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Cited by 55Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Regulation of synaptic plasticity in hippocampal area CA2

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Carstens, Kelly E, Dudek, Serena M·2019·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2018.07.008PMC PMC6361679
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Abstract

Synaptic plasticity in the hippocampus is thought to play a vital role in both the refinement of neuronal circuits during development and in learning in the mature brain. Synapses in hippocampal area CA1 are known for a robust capacity for long-term potentiation (LTP), whereas synapses in the stratum radiatum of hippocampal area CA2 are particularly resistant to such changes. Although we have yet to fully understand the mechanisms behind this resistance to plasticity, a number of genes and extracellular matrix components highly expressed in CA2 appear to function as molecular brakes on plasticity and develop postnatally in the rodent brain. Curiously, the developmental profile of several CA2-enriched molecules is suggestive of a still undefined critical window of plasticity in the hippocampus.

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Crossref · 10.1016/j.conb.2018.07.008

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  • Oxytocin lowers the threshold for depolarizing inputs to induce long-term potentiation (LTP) in hippocampal CA2 and olfactory bulb.

    “For example, oxytocin lowers the threshold for depolarizing inputs to induce long-term potentiation (LTP) in hippocampal CA2 (Pagani et al. 2015, Carstens & Dudek 2019) and olfactory bulb (Fang et al. 2008).”

    From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Carstens & Dudek 2019

    In “Plasticity inducers in CA2” (page not available), the review says oxytocin-receptor agonists induce potentiation at CA2 excitatory synapses and that this potentiation is mechanistically similar to LTP. It does not establish that oxytocin lowers the threshold for depolarizing inputs to induce LTP. The olfactory-bulb portion is cited to Fang et al., not to this review. (LLM, conf=0.85)

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Authors
Carstens, K. E., & Dudek, S. M.
Affiliations
  • National Institute of Environmental Health Sciences (US)
  • National Institutes of Health (US)
Corresponding author
Dudek, Serena M
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2019-02
Volume
54
Pages
194-199
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2018.07.008
PMC
PMC6361679
OpenAlex
W2886687035
Cited by
55
References
14
Citations by year
2026: 6 · 2025: 11 · 2024: 10 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 1 · 2019: 7
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (Z01ES100221, ZIAES100221)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
synaptic plasticity, long-term potentiation, stratum radiatum, extracellular matrix, critical period, postnatal development, learning
MeSH terms
Animals, Humans, Neuronal Plasticity, Synapses, Pyramidal Cells, CA2 Region, Hippocampal

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