Cited by 97Immunotherapy and Immune ResponsesRNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 Research

Recent innovations in mRNA vaccines

Ulmer, Jeffrey B, Geall, Andrew J·2016·Current Opinion in Immunology

Abstract

Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid DNA vaccines have been extensively evaluated in human clinical trials and have been shown to be safe and immunogenic, although none have yet been licensed for human use. Recently, mRNA based vaccines have emerged as an alternative approach. They promise the flexibility of plasmid DNA vaccines, without the need for electroporation, but with enhanced immunogenicity and safety. In addition, they avoid the limitations of anti-vector immunity seen with viral vectors, and can be dosed repeatedly. This review highlights the key papers published over the past few years and summarizes prospects for the near future.

Integrity signals

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Crossref · 10.1016/j.coi.2016.05.008

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  • Vaccines based on mRNA offer multifaceted advantages including flexible antigen design, a cost-effective manufacturing process allowing for parallel production of multiple mRNA vaccines, and rapid manufacturing.

    “Vaccines based on mRNA could meet these requirements because they offer multifaceted advantages including flexible antigen design, a cost-effective manufacturing process allowing for parallel production of multiple mRNA vaccines1–5 and rapid manufacturing, which could be of crucial importance during pandemics.6”

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Authors
Ulmer, J. B., & Geall, A. J.
Corresponding author
Geall, Andrew J
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2016-08
Volume
41
Pages
18-22
ISSN
0952-7915 (ISSN-L)
OpenAlex
W2397894493
Cited by
91
References
50
Citations by year
2026: 2 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 4 · 2021: 22 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 1
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
mRNA vaccines, nucleic acid-based vaccines, DNA vaccine, viral vector vaccines, immunogenicity, vaccine safety, anti-vector immunity, electroporation, vaccine adjuvants
MeSH terms
Animals, Humans, RNA, Messenger, Vaccines, DNA

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