to Withhold Iron From Microbial Invaders

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The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

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Zinc

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Human calprotectin is an iron-sequestering host-defense protein

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Nutritional supplements for people being treated for active tuberculosis

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Copper in Microbial Pathogenesis: Meddling with the Metal

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Role of Zinc Administration in Prevention of Childhood Diarrhea and Respiratory Illnesses: A Meta-analysis

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Suppression of Human Immunodeficiency Virus Type 1 Viral Load With Selenium Supplementation

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Nutritional immunity: S100 proteins at the host–pathogen interface

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Host-mediated regulation of superinfection in malaria

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Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

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The Iron age of host–microbe interactions

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Presence of the siderophores pyoverdine and pyochelin in the extracellular medium reduces toxic metal accumulation in Pseudomonas aeruginosa and increases bacterial metal tolerance

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Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

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The Yin and Yang of copper during infection

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MntABC and MntH Contribute to Systemic Staphylococcus aureus Infection by Competing with Calprotectin for Nutrient Manganese

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Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection

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Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children

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Mucormycosis – from the pathogens to the disease

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Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study

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Mortality Risk in Selenium-Deficient HIV-Positive Children

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Escape from bacterial iron piracy through rapid evolution of transferrin

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Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure

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Micronutrient supplementation in children and adults with HIV infection

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Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania

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Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

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Effect of Iron Fortification on Malaria Incidence in Infants and Young Children in Ghana: A Randomized Trial

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Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation

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Selenium supplementation to prevent short-term morbidity in preterm neonates

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Role of selenium in HIV infection

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Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

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Micronutrient Supplementation Increases CD4 Count in HIV-Infected Individuals on Highly Active Antiretroviral Therapy

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Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

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Zinc Supplementation in Critically Ill Patients: A Key Pharmaconutrient?

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Antioxidant Micronutrients in Major Trauma and Burns: Evidence and Practice

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Pathogenic adaptations to host-derived antibacterial copper

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Randomized, Controlled Clinical Trial of Zinc Supplementation to Prevent Immunological Failure in HIV‐Infected Adults

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Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis

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Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana

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Siderophore conjugates

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The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*

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Decreased Susceptibility to Plasmodium falciparum Infection in Pregnant Women with Iron Deficiency

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Impact of a Selenium Chemoprevention Clinical Trial on Hospital Admissions of HIV-Infected Participants

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Regular Review: Iron and infection

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Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection

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Metals in infectious diseases and nutritional immunity

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Micronutrient supplementation in the AIDS diarrhoea-wasting syndrome in Zambia: A randomized controlled trial

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Micronutrient Levels and HIV Disease Status in HIV-Infected Patients on Highly Active Antiretroviral Therapy in the Nutrition for Healthy Living Cohort

Jones, C. Y., Tang, A., Forrester, J. E., Huang, J., Hendricks, K. M., Knox, T. A., Spiegelman, D. L., Semba, R. D., & Woods, M. N. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000243096.27029.fe · Cited by 87

Selenium supplementation for critically ill adults

Allingstrup, M., & Afshari, A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003703.pub3 · Cited by 78

Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis

Abdulhamid, I. B., Beck, F. W., Millard, S., Chen, X., & Prasad, A. S. (2008) · Pediatric Pulmonology · doi:10.1002/ppul.20771 · Cited by 76

Selenium supplementation in critically ill patients: A systematic review and meta-analysis

Landucci, F., Mancinelli, P., De Gaudio, A. R., & Virgili, G. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.08.017 · Cited by 76

Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study

McDermid, J. M., Hennig, B. J., van der Sande, M., Hill, A. V., Whittle, H. C., Jaye, A., & Prentice, A. M. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-48 · Cited by 75

Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses

Vignesh, K. S., & Deepe, G. S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.02.020 · Cited by 74

Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation

Juttukonda, L. J., Chazin, W., & Skaar, E. P. (2016) · mBio · doi:10.1128/mbio.01475-16 · Cited by 74

Particle exposures and infections

Ghio, A. J. (2014) · Infection · doi:10.1007/s15010-014-0592-6 · Cited by 72

A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus

Gi, M., Lee, K., Kim, S. C., Yoon, J., Yoon, S. S., & Choi, J. Y. (2015) · Scientific Reports · doi:10.1038/srep14644 · Cited by 70

Iron Status Predicts Treatment Failure and Mortality in Tuberculosis Patients: A Prospective Cohort Study from Dar es Salaam, Tanzania

Isanaka, S., Aboud, S., Mugusi, F., Bosch, R. J., Willett, W. C., Spiegelman, D., Duggan, C., & Fawzi, W. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037350 · Cited by 67

Micronutrient Supplementation Increases Genital Tract Shedding of HIV-1 in Women

McClelland, R. S., Baeten, J. M., Overbaugh, J. M., Richardson, B. A., Mandaliya, K. N., Emery, S., Lavreys, L., Ndinya‐Achola, J. O., Bankson, D. D., Bwayo, J. J., et al. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200412150-00021 · Cited by 66

Dosing and Monitoring of Trace Elements in Long‐Term Home Parenteral Nutrition Patients

Btaiche, I. F., Carver, P. L., & Welch, K. B. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111413902 · Cited by 65

Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial,

McDonald, C. M., Manji, K. P., Kisenge, R. R., Aboud, S., Spiegelman, D. L., Fawzi, W. W., & Duggan, C. (2015) · Journal of Nutrition · doi:10.3945/jn.115.212308 · Cited by 62

Psychological Burden in the Era of Haart: Impact of Selenium Therapy

Shor‐Posner, G., Lecusay, R., Míguez‐Burbano, M. J., Moreno‐Black, G., Zhang, G., Rodriguez, N., Burbano, X., Baum, M. K., & Wilkie, F. L. (2003) · The International Journal of Psychiatry in Medicine · doi:10.2190/pffd-d920-v041-n5kd · Cited by 60

Selenium in critical illness

Geoghegan, M., McAuley, D. F., Eaton, S. D., & Powell-Tuck, J. (2006) · Current Opinion in Critical Care · doi:10.1097/01.ccx.0000216581.80051.d6 · Cited by 58

Effect of selenium supplementation on CD4+ T-cell recovery, viral suppression and morbidity of HIV-infected patients in Rwanda

Kamwesiga, J. T., Mutabazi, V., Kayumba, J., Tayari, J.-C., Uwimbabazi, J. C., Batanage, G., Uwera, G., Baziruwiha, M., Ntizimira, C. R., Murebwayire, A., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000673 · Cited by 58

Erratum: Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I. R., Costa‐Silva, B., Moreno‐Bueno, G., Hergueta‐Redondo, M., Williams, C., García‐Santos, G., Ghajar, C. M., et al. (2016) · Nature Medicine · doi:10.1038/nm1216-1502b · Cited by 58

Trace Metals and Infectious Diseases

Nriagu, J. O., & Skaar, E. P. (2015) · The MIT Press eBooks · doi:10.7551/mitpress/9780262029193.001.0001 · Cited by 57

Conflicting interests in the pathogen–host tug of war: fungal micronutrient scavenging versus mammalian nutritional immunity

Potrykus, J., Ballou, E. R., Childers, D. S., & Brown, A. J. P. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003910 · Cited by 52

The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial

Chelkeba, L., Ahmadi, A., Abdollahi, M., Najafi, A., Ghadimi, M. H., Mosaed, R., & Mojtahedzadeh, M. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0071-y · Cited by 51

Harnessing the power of fungal siderophores for the imaging and treatment of human diseases

Szebesczyk, A., Olshvang, E., Shanzer, A., Carver, P. L., & Gumienna‐Kontecka, E. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.05.001 · Cited by 48

Zinc supplements for preventing otitis media

Gulani, A., & Sachdev, H. S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006639.pub4 · Cited by 47

HIV-1, reactive oxygen species, and vascular complications

Porter, K. M., & Sutliff, R. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.019 · Cited by 45

The Effect of Zinc Supplements in Cystic Fibrosis Patients

Biervliet, S. V., Velde, S. V., Biervliet, J. P. V., & Robberecht, E. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000129650 · Cited by 39

Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils

Völlger, L., Akong, K., Cox, L., Goldmann, O., Wang, Y., Schäfer, S. T., Naim, H. Y., Nizet, V., & von Köckritz‐Blickwede, M. (2016) · Bioscience Reports · doi:10.1042/bsr20160031 · Cited by 39

Micronutrient supplementation in pregnant women with HIV infection

Siegfried, N., Irlam, J., Visser, M. E., & Rollins, N. C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009755 · Cited by 37

Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial

Martinez-Estevez, N. S., Alvarez-Guevara, A. N., & Rodríguez‐Martínez, C. E. (2016) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2015.12.006 · Cited by 37

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin

Laskaris, P., Atrouni, A., Calera, J. A., d'Enfert, C., Munier-Lehmann, H., Cavaillon, J.-M., Latgé, J.-P., & Ibrahim-Granet, O. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00324-16 · Cited by 37

Oral zinc and common childhood infections—An update

Basnet, S., Mathisen, M., & Strand, T. A. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.05.006 · Cited by 34

Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection

Sharma, G. R., Lodha, R., Shastri, S. S., Saini, S., Kapil, A., Singla, M., Mukherjee, A., Jat, K. R., Kabra, M., & Kabra, S. K. (2015) · Respiratory Care · doi:10.4187/respcare.04038 · Cited by 33

Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women

Drain, P. K., Baeten, J. M., Overbaugh, J. M., Wener, M. H., Bankson, D. D., Lavreys, L., Mandaliya, K. N., Ndinya‐Achola, J. O., & McClelland, R. S. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-85 · Cited by 28

Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers

Kupka, R., Msamanga, G., Spiegelman, D. L., Rifai, N., Hunter, D. J., & Fawzi, W. W. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602236 · Cited by 28

Selenium supplementation for sepsis: a meta-analysis of randomized controlled trials.

Kong, Z., Wang, F., Ji, S.-Z., Deng, X., & Xia, Z. (2013) · American Journal of Emergency Medicine · doi:10.1016/j.ajem.2013.04.020 · Cited by 28

Nutritional Immunity: Homology Modeling of Nramp Metal Import

Cellier, M. F. M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-0106-3_19 · Cited by 26

Serum Zinc Concentrations in Cystic Fibrosis Patients Aged Above 4 Years: A Cross-sectional Evaluation

Biervliet, S. V., Biervliet, J. P. V., Velde, S. V., & Robberecht, E. (2007) · Biological Trace Element Research · doi:10.1007/s12011-007-0041-9 · Cited by 25

Acute and subacute response of iron, zinc, copper and selenium in pigs experimentally infected with Actinobacillus pleuropneumoniae

Humann‐Ziehank, E., Menzel, A., Röhrig, P., Schwert, B., Ganter, M., & Hennig‐Pauka, I. (2014) · Metallomics · doi:10.1039/c4mt00148f · Cited by 24

The effect of Na-selenite treatment on the oxidative stress-antioxidants balance of multiple organ failure.

Woth, G., Nagy, B., Mérei, Á., Ernyey, B., Vincze, R., Kaurics, Z., Lantos, J., Bogár, L., & Mühl, D. (2014) · Journal of critical care · doi:10.1016/j.jcrc.2014.04.010 · Cited by 23

Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial

Some, J. W., Abbeddou, S., Jimenez, E. Y., Hess, S. Y., Ouédraogo, Z. P., Guissou, R. M., Vosti, S. A., Ouédraogo, J., & Brown, K. H. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-007828 · Cited by 23

Pre-Antiretroviral Therapy Serum Selenium Concentrations Predict WHO Stages 3, 4 or Death but not Virologic Failure Post-Antiretroviral Therapy

Shivakoti, R., Gupte, N., Yang, W.-T., Mwelase, N., Kanyama, C., Tang, A., Pillay, S., Samaneka, W. P., Riviere, C., Berendes, S., et al. (2014) · Nutrients · doi:10.3390/nu6115061 · Cited by 22

Metal Ions and Infectious Diseases. An Overview from the Clinic

Carver, P. L. (2013) · Metal ions in life sciences · doi:10.1007/978-94-007-7500-8_1 · Cited by 21

Microbial Virulence and Interactions With Metals

German, N., Lüthje, F. L., Hao, X., Rønn, R., & Rensing, C. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.05.010 · Cited by 21

The role of siderophores in metal homeostasis of members of the genus Burkholderia

Mathew, A., Jenul, C., Carlier, A. L., & Eberl, L. (2015) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12357 · Cited by 18

Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: a meta-analysis of randomised-controlled trials

Tie, H., Tan, Q., Luo, M.-Z., Li, Q., Yu, J., & Wu, Q. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005449 · Cited by 17

Serum Copper, Zinc and Magnesium Levels in Children with Enterobiosis

Koltaş, İ. S., Özcan, K., Tamer, L., & Aksungur, P. (1997) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/s0946-672x(97)80010-7 · Cited by 16

Selenium and aspirin in people living with HIV and AIDS in Nigeria

Durosinmi, M., Armistead, H., Akinola, N. O., Onayemi, O. E., Adediran, I., Olasode, O., Elujoba, A., Irinoye, O. O., Ogun, S., Odusoga, O., et al. (2008) · Nigerian Postgraduate Medical Journal · doi:10.4103/1117-1936.181054 · Cited by 15

Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

Zackular, J. P., Moore, J. L., Jordan, A., Juttukonda, L. J., Noto, M. J., Nicholson, M. R., Crews, J. D., Semler, M. W., Zhang, Y., Ware, L. B., et al. (2016) · Nature Medicine · doi:10.1038/nm1216-1502d · Cited by 14

Plasma Levels of Trace Elements Have an Implication on Interferon Treatment of Children with Chronic Hepatitis B Infection

Balamtekın, N., Kürekçi, A. E., Atay, A., Kalman, S., Okutan, V., Gökçay, E., Aydın, A., Şener, K., Safalı, M., & Özcan, O. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8507-6 · Cited by 13

Hypoferremia of infection: a double-edged sword?

Lokken, K. L., Tsolis, R. M., & Bäumler, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3526 · Cited by 10

The copper rush of the nineties

Solioz, M. (2016) · Metallomics · doi:10.1039/c6mt00111d · Cited by 4

Modulation of Clostridium difficile infection by dietary zinc

Seekatz, A. M., & Young, V. B. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.177 · Cited by 3

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

Iddir, M., Alex Brito, O., Dingeo, G., Sosa, S., Samouda, H., Frano, M. R. L., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 825

Iron in infection and immunity

Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 288

Is copper beneficial for COVID-19 patients?

Raha, S., Mallick, R., Basak, S., & Duttaroy, A. K. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109814 · Cited by 206

Iron in immune cell function and host defense

Haschka, D., Hoffmann, A., & Weiss, G. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.12.005 · Cited by 188

Metals in Host–Microbe Interaction: The Host Perspective

Rehder, D., Re, B., Bornhorst, J., Rr, D., DiRita, V. J., Navarro, M. M., Perry, R. D., Rink, L., Skaar, E. P., Mcp, S., et al. (2021) · Europe PMC (PubMed Central) · Cited by 2

doi: 10.3389/fcimb.2014.00190 Metal economy in host-microbe interactions

Veyrier, F. J., & Cellier, M. F. (2015)

The Fate of Intracellular Metal Ions in Microbes

Loutet, S. A., Chan, A., Kobylarz, M. J., Verstraete, M. M., Pfaffen, S., Ye, B., Arrieta, A. L., & Murphy, M. E. P. (2015) · The MIT Press eBooks · doi:10.7551/mitpress/9780262029193.003.0007 · Cited by 3

Metals and Disease

Bird, A. J. (2015) · BioScience · doi:10.1093/biosci/biv158 · Cited by 2

Metal economy in host-microbe interactions

Bozzaro, S., Buracco, S., & Peracino, B. (2015) · Frontiers research topics · doi:10.3389/978-2-88919-497-1 · Cited by 4