Interaction between the medial prefrontal cortex and hippocampal CA1 area is essential for episodic-like memory in rats
Abstract
The interplay between medial prefrontal cortex (mPFC) and hippocampus, particularly the hippocampal CA3 area, is critical for episodic memory. To what extent the mPFC also interacts with the hippocampus CA1 subregion still requires elucidation. To investigate this issue, male rats received unilateral N-methyl-D-aspartate lesions of the mPFC together with unilateral lesions of the hippocampal CA1 area, either in the same (control) or in the opposite hemispheres (disconnection). They underwent an episodic-like memory test, combining what-where-when information, and separate tests for novel object preference (what), object place preference (where) and temporal order memory (when). Compared to controls, the disconnected mPFC-CA1 rats exhibited disrupted episodic-like memory with an impaired integration of the what-where-when elements. Both groups showed intact memories for what and when, while only the control group showed intact memory for where. These findings suggest that the functional interaction of the mPFC-CA1 circuit is crucial for the processing of episodic memory and, in particular, for the integration of the spatial memory component.
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The counterintuitive result OS > OD indicates that the exploration pattern of objects according to their location is influenced by the temporal-order in which they were experienced.
“This counterintuitive result (OS > OD) indicates that the exploration pattern of objects according to their location is influenced by the temporal-order in which they have been experienced in the past (Chao et al., 2016a; Chao et al., 2017; de Souza Silva et al., 2016; Drieskens et al., 2017)”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
After PFC-CA1 disconnection, performance in the OPP test (where) was disrupted, whereas memories for NOP (what) and TOM (when) were intact.
“Furthermore, performance in the OPP test (where) was disrupted, whereas memories for NOP (what) and TOM (when), were intact.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
The PFC-CA1 circuit is critically involved in the processing of episodic-like memory itself.
“These findings indicate that the PFC-CA1 circuit is critically involved in the processing of episodic-like memory itself (Chao et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
When the PFC-CA1 circuit was interrupted, the ability to integrate distinct components into an episodic-like memory was impaired.
“When the PFC-CA1 circuit was interrupted, the ability to integrate distinct components into an episodic-like memory was impaired.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
PFC-CA1 disconnected animals showed intact spatial recognition in the ELM2-2 test (positive where index).
“The disruption of episodic-like memory could not have resulted from the impairment of object location memory since the PFC-CA1 disconnected animals showed intact spatial recognition in the ELM2–2 test (positive where index).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
Different extents of episodic-like memory deficits were observed depending on the region disconnected in studies disconnecting the mPFC from CA1, CA3 or LEC.
“Different extents of episodic-like memory deficits were observed, depending on the region disconnected in the studies of disconnecting the mPFC either from the CA1, CA3 or LEC (Chao et al., 2016a; Chao et al., 2017; de Souza Silva et al., 2016) (Table 5).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
Disconnection of the PFC-CA1 pathway, while preserving the indirect CA3-LEC-PFC circuit, impaired the interaction index.
“Disconnection of the PFC-CA1 pathway, while preserving the indirect CA3-LEC-PFC circuit, impaired the interaction index.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2017
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
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- Authors
- Chao, O. Y., Nikolaus, S., Lira Brandão, M., Huston, J. P., & de Souza Silva, M. A.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Düsseldorf University Hospital (DE)
- Corresponding author
- Huston, Joseph P.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 141
- Pages
- 72-77
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2605212557
- Cited by
- 38
- References
- 42
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 1 · 2018: 5 · 2017: 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heisenberg Fellowship (SO 1032/5-1)
- Deutsche Forschungsgemeischaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial prefrontal cortex, hippocampal CA1, episodic-like memory, NMDA lesions, spatial memory, temporal order memory, novel object recognition, rats
- MeSH terms
- Animals, Exploratory Behavior, Male, Neural Pathways, N-Methylaspartate, Rats, Wistar, Prefrontal Cortex, Excitatory Amino Acid Agonists, Recognition, Psychology, Rats, CA1 Region, Hippocampal, Memory, Episodic
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