Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin
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Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform a two-stage siRNA-based functional screen for mammalian TLS genes and identify 17 validated TLS genes. One of the genes, NPM1, is frequently mutated in acute myeloid leukaemia (AML). We show that NPM1 (nucleophosmin) regulates TLS via interaction with the catalytic core of DNA polymerase-η (polη), and that NPM1 deficiency causes a TLS defect due to proteasomal degradation of polη. Moreover, the prevalent NPM1c+ mutation that causes NPM1 mislocalization in ~30% of AML patients results in excessive degradation of polη. These results establish the role of NPM1 as a key TLS regulator, and suggest a mechanism for the better prognosis of AML patients carrying mutations in NPM1.
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The prevalent NPM1 mutation (c+) that leads to NPM1 mislocalization in one-third of AML patients results in a loss of DNA polymerase η.
“The prevalent NPM1 mutation (c+) leading in one-third of AML patients to NPM1 mislocalization results in a loss of pol h”
From DNA polymerase <b>η</b> mutational signatures are found in a variety of different types of cancer (2018) · cites this paper as [53]
NPM1 deficiency causes a translesion DNA synthesis defect due to proteasomal degradation of DNA polymerase η.
“NPM1 deficiency causes a TLS defect due to the proteasomal degradation of pol h.”
From DNA polymerase <b>η</b> mutational signatures are found in a variety of different types of cancer (2018) · cites this paper as [53]
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- Authors
- Ziv, O., Zeisel, A., Mirlas-Neisberg, N., Swain, U., Nevo, R., Ben-Chetrit, N., Martelli, M. P., Rossi, R., Schiesser, S., Canman, C. E., Carell, T., Geacintov, N. E., Falini, B., Domany, E., & Livneh, Z.
- Affiliations
- Weizmann Institute of Science (IL)
- University of Perugia (IT)
- Ludwig-Maximilians-Universität München (DE)
- University of Michigan (US)
- New York University (US)
- Corresponding author
- Livneh, Zvi
- ORCID
- Venue
- Nature Communications
- Published
- 2014-11-25
- Volume
- 5
- Issue
- 1
- Pages
- 5437-5437
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4263322
- OpenAlex
- W2034694386
- Cited by
- 59
- References
- 70
- Citations by year
- 2026: 3 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 3 · 2015: 4 · 2014: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Funders
- Flight Attendant Medical Research Institute
- Leona M. and Harry B. Helmsley Charitable Trust
- Clore Israel Foundation
- University of Sussex
- Deutsche Forschungsgemeinschaft (SFB 749)
- Universiteit Leiden
- Weizmann Institute of Science
- Israel Science Foundation (684/12)
- Associazione Italiana per la Ricerca sul Cancro (IG 2013)
- Leids Universitair Medisch Centrum
- National Cancer Institute (R01CA133046)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- translesion synthesis, nucleophosmin, NPM1, DNA polymerase eta, DNA damage tolerance, proteasomal degradation, acute myeloid leukemia, genomic instability, point mutations, siRNA screen
- MeSH terms
- Nucleophosmin, Y-Family DNA Polymerases, Cell Line, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Nuclear Proteins, Protein Binding, Ultraviolet Rays, Leukemia, Myeloid, Acute
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