Cited by 220Cytomegalovirus and herpesvirus researchTelomeres, Telomerase, and SenescenceImmune responses and vaccinations

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Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

Derhovanessian, Evelyna, Larbi, Anis, Pawelec, Graham·2009·Current Opinion in Immunology

DOI 10.1016/j.coi.2009.05.012

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Abstract

Age-associated failing systemic immunity, loosely termed 'immunosenescence', is thought to contribute to the increased incidence and severity of infectious disease in old people. It would therefore be of great practical as well as academic interest to accurately identify which of the multitude of alterations to immune parameters thus far reported are causally related to a person's clinically unfavourable health status, in order to identify the mechanisms of immune ageing and intervene to restore appropriate immunity. This is an enormous current challenge, as it requires longitudinal studies in a very long-lived species. Circumstantial evidence and longitudinal studies limited to the very elderly have begun to reveal 'immune signatures' or biomarkers of immune ageing consisting not of a single parameter, but clusters of parameters increasingly recognized as an 'immune risk profile', or IRP. Although hinted at many years ago, a marked impact of usually asymptomatic infection with the persistent beta-herpesvirus Cytomegalovirus (CMV) on markers of immunosenescence is now becoming incontrovertible. The fascinating cohabitation of CMV with the human immune system, which commits a very significant fraction of its entire resources to CMV-immunosurveillance, may suggest an early-life benefit from infection, which becomes deleterious for the majority of the population only in later life or under pathological conditions.

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Hearps, A. C., Schafer, K. R., High, K. P., & LANDAY, A. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_17 · Cited by 5
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Brinkhues, S., van Kuijk, S. M. J., Hoebe, C. J. P. A., Savelkoul, P. H. M., Kretzschmar, M., Jansen, M. W. J., de Vries, N. K., Sep, S. J. S., Dagnelie, P. C., Schaper, N. C., et al. (2017) · Epidemiology and Infection · doi:10.1017/s0950268817002187 · Cited by 5
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Kosugi, I. (2010) · Uirusu · doi:10.2222/jsv.60.209 · Cited by 5
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Müller, L., Pawelec, G., & Derhovanessian, E. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.4.631 · Cited by 5
Self-citation
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Interferon-gamma FlowSpot assay for the measurement of the T-cell response to cytomegalovirus
Ye, Q., Wang, J., Chen, M., Nie, W., Zhang, H., Su, X., Ling, L., Liu, X., Liu, L., Wang, C., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16792 · Cited by 4
Cytomegalovirus durably primes neutrophil oxidative burst
Marandu, T. F., Dombek, M., Gutknecht, M. F., Grießl, M., Riça, I. G., Vlková, B., Macáková, K., Panagioti, E., Griffith, A. M., Lederer, J. A., et al. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad091 · Cited by 4
Comparative analysis of NK cell receptor repertoire in adults and very elderly subjects with cytomegalovirus infection
Juárez‐Vega, G., Rangel-Ramírez, V. V., Monsiváis-Urenda, A. E., Niño-Moreno, P., García-Sepúlveda, C. A., Noyola, D. E., & González‐Amaro, R. (2017) · Human Immunology · doi:10.1016/j.humimm.2017.01.004 · Cited by 4
Somatische Veränderungen im Alter
Langsenlehner, U., Muchar, H., & Schippinger, W. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1581-7_4 · Cited by 4
Impact of Cytomegalovirus infection on immune signatures in cancer patients
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Self-citation
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Estrategias de monitorización inmunológica para la infección por citomegalovirus. Tratamientos de base inmunológica
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Accumulations of KIR+ T cells in the elderly
Pawelec, G. (2009) · Blood · doi:10.1182/blood-2009-08-235259 · Cited by 3
Self-citation
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Gloger, E. M., Judge, S. T., Reed, R. G., Presnell, S. R., Al‐Attar, A., Lutz, C. T., & Segerstrom, S. C. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100512 · Cited by 3
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Self-citation
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Immunity and Ageing
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Beneficial effect of resveratrol on T cell oxidative metabolism and anti-tumor function is conditioned by prior in vivo T cell history
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Zhou, S., Jian, L., Chen, H., Yin, H., Ji, F., Yang, M., & Wu, H. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09164-4 · Cited by 2
Antibodies to cytomegalovirus are elevated in myasthenia gravis
Probst, V., Trier, N. H., & Houen, G. (2021) · Clinical Immunology Communications · doi:10.1016/j.clicom.2021.09.001 · Cited by 2
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(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3
CMV and health care costs
Jones, R. (2011) · British Journal of Healthcare Management · doi:10.12968/bjhc.2011.17.4.168 · Cited by 2
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Preventing Infections and Healthy Aging
McElhaney, J. E., Andrew, M. K., McNeil, S., & Kuchel, G. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_16 · Cited by 1
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Boeira, M. C. R., Dorneles, G. P., Ferrari, W., & Peres, A. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.03.006 · Cited by 1
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Chauhan, T. S. (2014) · Journal of Genetics and Genome Research · doi:10.23937/2378-3648/1410003 · Cited by 1
Psychosocial and behavioral determinants of immune aging
Rector, J. L. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
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Macaulay, R. (2011) · UCL Discovery (University College London)
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Lee, F. J., & Katelaris, C. H. (2010) · Aging Health · doi:10.2217/ahe.10.33
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Morabito, K. M. (2015) · ProQuest Demo Repository
Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection
Aw, T.-R., & Chapman, J. (2015) · Journal of Immunology and Infectious Diseases · doi:10.15744/2394-6512.1.205
Introduction and General Principles
Solomon, T., & Geretti, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-55512-8.00030-2

Authors: Derhovanessian, E., Larbi, A., & Pawelec, G.
Affiliations: University of Tübingen (DE)
Corresponding author: Pawelec, Graham
ORCID: Larbi, Anis
Pawelec, Graham
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2009-08
Volume: 21
Issue: 4
Pages: 440-445
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2009.05.012
OpenAlex: W2061168748
Cited by: 220
References: 49
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 20 · 2020: 9 · 2019: 13 · 2018: 6 · 2017: 11 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 19 · 2012: 20
FWCI: 2.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: immunosenescence, cytomegalovirus infection, biomarkers, betaherpesviruses
MeSH terms: Age Factors, Aging, Cytomegalovirus Infections, Cytomegalovirus, Humans, Immune Tolerance, Biomarkers, Age of Onset, Disease Progression

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Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

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