Cited by 261Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Communication between gastrointestinal bacteria and the nervous system

Bravo, Javier A, Julio-Pieper, Marcela, Forsythe, Paul, Kunze, Wolfgang, Dinan, Timothy G, Bienenstock, John, Cryan, John F·2012·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2012.09.010

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Abstract

In the past few years, intestinal microbiota has emerged as a novel target for the treatment of gut-brain axis alterations. These include functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions. Thus, modulation of the microbiota (e.g. with the use of probiotics) could be proposed as a novel strategy not only for the treatment of IBS but also as an adjuvant for psychiatric treatment of anxiety and depression.

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Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
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Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
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Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
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Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
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O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
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Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392
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Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 2×
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Self-citation
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Self-citation
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“rodentium in mice [23 ].”
Background
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Corr, S. C., Li, Y., Riedel, C. U., O'Toole, P. W., Hill, C., & Gahan, C. G. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700440104 · Cited by 853
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Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799
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Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793
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Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742
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Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice.
Abrams, G. D., Bauer, H., & Sprinz, H. (1963) · PubMed · Cited by 482
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Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346
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Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328
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Self-citation
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The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins, S., Denou, E., Verdú, E., & Bercik, P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.023 · Cited by 130
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Collado, M. C., Isolauri, E., & Salminen, S. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01211.x · Cited by 86
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Bass, N. M. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1746-6342.2006.03218.x · Cited by 76
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Authors: Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F.
Affiliations: Pontificia Universidad Católica de Valparaíso (CL)
St. Joseph’s Healthcare Hamilton (CA)
McMaster University (CA)
University College Cork (IE)
Corresponding author: Bravo, Javier A
Cryan, John F
ORCID: Bravo, Javier A
Forsythe, Paul
Kunze, Wolfgang
Dinan, Timothy G
Bienenstock, John
Cryan, John F
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2012-12
Volume: 12
Issue: 6
Pages: 667-672
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2012.09.010
OpenAlex: W1988130273
Semantic Scholar: 3d0778a92190e47af7b4709128445b0d1d1b7f08
Cited by: 261
References: 52
Citations by year: 2026: 5 · 2025: 21 · 2024: 19 · 2023: 25 · 2022: 25 · 2021: 21 · 2020: 19 · 2019: 23 · 2018: 19 · 2017: 19 · 2016: 19 · 2015: 22 · 2014: 15 · 2013: 8 · 2012: 1
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut-brain axis, gut microbiota, gastrointestinal bacteria, irritable bowel syndrome, functional gastrointestinal disorders, probiotics, anxiety, depression, stress-related psychiatric disorders, microbiota modulation
MeSH terms: Animals, Anxiety, Central Nervous System, Depression, Gastrointestinal Diseases, Humans, Stress, Psychological, Probiotics, Gastrointestinal Tract, Irritable Bowel Syndrome

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Communication between gastrointestinal bacteria and the nervous system

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