Cited by 7Memory and Neural MechanismsNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Partially dissociable roles of the orbitofrontal cortex and dorsal hippocampus in context-dependent hierarchical associations

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Peterson, Sophie, Chavira, Jose, Garcia Arango, Jesus Alejandro, Seamans, David, Cimino, Emma D., Keiflin, Ronald·2024·Current Biology

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Abstract

Reward cues are often ambiguous; what is good in one context is not necessarily good in another. To solve this ambiguity, animals form hierarchical associations in which the context gates the retrieval of appropriate cue-evoked memories. These hierarchical associations regulate cue-elicited behavior and influence subsequent learning, promoting the inference of context-dependency. The orbitofrontal cortex (OFC) and dorsal hippocampus (DH) are both proposed to encode a "cognitive map" encompassing hierarchical, context-dependent associations. However, OFC- and DH-specific contributions to the different functional properties of hierarchical associations remain controversial. Using chemogenetic inactivation in rats, we show that the OFC is essential to both properties of hierarchical associations (performance regulation and learning bias). In contrast, DH's role appears limited to the contextual learning bias conferred by hierarchical associations. This work establishes the OFC as a critical orchestrator of hierarchical associations and provides insights into the extended circuits mediating the functional properties of these associations.

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Crossref · 10.1016/j.cub.2024.10.049

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Authors
Peterson, S., Chavira, J., Garcia Arango, J. A., Seamans, D., Cimino, E. D., & Keiflin, R.
Affiliations
University of California, Santa Barbara (US)
Corresponding author
Keiflin, Ronald
Venue
Current Biology
Publisher
Elsevier BV
Published
2024-12
Volume
34
Issue
23
Pages
5532-5545.e3
ISSN
0960-9822 (ISSN-L)
OpenAlex
W4404533963
Cited by
7
References
70
Citations by year
2026: 5 · 2025: 1 · 2024: 1
FWCI
1.70
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion, cc-by-nc-nd)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
University of California Santa Barbara
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
orbitofrontal cortex, dorsal hippocampus, contextual memory, chemogenetic inactivation, performance regulation, cognitive maps, memory retrieval
MeSH terms
Animals, Cues, Hippocampus, Learning, Male, Reward, Prefrontal Cortex, Rats, Long-Evans, Rats

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