Hippocampal-prefrontal theta oscillations support memory integration
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Integration of separate memories forms the basis of inferential reasoning--an essential cognitive process that enables complex behavior. Considerable evidence suggests that both hippocampus and medial prefrontal cortex (mPFC) play a crucial role in memory integration. Although previous studies indicate that theta oscillations facilitate memory processes, the electrophysiological mechanisms underlying memory integration remain elusive. To bridge this gap, we recorded magnetoencephalography data while participants performed an inference task and employed novel source reconstruction techniques to estimate oscillatory signals from the hippocampus. We found that hippocampal theta power during encoding predicts subsequent memory integration. Moreover, we observed increased theta coherence between hippocampus and mPFC. Our results suggest that integrated memory representations arise through hippocampal theta oscillations, possibly reflecting dynamic switching between encoding and retrieval states, and facilitating communication with mPFC. These findings have important implications for our understanding of memory-based decision making and knowledge acquisition.
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In humans, PFC-hippocampus theta coherence was increased in an inferential task requiring participants to integrate associations that shared common features.
“In humans, the PFC-hippocampus theta coherence was also increased in an inferential task which required participants to integrate associations that shared common features”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Backus et al., 2016
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Hippocampal and Prefrontal Theta-Band Mechanisms Underpin Implicit Spatial Context Learning
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- Authors
- Backus, A. R., Schoffelen, J.-M., Szebényi, S., Hanslmayr, S., & Doeller, C. F.
- Affiliations
- Radboud University Nijmegen (NL)
- University of Birmingham (GB)
- Corresponding author
- Backus, Alexander R.
- Doeller, Christian F.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 26
- Issue
- 4
- Pages
- 450-457
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2269315604
- Cited by
- 288
- References
- 52
- Citations by year
- 2026: 24 · 2025: 32 · 2024: 34 · 2023: 19 · 2022: 28 · 2021: 29 · 2020: 26 · 2019: 31 · 2018: 30 · 2017: 20 · 2016: 15
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (864.14.011)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal theta oscillations, medial prefrontal cortex, memory integration, inferential reasoning, theta coherence, memory retrieval, source localization, memory-based decision making, knowledge acquisition
- MeSH terms
- Adolescent, Adult, Decision Making, Female, Hippocampus, Humans, Male, Memory, Theta Rhythm, Magnetoencephalography, Prefrontal Cortex, Young Adult
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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