The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
The Extracellular Matrix Modulates the Metastatic Journey
Open accessAbstract
The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stroma and migration towards the vasculature. We describe the role of the tumor matrix on cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgrowth. Finally, we discuss the clinical outcome of therapeutics that normalize tumor-matrix interactions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252
RetractedDiscoidin Domain Receptors: Potential Actors and Targets in Cancer
Rammal, H., Saby, C., Magnien, K., Gulick, L. V., Garnotel, R., Buache, É., Btaouri, H. E., Jeannesson, P., & Morjani, H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00055 · Cited by 133
RetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Self-citationTensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
Self-citationThe Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692
Matrix metalloproteinases and the regulation of tissue remodelling
Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 2,630
Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO reports · doi:10.15252/embr.201439246 · Cited by 1,996
Self-citationPre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889
From 3D cell culture to organs-on-chips
Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834
Collagen reorganization at the tumor-stromal interface facilitates local invasion
Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804
Extracellular Matrix Assembly: A Multiscale Deconstruction
Mouw, J. K., Ou, G., & Weaver, V. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3902 · Cited by 1,534
Self-citationNeutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Küttner, V., et al. (2018) · Science · doi:10.1126/science.aao4227 · Cited by 1,476
Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,285
Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
Boudreau, N., Sympson, C. J., Werb, Z., & Bissell, M. J. (1995) · Science · doi:10.1126/science.7531366 · Cited by 1,175
The perivascular niche regulates breast tumour dormancy
Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148 · cited 2×
“Metastatic tumor cells are frequently found associated with the basement membrane surrounding the vascular niche in distal organs (Ghajar et al., 2013).”
BackgroundMechanisms of disseminated cancer cell dormancy: an awakening field
Sosa, M. S., Bragado, P., & Aguirre-Ghiso, J. A. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3793 · Cited by 1,126
Integrin-mediated mechanotransduction
Sun, Z., Guo, S. S., & Fässler, R. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201609037 · Cited by 1,079
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., Nywening, T. M., Hawkins, W. G., Shapiro, I. M., Weaver, D. T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4123 · Cited by 1,060
Acerbi, I., Cassereau, L., Dean, I., Shi, Q., Au, A., Park, C., Chen, Y. Y., Liphardt, J., Hwang, E. S., & Weaver, V. M. (2015) · Integrative Biology · doi:10.1039/c5ib00040h · Cited by 1,059
Self-citationThe Role of Mechanical Forces in Tumor Growth and Therapy
Jain, R. K., Martin, J. D., & Stylianopoulos, T. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105259 · Cited by 1,044 · cited 1×
“Thus, a fibrotic, highly cross-linked and stiffened ECM can induce the collapse of pre-existing vessels and even occlude blood flow to promote hypoxia (Jain et al., 2014).”
BackgroundChauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3516 · Cited by 1,031
Rothwell, P. M., Wilson, M., Price, J. F., Belch, J. F., Meade, T. W., & Mehta, Z. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60209-8 · Cited by 984
Wei, S. C., Fattet, L., Tsai, J. H., Guo, Y., Pai, V. H., Majeski, H. E., Chen, A. C., Sah, R. L., Taylor, S. S., Engler, A. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3157 · Cited by 948
Dynamic interplay between the collagen scaffold and tumor evolution
Egeblad, M., Rasch, M. G., & Weaver, V. M. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.015 · Cited by 896
Self-citationBarry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Vandenbroucke, R. E., & Libert, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4390 · Cited by 832
Diop-Frimpong, B., Chauhan, V. P., Krane, S., Boucher, Y., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018892108 · Cited by 733
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Paszek, M. J., DuFort, C. C., Rossier, O., Bainer, R., Mouw, J. K., Godula, K., Hudak, J. E., Lakins, J. N., Wijekoon, A. C., Cassereau, L., et al. (2014) · Nature · doi:10.1038/nature13535 · Cited by 699
Self-citationSottile, J., & Hocking, D. C. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0048 · Cited by 645
Mechanical compression drives cancer cells toward invasive phenotype
Tse, J. M., Cheng, G., Tyrrell, J. A., Wilcox-Adelman, S. A., Boucher, Y., Jain, R. K., & Munn, L. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118910109 · Cited by 631
Harney, A. S., Arwert, E. N., Entenberg, D., Wang, Y., Guo, P., Qian, B.-Z., Oktay, M. H., Pollard, J. W., Jones, J. G., & Condeelis, J. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0012 · Cited by 618
Targeting the TGFβ pathway for cancer therapy
Neuzillet, C., Tijeras-Raballand, A., Cohen, R., Cros, J., Faivre, S., Raymond, E., & de Gramont, A. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.001 · Cited by 611
Laklai, H., Miroshnikova, Y. A., Pickup, M. W., Collisson, E. A., Kim, G. E., Barrett, A. S., Hill, R. C., Lakins, J. N., Schlaepfer, D. D., Mouw, J. K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4082 · Cited by 603
Self-citationIntegrins and cell proliferation
Schwartz, M. A., & Assoian, R. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.14.2553 · Cited by 518
Gudjonsson, T., Rønnov-Jessen, L., Villadsen, R., Rank, F., Bissell, M. J., & Petersen, O. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.39 · Cited by 517
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
Yu, M., Ting, D. T., Stott, S. L., Wittner, B. S., Ozsolak, F., Paul, S., Ciciliano, J. C., Smas, M. E., Winokur, D., Gilman, A. J., et al. (2012) · Nature · doi:10.1038/nature11217 · Cited by 484
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
Frentzas, S., Simoneau, E., Bridgeman, V. L., Vermeulen, P. B., Foo, S., Kostaras, E., Nathan, M. R., Wotherspoon, A., Gao, Z.-H., Shi, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4197 · Cited by 454
A conduit to metastasis: circulating tumor cell biology
Micalizzi, D. S., Maheswaran, S., & Haber, D. A. (2017) · Genes & Development · doi:10.1101/gad.305805.117 · Cited by 446
Leight, J. L., Wozniak, M. A., Chen, S., Lynch, M. L., & Chen, C. S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0537 · Cited by 425
Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton
Barkan, D., Kleinman, H., Simmons, J. L., Asmussen, H., Kamaraju, A. K., Hoenorhoff, M. J., Liu, Z.-Y., Costes, S. V., Cho, E. H., Lockett, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6849 · Cited by 425
Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420
Matrix stiffening promotes a tumor vasculature phenotype
Bordeleau, F., Mason, B. N., Lollis, E. M., Mazzola, M., Zanotelli, M. R., Somasegar, S., Califano, J. P., Montague, C., LaValley, D. J., Huynh, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613855114 · Cited by 416
Intravascular Survival and Extravasation of Tumor Cells
Strilic, B., & Offermanns, S. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.001 · Cited by 397
Zhang, K., Corsa, C. A., Ponik, S. M., Prior, J. L., Piwnica-Worms, D., Eliceiri, K. W., Keely, P. J., & Longmore, G. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2743 · Cited by 393
Matrix-bound nanovesicles within ECM bioscaffolds
Huleihel, L., Hussey, G. S., Naranjo, J. D., Zhang, L., Dziki, J. L., Turner, N. J., Stolz, D. B., & Badylak, S. F. (2016) · Science Advances · doi:10.1126/sciadv.1600502 · Cited by 387
Oriented collagen fibers direct tumor cell intravasation
Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610347113 · Cited by 376
Integrins as therapeutic targets
Goodman, S. L., & Picard, M. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.002 · Cited by 376
Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis
Eddy, R. J., Weidmann, M. D., Sharma, V. P., & Condeelis, J. S. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.03.003 · Cited by 375
Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure
Fernández-Sánchez, M. E., Barbier, S., Whitehead, J., Béalle, G., Michel, A., Latorre-Ossa, H., Rey, C., Fouassier, L., Claperon, A., Brullé, L., et al. (2015) · Nature · doi:10.1038/nature14329 · Cited by 371
Shibue, T., & Weinberg, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904227106 · Cited by 364
Mason, B. N., Starchenko, A., Williams, R. M., Bonassar, L. J., & Reinhart-King, C. A. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.007 · Cited by 363
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Goel, S., Wong, A. H.-K., & Jain, R. K. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006486 · Cited by 352
Hingorani, S. R., Harris, W. P., Beck, J. T., Berdov, B. A., Wagner, S. A., Pshevlotsky, E. M., Tjulandin, S. A., Gladkov, O. A., Holcombe, R. F., Korn, R., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2010 · Cited by 333
Liu, J., Liao, S., Diop-Frimpong, B., Chen, W., Goel, S., Naxerova, K., Ancukiewicz, M., Boucher, Y., Jain, R. K., & Xu, L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117610109 · Cited by 330
Xu, X. R., Yousef, G. M., & Ni, H. (2018) · Blood · doi:10.1182/blood-2017-05-743187 · Cited by 325
Three-dimensional context regulation of metastasis
Erler, J. T., & Weaver, V. M. (2009) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9209-8 · Cited by 313
Self-citationThe α v β 1 integrin plays a critical in vivo role in tissue fibrosis
Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa5094 · Cited by 311
Er, E. E., Valiente, M., Ganesh, K., Zou, Y., Agrawal, S., Hu, J., Griscom, B., Rosenblum, M., Boire, A., Brogi, E., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0138-8 · Cited by 292
Miller, B. W., Morton, J. P., Pinese, M., Saturno, G., Jamieson, N. B., McGhee, E., Timpson, P., Leach, J., McGarry, L., Shanks, E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404827 · Cited by 286
Syndecans – key regulators of cell signaling and biological functions
Afratis, N. A., Nikitovic, D., Multhaupt, H. A. B., Theocharis, A. D., Couchman, J. R., & Karamanos, N. K. (2017) · The FEBS Journal · doi:10.1111/febs.13940 · Cited by 283
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Haemmerle, M., Taylor, M. L., Gutschner, T., Pradeep, S., Cho, M. S., Sheng, J., Lyons, Y. M., Nagaraja, A. S., Dood, R. L., Wen, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00411-z · Cited by 274
Pommier, A., Anaparthy, N., Memos, N., Kelley, Z. L., Gouronnec, A., Yan, R., Auffray, C., Albrengues, J., Egeblad, M., Iacobuzio-Donahue, C. A., et al. (2018) · Science · doi:10.1126/science.aao4908 · Cited by 271
Gligorijevic, B., Wyckoff, J., Yamaguchi, H., Wang, Y., Roussos, E. T., & Condeelis, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.092726 · Cited by 269
The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
Schietke, R., Warnecke, C., Wacker, I., Schödel, J., Mole, D. R., Campean, V., Amann, K., Goppelt-Struebe, M., Behrens, J., Eckardt, K.-U., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042424 · Cited by 253
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy
Carlson, P., Dasgupta, A., Grzelak, C. A., Kim, J., Barrett, A., Coleman, I. M., Shor, R. E., Goddard, E. T., Dai, J., Schweitzer, E. M., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0267-0 · Cited by 251
Gao, H., Chakraborty, G., Zhang, Z., Akalay, I., Gadiya, M., Gao, Y., Sinha, S., Hu, J., Jiang, C., Akram, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.009 · Cited by 246
Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
Kai, F., Laklai, H., & Weaver, V. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.03.007 · Cited by 243
Self-citationMammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition
Park, J., & Schwarzbauer, J. E. (2014) · Oncogene · doi:10.1038/onc.2013.118 · Cited by 240
Bass, M. D., Roach, K. A., Morgan, M. R., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., Mayer, U., Ballestrem, C., Spatz, J. P., & Humphries, M. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610076 · Cited by 236
Roovers, K., Davey, G., Zhu, X., Bottazzi, M. E., & Assoian, R. K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3197 · Cited by 212
Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions
Neve, A., Cantatore, F. P., Maruotti, N., Corrado, A., & Ribatti, D. (2014) · BioMed Research International · doi:10.1155/2014/756078 · Cited by 208
Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
Takai, K., Le, A., Weaver, V. M., & Werb, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12658 · Cited by 207
Self-citationTumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression
Oudin, M. J., Jonas, O., Kosciuk, T., Broye, L. C., Guido, B. C., Wyckoff, J., Riquelme, D., Lamar, J. M., Asokan, S. B., Whittaker, C., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1183 · Cited by 205
Oudin, M. J., & Weaver, V. M. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030817 · Cited by 196
Self-citationBenson, A. B., Wainberg, Z. A., Hecht, J. R., Vyushkov, D., Dong, H., Bendell, J., & Kudrik, F. (2017) · The Oncologist · doi:10.1634/theoncologist.2017-0024 · Cited by 195
Molecular Pathways: Targeting the TGF-β Pathway for Cancer Therapy
Smith, A. L., Robin, T. P., & Ford, H. L. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3224 · Cited by 193
Yuzhalin, A. E., Gordon-Weeks, A. N., Tognoli, M. L., Jones, K., Markelc, B., Konietzny, R., Fischer, R., Muth, A., O’Neill, E., Thompson, P. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07306-7 · Cited by 188
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
Gao, Y., Xiao, Q., Ma, H., Li, L., Liu, J., Feng, Y., Fang, Z., Wu, J., Han, X., Zhang, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004952107 · Cited by 187
Pirfenidone normalizes the tumor microenvironment to improve chemotherapy
Polydorou, C., Mpekris, F., Papageorgis, P., Voutouri, C., & Stylianopoulos, T. (2017) · Oncotarget · doi:10.18632/oncotarget.15534 · Cited by 185
The Where, When, How, and Why of Hyaluronan Binding by Immune Cells
Lee-Sayer, S. S. M., Dong, Y., Arif, A. A., Olsson, M., Brown, K. L., & Johnson, P. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00150 · Cited by 184
Dormant tumour cells, their niches and the influence of immunity
Goddard, E. T., Bozic, I., Riddell, S. R., & Ghajar, C. M. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0214-0 · Cited by 178
Mayorca-Guiliani, A. E., Madsen, C. D., Cox, T. R., Horton, E. R., Venning, F. A., & Erler, J. T. (2017) · Nature Medicine · doi:10.1038/nm.4352 · Cited by 177
A Human Breast Cell Model of Preinvasive to Invasive Transition
Rizki, A., Weaver, V. M., Lee, S.-Y., Rozenberg, G. I., Chin, K., Myers, C. A., Bascom, J. L., Mott, J. D., Semeiks, J. R., Grate, L. R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2225 · Cited by 161
Self-citationvan Helvert, S., & Friedl, P. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01755 · Cited by 161
Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Salvador, F., Martín, A., López‐Menéndez, C., Moreno‐Bueno, G., Santos, V., Vázquez-Naharro, A., Santamaría, P. G., Morales, S., Dubus, P. R., Muinelo‐Romay, L., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3152 · Cited by 159
Self-citationIntegrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation
Vachon, P. H. (2011) · Journal of Signal Transduction · doi:10.1155/2011/738137 · Cited by 158
A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma
Barnes, J. M., Kaushik, S., Bainer, R. O., Sa, J. K., Woods, E. C., Kai, F., Przybyla, L., Lee, M., Lee, H. W., Tung, J. C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0183-3 · Cited by 158
Self-citationMechanoregulation and pathology of YAP/TAZ via Hippo and non‐Hippo mechanisms
Dobrokhotov, O., Samsonov, M., Sokabe, M., & Hirata, H. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0202-9 · Cited by 157
Hanjaya‐Putra, D., Yee, J., Ceci, D., Truitt, R., Yee, D., & Gerecht, S. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00981.x · Cited by 147
Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion
Malik, G., Knowles, L. M., Dhir, R., Xu, S., Yang, S., Ruoslahti, E. I., & Pilch, J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3312 · Cited by 144
Ciobănaşu, C., Faivre, B., & Clainche, C. L. (2014) · Nature Communications · doi:10.1038/ncomms4095 · Cited by 142
Mekhdjian, A. H., Kai, F., Rubashkin, M. G., Prahl, L. S., Przybyla, L., McGregor, A., Bell, E. S., Barnes, J. M., DuFort, C. C., Ou, G., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0654 · Cited by 142
Self-citationHecht, J. R., Benson, A. B., Михайлович, В. Д., Yang, Y., Bendell, J. C., & Verma, U. N. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0479 · Cited by 141
Yang, N., Mosher, R., Seo, S., Beebe, D. J., & Friedl, A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.039 · Cited by 139
The Propeptide Domain of Lysyl Oxidase Induces Phenotypic Reversion of Ras-transformed Cells
Palamakumbura, A. H., Jeay, S., Guo, Y., Pischon, N., Sommer, P., Sonenshein, G. E., & Trackman, P. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406639200 · Cited by 137
Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin
Deryugina, E. I., & Bourdon, M. A. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.3.643 · Cited by 136
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang, J., Lucas, M. C., Leonte, L. E., García-Montolio, M., Singh, L. B., Findlay, A. D., Deodhar, M., Foot, J. S., Jarolimek, W., Timpson, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15257 · Cited by 118
FAK inhibitors in Cancer, a patent review
Lv, P.-C., Jiang, A.-Q., Zhang, W.-M., & Zhu, H.-L. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1414183 · Cited by 114
Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment
Rejniak, K. A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42023-3_5 · Cited by 110
Wang, Z., Xiong, S., Mao, Y., Chen, M., Ma, X., Zhou, X., Ma, Z., Liu, F., Huang, Z., Luo, Q., et al. (2016) · The Journal of Pathology · doi:10.1002/path.4747 · Cited by 106
Nyberg, P., Xie, L., Sugimoto, H., Colorado, P. C., Sund, M., Holthaus, K. A., Sudhakar, A., Salo, T. A., & Kalluri, R. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.08.011 · Cited by 100
Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Kalli, M., Papageorgis, P., Gkretsi, V., & Stylianopoulos, T. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-1997-7 · Cited by 99
A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype
Cassereau, L., Miroshnikova, Y. A., Ou, G., Lakins, J. N., & Weaver, V. M. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.11.008 · Cited by 98
Self-citationBarbazán, J., Alonso‐Alconada, L., Elkhatib, N., Geraldo, S., Gurchenkov, V., Glentis, A., van Niel, G., Palmulli, R., Fernández, B., Viaño, P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1917 · Cited by 95
Wu, M., Min, C., Wang, X., Yu, Z., Kirsch, K. H., Trackman, P. C., & Sonenshein, G. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0776 · Cited by 90
Molecular Characterization of Circulating Tumor Cells in Human Metastatic Colorectal Cancer
Barbazán, J., Alonso‐Alconada, L., Muinelo‐Romay, L., Vieito, M., Abalo, A., Alonso‐Nocelo, M., Candamio, S., Gallardo, E., Fernández, B., Abdulkader, I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040476 · Cited by 90
Studies on beta‐aminopropionitrile in patients with scleroderma
Keiser, H. R., & Sjoerdsma, A. (1967) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt196784593 · Cited by 80
Matrix stiffness enhances VEGFR-2 internalization, signaling, and proliferation in endothelial cells
LaValley, D. J., Zanotelli, M. R., Bordeleau, F., Wang, W., Schwager, S. C., & Reinhart‐King, C. A. (2017) · Convergent Science Physical Oncology · doi:10.1088/2057-1739/aa9263 · Cited by 79
Miroshnikova, Y. A., Rozenberg, G. I., Cassereau, L., Pickup, M. W., Mouw, J. K., Ou, G., Templeman, K. L., Hannachi, E.-I., Gooch, K. J., Sieminski, A. L., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-02-0126 · Cited by 77
Self-citationTenascin-C: Exploitation and collateral damage in cancer management
Spenlé, C., Saupe, F., Midwood, K. S., Burckel, H., Noël, G., & Orend, G. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2014.1000074 · Cited by 76
A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression
Woods, E. C., Barnes, J. M., Pickup, M. W., Pedram, K., Kai, F., Hollander, M. J., Weaver, V. M., & Bertozzi, C. R. (2017) · eLife · doi:10.7554/elife.25752 · Cited by 76
Self-citationAcute compressive stress activates RHO/ROCK-mediated cellular processes
Boyle, S. T., Kular, J., Nobis, M., Ruszkiewicz, A. R., Timpson, P., & Samuel, M. S. (2018) · Small GTPases · doi:10.1080/21541248.2017.1413496 · Cited by 66
Lü, J., Zhou, S., Siech, M., Habisch, H., Seufferlein, T. T. W., & Bachem, M. G. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.706 · Cited by 62
Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis
Coelho, N. M., & McCulloch, C. A. (2018) · Cell Adhesion & Migration · doi:10.1080/19336918.2018.1448353 · Cited by 60
Renner, G., Noulet, F., Mercier, M.-C., Choulier, L., Étienne-Selloum, N., Gies, J., Lehmann, M., Lelong-Rebel, I. H., Martin, S., & Dontenwill, M. (2016) · Oncotarget · doi:10.18632/oncotarget.11552 · Cited by 58
Promising human brain tumors therapy with interference RNA intervention (iRNAi)
Rolle, K., Nowak, S., Wyszko, E., Nowak, M., Zukiel, R., Piestrzeniewicz, R., Gawrońska, I., Barciszewska, M. Z., & Barciszewski, J. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.5.10958 · Cited by 48
Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption
Lampi, M. C., Faber, C. J., Huynh, J., Bordeleau, F., Zanotelli, M. R., & Reinhart‐King, C. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147033 · Cited by 48
Mollard, S., Ciccolini, J., Imbs, D.-C., Cheikh, R. E., Barbolosi, D., & Benzekry, S. (2017) · Oncotarget · doi:10.18632/oncotarget.15484 · Cited by 36
Pirfenidone: Clinical trials and clinical practice in patients with idiopathic pulmonary fibrosis
Bando, M. (2016) · Respiratory Investigation · doi:10.1016/j.resinv.2016.03.007 · Cited by 12
Cited by
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296
Monteran, L., & Erez, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01835 · Cited by 675
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 544
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 474
Metadata
- Authors
- Kai, F., Drain, A. P., & Weaver, V. M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 49
- Issue
- 3
- Pages
- 332-346
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2943229766
- Cited by
- 537
- References
- 125
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
