The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

Angiogenesis in cancer and other diseases

Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,711

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

Wang, H. U., Chen, Z.-F., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,669

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Hartsock, A., & Nelson, W. J. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.012 · Cited by 1,559

Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis

Bazzoni, G., & Dejana, E. (2004) · Physiological Reviews · doi:10.1152/physrev.00035.2003 · Cited by 1,389

Endothelial cell–cell junctions: happy together

Dejana, E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1357 · Cited by 1,188

CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT

Van Itallie, C. M., & Anderson, J. M. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.131404 · Cited by 1,131

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

Goumans, M.-J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1743 · Cited by 1,123

Notch signaling is essential for vascular morphogenesis in mice

Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,060

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

Adams, R. H., Wilkinson, G. A., Weiss, C., Diella, F., Gale, N. W., Deutsch, U., Risau, W., & Klein, R. (1999) · Genes & Development · doi:10.1101/gad.13.3.295 · Cited by 1,025

VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,018

Functionally specialized junctions between endothelial cells of lymphatic vessels

Baluk, P., Fuxe, J., Hashizume, H., Romano, T., Lashnits, E., Butz, S., Vestweber, D., Corada, M., Molendini, C., Dejana, E., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062596 · Cited by 1,006

The role of adherens junctions and VE-cadherin in the control of vascular permeability

Dejana, E., Orsenigo, F., & Lampugnani, M. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.017897 · Cited by 986

The Vascular Anatomy of the Developing Zebrafish: An Atlas of Embryonic and Early Larval Development

Isogai, S., Horiguchi, M., & Weinstein, B. M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9995 · Cited by 896

Signalling to and from tight junctions

Matter, K., & Balda, M. S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1055 · Cited by 884

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 860

Untitled work

Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806

Crosstalk of tight junction components with signaling pathways

González-Mariscal, L., Tapia, R., & Chamorro, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.018 · Cited by 759

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

Gerety, S. S., Wang, H. U., Chen, Z.-F., & Anderson, D. J. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80342-1 · Cited by 707

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

Fischer, A., Schumacher, N., Maier, M., Sendtner, M., & Gessler, M. (2004) · Genes & Development · doi:10.1101/gad.291004 · Cited by 655

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

Taddei, A., Giampietro, C., Conti, A., Orsenigo, F., Breviario, F., Pirazzoli, V., Potente, M., Daly, C., Dimmeler, S., & Dejana, E. (2008) · Nature Cell Biology · doi:10.1038/ncb1752 · Cited by 653

Occludin as a possible determinant of tight junction permeability in endothelial cells

Hirase, T., Staddon, J. M., Saitou, M., Ando-Akatsuka, Y., Itoh, M., Furuse, M., Fujimoto, K., Tsukita, S., & Rubin, L. L. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.14.1603 · Cited by 646

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600

Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation

Takai, Y., Miyoshi, J., Ikeda, W., & Ogita, H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2457 · Cited by 586

Dosage‐sensitive requirement for mouse Dll4 in artery development

Duarte, A., Hirashima, M., Benedito, R., Trindade, A., Diniz, P., Bekman, E., Costa, L., Henrique, D., & Rossant, J. (2004) · Genes & Development · doi:10.1101/gad.1239004 · Cited by 563

A role for Rac in Tiaml-induced membrane ruffling and invasion

Michiels, F., Habets, G. G. M., Stam, J. C., van der Kammen, R. A., & Collard, J. G. (1995) · Nature · doi:10.1038/375338a0 · Cited by 556

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 532

Claudins in occluding junctions of humans and flies

Furuse, M., & Tsukita, S. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.006 · Cited by 528

Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

Lampugnani, M. G., Orsenigo, F., Gagliani, M. C., Tacchetti, C., & Dejana, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602080 · Cited by 525

The role of junctional adhesion molecules in vascular inflammation

Weber, C., Fraemohs, L., & Dejana, E. (2007) · Nature Reviews Immunology · doi:10.1038/nri2096 · Cited by 503

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

Limaye, N., Wouters, V., Uebelhoer, M., Tuominen, M., Wirkkala, R., Mulliken, J. B., Eklund, L., Boon, L. M., & Vikkula, M. (2009) · Nature Genetics · doi:10.1038/ng.272 · Cited by 492

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

Wallez, Y., & Huber, P. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.09.003 · Cited by 473

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1715 · Cited by 471

Rho GTPases and the regulation of endothelial permeability

Wojciak-Stothard, B., & Ridley, A. J. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(03)00008-9 · Cited by 470

A murine model of hereditary hemorrhagic telangiectasia

Bourdeau, A., Dumont, D. J., & Letarte, M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8088 · Cited by 468

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

Urness, L. D., Sorensen, L. K., & Li, D. Y. (2000) · Nature Genetics · doi:10.1038/81634 · Cited by 440

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

Arthur, H. M., Ure, J., Smith, A. J. H., Renforth, G., Wilson, D. I., Torsney, E., Charlton, R., Parums, D. V., Jowett, T., Marchuk, D. A., et al. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9534 · Cited by 436

Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations

Revencu, N., Boon, L. M., Mulliken, J. B., Enjolras, O., Cordisco, M. R., Burrows, P. E., Clapuyt, P., Hammer, F., Dubois, J., Baselga, E., et al. (2008) · Human Mutation · doi:10.1002/humu.20746 · Cited by 435

p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho

Wildenberg, G. A., Dohn, M. R., Carnahan, R. H., Davis, M. A., Lobdell, N. A., Settleman, J., & Reynolds, A. B. (2006) · Cell · doi:10.1016/j.cell.2006.09.046 · Cited by 422

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

David, L., Mallet, C., Keramidas, M., Lamandé, N., Gasc, J.-M., Dupuis-Girod, S., Plauchu, H., Feige, J.-J., & Bailly, S. (2008) · Circulation Research · doi:10.1161/circresaha.107.165530 · Cited by 416

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

Gavard, J., Patel, V., & Gutkind, J. S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.10.019 · Cited by 411

Cyclic AMP Potentiates Vascular Endothelial Cadherin-Mediated Cell-Cell Contact To Enhance Endothelial Barrier Function through an Epac-Rap1 Signaling Pathway

Fukuhara, S., Sakurai, A., Sano, H., Yamagishi, A., Somekawa, S., Takakura, N., Saito, Y., Kangawa, K., & Mochizuki, N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.136-146.2005 · Cited by 409

A two-tiered mechanism for stabilization and immobilization of E-cadherin

Cavey, M., Rauzi, M., Lenne, P.-F., & Lecuit, T. (2008) · Nature · doi:10.1038/nature06953 · Cited by 401

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

Fukuhara, S., Sako, K., Minami, T., Noda, K., Kim, H. Z., Kodama, T., Shibuya, M., Takakura, N., Koh, G. Y., & Mochizuki, N. (2008) · Nature Cell Biology · doi:10.1038/ncb1714 · Cited by 387

Genetics of cavernous angiomas

Labauge, P., Denier, C., Bergametti, F., & Tournier-Lasserve, E. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70053-4 · Cited by 383

Development of the blood-brain barrier

Engelhardt, B. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0751-z · Cited by 379

Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

Uhlik, M. T., Abell, A. N., Johnson, N. L., Sun, W., Cuevas, B. D., Lobel-Rice, K. E., Horne, E. A., Dell'Acqua, M. L., & Johnson, G. L. (2003) · Nature Cell Biology · doi:10.1038/ncb1071 · Cited by 378

β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse

Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., Piccolo, S., & Dejana, E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403050 · Cited by 376

Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels

Roman, B. L., Pham, V. N., Lawson, N. D., Kulik, M., Childs, S., Lekven, A. C., Garrity, D. M., Moon, R. T., Fishman, M. C., Lechleider, R. J., et al. (2002) · Development · doi:10.1242/dev.129.12.3009 · Cited by 365

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

Goudreault, M., D'Ambrosio, L. M., Kean, M. J., Mullin, M. J., Larsen, B. G., Sanchez, A., Chaudhry, S., Chen, G. I., Sicheri, F., Nesvizhskii, A. I., et al. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800266-mcp200 · Cited by 359

Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction

Weis, S., Shintani, S., Weber, A., Kirchmair, R., Wood, M., Cravens, A., McSharry, H., Iwakura, A., Yoon, Y.-S., Himes, N., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420702 · Cited by 353

Endoglin in angiogenesis and vascular diseases

ten Dijke, P., Goumans, M.-J., & Pardali, E. (2008) · Angiogenesis · doi:10.1007/s10456-008-9101-9 · Cited by 327

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

Clatterbuck, R. E. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.2.188 · Cited by 324

Rap1: a key regulator in cell-cell junction formation

Kooistra, M. R. H., Dubé, N., & Bos, J. L. (2007) · Journal of Cell Science · doi:10.1242/jcs.03306 · Cited by 321

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions

Glading, A., Han, J., Stockton, R. A., & Ginsberg, M. H. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705175 · Cited by 315

The FGF system has a key role in regulating vascular integrity

Murakami, M., Nguyen, L. T., Zhang, Z. W., Moodie, K. L., Carmeliet, P., Stan, R. V., & Simons, M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35298 · Cited by 303

Arterial Endothelium-Specific Activin Receptor-Like Kinase 1 Expression Suggests Its Role in Arterialization and Vascular Remodeling

Seki, T., Yun, J., & Oh, S. P. (2003) · Circulation Research · doi:10.1161/01.res.0000095246.40391.3b · Cited by 275

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

Dvorak, A. M., Kohn, S., Morgan, E. S., Fox, P., Nagy, J. A., & Dvorak, H. F. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.1.100 · Cited by 270

Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin

Birdsey, G. M., Dryden, N. H., Amsellem, V., Gebhardt, F., Sahnan, K., Haskard, D. O., Dejana, E., Mason, J. C., & Randi, A. M. (2008) · Blood · doi:10.1182/blood-2007-08-105346 · Cited by 268

Genetic causes of vascular malformations

Brouillard, P., & Vikkula, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm211 · Cited by 268

Cardiovascular ephrinB2 function is essential for embryonic angiogenesis

Gerety, S. S., & Anderson, D. J. (2002) · Development · doi:10.1242/dev.129.6.1397 · Cited by 263

Depletion of E-Cadherin Disrupts Establishment but Not Maintenance of Cell Junctions in Madin-Darby Canine Kidney Epithelial Cells

Capaldo, C. T., & Macara, I. G. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0471 · Cited by 258

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

Zawistowski, J. S., Stalheim, L., Uhlik, M. T., Abell, A. N., Ancrile, B. B., Johnson, G. L., & Marchuk, D. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi256 · Cited by 254

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., Volkery, S., Li, H., Nasdala, I., Brandau, O., Fässler, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060565 · Cited by 250

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

Koo, B.-K., Lim, H.-S., Song, R., Yoon, M.-J., Yoon, K.-J., Moon, J.-S., Kim, Y.-W., Kwon, M.-C., Yoo, K.-W., Kong, M.-P., et al. (2005) · Development · doi:10.1242/dev.01922 · Cited by 247

VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam

Lampugnani, M. G., Zanetti, A., Breviario, F., Balconi, G., Orsenigo, F., Corada, M., Spagnuolo, R., Betson, M., Braga, V., & Dejana, E. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-07-0368 · Cited by 240

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

Park, S. O., Lee, Y. J., Seki, T., Hong, K.-H., Fliess, N., Jiang, Z., Park, A., Wu, X., Kaartinen, V., Roman, B. L., et al. (2008) · Blood · doi:10.1182/blood-2007-08-107359 · Cited by 227

Basal-to-apical cadherin flow at cell junctions

Kametani, Y., & Takeichi, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1520 · Cited by 222

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

Serebriiskii, I., Estojak, J., Sonoda, G., Testa, J. R., & Golemis, E. A. (1997) · Oncogene · doi:10.1038/sj.onc.1201268 · Cited by 215

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations

Whitehead, K. J., Plummer, N. W., Adams, J. A., Marchuk, D. A., & Li, D. Y. (2004) · Development · doi:10.1242/dev.01036 · Cited by 202

KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis

Zawistowski, J. S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.4.389 · Cited by 196

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

Voß, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T. D., & Felbor, U. (2007) · Neurogenetics · doi:10.1007/s10048-007-0098-9 · Cited by 176

Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin–mediated cell–cell contacts

Orlova, V. V., Economopoulou, M., Lupu, F., Santoso, S., & Chavakis, T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051730 · Cited by 166

Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

Bäumer, S., Keller, L., Holtmann, A., Funke, R., August, B., Gamp, A., Wolburg, H., Wolburg-Buchholz, K., Deutsch, U., & Vestweber, D. (2006) · Blood · doi:10.1182/blood-2006-01-0141 · Cited by 158

VE‐cadherin is a critical endothelial regulator of TGF‐β signalling

Rudini, N., Felici, A., Giampietro, C., Lampugnani, M. G., Corada, M., Swirsding, K., Garrè, M., Liebner, S., Letarte, M., ten Dijke, P., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.46 · Cited by 157

Biallelic Somatic and Germ Line CCM1 Truncating Mutations in a Cerebral Cavernous Malformation Lesion

Gault, J., Shenkar, R., Recksiek, P., & Awad, I. A. (2005) · Stroke · doi:10.1161/01.str.0000157586.20479.fd · Cited by 157

p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility

Stockton, R. A., Schaefer, E., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408877200 · Cited by 154

MAGI-1 Is Required for Rap1 Activation upon Cell-Cell Contact and for Enhancement of Vascular Endothelial Cadherin-mediated Cell Adhesion

Sakurai, A., Fukuhara, S., Yamagishi, A., Sako, K., Kamioka, Y., Masuda, M., Nakaoka, Y., & Mochizuki, N. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0647 · Cited by 152

Proteomic Identification of the Cerebral Cavernous Malformation Signaling Complex

Hilder, T. L., Malone, M. H., Bencharit, S., Colicelli, J., Haystead, T., Johnson, G. L., & Wu, C. C. (2007) · Journal of Proteome Research · doi:10.1021/pr0704276 · Cited by 151

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor

Sorensen, L. K., Brooke, B. S., Li, D. Y., & Urness, L. D. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00158-1 · Cited by 150

Vascular morphogenesis: tales of two syndromes

Marchuk, D. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg103 · Cited by 150

santaandvalentinepattern concentric growth of cardiac myocardium in the zebrafish

Mably, J. D., Chuang, L. P., Serluca, F. C., Mohideen, M.-A. P. K., Chen, J., & Fishman, M. C. (2006) · Development · doi:10.1242/dev.02469 · Cited by 149

Loss of p53 Sensitizes Mice with a Mutation in Ccm1 (KRIT1) to Development of Cerebral Vascular Malformations

Plummer, N. W., Gallione, C. J., Srinivasan, S., Zawistowski, J. S., Louis, D. N., & Marchuk, D. A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63409-8 · Cited by 119

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

Hogan, B. M., Bussmann, J., Wolburg, H., & Schulte‐Merker, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn142 · Cited by 116

Vascular malformations: localized defects in vascular morphogenesis

Brouillard, P., & Vikkula, M. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00092.x · Cited by 115

Tissue-specific conditionalCCM2knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

Boulday, G., Blécon, A., Petit, N., Chareyre, F., García, L., Niwa‐Kawakita, M., Giovannini, M., & Tournier‐Lasserve, E. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001263 · Cited by 115

Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

Seki, T., Hong, K., & Oh, S. P. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700376 · Cited by 114

The Multiple Languages of Endothelial Cell-to-Cell Communication

Liebner, S., Cavallaro, U., & Dejana, E. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000218510.04541.5e · Cited by 101

Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals

Park, J., Ji, H. L., Jun, S., Gu, D., Hikasa, H., Li, L., Sokol, S. Y., & McCrea, P. D. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.022 · Cited by 99

Targeted Disruption of hesr2 Results in Atrioventricular Valve Anomalies That Lead to Heart Dysfunction

Kokubo, H., Miyagawa‐Tomita, S., Tomimatsu, H., Nakashima, Y., Nakazawa, M., Saga, Y., & Johnson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000141136.85194.f0 · Cited by 99

TAL-1/SCL and Its Partners E47 and LMO2 Up-Regulate VE-Cadherin Expression in Endothelial Cells

Deleuze, V., Chalhoub, E., El-Hajj, R., Dohet, C., Clech, M. L., Couraud, P., Huber, P., & Mathieu-Mahul, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00493-06 · Cited by 80

Genetics of cerebral cavernous malformations

Plummer, N. W., Zawistowski, J. S., & Marchuk, D. A. (2005) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-005-0063-7 · Cited by 72

Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development

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Endoglin-Mediated Vascular Remodeling: Mechanisms Underlying Hereditary Hemorrhagic Telangiectasia

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Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke

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Forging the endothelium during inflammation: pushing at a half-open door?

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Linkage to the CCM2 Locus and Genetic Heterogeneity in Familial Cerebral Cavernous Malformation

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Variable expression of cerebral cavernous malformations in carriers of a premature termination codon in exon 17 of the Krit1 gene

Lucas, M., Costa, A. F., García-Moreno, J. M., Solano, F., Gamero-García, M. Á., & Izquierdo, G. (2003) · BMC Neurology · doi:10.1186/1471-2377-3-5 · Cited by 18

Activin receptor-like kinase 1 is essential for placental vascular development in mice

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Molecular mechanisms and clinical applications of angiogenesis

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Pericytes regulate the blood–brain barrier

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The gut microbiota influences blood-brain barrier permeability in mice

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Normalization of the Vasculature for Treatment of Cancer and Other Diseases

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Dynamics of endothelial cell behavior in sprouting angiogenesis

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