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27 MHz constant field dielectric warming of kidneys cryopreserved by vitrification

Wowk, Brian, Phan, John, Pagotan, Roberto, Galvez, Erika, Fahy, Gregory M.·2024·Cryobiology
DOI 10.1016/j.cryobiol.2024.104893
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Abstract

Organs cryopreserved by vitrification are exposed to the lowest possible concentration of cryoprotectants for the least time necessary to successfully avoid ice formation. Faster cooling and warming rates enable lower concentrations and perfusion times, reducing toxicity. Since warming rates necessary to avoid ice formation during recovery from vitrification are typically faster than cooling rates necessary for vitrification, warming speed is a major determining factor for successful vitrification. Dielectric warming uses an oscillating electric field to directly heat water and cryoprotectant molecules inside organs to achieve warming that's faster and more uniform than can be achieved by heat conduction from the organ surface. This work studied 27 MHz dielectric warming of rabbit kidneys perfused with M22 vitrification solution. The 27 MHz frequency was chosen because its long wavelength and penetration depth are suitable for human organs, because it had an anticipated favorable temperature of maximum dielectric absorption in M22, and because it's an allocated frequency for industrial and amateur use with inexpensive amplifiers available. Previously vitrified kidneys were warmed from -100 °C by placement in a 27 MHz electric field formed between parallel capacitor plates in a resonant circuit. Power was varied during warming to maintain constant electric field amplitude between the plates. Maximum power absorption occurred near -70 °C, with a peak warming rate near 150 °C/mi…

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Metadata

Authors
Wowk, B., Phan, J., Pagotan, R., Galvez, E., & Fahy, G. M.
Venue
Cryobiology
Publisher
Elsevier BV
Published
2024-06
Volume
115
Pages
104893
ISSN
0011-2240
DOI
10.1016/j.cryobiol.2024.104893
Cited by
32
References
1
Language
en
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Wowk, B., Phan, J., Pagotan, R., Galvez, E., & Fahy, G. M. (2024). 27 MHz constant field dielectric warming of kidneys cryopreserved by vitrification. Cryobiology. https://doi.org/10.1016/j.cryobiol.2024.104893