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The role of myelin and oligodendrocytes in axonal energy metabolism

Saab, Aiman S, Tzvetanova, Iva D, Nave, Klaus-Armin·2013·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2013.09.008
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Abstract

In vertebrates, the myelination of long axons by oligodendrocytes and Schwann cells enables rapid impulse propagation. However, myelin sheaths are not only passive insulators. Oligodendrocytes are also known to support axonal functions and long-term integrity. Some of the underlying mechanisms have now been identified. It could be shown that oligodendrocytes can survive in vivo by aerobic glycolysis. Myelinating oligodendrocytes release lactate through the monocarboxylate transporter MCT1. Lactate is then utilized by axons for mitochondrial ATP generation. Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails. These include neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.

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Metadata

Authors
Saab, A. S., Tzvetanova, I. D., & Nave, K.-A.
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2013-12
Volume
23
Issue
6
Pages
1065-1072
ISSN
0959-4388
DOI
10.1016/j.conb.2013.09.008
Cited by
324
References
12
Language
en
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