Hippocampal activation of Rac1 regulates the forgetting of object recognition memory
Open accessAbstract
Forgetting is a universal feature for most types of memories. The best-defined and extensively characterized behaviors that depict forgetting are natural memory decay and interference-based forgetting [1, 2]. Molecular mechanisms underlying the active forgetting remain to be determined for memories in vertebrates. Recent progress has begun to unravel such mechanisms underlying the active forgetting [3-11] that is induced through the behavior-dependent activation of intracellular signaling pathways. In Drosophila, training-induced activation of the small G protein Rac1 mediates natural memory decay and interference-based forgetting of aversive conditioning memory [3]. In mice, the activation of photoactivable-Rac1 in recently potentiated spines in a motor learning task erases the motor memory [12]. These lines of evidence prompted us to investigate a role for Rac1 in time-based natural memory decay and interference-based forgetting in mice. The inhibition of Rac1 activity in hippocampal neurons through targeted expression of a dominant-negative Rac1 form extended object recognition memory from less than 72 hr to over 72 hr, whereas Rac1 activation accelerated memory decay within 24 hr. Interference-induced forgetting of this memory was correlated with Rac1 activation and was completely blocked by inhibition of Rac1 activity. Electrophysiological recordings of long-term potentiation provided independent evidence that further supported a role for Rac1 activation in forgetting. Thus, Rac1-dependent forgetting is evolutionarily conserved from invertebrates to vertebrates.
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Rodents have memory for objects for up to 24 hours, and even up to 48 hours.
“Early studies have indicated that rodents have memory for objects for up to 24 hours (Ennaceur and Delacour, 1988), and even up to 48 hours (Liu et al., 2016).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Liu et al., 2016
Rac1 activity in the hippocampus dually controls NOP memory.
“suggesting that Rac1 activity in the hippocampus dually controls NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Liu et al., 2016
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- Authors
- Liu, Y., Du, S., Lv, L., Lei, B., Shi, W., Tang, Y., Wang, L., & Zhong, Y.
- Affiliations
- Tsinghua University (CN)
- Corresponding author
- Zhong, Yi
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 26
- Issue
- 17
- Pages
- 2351-2357
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2514991315
- Cited by
- 114
- References
- 41
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 19 · 2023: 11 · 2022: 16 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 4
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Tsinghua University
- National Key Research and Development Program of China
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- Rac1, forgetting, object recognition memory, hippocampus, small GTPases, dominant negative Rac1, long-term potentiation, memory consolidation, memory erasure, evolution of memory
- MeSH terms
- Animals, Hippocampus, Male, Memory, Mice, Inbred C57BL, Neurons, Neuropeptides, Visual Perception, Long-Term Potentiation, rac1 GTP-Binding Protein, Recognition, Psychology, Mice
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