Cited by 423Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 6 of the 8 references it cites were found in a registry or an index.

The hypothalamus

Open access

Saper, Clifford B., Lowell, Bradford B.·2014·Current Biology

DOI 10.1016/j.cub.2014.10.023

Open this paper in CoChat — free account Open PDF

Integrity signals

Registry

Crossref · 10.1016/j.cub.2014.10.023

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sleep state switching
Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.032 · Cited by 1,404
Self-citation
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure
Morrison, S. F., Madden, C. J., & Tupone, D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.007 · Cited by 437
Neural circuitry engaged by prostaglandins during the sickness syndrome
Saper, C. B., Romanovsky, A. A., & Scammell, T. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3159 · Cited by 285
Self-citation
Optogenetics, Sex, and Violence in the Brain: Implications for Psychiatry
Anderson, D. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.012 · Cited by 129
2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: Central neural pathways for thermoregulatory cold defense
Morrison, S. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01227.2010 · Cited by 105

Flagged first, then by citations

Show all 8 references

2 of the 8 references couldn’t be matched to a known paper.

Sorted by citations

A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,203
Ventromedial hypothalamic neurons control a defensive emotion state
Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Balban, M. Y., Meister, M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.06633 · Cited by 1,130
Neural circuits of interoception
Berntson, G. G., & Khalsa, S. S. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.011 · Cited by 419
The Basal Ganglia Over 500 Million Years
Grillner, S. E., & Robertson, B. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.041 · Cited by 379
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
Steuernagel, L., Lam, B. Y. H., Klemm, P., Dowsett, G. K. C., Bauder, C. A., Tadross, J. A., Hitschfeld, T. S., del Rio Martin, A., Chen, W., de Solis, A. J., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00657-y · Cited by 267
Multimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259
A hypothalamic novelty signal modulates hippocampal memory
Chen, S., He, L., Huang, A. J. Y., Boehringer, R., Robert, V., Wintzer, M. E., Polygalov, D., Weitemier, A. Z., Tao, Y., Gu, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2771-1 · Cited by 258
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208
Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles
Xu, S., Yang, H., Menon, V., Lemire, A. L., Wang, L., Henry, F. E., Turaga, S. C., & Sternson, S. M. (2020) · Science · doi:10.1126/science.abb2494 · Cited by 201
A hypothalamus-habenula circuit controls aversion
Lazaridis, I., Tzortzi, O., Weglage, M., Märtin, A., Xuan, Y., Parent, M. A., Johansson, Y., Fuzik, J., Fürth, D., Fenno, L. E., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0369-5 · Cited by 187
Molecular design of hypothalamus development
Romanov, R. A., Tretiakov, E. O., Kastriti, M. E., Zupančič, M., Häring, M., Korchynska, S., Popadin, K. Y., Benevento, M., Rebernik, P., Lallemend, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2266-0 · Cited by 178
The Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases
Qin, C., Li, J., & Tang, K. (2018) · Endocrinology · doi:10.1210/en.2018-00453 · Cited by 170
Stress and central autonomic network
Lamotte, G. J., Shouman, K., & Benarroch, E. E. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102870 · Cited by 162
Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
Lo, L., Yao, S., Kim, D., Cetin, A. H., Harris, J. A., Zeng, H., Anderson, D. J., & Weissbourd, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817503116 · Cited by 141
A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region
Neudorfer, C., Germann, J., Elias, G. J. B., Gramer, R., Boutet, A., & Lozano, A. M. (2020) · Scientific Data · doi:10.1038/s41597-020-00644-6 · Cited by 139
An approximate line attractor in the hypothalamus encodes an aggressive state
Nair, A., Karigo, T., Yang, B., Ganguli, S., Schnitzer, M. J., Linderman, S. W., Anderson, D. J., & Kennedy, A. (2023) · Cell · doi:10.1016/j.cell.2022.11.027 · Cited by 148
Neural Circuits for Emotion
Malézieux, M., Klein, A. S., & Gogolla, N. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-103314 · Cited by 144
Development of the Neuroendocrine Hypothalamus
Burbridge, S., Stewart, I. D., & Placzek, M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150023 · Cited by 115
Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake
Ryan, P. J., Ross, S. I., Campos, C., Derkach, V. A., & Palmiter, R. D. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0014-z · Cited by 114
Multiple convergent hypothalamus–brainstem circuits drive defensive behavior
Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A. S., Wagle, M. D., Guo, S., & Deisseroth, K. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0655-1 · Cited by 116
The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
Rosario, W., Singh, I., Wautlet, A., Patterson, C., Flak, J., Becker, T., Ali, A. F., Tamarina, N., Philipson, L., Enquist, L., et al. (2016) · Diabetes · doi:10.2337/db15-0629 · Cited by 98
The structural and functional complexity of the integrative hypothalamus
Fong, H., Zheng, J., & Kurrasch, D. M. (2023) · Science · doi:10.1126/science.adh8488 · Cited by 107
The Structural Connectome of the Human Central Homeostatic Network
Edlow, B. L., McNab, J. A., Witzel, T., & Kinney, H. C. (2015) · Brain Connectivity · doi:10.1089/brain.2015.0378 · Cited by 99
Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states
Livneh, Y., & Andermann, M. L. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.036 · Cited by 105
Skeletal interoception in bone homeostasis and pain
Lv, X., Gao, F., & Cao, X. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.025 · Cited by 94
A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss
Yang, F., Liu, Y., Chen, S., Dai, Z., Yang, D., Gao, D., Shao, J., Wang, Y., Wang, T., Zhang, Z., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136105 · Cited by 87
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
Solís, A. J. D., Río-Martín, A. D., Radermacher, J., Chen, W., Steuernagel, L., Bauder, C. A., Eggersmann, F. R., Morgan, D. A., Lena, C. A., Sue, M. W., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00987-z · Cited by 94
The self on its axis: a framework for understanding depression
Davey, C. G., & Harrison, B. J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01790-8 · Cited by 94
Histamine and the striatum
Bolam, J. P., & Ellender, T. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.013 · Cited by 87
Non-Contact Infrared Thermometers and Thermal Scanners for Human Body Temperature Monitoring: A Systematic Review
Zhao, Y., & Bergmann, J. (2023) · Sensors · doi:10.3390/s23177439 · Cited by 90
Neurogenetic basis for circadian regulation of metabolism by the hypothalamusPreprint
Cedernaes, J., Waldeck, N. J., & Bass, J. T. (2019) · Genes & Development · doi:10.1101/gad.328633.119 · Cited by 89
Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus
Mickelsen, L. E., Flynn, W. F., Springer, K., Wilson, L., Beltrami, E. J., Bolisetty, M. T., Robson, P., & Jackson, A. C. (2020) · eLife · doi:10.7554/elife.58901 · Cited by 79
Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis
Rizzoti, K., & Lovell-Badge, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.020 · Cited by 79
Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus
Zhou, X., Zhong, S., Peng, H., Liu, J., Ding, W., Sun, L., Ma, Q., Liu, Z., Chen, R., Wu, Q., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17890-2 · Cited by 74
The anterior hypothalamus in cluster headache
Arkink, E. B., Schmitz, N., Schoonman, G. G., van Vliet, J. A., Haan, J., van Buchem, M. A., Ferrari, M. D., & Kruit, M. C. (2016) · Cephalalgia · doi:10.1177/0333102416660550 · Cited by 76
Molecular and Neural Functions of Rai1 , the Causal Gene for Smith-Magenis Syndrome
Huang, W., Guenthner, C. J., Xu, J., Nguyen, T., Schwarz, L. A., Wilkinson, A. W., Gozani, O., Chang, H. Y., Shamloo, M., & Luo, L. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.019 · Cited by 74
The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications
Fröhlich, E., & Wahl, R. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.006 · Cited by 79
The neural basis of sex differences in sexual behavior: A quantitative meta-analysis
Poeppl, T. B., Langguth, B., Rupprecht, R., Safron, A., Bzdok, D., Laird, A. R., & Eickhoff, S. B. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.10.001 · Cited by 69
Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms
Yang, X., Qiu, K., Jiang, Y., Huang, Y., Zhang, Y., & Liao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147621 · Cited by 75
Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms
Banwinkler, M., Theis, H., Prange, S., & van Eimeren, T. (2022) · Brain Sciences · doi:10.3390/brainsci12091248 · Cited by 70
Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior
Wircer, E., Blechman, J., Borodovsky, N., Tsoory, M., Nunes, A. R., Oliveira, R. F., & Levkowitz, G. (2017) · eLife · doi:10.7554/elife.22170 · Cited by 63
Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Milbank, E., & López, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00830 · Cited by 63
Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors
Botticelli, L., Bonaventura, E. M. D., Bello, F. D., Giorgioni, G., Piergentili, A., Romano, A., Quaglia, W., Cifani, C., & Bonaventura, M. V. M. D. (2020) · Nutrients · doi:10.3390/nu12082288 · Cited by 63
Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development
Zhou, X., Lu, Y., Zhao, F., Dong, J., Ma, W., Zhong, S., Wang, M., Wang, B., Zhao, Y., Shi, Y., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.11.009 · Cited by 59
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
Herb, B. R., Glover, H. J., Bhaduri, A., Colantuoni, C., Bale, T. L., Siletti, K., Linnarsson, S., Hodge, R. D., Lein, E. S., Kriegstein, A. R., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf6251 · Cited by 57
The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective
Roger, C., Lasbleiz, A., Guye, M., Dutour, A., Gaborit, B., & Ranjeva, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.760914 · Cited by 61
Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish
Nagpal, J. K., Herget, U., Choi, M. K., & Ryu, S. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2900-4 · Cited by 55
Construction of complex memories via parallel distributed cortical–subcortical iterative integration
McNaughton, N., & Vann, S. D. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.04.006 · Cited by 52
Hypothalamic expression of inflammatory mediators in an animal model of binge eating
Alboni, S., Bonaventura, M. V. M. D., Benatti, C., Giusepponi, M. E., Brunello, N., & Cifani, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.044 · Cited by 54
Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer’s disease
Liguori, C., Chiaravalloti, A., Nuccetelli, M., Izzi, F., Sancesario, G., Cimini, A., Bernardini, S., Schillaci, O., Mercuri, N. B., & Placidi, F. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8613-x · Cited by 52
Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension
Basting, T. M., Xu, J., Mukerjee, S., Epling, J. P., Fuchs, R., Sriramula, S., & Lazartigues, E. D. (2018) · The Journal of Physiology · doi:10.1113/jp276229 · Cited by 51
Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center
Siemens, J., & Kamm, G. B. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2101-0 · Cited by 49
Craniopharyngiomas Primarily Involving the Hypothalamus: A Model of Neurosurgical Lesions to Elucidate the Neurobiological Basis of Psychiatric Disorders
Pascual, J. M., Prieto, R., Castro-Dufourny, I., Mongardi, L., Rosdolsky, M., Strauss, S., Carrasco, R., & Barrios, L. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.09.053 · Cited by 50
The hypothalamus at the crossroads of psychopathology and neurosurgery
Barbosa, D. A. N., de Oliveira‐Souza, R., Santo, F. M., Faria, A. C. D. O., Gorgulho, A. A., & Salles, A. A. F. D. (2017) · Neurosurgical FOCUS · doi:10.3171/2017.6.focus17256 · Cited by 47
The neuroscience of adaptive thermoregulation
Angilletta, M. J., Youngblood, J. P., Neel, L. K., & VandenBrooks, J. M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.046 · Cited by 50
The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period
Bienboire‐Frosini, C., Wang, D., Marcet‐Rius, M., Villanueva‐García, D., Gazzano, A., Domínguez-Oliva, A., Olmos-Hernández, A. S., Hernández-Ávalos, I., Lezama-García, K., Verduzco-Mendoza, A., et al. (2023) · Animals · doi:10.3390/ani13132173 · Cited by 54
Endocannabinoids in Body Weight Control
Horn, H., Böhme, B., Dietrich, L., & Koch, M. (2018) · Pharmaceuticals · doi:10.3390/ph11020055 · Cited by 49
High-fat Diet and Physical Exercise Differentially Modulate Adult Neurogenesis in the Mouse Hypothalamus
Klein, C., Jonas, W., Wiedmer, P., Schreyer, S., Akyüz, L., Spranger, J., Hellweg, R., & Steiner, B. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.037 · Cited by 46
Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease; What Are the Unanswered Questions?
Martin, W. P., White, J. P., López-Hernández, F. J., Docherty, N. G., & le Roux, C. W. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00289 · Cited by 49
A novel endoscopic classification for craniopharyngioma based on its origin
Tang, B., Xie, S., Li, X., Huang, G. L., Wang, Z. G., Yang, L., Yang, X., Xu, S., Chen, Y. Y., Ji, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28282-4 · Cited by 46
Skeletal interoception in osteoarthritis
Yang, D., Xu, J., Xu, K., & Xu, P. (2024) · Bone Research · doi:10.1038/s41413-024-00328-6 · Cited by 51
Decoding neuronal composition and ontogeny of individual hypothalamic nuclei
Ma, T., Wong, S. Z. H., Lee, B., Ming, G., & Song, H. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.026 · Cited by 41
Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome
Corrêa‐da‐Silva, F., Fliers, E., Swaab, D. F., & Yi, C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12994 · Cited by 40
Loss of transient receptor potential channel 5 causes obesity and postpartum depression
Li, Y., Cacciottolo, T. M., Yin, N., He, Y., Liu, H., Liu, H., Yang, Y., Henning, E., Keogh, J. M., Lawler, K., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.001 · Cited by 42
Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila
Cury, K. M., & Axel, R. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01332-5 · Cited by 40
Neuronal cAMP/PKA Signaling and Energy Homeostasis
Yang, L. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_3 · Cited by 39
Cancer as a homeostatic challenge: the role of the hypothalamus
Francis, N., & Borniger, J. C. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.08.008 · Cited by 42
Sex difference in thermal preference of adult mice does not depend on presence of the gonads
Kaikaew, K., Steenbergen, J., Themmen, A. P. N., Visser, J. A., & Grefhorst, A. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0145-7 · Cited by 40
Cerebrospinal fluid dynamics along the optic nerve
Sheng, J., Li, Q., Liu, T., & Wang, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.931523 · Cited by 41
Single-cell analysis of early chick hypothalamic development reveals that hypothalamic cells are induced from prethalamic-like progenitors
Kim, D. W., Place, E., Chinnaiya, K., Manning, E., Sun, C., Dai, W., Groves, I., Ohyama, K., Burbridge, S., Placzek, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110251 · Cited by 36
Exercise and the hypothalamic–pituitary–adrenal axis: a special focus on acute cortisol and growth hormone responses
Anderson, T., Berry, N. T., & Wideman, L. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.08.002 · Cited by 34
A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure
Benevento, M., Alpár, A., Gundacker, A., Afjehi, L., Balueva, K., Hevesi, Z., Hanics, J., Rehman, S., Pollak, D. D., Lübec, G., et al. (2024) · Nature · doi:10.1038/s41586-024-07232-3 · Cited by 35
Emerging roles for hypothalamic microglia as regulators of physiological homeostasis
Rosin, J. M., & Kurrasch, D. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100748 · Cited by 37
Developmental Genes and Malformations in the Hypothalamus
Dı́az, C., & Puelles, L. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.607111 · Cited by 35
Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus
Corman, T. S., Zevallos, S. E., & Epstein, D. J. (2018) · Development · doi:10.1242/dev.167379 · Cited by 32
Effect of short and long-term treatment with antipsychotics on orexigenic/anorexigenic neuropeptides expression in the rat hypothalamus
Rojczyk, E., Pałasz, A., & Wiaderkiewicz, R. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.04.001 · Cited by 33
Adult Neurogenesis in Sheep: Characterization and Contribution to Reproduction and Behavior
Lévy, F., Batailler, M., Meurisse, M., & Migaud, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00570 · Cited by 34
Interoception and Obsessive-Compulsive Disorder: A Review of Current Evidence and Future Directions
Bragdon, L. B., Eng, G. K., Belanger, A., Collins, K. A., & Stern, E. R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.686482 · Cited by 38
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
Korchynska, S., Rebernik, P., Pende, M., Boi, L., Alpár, A., Tasan, R. O., Becker, K., Balueva, K., Saghafi, S., Wulff, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33584-3 · Cited by 33
Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia
Fang, S., & Zhang, W. Y. (2024) · Biomedicines · doi:10.3390/biomedicines12081719 · Cited by 40
The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways
Derous, D., Mitchell, S. E., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D., Lusseau, D., Speakman, J. R., & Douglas, A. (2016) · Aging · doi:10.18632/aging.100895 · Cited by 34
Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction
Dawson, M., Terstege, D. J., Jamani, N. F., Tsutsui, M., Pavlov, D., Bugescu, R., Epp, J. R., Leinninger, G. M., & Sargin, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112815 · Cited by 34
Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis
Nelson, A. T., & Trotti, D. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01262-3 · Cited by 31
Neuropeptides in Cancer: Friend and Foe?
Wu, Y., Berisha, A., & Borniger, J. C. (2022) · Advanced Biology · doi:10.1002/adbi.202200111 · Cited by 30
Maternal fat-soluble vitamins, brain development, and regulation of feeding behavior: an overview of research
Sánchez‐Hernández, D., Anderson, G. H., Poon, A. N., Pannia, E., Cho, C. E., Huot, P. S. P., & Kubant, R. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.09.009 · Cited by 30
Hypothalamic MCH Neurons: From Feeding to Cognitive Control
Concetti, C., Peleg-Raibstein, D., & Burdakov, D. (2023) · Function · doi:10.1093/function/zqad059 · Cited by 28
A Neural Model of Empathic States in Attachment-Based Psychotherapy
Cittern, D., & Edalat, A. (2017) · Computational Psychiatry · doi:10.1162/cpsy_a_00006 · Cited by 30
Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection
Walsh, M. J. M., Pagni, B. A., Monahan, L., Delaney, S., Smith, C. J., Baxter, L. C., & Braden, B. B. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac069 · Cited by 29
Influencing cognitive performance via social interactions: a novel therapeutic approach for brain disorders based on neuroanatomical mapping?
Lanooij, S. D., Eisel, U. L. M., Drinkenburg, W. H. I. M., van der Zee, E. A., & Kas, M. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01698-1 · Cited by 27
Central Autonomic Network
Shouman, K., & Benarroch, E. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-62263-3_2 · Cited by 33
Hijacking homeostasis: the brain-body neural circuitry in tumor pathogenesis and emerging therapeutic frontiers
Wang, Y., Dong, Z.-K., & Jin, W. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02396-6 · Cited by 32
Orexins (hypocretins) and energy balance: More than feeding
Fernø, J., Señarís, R. M., Diéguez, C., Tena‐Sempere, M., & López, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.022 · Cited by 27
Neural Responses of Pet Dogs Witnessing Their Caregiver’s Positive Interactions with a Conspecific: An fMRI Study
Karl, S., Sladky, R., Lamm, C., & Huber, L. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab047 · Cited by 26
AMPA Receptor Function in Hypothalamic Synapses
Royo, M., Aznar-Escolano, B., Madrigal, M. P., & Jurado, S. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.833449 · Cited by 33
Distinct Firing Activities of the Hypothalamic Arcuate Nucleus Neurons to Appetite Hormones
Na, J., Park, B. S., Jang, D., Kim, D., Tu, T. H., Ryu, Y., Ha, C. M., Koch, M., Yang, S., Kim, J. K., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052609 · Cited by 26
Interneuron control of C. elegans developmental decision-making
Chai, C. M., Torkashvand, M., Seyedolmohadesin, M., Park, H., Venkatachalam, V., & Sternberg, P. W. (2022) · Current Biology · doi:10.1016/j.cub.2022.03.077 · Cited by 25
Orexins and primary headaches: an overview of the neurobiology and clinical impact
Stanyer, E. C., Hoffmann, J., & Holland, P. R. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2328728 · Cited by 27
Neurocardiology: translational advancements and potential
Herring, N., Ajijola, O. A., Foreman, R. D., Gourine, A. V., Green, A. L., Osborn, J. W., Paterson, D. J., Paton, J. F. R., Ripplinger, C. M., Smith, C. E. R., et al. (2024) · The Journal of Physiology · doi:10.1113/jp284740 · Cited by 28
Projectome-based characterization of hypothalamic peptidergic neurons in male mice
Jiao, Z., Gao, T., Wang, X., Wang, A., Ma, Y., Li, F., Gao, L., Gou, L., Zhang, W., Biglari, N., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01919-0 · Cited by 27
A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation
Notley, S. R., Mitchell, D., & Taylor, N. A. S. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05272-7 · Cited by 27

Authors: Saper, C. B., & Lowell, B. B.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Saper, Clifford B.
ORCID: Saper, Clifford B.
Lowell, Bradford B.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2014-12
Volume: 24
Issue: 23
Pages: R1111-R1116
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2014.10.023
OpenAlex: W4235269668
Cited by: 423
References: 8
Citations by year: 2026: 49 · 2025: 47 · 2024: 60 · 2023: 60 · 2022: 68 · 2021: 40 · 2020: 20 · 2019: 23 · 2018: 18 · 2017: 13 · 2016: 15 · 2015: 10
FWCI: 6.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: hypothalamus, neural circuits, energy metabolism, feeding, thermoregulation, fluid and electrolyte balance, sleep-wake cycle, stress response, homeostasis
MeSH terms: Aggression, Animals, Body Temperature Regulation, Energy Metabolism, Female, Fever, Humans, Hypothalamus, Male, Sexual Behavior, Sleep

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The hypothalamus

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks