Recent innovations in mRNA vaccines
Abstract
Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid DNA vaccines have been extensively evaluated in human clinical trials and have been shown to be safe and immunogenic, although none have yet been licensed for human use. Recently, mRNA based vaccines have emerged as an alternative approach. They promise the flexibility of plasmid DNA vaccines, without the need for electroporation, but with enhanced immunogenicity and safety. In addition, they avoid the limitations of anti-vector immunity seen with viral vectors, and can be dosed repeatedly. This review highlights the key papers published over the past few years and summarizes prospects for the near future.
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Vaccines based on mRNA offer multifaceted advantages including flexible antigen design, a cost-effective manufacturing process allowing for parallel production of multiple mRNA vaccines, and rapid manufacturing.
“Vaccines based on mRNA could meet these requirements because they offer multifaceted advantages including flexible antigen design, a cost-effective manufacturing process allowing for parallel production of multiple mRNA vaccines1–5 and rapid manufacturing, which could be of crucial importance during pandemics.6”
From Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines (2017) · cites this paper as [4]
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Additional file 7 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621263
Additional file 2 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621248
Additional file 3 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621251
Additional file 4 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621254
Additional file 6 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621260
Additional file 5 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621257
Additional file 1 of Non-interfacial self-assembly of synthetic protocells
Xu, X., Guan, W., Yu, X., Xu, G., & Wang, C. (2023) · Figshare · doi:10.6084/m9.figshare.23621245
mRNA-based seasonal influenza vaccines: an overview of immunogenicity, efficacy, and safety
Domnich, A., & Orsi, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1965512
- Authors
- Ulmer, J. B., & Geall, A. J.
- Corresponding author
- Geall, Andrew J
- ORCID
- Geall, Andrew J
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 41
- Pages
- 18-22
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2397894493
- Cited by
- 91
- References
- 50
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 4 · 2021: 22 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- mRNA vaccines, nucleic acid-based vaccines, DNA vaccine, viral vector vaccines, immunogenicity, vaccine safety, anti-vector immunity, electroporation, vaccine adjuvants
- MeSH terms
- Animals, Humans, RNA, Messenger, Vaccines, DNA
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