Cited by 261Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Communication between gastrointestinal bacteria and the nervous system

Bravo, Javier A, Julio-Pieper, Marcela, Forsythe, Paul, Kunze, Wolfgang, Dinan, Timothy G, Bienenstock, John, Cryan, John F·2012·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2012.09.010

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Abstract

In the past few years, intestinal microbiota has emerged as a novel target for the treatment of gut-brain axis alterations. These include functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions. Thus, modulation of the microbiota (e.g. with the use of probiotics) could be proposed as a novel strategy not only for the treatment of IBS but also as an adjuvant for psychiatric treatment of anxiety and depression.

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Authors: Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F.
Affiliations: Pontificia Universidad Católica de Valparaíso (CL)
St. Joseph’s Healthcare Hamilton (CA)
McMaster University (CA)
University College Cork (IE)
Corresponding author: Bravo, Javier A
Cryan, John F
ORCID: Bravo, Javier A
Forsythe, Paul
Kunze, Wolfgang
Dinan, Timothy G
Bienenstock, John
Cryan, John F
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2012-12
Volume: 12
Issue: 6
Pages: 667-672
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2012.09.010
OpenAlex: W1988130273
Semantic Scholar: 3d0778a92190e47af7b4709128445b0d1d1b7f08
Cited by: 261
References: 52
Citations by year: 2026: 5 · 2025: 21 · 2024: 19 · 2023: 25 · 2022: 25 · 2021: 21 · 2020: 19 · 2019: 23 · 2018: 19 · 2017: 19 · 2016: 19 · 2015: 22 · 2014: 15 · 2013: 8 · 2012: 1
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut-brain axis, gut microbiota, gastrointestinal bacteria, irritable bowel syndrome, functional gastrointestinal disorders, probiotics, anxiety, depression, stress-related psychiatric disorders, microbiota modulation
MeSH terms: Animals, Anxiety, Central Nervous System, Depression, Gastrointestinal Diseases, Humans, Stress, Psychological, Probiotics, Gastrointestinal Tract, Irritable Bowel Syndrome

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