Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval
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The medial temporal lobes, prefrontal cortex and parts of parietal cortex form the neural underpinnings of episodic memory, which includes remembering both where and when an event occurred. However, the manner in which these three regions interact during retrieval of spatial and temporal context remains untested. We employed simultaneous electrocorticographical recordings across multilobular regions in patients undergoing seizure monitoring while they retrieved spatial and temporal context associated with an episode, and we used phase synchronization as a measure of network connectivity. Successful memory retrieval was characterized by greater global connectivity compared with incorrect retrieval, with the medial temporal lobe acting as a hub for these interactions. Spatial versus temporal context retrieval resulted in prominent differences in both the spectral and temporal patterns of network interactions. These results emphasize dynamic network interactions as being central to episodic memory retrieval, providing insight into how multiple contexts underlying a single event can be recreated in the same network.
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Electrophysiological recordings from epileptic patients during correct retrieval of episodic memory suggest the medial temporal lobe acts as a hub to interact with the lateral PFC and parietal cortex to form inter-regional connecting networks.
“Electrophysiological recordings from epileptic patients during correct retrieval of episodic memory suggest the medial temporal lobe to act as a hub to interact with the lateral PFC and parietal cortex to form inter-regional connecting networks (Watrous et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Watrous et al., 2013
Interacting networks of brain regions including specialized hubs help to support navigation and spatial memory.
“Interacting networks of brain regions including specialized 'hubs' help to support navigation and spatial memory 61,[142][143][144] (Fig. 1).”
From From cognitive maps to spatial schemas (2023) · cites this paper as [143]
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EmT: A Novel Transformer for Generalized Cross-Subject EEG Emotion Recognition
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Electrophysiological Signatures of Spatial Boundaries in the Human Subiculum
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- Authors
- Watrous, A. J., Tandon, N., Conner, C. R., Pieters, T., & Ekstrom, A. D.
- Affiliations
- University of California, Davis (US)
- Memorial Hermann (US)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Ekstrom, Arne D
- Venue
- Nature Neuroscience
- Published
- 2013-01-27
- Volume
- 16
- Issue
- 3
- Pages
- 349-356
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3581758
- OpenAlex
- W1982567191
- Cited by
- 296
- References
- 54
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 16 · 2020: 29 · 2019: 35 · 2018: 29 · 2017: 25 · 2016: 20 · 2015: 24 · 2014: 28 · 2013: 12 · 2012: 1
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS076856)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- episodic memory retrieval, spatiotemporal memory, network connectivity, oscillatory coupling, phase synchronization, medial temporal lobe, spatial memory, temporal memory, prefrontal cortex, parietal cortex, seizure monitoring, electrocorticography
- MeSH terms
- Adult, Brain, Brain Mapping, Epilepsy, Humans, Memory, Nerve Net, Neuropsychological Tests, Mental Recall, Space Perception, Functional Neuroimaging
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