Cited by 207Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Obligatory Role of NR2A for Metaplasticity in Visual Cortex

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Philpot, Benjamin D., Cho, Kathleen K.A., Bear, Mark F.·2007·Neuron

Abstract

Light deprivation lowers the threshold for long-term depression (LTD) and long-term potentiation (LTP) in visual cortex by a process termed metaplasticity, but the mechanism is unknown. The decreased LTD/P threshold correlates with a decrease in the ratio of NR2A to NR2B subunits of cortical NMDA receptors (NMDARs) and a slowing of NMDAR-mediated excitatory postsynaptic currents (EPSCs). However, whether and how changes in NR2 subunit expression contribute to LTD and LTP have been controversial. In the present study, we used an NR2A knockout (KO) mouse to examine the role of this subunit in the experience-dependent modulation of NMDAR properties, LTD, and LTP. We found that deletion of NR2A abrogates the effects of visual experience on NMDAR EPSCs and prevents metaplasticity of LTP and LTD. These data support the hypothesis that experience-dependent changes in NR2A/B are functionally significant and yield a mechanism for an adjustable synaptic modification threshold in visual cortex.

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Crossref · 10.1016/j.neuron.2007.01.027

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Authors
Philpot, B. D., Cho, K. K. A., & Bear, M. F.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Bear, Mark F.
Venue
Neuron
Publisher
Elsevier BV
Published
2007-02
Volume
53
Issue
4
Pages
495-502
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2161352090
Cited by
207
References
63
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 15 · 2017: 9 · 2016: 5 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 13
FWCI
9.39
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • National Institute of Mental Health (P50MH058880)
  • National Eye Institute (R01EY012309)
  • National Institute of Neurological Disorders and Stroke (P01NS039321)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
metaplasticity, NR2A subunit, long-term depression, long-term potentiation, visual cortex, light deprivation, experience-dependent synaptic plasticity, excitatory postsynaptic currents
MeSH terms
Action Potentials, Analysis of Variance, Animals, Animals, Newborn, Brain Chemistry, Dark Adaptation, Dose-Response Relationship, Radiation, Electric Stimulation, Gene Expression Regulation, Mice, Inbred C57BL, Neuronal Plasticity, Neurons, Synaptosomes, Visual Cortex, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, Patch-Clamp Techniques, Mice, In Vitro Techniques

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