Cited by 362Neurogenesis and neuroplasticity mechanismsEpigenetics and DNA MethylationNeuroscience and Neuropharmacology Research

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Epigenetic influences on brain development and plasticity

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Fagiolini, Michela, Jensen, Catherine L, Champagne, Frances A·2009·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2009.05.009PMC PMC2745597

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Abstract

A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.

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Authors: Fagiolini, M., Jensen, C. L., & Champagne, F. A.
Affiliations: Boston Children's Hospital (US)
Columbia University (US)
Corresponding author: Champagne, Frances A
ORCID: Fagiolini, Michela
Champagne, Frances A
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2009-04
Volume: 19
Issue: 2
Pages: 207-212
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2009.05.009
PMC: PMC2745597
OpenAlex: W2031043159
Cited by: 362
References: 47
Citations by year: 2026: 12 · 2025: 8 · 2024: 11 · 2023: 55 · 2022: 17 · 2021: 15 · 2020: 20 · 2019: 15 · 2018: 22 · 2017: 30 · 2016: 23 · 2015: 27 · 2014: 21 · 2013: 31 · 2012: 14
FWCI: 1.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1dp2od001674-01)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007430)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: epigenetics, brain development, neuroplasticity, sensory experience, gene expression regulation, neural circuit formation, critical period, environmental stimuli, behavioral phenotypes, adult neuroplasticity
MeSH terms: Aging, Animals, Brain, Critical Period, Psychological, Humans, Synaptic Transmission, Neuronal Plasticity, Gene Expression Regulation, Developmental

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Epigenetic influences on brain development and plasticity

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