Gaps and forks in DNA replication: rediscovering old models

Lehmann, Alan R.; Fuchs, Robert P.

doi:10.1016/j.dnarep.2006.07.002

Cited by 170DNA Repair MechanismsBacterial Genetics and BiotechnologyDNA and Nucleic Acid Chemistry

Gaps and forks in DNA replication: rediscovering old models

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Lehmann, Alan R., Fuchs, Robert P.·2006·DNA Repair

DOI 10.1016/j.dnarep.2006.07.002

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Abstract

Most current models for replication past damaged lesions envisage that translesion synthesis occurs at the replication fork. However older models suggested that gaps were left opposite lesions to allow the replication fork to proceed, and these gaps were subsequently sealed behind the replication fork. Two recent articles lend support to the idea that bypass of the damage occurs behind the fork. In the first paper, electron micrographs of DNA replicated in UV-irradiated yeast cells show regions of single-stranded DNA both at the replication forks and behind the fork, the latter being consistent with the presence of gaps in the daughter-strands opposite lesions. The second paper describes an in vitro DNA replication system reconstituted from purified bacterial proteins. Repriming of synthesis downstream from a blocked fork occurred not only on the lagging strand as expected, but also on the leading strand, demonstrating that contrary to widely accepted beliefs, leading strand synthesis does not need to be continuous.

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Two models are proposed for TLS: at the blocked replication fork or via a post-replicative gap-filling mechanism.
“Two models are currently proposed for TLS: at the blocked replication fork or via a post-replicative gap-filling mechanism [8,9].”
From Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome (2014) · cites this paper as [8]

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Self-citation

Authors: Lehmann, A. R., & Fuchs, R. P.
Affiliations: University of Sussex (GB)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Lehmann, Alan R.
ORCID: Lehmann, Alan R.
Fuchs, Robert P.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2006-12
Volume: 5
Issue: 12
Pages: 1495-1498
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2006.07.002
OpenAlex: W2169534711
Cited by: 170
References: 17
Citations by year: 2026: 3 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 9 · 2013: 12 · 2012: 8
FWCI: 5.16
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Sussex Research Online (University of Sussex) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: DNA replication, translesion synthesis, replication fork, DNA damage bypass, UV-induced DNA damage, single-stranded DNA, leading strand synthesis, lagging strand
MeSH terms: DNA Repair, DNA Replication, Escherichia coli, Models, Biological, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins

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Gaps and forks in DNA replication: rediscovering old models

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