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Transcription factors drive B cell development

Hagman, James, Lukin, Kara·2006·Current Opinion in Immunology
DOI 10.1016/j.coi.2006.01.007
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Abstract

Transcription factors including PU.1, E2A and early B cell factor (EBF) are essential for the earliest stages of B lymphocyte development. Recent advances suggest that, although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages of development. E2A proteins are also crucial for B cell lineage determination, as shown by the pluripotency of E2A-deficient progenitors. Both PU.1 and E2A are required for expression of EBF. EBF activates the early program of genes unique to B cells, including the lineage commitment factor Pax5. EBF also facilitates the function of Pax5 by mediating epigenetic changes necessary for the function of Pax5 at gene targets. Together, these proteins function in a hierarchy of factors that orchestrates B cell development.

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Research works printed but not linked: 60

  1. Busslinger, 2004, Transcriptional control of early B cell development, Annu Rev Immunol, 22, 55, 10.1146/annurev.immunol.22.012703.104807 · DOI
  2. Scott, 1994, Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages, Science, 265, 1573, 10.1126/science.8079170 · DOI · Paper page
  3. Scott, 1997, PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors, Immunity, 6, 437, 10.1016/S1074-7613(00)80287-3 · DOI · Paper page
  4. McKercher, 1996, Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J, 15, 5647, 10.1002/j.1460-2075.1996.tb00949.x · DOI · Paper page
  5. DeKoter, 2000, Regulation of B lymphocyte and macrophage development by graded expression of PU.1, Science, 288, 1439, 10.1126/science.288.5470.1439 · DOI · Paper page
  6. DeKoter, 2002, PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors, Immunity, 16, 297, 10.1016/S1074-7613(02)00269-8 · DOI · Paper page
  7. Zou, 2005, Knockdown of Pu.1 by small interfering RNA in CD34+ embryoid body cells derived from mouse ES cells turns cell fate determination to pro-B cells, Proc Natl Acad Sci USA, 102, 13236, 10.1073/pnas.0506218102 · DOI
  8. McDevit, 2005, The Ig κ 3′ enhancer is activated by gradients of chromatin accessibility and protein association, J Immunol, 174, 2834, 10.4049/jimmunol.174.5.2834 · DOI
  9. Marecki, 2004, PU.1 as a chromatin accessibility factor for immunoglobulin genes, Mol Immunol, 40, 723, 10.1016/j.molimm.2003.08.007 · DOI · Paper page
  10. Maitra, 2000, BSAP can repress enhancer activity by targeting PU.1 function, Mol Cell Biol, 20, 1911, 10.1128/MCB.20.6.1911-1922.2000 · DOI
  11. Nikolajczyk, 1999, ETS protein-dependent accessibility changes at the immunoglobulin mu heavy chain enhancer, Immunity, 11, 11, 10.1016/S1074-7613(00)80077-1 · DOI · Paper page
  12. van der Stoep, 2004, E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII), Blood, 104, 2849, 10.1182/blood-2004-03-0790 · DOI
  13. Ying, 1998, Regulation of mouse CD72 gene expression during B lymphocyte development, J Immunol, 161, 4760, 10.4049/jimmunol.161.9.4760 · DOI
  14. Torlakovic, 2005, PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU. 1 putative binding sites in the BCL-6 promotor, J Pathol, 206, 312, 10.1002/path.1777 · DOI
  15. EL-Gazzar, 2001, PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP, J Biol Chem, 276, 48000, 10.1074/jbc.M106696200 · DOI
  16. Polli, 2005, The development of functional B lymphocytes in conditional PU.1 knock-out mice, Blood, 106, 2083, 10.1182/blood-2005-01-0283 · DOI
  17. Ye, 2005, PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch, J Exp Med, 202, 1411, 10.1084/jem.20051089 · DOI
  18. McDevit DC, Nikolajczyk BS, Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. Mol Immunol 2005, in press. · DOI
  19. Ishii, 2004, Combinatorial control of DNase I-hypersensitive site formation and erasure by immunoglobulin heavy chain enhancer-binding proteins, J Biol Chem, 279, 7331, 10.1074/jbc.M308973200 · DOI
  20. Szutorisz, 2005, Formation of an active tissue-specific chromatin domain intitiated by epigenetic marking at the embryonic stem cell stage, Mol Cell Biol, 25, 1804, 10.1128/MCB.25.5.1804-1820.2005 · DOI
  21. Su, 1996, The Ets protein Spi-B is expressed exclusively in B cells and T cells during development, J Exp Med, 184, 203, 10.1084/jem.184.1.203 · DOI
  22. Hashimoto, 1999, Prf, a novel Ets family protein that binds to the PU.1 binding motif, is specifically expressed in restricted stages of B cell development, Int Immunol, 11, 1423, 10.1093/intimm/11.9.1423 · DOI
  23. Bemark, 1999, Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development, J Biol Chem, 274, 10259, 10.1074/jbc.274.15.10259 · DOI
  24. Carlsson, 2003, SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus, Mol Immunol, 39, 1035, 10.1016/S0161-5890(03)00032-4 · DOI
  25. Xue, 2004, GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells, Nat Immun, 5, 1036, 10.1038/ni1117 · DOI
  26. Garrett-Sinha, 1999, PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction, Immunity, 10, 399, 10.1016/S1074-7613(00)80040-0 · DOI
  27. Hu, 2001, PU.1/Spi-B regulation of c-rel is essential for mature B cell survival, Immunity, 15, 545, 10.1016/S1074-7613(01)00219-9 · DOI
  28. Murre, 2005, Helix-loop-helix proteins and lymphocyte development, Nat Immunol, 6, 1079, 10.1038/ni1260 · DOI
  29. Hagman, 2005, Early B cell Factor ‘pioneers’ the way to B cell development, Trends Immunol, 26, 455, 10.1016/j.it.2005.07.001 · DOI
  30. Murre, 1989, Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence, Cell, 58, 537, 10.1016/0092-8674(89)90434-0 · DOI
  31. Sigvardsson, 2002, Early B cell Factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter, Mol Cell Biol, 22, 8539, 10.1128/MCB.22.24.8539-8551.2002 · DOI
  32. Sayegh, 2003, E-proteins directly regulate expression of activation-induced deaminase in mature B cells, Nat Immunol, 4, 586, 10.1038/ni923 · DOI
  33. Massari, 1999, A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex, Mol Cell, 4, 63, 10.1016/S1097-2765(00)80188-4 · DOI
  34. Hagman, 1993, Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression, Genes Dev, 7, 760, 10.1101/gad.7.5.760 · DOI
  35. Hagman, 1995, EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains, EMBO J, 14, 2907, 10.1002/j.1460-2075.1995.tb07290.x · DOI
  36. Bain, 1994, E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements, Cell, 79, 885, 10.1016/0092-8674(94)90077-9 · DOI · Paper page
  37. Zhuang, 1994, The helix-loop-helix gene E2A is required for B cell formation, Cell, 79, 875, 10.1016/0092-8674(94)90076-0 · DOI · Paper page
  38. Lin, 1995, Failure of B-cell differentiation in mice lacking the transcription factor EBF, Nature, 376, 263, 10.1038/376263a0 · DOI · Paper page
  39. O’Riordan, 1999, Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A, Immunity, 11, 21, 10.1016/S1074-7613(00)80078-3 · DOI
  40. Sigvardsson, 1997, EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes, Immunity, 7, 25, 10.1016/S1074-7613(00)80507-5 · DOI
  41. Gisler, 2002, The human V-preB promoter is a target for coordinated activation by early B cell factor and E47, J Immunol, 168, 5130, 10.4049/jimmunol.168.10.5130 · DOI
  42. Sigvardsson, 2000, Overlapping expression of Early B cell Factor and basic helix-loop-helix proteins as a mechanism to dictate B lineage specific activity of the λ5 promoter, Mol Cell Biol, 20, 3640, 10.1128/.20.10.3640-3654.2000 · DOI
  43. Romanow, 2000, E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells, Mol Cell, 5, 343, 10.1016/S1097-2765(00)80429-3 · DOI
  44. Goebel, 2001, Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells, J Exp Med, 194, 645, 10.1084/jem.194.5.645 · DOI
  45. Hsu, 2003, A conserved transcriptional enhancer regulates RAG gene expression in developing B cells, Immunity, 19, 105, 10.1016/S1074-7613(03)00181-X · DOI
  46. van Zelm, 2005, Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression, J Immunol, 175, 5912, 10.4049/jimmunol.175.9.5912 · DOI
  47. Ikawa, 2004, Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent, Immunity, 20, 349, 10.1016/S1074-7613(04)00049-4 · DOI
  48. Nutt, 1999, Commitment to the B-lymphoid lineage depends on the transcription factor Pax5, Nature, 401, 556, 10.1038/44076 · DOI
  49. Rolink, 1999, Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors, Nature, 401, 603, 10.1038/44164 · DOI
  50. Greenbaum, 2002, Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system, Proc Natl Acad Sci USA, 99, 15030, 10.1073/pnas.232299999 · DOI
  51. Månsson, 2004, Pearson correlation analysis of microarray data allows for the identification of genetic targets for early B cell factor, J Biol Chem, 279, 17905, 10.1074/jbc.M400589200 · DOI
  52. Medina, 2004, Defining a regulatory network for specification of the B cell fate, Dev Cell, 7, 607, 10.1016/j.devcel.2004.08.006 · DOI
  53. Medina, 2005, Genetic networks that regulate B lymphopoiesis, Curr Opin Hematol, 12, 203, 10.1097/01.moh.0000160735.67596.a0 · DOI
  54. Seet, 2004, Early B cell factor promotes B lymphopoiesis with reduced interleukin-7 responsiveness in the absence of E2A, J Exp Med, 199, 1689, 10.1084/jem.20032202 · DOI
  55. Zhang, 2003, Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage, EMBO J, 22, 4759, 10.1093/emboj/cdg464 · DOI
  56. Kee, 1998, Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12, J Exp Med, 188, 699, 10.1084/jem.188.4.699 · DOI
  57. Smith, 2002, Cloning and characterization of a promoter flanking the Early B cell Factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression, J Immunol, 169, 261, 10.4049/jimmunol.169.1.261 · DOI
  58. Maier, 2003, Activation of the early B cell-specific mb-1 (Ig-α) gene by Pax-5 is dependent on an unmethylated Ets binding site, Mol Cell Biol, 23, 1946, 10.1128/MCB.23.6.1946-1960.2003 · DOI
  59. Maier, 2004, Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription, Nat Immunol, 5, 1069, 10.1038/ni1119 · DOI
  60. Baba, 2005, Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors, Immunity, 23, 599, 10.1016/j.immuni.2005.10.009 · DOI

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Metadata

Authors
Hagman, J., & Lukin, K.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2006-04
Volume
18
Issue
2
Pages
127-134
ISSN
0952-7915
DOI
10.1016/j.coi.2006.01.007
Cited by
82
References
7
Language
en
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CoChat. (2026). Citation check: Transcription factors drive B cell development. https://app.cochat.ai/papers/10.1016/j.coi.2006.01.007
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Hagman, J., & Lukin, K. (2006). Transcription factors drive B cell development. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2006.01.007