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Cited by 365

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Cell membrane modulation as adjuvant in cancer therapy

Open access
Zalba, Sara, ten Hagen, Timo L.M.·2017·Cancer Treatment Reviews
DOI 10.1016/j.ctrv.2016.10.008
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Abstract

Cancer is a complex disease involving numerous biological processes, which can exist in parallel, can be complementary, or are engaged when needed and as such can replace each other. This redundancy in possibilities cancer cells have, are fundamental to failure of therapy. However, intrinsic features of tumor cells and tumors as a whole provide also opportunities for therapy. Here we discuss the unique and specific makeup and arrangement of cell membranes of tumor cells and how these may help treatment. Interestingly, knowledge on cell membranes and associated structures is present already for decades, while application of membrane modification and manipulation as part of cancer therapy is lagging. Recent developments of scientific tools concerning lipids and lipid metabolism, opened new and previously unknown aspects of tumor cells and indicate possible differences in lipid composition and membrane function of tumor cells compared to healthy cells. This field, coined Lipidomics, demonstrates the importance of lipid components in cell membrane in several illnesses. Important alterations in cancer, and specially in resistant cancer cells compared to normal cells, opened the door to new therapeutic strategies. Moreover, the ability to modulate membrane components and/or properties has become a reality. Here, developments in cancer-related Lipidomics and strategies to interfere specifically with cancer cell membranes and how these affect cancer treatment are discussed. We hypothesize that combination of lipid or membrane targeted strategies with available care to improve chemotherapy, radiotherapy and immunotherapy will bring the much needed change in treatment in the years to come.

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Metadata

Authors
Zalba, S., & ten Hagen, T. L. M.
Venue
Cancer Treatment Reviews
Publisher
Elsevier BV
Published
2017-01
Volume
52
Pages
48-57
ISSN
0305-7372 (ISSN-L)
DOI
10.1016/j.ctrv.2016.10.008
OpenAlex
W2549531301
Cited by
365
References
99
FWCI
6.67
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.