Targeted activation of the hippocampal CA2 area strongly enhances social memory
Open accessAbstract
Social cognition enables individuals to understand others' intentions. Social memory is a necessary component of this process, for without it, subsequent encounters are devoid of any historical information. The CA2 area of the hippocampus, particularly the vasopressin 1b receptor (Avpr1b) expressed there, is necessary for memory formation. We used optogenetics to excite vasopressin terminals, originating from the hypothalamic paraventricular nucleus, in the CA2 of mice. This markedly enhanced their social memory if the stimulation occurred during memory acquisition, but not retrieval. This effect was blocked by an Avpr1b antagonist. Finally, this enhanced memory is resistant to the social distraction of an introduced second mouse, important for socially navigating populations of individuals. Our results indicate the CA2 can increase the salience of social signals. Targeted pharmacotherapy with Avpr1b agonists or deep brain stimulation of the CA2 are potential avenues of treatment for those with declining social memory as in various dementias.
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Optogenetic activation of paraventricular nucleus vasopressin inputs to CA2 enhances social memory in an Avpr1bR-dependent manner.
“Specifically, optogenetic activation of PVN Avp inputs to CA2 enhances social memory in an Avpr1bR-dependent manner [80].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [80]
Oxytocin and vasopressin-expressing cells in the paraventricular and supraoptic nuclei send projections to the hippocampus, with the highest fiber density seen in the CA2 region for vasopressin and CA2/CA3 regions for oxytocin projections.
“OXT and AVPexpressing cells in PVN and SON send projections to the hippocampus, with the highest fiber density seen in the CA2 region for AVP and CA2/CA3 regions for OXT projections (97-100).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [99]
Optogenetic activation of the paraventricular vasopressin cell inputs to hippocampal CA2 area enhances social memory via a V1bR mechanism in mice.
“For example, Smith et al (99) demonstrated that optogenetic activation of the PVN AVP cell inputs to hippocampal CA2 area enhances social memory, via a V1bR mechanism, in mice.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [99]
Growing evidence suggests an important role for V1bR in behavioral and neuroendocrine modulation.
“Growing evidence suggests an important role for V1bR in behavioral and neuroendocrine modulation (Griebel et al., 2003; Smith et al., 2016; Stevenson and Caldwell, 2012).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Smith et al., 2016
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- Authors
- Smith, A. S., Williams Avram, S. K., Cymerblit-Sabba, A., Song, J., & Young, W. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Smith, A S
- Young, W S
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2016-01-05
- Volume
- 21
- Issue
- 8
- Pages
- 1137-1144
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4935650
- OpenAlex
- W2227829864
- Cited by
- 236
- References
- 55
- Citations by year
- 2026: 9 · 2025: 24 · 2024: 30 · 2023: 33 · 2022: 24 · 2021: 23 · 2020: 26 · 2019: 21 · 2018: 23 · 2017: 13 · 2016: 10
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002498)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal CA2, social memory, AVPR1B, paraventricular nucleus, optogenetic stimulation, memory consolidation, social cognition, deep brain stimulation, dementia treatment
- MeSH terms
- Aggression, Animals, Arginine Vasopressin, Hippocampus, Male, Memory, Social Behavior, Receptors, Vasopressin, Mice, CA2 Region, Hippocampal, Optogenetics
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