The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
Abstract
Age-associated failing systemic immunity, loosely termed 'immunosenescence', is thought to contribute to the increased incidence and severity of infectious disease in old people. It would therefore be of great practical as well as academic interest to accurately identify which of the multitude of alterations to immune parameters thus far reported are causally related to a person's clinically unfavourable health status, in order to identify the mechanisms of immune ageing and intervene to restore appropriate immunity. This is an enormous current challenge, as it requires longitudinal studies in a very long-lived species. Circumstantial evidence and longitudinal studies limited to the very elderly have begun to reveal 'immune signatures' or biomarkers of immune ageing consisting not of a single parameter, but clusters of parameters increasingly recognized as an 'immune risk profile', or IRP. Although hinted at many years ago, a marked impact of usually asymptomatic infection with the persistent beta-herpesvirus Cytomegalovirus (CMV) on markers of immunosenescence is now becoming incontrovertible. The fascinating cohabitation of CMV with the human immune system, which commits a very significant fraction of its entire resources to CMV-immunosurveillance, may suggest an early-life benefit from infection, which becomes deleterious for the majority of the population only in later life or under pathological conditions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These T cells do not express the co-stimulatory molecule CD28, required for the activation of T cells.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“In addition, they are producers of pro-inflammatory cytokines (17, 18, 41–47).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“CD28 seems a good biomarker of immunosenescence, as further suggested by findings that late-differentiated CD8+/CD28− T cells tend to accumulate particularly in older people, frail or affected by age-related diseases.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“Late-stage memory senescent T-cells may also acquire new functions, such as suppressive activity, as demonstrated in vitro.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“The loss of CD28 occurs following cell proliferation, according to the observation that the CD28− T cells have shorter telomeres than CD28+ cells.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [45]
In the citing paper
“The impact of HIV disease on this process is not known, but emerging data suggest that these co-infections interact in a potential negative manner (41–44).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [42]
Citations
Cites
Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review
Rafailidis, P. I., Mourtzoukou, E. G., Varbobitis, I. C., & Falagas, M. E. (2008) · Virology Journal · doi:10.1186/1743-422x-5-47 · Cited by 639
T Cell Responses Are Better Correlates of Vaccine Protection in the Elderly
McElhaney, J. E., Xie, D., Hager, W. D., Barry, M. B., Wang, Y., Kleppinger, A., Ewen, C., Kane, K. P., & Bleackley, R. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.6333 · Cited by 561
Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B. E. A., Pawelec, G., Straten, P. T., & Wikby, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2645 · Cited by 471
Self-citationAgeing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463
B‐cell diversity decreases in old age and is correlated with poor health status
Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433
The ageing immune system: is it ever too old to become young again?
Dorshkind, K. A., Montecino‐Rodriguez, E., & Signer, R. A. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 424
Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402
Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., & Chougnet, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1835 · Cited by 399
Trzonkowski, P., Myśliwska, J. M., Szmit, E., Wickiewicz, J., Łukaszuk, K., Brydak, L. B., Machała, M. K., & Myśliwski, A. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00309-8 · Cited by 341
Cytomegalovirus and human immunosenescence
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339
Self-citationPlatelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection
Soroceanu, L., Akhavan, A., & Cobbs, C. (2008) · Nature · doi:10.1038/nature07209 · Cited by 297
Peripheral blood dendritic cells and monocytes are differently regulated in the elderly
Bella, S. D., Bierti, L., Presicce, P., Arienti, R., Valenti, M., Saresella, M., Vergani, C., & Villa, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.09.012 · Cited by 280
Chronic herpesvirus reactivation occurs in aging
Stowe, R., KOZLOVA, E., Yetman, D. L., Walling, D. M., Goodwin, J. S., & Glaser, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.005 · Cited by 279
Goronzy, J. J., Lee, W., & Weyand, C. M. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.016 · Cited by 269
Wikby, A., Månsson, I. A., Johansson, B. E. A., Strindhall, J., & Nilsson, S. E. (2008) · Biogerontology · doi:10.1007/s10522-008-9138-6 · Cited by 259
Chidrawar, S. M., Khan, N., Wei, W., McLarnon, A., Smith, N., Nayak, L., & Moss, P. A. H. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03785.x · Cited by 244
Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence
KOCH, S., LARBI, A., ÖZCELIK, D., SOLANA, R., GOUTTEFANGEAS, C., ATTIG, S., WIKBY, A., STRINDHALL, J., FRANCESCHI, C., & PAWELEC, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.043 · Cited by 242
Self-citationAccelerated immune senescence and HIV-1 infection
APPAY, V, ALMEIDA, J., SAUCE, D., AUTRAN, B., & PAPAGNO, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.003 · Cited by 236
Memory CD8 T-cell compartment grows in size with immunological experience
Vezys, V., Yates, A. J., Casey, K. A., Lanier, G., Ahmed, R., Antia, R., & Masopust, D. (2008) · Nature · doi:10.1038/nature07486 · Cited by 220
Immunosenescence: deficits in adaptive immunity in the elderly
Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 218
Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H. (2007) · Journal of Virology · doi:10.1128/jvi.01262-06 · Cited by 214
DOWD, J. B., AIELLO, A. E., & ALLEY, D. E. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808000551 · Cited by 210
Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.001 · Cited by 209
Self-citationChallenges for vaccination in the elderly
Aspinall, R., Giudice, G. D., Effros, R. B., Grubeck‐Loebenstein, B., & Sambhara, S. R. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-9 · Cited by 208
Tsaknaridis, L., Spencer, L., Culbertson, N. E., Hicks, K., LaTocha, D. H., Chou, Y. K., Whitham, R. H., Bakke, A. C., Jones, R. E., Offner, H., et al. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10766 · Cited by 197
Immunosenescence and Immunogenetics of Human Longevity
Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 189
Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4283 · Cited by 173
Immunity from Smallpox Vaccine Persists for Decades: A Longitudinal Study
Taub, D. D., Ershler, W. B., Janowski, M., Artz, A. S., Key, M. L., McKelvey, J., Muller, D. C., Moss, B., Ferrucci, L., Duffey, P. L., et al. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.08.019 · Cited by 173
van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Infectious Diseases · doi:10.1086/516788 · Cited by 159
Day, E., Carmichael, A., ten Berge, I. J. M., Waller, E. C. P., Sissons, J. G. P., & Wills, M. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3203 · Cited by 153
Role of T lymphocyte replicative senescence in vaccine efficacy
Effros, R. B. (2007) · Vaccine · doi:10.1016/j.vaccine.2006.08.032 · Cited by 152
Weinberger, B., Lazuardi, L., Weiskirchner, I., Keller, M., Neuner, C., Fischer, K.-H., Neuman, B., Würzner, R., & Grubeck‐Loebenstein, B. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.10.019 · Cited by 138
Sergio, G. (2008) · Inflammation Research · doi:10.1007/s00011-008-7243-2 · Cited by 125
Jenkins, C., Garcia, W., Godwin, M., Spencer, J. V., Stern, J. L., Abendroth, A., & Slobedman, B. (2008) · Journal of Virology · doi:10.1128/jvi.02173-07 · Cited by 116
Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation
Miles, D. J. C., van der Sande, M. A. B., Jeffries, D. J., Kaye, S., Ismaili, J., Ojuola, O. O., Sanneh, M., Touray, E. S., Waight, P., Rowland‐Jones, S., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00052-07 · Cited by 111
Biology of Dendritic Cells in Aging
Agrawal, A., Agrawal, S., Tay, J., & Gupta, S. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9127-6 · Cited by 111
CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation
Carrasco, J., Godelaine, D., Pel, A. V., Boon, T., & van der Bruggen, P. (2006) · Blood · doi:10.1182/blood-2005-11-007237 · Cited by 97
Benedict, C. A., Loewendorf, A. I., Garcia, Z., Blazar, B. R., & Janssen, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4836 · Cited by 94
Loss of T cell receptor-induced Bmi-1 in the KLRG1 + senescent CD8 + T lymphocyte
Heffner, M., & Fearon, D. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706040104 · Cited by 92
B Cell Immunosenescence in the Elderly and in Centenarians
Colonna‐Romano, G., Bulati, M., Aquino, A., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0664 · Cited by 59
Maribavir: A Novel Antiviral Agent with Activity Against Cytomegalovirus
Trofe, J., Pote, L., Wade, E. L., Blumberg, E. A., & Bloom, R. D. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1l065 · Cited by 57
Johansen, J. S., Pedersen, B. K., Schroll, M., Jørgensen, T., Pedersen, B. K., & Brüünsgaard, H. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03561.x · Cited by 56
Xie, D., & McElhaney, J. E. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.05.001 · Cited by 44
Ben‐Smith, A., Gorak‐Stolinska, P., Floyd, S., Weir, R. E., Lalor, M. K., Mvula, H., Crampin, A. C., Wallace, D. L., Beverley, P. C. L., Fine, P., et al. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-139 · Cited by 43
Schwanninger, A., Weinberger, B., Weiskopf, D., Herndler‐Brandstetter, D., Reitinger, S., Gassner, C., Schennach, H., Parson, W., Würzner, R., & Grubeck‐Loebenstein, B. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-14 · Cited by 42
Do adaptive immune cells suppress or activate innate immunity?
Zhao, J., Yang, X., Auh, S. L., Kim, K. D., Tang, H., & Fu, Y. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.10.003 · Cited by 40
Immunosenescence and cancer vaccines
Provinciali, M. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0665-z · Cited by 30
Flagged first, then by citations
Cited by
Sorted by citations
Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Aging, frailty and age-related diseases
Fülöp, T., Larbi, A., Witkowski, J. M., McElhaney, J. E., Loeb, M. B., Mitnitski, A., & Pawelec, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9287-2 · Cited by 687
Self-citationHigh, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Epigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518
Self-citation
Metadata
- Authors
- Derhovanessian, E., Larbi, A., & Pawelec, G.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Pawelec, Graham
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 21
- Issue
- 4
- Pages
- 440-445
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2061168748
- Cited by
- 220
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 20 · 2020: 9 · 2019: 13 · 2018: 6 · 2017: 11 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 19 · 2012: 20
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, cytomegalovirus infection, biomarkers, betaherpesviruses
- MeSH terms
- Age Factors, Aging, Cytomegalovirus Infections, Cytomegalovirus, Humans, Immune Tolerance, Biomarkers, Age of Onset, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
