The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
Abstract
Age-associated failing systemic immunity, loosely termed 'immunosenescence', is thought to contribute to the increased incidence and severity of infectious disease in old people. It would therefore be of great practical as well as academic interest to accurately identify which of the multitude of alterations to immune parameters thus far reported are causally related to a person's clinically unfavourable health status, in order to identify the mechanisms of immune ageing and intervene to restore appropriate immunity. This is an enormous current challenge, as it requires longitudinal studies in a very long-lived species. Circumstantial evidence and longitudinal studies limited to the very elderly have begun to reveal 'immune signatures' or biomarkers of immune ageing consisting not of a single parameter, but clusters of parameters increasingly recognized as an 'immune risk profile', or IRP. Although hinted at many years ago, a marked impact of usually asymptomatic infection with the persistent beta-herpesvirus Cytomegalovirus (CMV) on markers of immunosenescence is now becoming incontrovertible. The fascinating cohabitation of CMV with the human immune system, which commits a very significant fraction of its entire resources to CMV-immunosurveillance, may suggest an early-life benefit from infection, which becomes deleterious for the majority of the population only in later life or under pathological conditions.
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“These T cells do not express the co-stimulatory molecule CD28, required for the activation of T cells.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“In addition, they are producers of pro-inflammatory cytokines (17, 18, 41–47).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“CD28 seems a good biomarker of immunosenescence, as further suggested by findings that late-differentiated CD8+/CD28− T cells tend to accumulate particularly in older people, frail or affected by age-related diseases.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“Late-stage memory senescent T-cells may also acquire new functions, such as suppressive activity, as demonstrated in vitro.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“The loss of CD28 occurs following cell proliferation, according to the observation that the CD28− T cells have shorter telomeres than CD28+ cells.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“The impact of HIV disease on this process is not known, but emerging data suggest that these co-infections interact in a potential negative manner (41–44).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [42]
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Self-citation
Metadata
- Authors
- Derhovanessian, E., Larbi, A., & Pawelec, G.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Pawelec, Graham
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 21
- Issue
- 4
- Pages
- 440-445
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2061168748
- Cited by
- 220
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 20 · 2020: 9 · 2019: 13 · 2018: 6 · 2017: 11 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 19 · 2012: 20
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, cytomegalovirus infection, biomarkers, betaherpesviruses
- MeSH terms
- Age Factors, Aging, Cytomegalovirus Infections, Cytomegalovirus, Humans, Immune Tolerance, Biomarkers, Age of Onset, Disease Progression
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