Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: A long and winding road

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks

Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260 · see citing works

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

Sommer, B., KEINÄNEN, K. P., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., Köhler, M. G., Takagi, T., Sakmann, B. J., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.1699275 · Cited by 1,259 · see citing works

NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons

Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

Carlén, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., Vierling-Claassen, D., Rühlmann, C., Jones, S. R., Deisseroth, K., Sheng, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.31 · Cited by 669 · see citing works

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.136 · Cited by 605 · see citing works

Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

Liu, S. J., & Zukin, R. S. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.006 · Cited by 530 · see citing works

Glutamate as a therapeutic target in psychiatric disorders

Javitt, D. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001551 · Cited by 524 · see citing works

Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression

Fatemi, S. H., Earle, J. A., & McMenomy, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000783 · Cited by 447 · see citing works

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

Greger, I. H., Watson, J. F., & Cull-Candy, S. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.009 · Cited by 392 · see citing works

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

Zhou, W., Wang, N., Yang, C., Li, X.-M., Zhou, Z.-Q., & Yang, J.-J. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2013.10.005 · Cited by 390 · see citing works

Single-dose infusion ketamine and non-ketamine <i>N</i> -methyl- <scp>d</scp> -aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories

Kishimoto, T., Chawla, J. M., Hagi, K., Zarate, C. A., Kane, J. M., Bauer, M., & Correll, C. U. (2016) · Psychological Medicine · doi:10.1017/s0033291716000064 · Cited by 359 · see citing works

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

Zhang, J.-C., Li, S.-X., & Hashimoto, K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.033 · Cited by 357 · see citing works

Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism

de Kloet, E. R., & Molendijk, M. L. (2016) · Neural Plasticity · doi:10.1155/2016/6503162 · Cited by 353 · see citing works

Facilitation of glutamate receptors enhances memory.

Staubli, U. V., Rogers, G. A., & LYNCH, G. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.777 · Cited by 328 · see citing works

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304 · see citing works

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

Kehrer, C. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.006.2008 · Cited by 287 · see citing works

Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice

Guo, B., Chen, J., Chen, Q., Ren, K., Feng, D., Mao, H., Yao, H., Yang, J., Liu, H., Liu, Y., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0445-9 · Cited by 287 · see citing works

Piracetam and Piracetam-Like Drugs

Malykh, A., & Sadaie, M. R. (2010) · Drugs · doi:10.2165/11319230-000000000-00000 · Cited by 270 · see citing works

Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects

Nugent, A. C., Ballard, E. D., Gould, T. D., Park, L. T., Moaddel, R., Brutsche, N. E., & Zarate, C. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0028-2 · Cited by 250 · see citing works

Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

Jin, R., Clark, S., Weeks, A. M., Dudman, J. T., Gouaux, E., & Partin, K. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2567-05.2005 · Cited by 246 · see citing works

A role for AMPA receptors in mood disorders

Alt, A., Nisenbaum, E. S., Bleakman, D., & Witkin, J. M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.022 · Cited by 238 · see citing works

Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

Sanacora, G., Smith, M. A., Pathak, S., Su, H.-L., Boeijinga, P. H., McCarthy, D. J., & Quirk, M. C. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.130 · Cited by 236 · see citing works

Positive AMPA Receptor Modulation Rapidly Stimulates BDNF Release and Increases Dendritic mRNA Translation

Jourdi, H., Hsu, Y.-T., Zhou, M., Qin, Q., Bi, X., & Baudry, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6078-08.2009 · Cited by 226 · see citing works

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

Li, X., Tizzano, J. P., Griffey, K., Clay, M., Lindstrom, T., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00194-5 · Cited by 225 · see citing works

AMPA Receptor Potentiators for the Treatment of CNS Disorders

O’Neill, M. J., Bleakman, D., Zimmerman, D. M., & Nisenbaum, E. S. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337508 · Cited by 223 · see citing works

How AMPA Receptor Desensitization Depends on Receptor Occupancy

Robert, A., & Howe, J. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00847.2003 · Cited by 218 · see citing works

Pharmacology of Ampakine Modulators: From AMPA Receptors to Synapses and Behavior

Arai, A., & Kessler, M. (2007) · Current Drug Targets · doi:10.2174/138945007780618490 · Cited by 211 · see citing works

Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide

Duman, R. S. (2018) · F1000Research · doi:10.12688/f1000research.14344.1 · Cited by 208 · see citing works

GABAB-mediated rescue of altered excitatory–inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction

Gandal, M. J., Sisti, J., Klook, K., Ortinski, P. I., Leitman, V, Liang, Y., Thieu, T., Anderson, R., Pierce, R. C., Jonak, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.69 · Cited by 204 · see citing works

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy

Widman, A. J., & McMahon, L. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718883115 · Cited by 204 · see citing works

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works

Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent

PRESKORN, S., MACALUSO, M., MEHRA, D. V., ZAMMIT, G., MOSKAL, J. R., & BURCH, R. M. (2015) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000462606.17725.93 · Cited by 193 · see citing works

Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus

Qiu, S., Zhao, L. F., Korwek, K. M., & Weeber, E. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2561-06.2006 · Cited by 186 · see citing works

A Placebo-Controlled Add-On Trial of the Ampakine, CX516, for Cognitive Deficits in Schizophrenia

GOFF, D. C., Lamberti, J. S., Leon, A. C., Green, M. F., Miller, A. L., Patel, J. K., Manschreck, T. C., Freudenreich, O., & Johnson, S. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301444 · Cited by 181 · see citing works

Effects of a ketamine metabolite on synaptic NMDAR function

Suzuki, K., Nosyreva, E., Hunt, K. W., Kavalali, E. T., & Monteggia, L. M. (2017) · Nature · doi:10.1038/nature22084 · Cited by 180 · see citing works

Memory enhancement: the search for mechanism-based drugs

LYNCH, G. S. (2002) · Nature Neuroscience · doi:10.1038/nn935 · Cited by 175 · see citing works

Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments

Kadriu, B., Musazzi, L., Henter, I. D., Graves, M., Popoli, M., & Zarate, C. A. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy094 · Cited by 165 · see citing works

Antidepressant-relevant concentrations of the ketamine metabolite (2 <i>R</i> ,6 <i>R</i> )-hydroxynorketamine do not block NMDA receptor function

Lumsden, E. W., Troppoli, T. A., Myers, S. J., Zanos, P., Aracava, Y., Kehr, J., Lovett, J., Kim, S., Wang, F.-H., Schmidt, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816071116 · Cited by 158 · see citing works

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

Koike, H., & Chaki, S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.065 · Cited by 157 · see citing works

Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling

Cavalleri, L., Merlo Pich, E., Millan, M. J., Chiamulera, C., Kunath, T., Spano, P. F., & Collo, G. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.241 · Cited by 156 · see citing works

Effect of CX516, an AMPA-Modulating Compound, on Cognition and Behavior in Fragile X Syndrome: AControlled Trial

Berry-Kravis, E., Krause, S. E., Block, S. S., Guter, S., Wuu, J., Leurgans, S., Decle, P., Potanos, K., Cook, E., Salt, J., et al. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.525 · Cited by 155 · see citing works

Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance

Hampson, R. E., Rogers, G. A., LYNCH, G. S., & Deadwyler, S. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02740.1998 · Cited by 153 · see citing works

( <i>2R,6R</i> )-hydroxynorketamine exerts mGlu ₂ receptor-dependent antidepressant actions

Zanos, P., Highland, J. N., Stewart, B. W., Georgiou, P., Jenne, C. E., Lovett, J., Morris, P. J., Thomas, C. J., Moaddel, R., Zarate, C. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819540116 · Cited by 152 · see citing works

Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical–Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings

Rivolta, D., Heidegger, T., Scheller, B., Sauer, A., Schaum, M., Birkner, K., Singer, W., Wibral, M., & Uhlhaas, P. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv051 · Cited by 147 · see citing works

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

Bai, F., Bergeron, M., & Nelson, D. L. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00104-7 · Cited by 144 · see citing works

New insights into Reelin-mediated signaling pathways

Lee, G. H., & D’Arcangelo, G. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00122 · Cited by 144 · see citing works

Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model

Knapp, R. J., Goldenberg, R., Shuck, C., Cecil, A., Watkins, J. B., Miller, C., Crites, G. J., & Malatyńska, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01338-9 · Cited by 142 · see citing works

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

Sarkar, A., & Kabbaj, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.025 · Cited by 133 · see citing works

Clinical Efficacy of Piracetam in Cognitive Impairment: A Meta-Analysis

Waegemans, T., Wilsher, C. R., Danniau, A., Ferris, S. H., Kurz, A., & Winblad, B. G. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000057700 · Cited by 132 · see citing works

An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

Maćkowiak, M., O’Neill, M. J., Hicks, C. A., Bleakman, D., & Skolnick, P. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00066-7 · Cited by 125 · see citing works

Brain damages in ketamine addicts as revealed by magnetic resonance imaging

Wang, C., Zheng, D., Xu, J., Lam, W., & Yew, D. T. W. (2013) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2013.00023 · Cited by 124 · see citing works

Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex

Shaw, A. D., Saxena, N., E. Jackson, L., Hall, J. E., Singh, K. D., & Muthukumaraswamy, S. D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.012 · Cited by 122 · see citing works

Acute Effects of the Ampakine Farampator on Memory and Information Processing in Healthy Elderly Volunteers

Wezenberg, E., Verkes, R. J., Ruigt, G. S. F., Hulstijn, W., & Sabbe, B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301257 · Cited by 122 · see citing works

Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine

Dong, C., Zhang, J.-C., Yao, W., Ren, Q., Ma, M., Yang, C., Chaki, S., & Hashimoto, K. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw089 · Cited by 116 · see citing works

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Ren, Z., Pribiag, H., Jefferson, S. J., Shorey, M., Fuchs, T., Stellwagen, D., & Luscher, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.009 · Cited by 114 · see citing works

Pharmacological interventions for apathy in Alzheimer's disease

Ruthirakuhan, M. T., Herrmann, N., Abraham, E. H., Chan, S., & Lanctôt, K. L. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012197.pub2 · Cited by 113 · see citing works

LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson’s Disease

Murray, T. K., Whalley, K., Robinson, C. S., Ward, M., Hicks, C. A., Lodge, D., Vandergriff, J. L., Baumbarger, P. J., Siuda, E. R., Gates, M. R., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049445 · Cited by 107 · see citing works

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

Legutko, B., Li, X., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00006-5 · Cited by 106 · see citing works

The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice

Lindholm, J., Autio, H., Vesa, L., Antila, H., Lindemann, L., Hoener, M. C., Skolnick, P., Rantamäki, T., & Ċastrén, E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.015 · Cited by 102 · see citing works

Nootropic Drugs Positively Modulate α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid‐Sensitive Glutamate Receptors in Neuronal Cultures

Copani, A., Genazzani, A. A., Aleppo, G., Casabona, G., Canonico, P. L., Scapagnini, U., & Nicoletti, F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11329.x · Cited by 97 · see citing works

Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm

Farley, S., Apazoglou, K., Witkin, J. M., Giros, B., & Tzavara, E. T. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991076 · Cited by 96 · see citing works

AMPA Receptor Potentiators: Application for Depression and Parkinsons Disease

O'Neill, M., & Witkin, J. M. (2007) · Current Drug Targets · doi:10.2174/138945007780618517 · Cited by 94 · see citing works

AMPA receptor potentiators: from drug design to cognitive enhancement

Partin, K. M. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.002 · Cited by 93 · see citing works

LY404187: A Novel Positive Allosteric Modulator of AMPA Receptors

Quirk, J. C., & Nisenbaum, E. S. (2002) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2002.tb00228.x · Cited by 93 · see citing works

Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

Schmidt, M. V., Trümbach, D., Weber, P., Wagner, K., Scharf, S. H., Liebl, C., Datson, N., Namendorf, C., Gerlach, T., Kühne, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4668-10.2010 · Cited by 91 · see citing works

The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test

Szewczyk, B., Poleszak, E., Sowa-Kućma, M., Wróbel, A., Słotwiński, S., Listos, J., Właź, P., Cichy, A., Siwek, A., Dybała, M., et al. (2009) · Amino Acids · doi:10.1007/s00726-009-0412-y · Cited by 91 · see citing works

Ketamine-Associated Brain Changes: A Review of the Neuroimaging Literature

Ionescu, D. F., Felicione, J. M., Gosai, A., Cusin, C., Shin, P., Shapero, B. G., & Deckersbach, T. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000179 · Cited by 91 · see citing works

AMPA potentiator treatment of cognitive deficits in Alzheimer disease

Chappell, A. S., Gonzales, C., Williams, J., Witte, M. M., Mohs, R. C., & Sperling, R. (2007) · Neurology · doi:10.1212/01.wnl.0000260240.46070.7c · Cited by 89 · see citing works

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.

Lussier, A. L., Lebedeva, K., Fenton, E. Y., Guskjolen, A., Caruncho, H., & Kalynchuk, L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.012 · Cited by 88 · see citing works

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

Poehlsgaard, J., Frydenvang, K., Madsen, U., & Kastrup, J. S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.08.004 · Cited by 85 · see citing works

Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity

Tatsukawa, T., Raveau, M., Ogiwara, I., Hattori, S., Miyamoto, H., Mazaki, E., Itohara, S., Miyakawa, T., Montal, M., & Yamakawa, K. (2019) · Molecular Autism · doi:10.1186/s13229-019-0265-5 · Cited by 84 · see citing works

Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus.

Arai, A., Xia, Y.-F., & Suzuki, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.033 · Cited by 81 · see citing works

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

Miu, P., Jarvie, K. R., Radhakrishnan, V., Gates, M. R., Ogden, A.-M., Ornstein, P. L., Zarrinmayeh, H., Ho, K. H., Peters, D., Grabell, J., et al. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00027-2 · Cited by 79 · see citing works

Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats

Lebrun, C., Pillière, E., & Lestage, P. J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00429-5 · Cited by 77 · see citing works

Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Ornstein, P. L., Zimmerman, D. M., Arnold, M. B., Bleisch, T. J., Cantrell, B., Simon, R., Zarrinmayeh, H., Baker, S. R., Gates, M., Tizzano, J. P., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm0002836 · Cited by 77 · see citing works

Rapid-acting antidepressants

Witkin, J. M., Martin, A. E., Golani, L. K., Xu, N. Z., & Smith, J. L. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.03.002 · Cited by 75 · see citing works

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

Nations, K. R., Dogterom, P., Bursi, R., Schipper, J., Greenwald, S. D., Zraket, D., Gertsik, L., Johnstone, J., Lee, A. T. C., Pande, Y., et al. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112458728 · Cited by 74 · see citing works

mGlu2/3 Receptor Antagonists as Novel Antidepressants

Chaki, S. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.03.008 · Cited by 73 · see citing works

Challenges for and current status of research into positive modulators of AMPA receptors

Ward, S. E., Bax, B. D., & Harries, M. H. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00726.x · Cited by 72 · see citing works

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

Lauterborn, J. C., Pineda, E., Chen, L. Y., Ramirez, E. A., LYNCH, G. S., & Gall, C. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.018 · Cited by 70 · see citing works

Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series

Marenco, S., Egan, M. F., Goldberg, T. E., Knable, M. B., McClure, R. K., Winterer, G., & Weinberger, D. R. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00311-5 · Cited by 69 · see citing works

Ampakine (CX717) Effects on Performance and Alertness During Simulated Night Shift Work

Wesensten, N. J., Reichardt, R. M., & Balkin, T. J. (2007) · Aviation Space and Environmental Medicine · doi:10.3357/asem.2055.2007 · Cited by 66 · see citing works

Gating Modes in AMPA Receptors

Prieto, M. L., & Wollmuth, L. P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5613-09.2010 · Cited by 65 · see citing works

Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats

Koike, H., Iijima, M., & Chaki, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.03.017 · Cited by 65 · see citing works

A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression

Park, L. T., Kadriu, B., Gould, T. D., Zanos, P., Greenstein, D., Evans, J. W., Yuan, P., Farmer, C. A., Oppenheimer, M., George, J. M., et al. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa025 · Cited by 63 · see citing works

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease

O’Neill, M. J., Murray, T. K., Whalley, K., Ward, M., Hicks, C. A., Woodhouse, S., Osborne, D. J., & Skolnick, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.12.023 · Cited by 62 · see citing works

BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices

Jourdi, H., Hamo, L., Oka, T., Seegan, A., & Baudry, M. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.015 · Cited by 60 · see citing works

S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

Mendez‐David, I., Guilloux, J., Papp, M., Tritschler, L., Mocaër, E., Gardier, A. M., Bretin, S., & David, D. J. P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00462 · Cited by 59 · see citing works

A Translational Approach to Evaluate the Efficacy and Safety of the Novel AMPA Receptor Positive Allosteric Modulator Org 26576 in Adult Attention-Deficit/Hyperactivity Disorder

Adler, L. A., Kroon, R., Stein, M. A., Shahid, M., Tarazi, F. I., Szegedi, A., Schipper, J., & Cazorla, P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.012 · Cited by 56 · see citing works

Dynamics and allosteric potential of the AMPA receptor N‐terminal domain

Sukumaran, M., Rossmann, M., Shrivastava, I. H., Dutta, A., Bahar, İ., & Greger, I. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.17 · Cited by 56 · see citing works

Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep

Boyle, J., Stanley, N., James, L. M., Wright, N., Johnsen, S., Arbon, E. L., & Dijk, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111405353 · Cited by 55 · see citing works

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717

Hampson, R. E., España, R. A., Rogers, G. A., Porrino, L. J., & Deadwyler, S. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1360-z · Cited by 54 · see citing works

Structural biology of glutamate receptor ion channels: towards an understanding of mechanism

Greger, I. H., & Mayer, M. L. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.05.004 · Cited by 54 · see citing works

Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease

Trzepacz, P. T., Cummings, J., Konechnik, T., Forrester, T. D., Chang, C., Dennehy, E. B., Willis, B. A., Shuler, C., Tabas, L. B., & Lyketsos, C. (2013) · International Psychogeriatrics · doi:10.1017/s1041610212002141 · Cited by 53 · see citing works

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat

Woolley, M. L., Waters, K. A., Gartlon, J. E., Lacroix, L. P., Jennings, C. A., Shaughnessy, F., Ong, A. B., Pemberton, D. J., Harries, M. H., Southam, E., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1325-2 · Cited by 49 · see citing works

LY503430: Pharmacology, Pharmacokinetics, and Effects in Rodent Models of Parkinson's Disease

O’Neill, M. J., Murray, T. K., Clay, M. P., Lindstrom, T. D., Yang, C. R., & Nisenbaum, E. S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00037.x · Cited by 49 · see citing works

The Ampakine CX546 Restores the Prepulse Inhibition and Latent Inhibition Deficits in mGluR5-Deficient Mice

Lipina, T. V., Weiss, K. C., & Roder, J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301191 · Cited by 48 · see citing works

Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action

Andreasen, J. T., Fitzpatrick, C. M., Larsen, M., Skovgaard, L., Nielsen, S. D., Clausen, R. P., Troelsen, K. B., & Pickering, D. S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.001 · Cited by 48 · see citing works

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats

Damgaard, T. D., Larsen, D. B., Hansen, S. L., Grayson, B., Neill, J. C., & Plath, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.048 · Cited by 47 · see citing works

Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242

Ranganathan, M., DeMartinis, N. A., Huguenel, B. M., Gaudreault, F., Bednar, M. M., Shaffer, C. L., Gupta, S., Cahill, J. D., Sherif, M. A., Mancuso, J. Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.6 · Cited by 46 · see citing works

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45 · see citing works

Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction

Roberts, B. M., Holden, D., Shaffer, C. L., Seymour, P. A., Menniti, F. S., Schmidt, C. J., Williams, G. V., & Castner, S. A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.039 · Cited by 43 · see citing works

Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging

Bloss, E. B., Hunter, R. G., Waters, E. M., Muñoz, C., Bernard, K., & McEwen, B. S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.007 · Cited by 43 · see citing works

Reelin-Related Disturbances in Depression: Implications for Translational Studies

Caruncho, H. J., Brymer, K. J., Romay-Tallón, R., Mitchell, M. A., Baltanás, T. R., Botterill, J. J., Olivares, J. M., & Kalynchuk, L. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00048 · Cited by 42 · see citing works

Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington’s Disease: Exercise, Adenosine Receptors and Ampakines

Cepeda, C., Cummings, D. M., Hickey, M. A., Max Kleiman-weiner, A., Chen, J., Watson, J. B., & Levine, M. S. (2010) · PLoS Currents · doi:10.1371/currents.rrn1182 · Cited by 41 · see citing works

Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

Brymer, K. J., Johnston, J. N., Botterill, J. J., Romay-Tallón, R., Mitchell, M. A., Allen, J., Pinna, G., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0609-z · Cited by 41 · see citing works

Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test

Wolak, M., Siwek, A., Szewczyk, B., Poleszak, E., Pilc, A., Popik, P., & Nowak, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71080-6 · Cited by 40 · see citing works

The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions

García‐Nafría, J., Herguedas, B., Watson, J. F., & Greger, I. H. (2016) · The Journal of Physiology · doi:10.1113/jp271844 · Cited by 40 · see citing works

Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism

Rhine, M. A., Parrott, J. M., Schultz, M. N., Kazdoba, T. M., & Crawley, J. N. (2019) · Autism Research · doi:10.1002/aur.2066 · Cited by 40 · see citing works

Hippocampal CA4 Reelin-positive neurons

Fatemi, S. H., Earle, J. A., & McMenomy, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000794 · Cited by 39 · see citing works

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA‐Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

Bernard, K., Danober, L., Thomas, J., Lebrun, C., Muñoz, C., Cordi, A. A., Désos, P., Lestage, P. J., & Morain, P. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00088.x · Cited by 38 · see citing works

Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors

Gordillo-Salas, M., Pascual-Antón, R., Ren, J. T., Greer, J. J., & Adell, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01954-x · Cited by 38 · see citing works

Rapid-onset antidepressant efficacy of glutamatergic system modulators: The neural plasticity hypothesis of depression

Wang, J., Jing, L., Toledo-Salas, J.-C., & Xu, L. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1484-6 · Cited by 37 · see citing works

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

Jamieson, C. J., Basten, S., Campbell, R. A., Cumming, I. A., Gillen, K. J., Gillespie, J., Kazemier, B., Kiczun, M., Lamont, Y. M., Lyons, A. J., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.07.138 · Cited by 36 · see citing works

Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2−/y Mice

Murru, L., Vezzoli, E., Longatti, A., Ponzoni, L., Falqui, A., Folci, A., Moretto, E., Bianchi, V., Braida, D., Sala, M., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx221 · Cited by 36 · see citing works

mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects

Witkin, J. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172854 · Cited by 36 · see citing works

Zanos et al. reply

Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J. M., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N., et al. (2017) · Nature · doi:10.1038/nature22085 · Cited by 34 · see citing works

Sex Differences in the Temporal Neuromolecular and Synaptogenic Effects of the Rapid-acting Antidepressant Drug Ketamine in the Mouse Brain

Thelen, C., Flaherty, E., Saurine, J., Sens, J. P., Mohamed, S., & Pitychoutis, P. M. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.053 · Cited by 34 · see citing works

The Discovery and Characterization of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N -{(3 S ,4 S )-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)

Shaffer, C. L., Patel, N. C., Schwarz, J. B., Scialis, R. J., Wei, Y., Hou, X., Xie, L., Karki, K., Bryce, D. K., Osgood, S. M., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00300 · Cited by 33 · see citing works

The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice

Giralt, A., Gómez‐Climent, M. Á., Alcalá‐Vida, R., Bretin, S., Bertrand, D., Delgado-Garcia, J. M., Pérez‐Navarro, E., Alberch, J., & Gruart, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.009 · Cited by 32 · see citing works

Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain

Radin, D. P., Johnson, S., Purcell, R., & LIPPA, A. S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.008 · Cited by 32 · see citing works

Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus

Su, X., Li, X.-Y., Banasr, M., Koo, J. W., Shahid, M., Henry, B., & Duman, R. S. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1598-0 · Cited by 30 · see citing works

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors

Bretin, S., Louis, C., Seguin, L., Wagner, S., Thomas, J., Challal, S., Rogez, N., Albinet, K., Iop, F., Villain, N., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184429 · Cited by 29 · see citing works

HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production

Kunugi, A., Tajima, Y., Kuno, H., Sogabe, S., & Kimura, H. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245050 · Cited by 29 · see citing works

LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons

Baumbarger, P. J., Muhlhauser, M. A., Yang, C. R., & Nisenbaum, E. S. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00195-7 · Cited by 28 · see citing works

Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine

Shaffer, C. L., Dutra, J. K., Tseng, W. C., Weber, M. L., Bogart, L. J., Hales, K., Pang, J., Volfson, D., am Ende, C. W., Green, M. E., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.04.019 · Cited by 28 · see citing works

A key requirement for synaptic Reelin signaling in ketamine-mediated behavioral and synaptic action

Kim, J., Herz, J., Kavalali, E. T., & Monteggia, L. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103079118 · Cited by 28 · see citing works

The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis

Destot-Wong, K.-D., Liang, K., GUPTA, S. K., Favrais, G., Schwendimann, L., Pansiot, J., Baud, O., Spedding, M., Lelièvre, V., Mani, S., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.05.010 · Cited by 27 · see citing works

Positive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Modulators Have Different Impact on Synaptic Transmission in the Thalamus and Hippocampus

Xia, Y., Kessler, M., & Arai, A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078196 · Cited by 27 · see citing works

A 24‐week double‐blind placebo‐controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptoms

Bernard, K., Gouttefangeas, S., Bretin, S., Galtier, S., Robert, P. H., Holthoff‐Detto, V., Cummings, J. L., & Pueyo, M. E. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.04.002 · Cited by 27 · see citing works

The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats

Morley‐Fletcher, S., Zuena, A. R., Mairesse, J., Gatta, E., Camp, G. V., Bouwalerh, H., Riozzi, B., Battaglia, G., Pittaluga, A., Olivero, G., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.018 · Cited by 26 · see citing works

TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats

Suzuki, A., Murakami, K., Tajima, Y., Hara, H., Kunugi, A., & Kimura, H. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.06.004 · Cited by 26 · see citing works

Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Johnston, J. N., Thacker, J. S., Desjardins, C., Kulyk, B. D., Romay-Tallón, R., Kalynchuk, L. E., & Caruncho, H. J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.559627 · Cited by 26 · see citing works

Targeting metabotropic glutamate receptors for rapid-acting antidepressant drug discovery

Musazzi, L. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1822814 · Cited by 26 · see citing works

AMPA Receptor Potentiation can Prevent Ethanol-Induced Intoxication

Jones, N., Messenger, M. J., O’Neill, M. J., Oldershaw, A., Gilmour, G., Simmons, R. M. A., Iyengar, S., Libri, V., Tricklebank, M. D., & Williams, S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301562 · Cited by 25 · see citing works

Effects of the Putative Cognitive-Enhancing Ampakine, CX717, on Attention and Object Recognition Memory

Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2011) · Current Alzheimer Research · doi:10.2174/156720511798192709 · Cited by 25 · see citing works

Molecular mechanisms of neurite growth with AMPA receptor potentiation

Voss, O. P., Milne, S. A., Sharkey, J., O’Neill, M. J., & McCulloch, J. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.09.001 · Cited by 25 · see citing works

Auxiliary Proteins are the Predominant Determinants of Differential Efficacy of Clinical Candidates Acting as AMPA Receptor Positive Allosteric Modulators

Ishii, T., Stolz, J. R., & Swanson, G. T. (2020) · Molecular Pharmacology · doi:10.1124/mol.119.118554 · Cited by 25 · see citing works

Ketamine Mechanism of Action: Separating the Wheat from the Chaff

Gould, T. D., Zanos, P., & Zarate, C. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.210 · Cited by 24 · see citing works

Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia

Tanaka, M., Kunugi, A., Suzuki, A., Suzuki, N., Suzuki, M., & Kimura, H. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.479 · Cited by 24 · see citing works

The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus

Fumagalli, F., Calabrese, F., Luoni, A., Shahid, M., Racagni, G., & Riva, M. A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.10.004 · Cited by 23 · see citing works

Prolonged ampakine exposure prunes dendritic spines and increases presynaptic release probability for enhanced long‐term potentiation in the hippocampus

Chang, P. K. ‐., Prenosil, G. A., Verbich, D., Gill, R., & McKinney, R. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12638 · Cited by 23 · see citing works

Upregulation of neurotrophins by S 47445, a novel positive allosteric modulator of AMPA receptors in aged rats

Calabrese, F., Savino, E., Mocaër, E., Bretin, S., Racagni, G., & Riva, M. A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.019 · Cited by 23 · see citing works

Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil

Béracochéa, D., Philippin, J.-N., Meunier, S., Morain, P., & Bernard, K. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0765-4 · Cited by 22 · see citing works

Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures

Schitine, C., Xapelli, S., Agasse, F., Sardà‐Arroyo, L., Silva, A. P., Reis, R. A. D. M., Mello, F. G. D., & Malva, J. O. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08072.x · Cited by 21 · see citing works

S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine

Vandesquille, M., Krazem, A., Louis, C., Lestage, P. J., & Béracochéa, D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2168-9 · Cited by 21 · see citing works

S18986: A positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures

Lockhart, B. P., Rodriguez, M., Mourlevat, S., Péron, P., Catesson, S., Villain, N., Galizzi, J., Boutin, J. A., & Lestage, P. J. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.030 · Cited by 19 · see citing works

Pharmacological Characterization of cGMP Regulation by the Biarylpropylsulfonamide Class of Positive, Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

Ryder, J. W., Falcone, J. F., Manro, J. R., Svensson, K. A., & Merchant, K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105734 · Cited by 18 · see citing works

S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice

Pilar-Cuéllar, F., Castro, E., Bretin, S., Mocaër, E., Pazos, Á., & Díaz, Á. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.04.005 · Cited by 18 · see citing works

Abnormal early dynamic individual patterns of functional networks in low gamma band for depression recognition

Bi, K., Chattun, M. R., Liu, X., Wang, Q., Tian, S., Zhang, S., Lü, Q., & Yao, Z. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.05.078 · Cited by 17 · see citing works

Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission

Jardemark, K. E., Marcus, M. M., Malmerfelt, A., Shahid, M., & Svensson, T. H. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2554-3 · Cited by 16 · see citing works

The AMPA modulator S 18986 improves declarative and working memory performances in aged mice

Marighetto, A., Valério, S., Jaffard, R., Mormède, C., Muñoz, C., Bernard, K., & Morain, P. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282feb0c1 · Cited by 16 · see citing works

CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer's disease.

Mozafari, N., Shamsizadeh, A., Fatemi, I., Allahtavakoli, M., Ahmadi, A. M., Kaviani, E., & Kaeidi, A. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.28544.6934 · Cited by 16 · see citing works

Targeting of Metabotropic Glutamate Receptors for the Development of Novel Antidepressants

Chaki, S., Koike, H., & Fukumoto, K. (2019) · Chronic Stress · doi:10.1177/2470547019837712 · Cited by 16 · see citing works

Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ−8 Through Investigations of TARP γ−8 Null Mice§

Gleason, S. D., Kato, A., Bui, H. H., Thompson, L., Valli, S., Stutz, P. V., Kuo, M., Falcone, J. F., Anderson, W. H., Li, X., et al. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150429114818 · Cited by 15 · see citing works

Not So Fast

Kadriu, B., Deng, Z., Kraus, C., Henter, I. D., Lisanby, S. H., & Zarate, C. A. (2020) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.19ac13138 · Cited by 15 · see citing works

The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss

Bednar, M. M., DeMartinis, N. A., Banerjee, A., Bowditch, S. P., Gaudreault, F., Zumpano, L., & Lin, F. R. (2015) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2015.0791 · Cited by 13 · see citing works

Crystal structure of the GluA2o LBD in complex with glutamate and HBT1

Sogabe, S., Igaki, S., Hirokawa, A., Zama, Y., Lane, W., & Snell, G. (2017) · Worldwide Protein Data Bank · doi:10.2210/pdb5ybf/pdb · Cited by 13 · see citing works

Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats

Kelly, S. J., Bernard, K., Muñoz, C., Lawrence, R. C., Thacker, J. S., Grillo, C. A., Piroli, G. G., & Reagan, L. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1301-x · Cited by 12 · see citing works

Comparison of single vs. multiple administrations of the AMPA receptors modulator S 18986 in the object recognition task in rats

Bertaina‐Anglade, V., Rochelle, C. D. L., Muñoz, C., Morain, P., & Bernard, K. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00487.x · Cited by 11 · see citing works

Glutamate-based Therapies for Psychiatric Disorders

Skolnick, P. (2010) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0241-9 · Cited by 11 · see citing works

Positive allosteric modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action

Fitzpatrick, C. M., Larsen, M., Madsen, L. H., Caballero-Puntiverio, M., Pickering, D. S., Clausen, R. P., & Andreasen, J. T. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000243 · Cited by 10 · see citing works

Electrophysiological characterization of a novel AMPA receptor potentiator, TAK-137, in rat hippocampal neurons

Suzuki, A., Tajima, Y., Kunugi, A., & Kimura, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134488 · Cited by 10 · see citing works

Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice

Kara, N. Z., Flaisher-Grinberg, S., & Einat, H. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.02.008 · Cited by 7 · see citing works

Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy

Nisenbaum, E. S., & Witkin, J. M. (2010) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0241-9_3 · Cited by 7 · see citing works

AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability

Lykens, N. M., Coughlin, D. J., Reddi, J. M., Lutz, G. J., & Tallent, M. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171538 · Cited by 7 · see citing works

Hippocampal gamma rhythms during Y‐maze navigation in the juvenile rat

McHail, D. G., & Dumas, T. C. (2019) · Hippocampus · doi:10.1002/hipo.23168 · Cited by 7 · see citing works

Reverse and Forward Translational Neuropharmacology in Psychiatric Drug Discovery

Shaffer, C. L. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.901 · Cited by 5 · see citing works

New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task

Louis, C., Llopis, K., Danober, L., Panayi, F., Lestage, P. J., & Béracochéa, D. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000418 · Cited by 3 · see citing works

Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states

González-Arias, C., Sánchez-Ruiz, A., Esparza, J., Sánchez‐Puelles, C., Arancibia, L., Ramírez‐Franco, J., Gobbo, D., Kirchhoff, F., & Perea, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02269-8 · Cited by 122 · see citing works

Ketamine in neuropsychiatric disorders: an update

Johnston, J. N., Kadriu, B., Kraus, C., Henter, I. D., & Zarate, C. A. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01632-1 · Cited by 108 · see citing works

New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics

Lobo, M. C., Whitehurst, T., Kaar, S. J., & Howes, O. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.032 · Cited by 93 · see citing works

Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments

Krystal, J., Kaye, A. P., Jefferson, S., Girgenti, M., Wilkinson, S. T., Sanacora, G., & Esterlis, I. (2023) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2305772120 · Cited by 69 · see citing works

Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant

Suzuki, A., Hara, H., & Kimura, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109308 · Cited by 46 · see citing works

Plasticity of synapses and reward circuit function in the genesis and treatment of depression

Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects

Golubeva, E. A., Lavrov, M. I., Radchenko, E. V., & Palyulin, V. A. (2022) · Biomolecules · doi:10.3390/biom13010056 · Cited by 37 · see citing works

NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus

Studtmann, C., Ladislav, M., Topolski, M. A., Safari, M., & Swanger, S. A. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105672 · Cited by 39 · see citing works

Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential

Allen, J., Dames, S., Foldi, C. J., & Shultz, S. R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02360-0 · Cited by 38 · see citing works

Dysfunction of Glutamatergic Synaptic Transmission in Depression: Focus on AMPA Receptor Trafficking

He, J.-G., Zhou, H.-Y., Wang, F., & Chen, J.-G. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.02.007 · Cited by 36 · see citing works

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

Hara, H., Suzuki, A., Kunugi, A., Tajima, Y., Yamada, R. X., & Kimura, H. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173289 · Cited by 24 · see citing works

Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice

Xue, S.-G., He, J., Lu, L.-L., Song, S.-J., Chen, M., Wang, F., & Chen, J. (2023) · Nature Communications · doi:10.1038/s41467-023-42780-8 · Cited by 24 · see citing works

All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

Freudenberg, F., Reif-Leonhard, C., Dawson, G. R., McKernan, R. M., & Reif, A. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107918 · Cited by 23 · see citing works

Revolutionizing Neurological Disorder Treatment: Integrating Innovations in Pharmaceutical Interventions and Advanced Therapeutic Technologies

Arora, R., & Baldi, A. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128284824240328071911 · Cited by 21 · see citing works

Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism

Pilc, A., Machaczka, A., Kawalec, P., Smith, J. L., & Witkin, J. M. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2111415 · Cited by 21 · see citing works

Role of Ion Channels in Alzheimer’s Disease Pathophysiology

Bhoi, R., Mitra, T., Tejaswi, K., Manoj, V., & Ghatak, S. (2025) · The Journal of Membrane Biology · doi:10.1007/s00232-025-00341-8 · Cited by 19 · see citing works

Glutamate-Based Therapeutic Strategies for Schizophrenia: Emerging Approaches Beyond Dopamine

Stănculete, M. F., & Căpățînă, O. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094331 · Cited by 20 · see citing works

The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice

Chen, J.-Y., Wu, K., Guo, M., Song, W., Huang, S.-T., & Zhang, Y.-M. (2023) · iScience · doi:10.1016/j.isci.2023.107878 · Cited by 18 · see citing works

Clinical pharmacological innovation in the treatment of depression

Witkin, J. M., Golani, L. K., & Smith, J. L. (2023) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2023.2198703 · Cited by 16 · see citing works

Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms

Bellingacci, L., Sciaccaluga, M., Megaro, A., Cardinale, A., Canonichesi, J., Carluccio, M. D., Mastrantonio, R., Costa, C., Filippo, M. D., Usiello, A., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01075-z · Cited by 14 · see citing works

Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice

Du, Y., Gao, F., Sun, H., Wu, C., Zhu, G., & Zhu, M. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115855 · Cited by 13 · see citing works

AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit

Witkin, J. M., Radin, D. P., Rana, S. D., Fuller, D. D., Fusco, A. F., Demers, J. C., Thakre, P. P., Smith, J. L., LIPPA, A. S., & Cerne, R. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116302 · Cited by 13 · see citing works

Neuroprotection beyond neurons: integrated biomarker-based and astroglia- or microglia-targeted approaches to combat neurodegenerative diseases

Volonté, C., Hu, G., Shaw, C. A., Claudio, V. J., dos Santos, J. A., Vaz, S. H., Sebastião, A. M., Balcar, V. J., Mozley, P. D., Verde, F., et al. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004136 · Cited by 12 · see citing works

Advancing past ketamine: emerging glutamatergic compounds for the treatment of depression

Freudenberg, F., Reif-Leonhard, C., & Reif, A. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01875-z · Cited by 12 · see citing works

The severity of SLC1A2-associated neurodevelopmental disorders correlates with transporter dysfunction

Kovermann, P., Bayat, A., Fenger, C., Leeuwen, L., Borovikov, A. O., Sharkov, A. A., Levrat, V., Lesca, G., Perrin, L., Lévy, J., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105648 · Cited by 11 · see citing works

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., Tullio, P. D., Beaufour, C., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116036 · Cited by 9 · see citing works

Amplification of the therapeutic potential of AMPA receptor potentiators from the nootropic era to today

Radin, D. P., LIPPA, A. S., Rana, S. D., Fuller, D. D., Smith, J. L., Cerne, R., & Witkin, J. M. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173967 · Cited by 9 · see citing works

New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis

Golubeva, E. A., Lavrov, M. I., Veremeeva, P. N., V’yunova, T. V., Shevchenko, K. V., Topchiy, M. A., Asachenko, A. F., & Palyulin, V. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210293 · Cited by 8 · see citing works

3,4-Dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs act as potential AMPA receptor potentiators with antidepressant activity.

Wei, L., Qi, X.-Y., Yu, X.-L., Zheng, Y., Luo, X.-R., Wei, Y., Ni, P.-Y., Zhao, L.-S., Wang, Q., Ma, X.-H., et al. (2023) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2023.115252 · Cited by 5 · see citing works

Neuropsychiatric drug development: Perspectives on the current landscape, opportunities and potential future directions

Loïodice, S., D’Acquisto, F., Drinkenburg, P., Suojanen, C., Llorca, P., & Manji, H. K. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104255 · Cited by 6 · see citing works

Novel α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor ( AMPAR ) potentiator LT ‐102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia

Qi, X., Yu, X., Long, W., Jiang, H., Dong, J., Li, H., Wei, Y., Zhao, L., Deng, W., Guo, W., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14713 · Cited by 5 · see citing works

MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF

Morè, L., Privitera, L., Lopes, M., Arthur, J. S. C., Lauterborn, J. C., Corrêa, S. A. L., & Frenguelli, B. G. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110110 · Cited by 6 · see citing works

Mutually Dependent Clustering of SynDIG4/PRRT1 and AMPA Receptor Subunits GluA1 and GluA2 in Heterologous Cells and Primary Neurons

Plambeck, K. E., He, C.-W., Navarro, H. H., & Dı́az, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.788620 · Cited by 6 · see citing works

Antidepressant-induced increase in GluA2 expression does not translate in changes of AMPA receptor-mediated synaptic transmission at CA3/CA1 synapses in rats

Gerace, E., Polenzani, L., Magnani, M., Zianni, E., Stocca, G., Gardoni, F., Pellegrini-Giampietro, D. E., & Corradetti, R. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109307 · Cited by 6 · see citing works

Effects of the selective AMPA modulator NBI ‐1065845 on the pharmacokinetics of midazolam or ethinyl estradiol–levonorgestrel in healthy adults

Lin, S., Ionescu, A., Maynard‐Scott, J., Kennedy, M., Walling, D. P., Furey, M., & Singh, J. B. (2024) · Clinical and Translational Science · doi:10.1111/cts.13791 · Cited by 5 · see citing works

Ampakines — a promising approach to neuroprotection

Киселев, А. В., Котов, А. С., Mikhaleva, M. G., Stovbun, S. V., & Kotov, S. V. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212209154 · Cited by 4 · see citing works

5-Nitroisoxazoles in SNAr Reactions: A Novel Chemo- and Regioselective Approach to Isoxazole-Based Bivalent Ligands of AMPA Receptors

Vasilenko, D. A., Temnyakova, N. S., Dronov, S. E., Radchenko, E. V., Grishin, Y. K., Gabrel’yan, A. V., Zamoyski, V. L., Grigoriev, V. V., Averina, E. B., & Palyulin, V. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216135 · Cited by 4 · see citing works

The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function

Wan, L. P., Li, Y., Zhao, S., Zhao, S., Song, N., Yuan, K., Yang, C., Ding, Y., Mao, B., Sheng, N., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426375122 · Cited by 3 · see citing works

Synthesis and modulatory activity of 3-acetyl-7-(benzofuran-5-carbonyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one on AMPA receptors

Matthews, J., Veremeeva, P. N., Golubeva, E. A., Lavrov, M. I., Radchenko, E. V., Zamoyski, V. L., Grigoriev, V. V., & Palyulin, V. A. (2024) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-024-03377-1 · Cited by 3 · see citing works

TAK-653 Reverses Core Depressive Symptoms in Chronic Stress-Induced Monkey Model

Li, L., Zhang, Z., Liu, X., Zhou, M., Wen, S., & Dai, J. (2025) · Biomedicines · doi:10.3390/biomedicines13061389 · Cited by 2 · see citing works

NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine

Nakajima, W., Arisawa, T., Jitsuki, S., Yamanoue, T., Fujikawa, K., Hara, M., Sano, A., Takada, Y., Iai, R., Kimura, K., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03527-1 · Cited by 2 · see citing works

Synaptic and intrinsic mechanisms impair reticular thalamus and thalamocortical neuron function in a Dravet syndrome mouse modelPreprint

Studtmann, C., Ladislav, M., Topolski, M. A., Safari, M., & Swanger, S. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.03.458635 · Cited by 2 · see citing works

Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

Sedenkova, K. N., Kositov, S. V., Zverev, D. V., Radchenko, E. V., Grishin, Y. K., Gabrel’yan, A. V., Zamoyski, V. L., Grigoriev, V. V., Averina, E. B., & Palyulin, V. A. (2024) · Mendeleev Communications · doi:10.1016/j.mencom.2024.01.002 · Cited by 1 · see citing works

Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

Papassotiropoulos, A., & de Quervain, D. J. ‐. (2024) · Science Signaling · doi:10.1126/scisignal.adp5354 · Cited by 1 · see citing works

Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators

Shokr, M. M., Fawzy, M. N., & Abdelaziz, A. M. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104076 · Cited by 2 · see citing works

Role of phospholipase A2 and glutamate in Alzheimer's disease

Samant, N. P., & Gupta, G. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21800-2.00011-7

The Current Status of Antidepressant Drugs and the Exploration of New Targets

张, 陈. (2025) · Hans Journal of Medicinal Chemistry · doi:10.12677/hjmce.2025.132021

3-Acetyl-1,5-dimethyl-7-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one: synthesis, structure, and modulation of the AMPA receptor

Matthews, J., Arsentyeva, E. K., Veremeeva, P. N., Golubeva, E. A., Lavrov, M. I., Radchenko, E. V., Тафеенко, В. А., Zamoyski, V. L., Grigoriev, V. V., & Palyulin, V. A. (2025) · Russian Chemical Bulletin · doi:10.1007/s11172-025-4636-0

Recent advances in rapid-acting antidepressants

Pan, L., He, Y., Wang, G., & Shen, J. (2025) · Scientia Sinica Chimica · doi:10.1360/ssc-2025-0157

GluK2 kainate receptor subunit-selective, potentiating RNA aptamer

Ingenito, S. R., Saunders, N., Lininger, K. J., & Niu, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-15323-y

Mechanisms of Neuronal Damage and Dysfunction

Ansari, U. A. (2025) · Springer eBooks · doi:10.1007/978-981-95-0125-0_1

Receptor targets in Alzheimer's disease drug discovery

Stanley, B., Wallach, J. V., & Adejare, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30008-0.00013-2

PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress

Chang-min, W., Li, Y., Yi, Y., Chen, X., Lan, T., Lou, H.-Y., Jian, W., Wang, M.-J., & Yu, S.-Y. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01790-0

AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation

Ziemichód, W., Kajka, N., Kister, K., Kasprzak, K., Karakuła, K. H., & Juchnowicz, D. (2026) · Pharmacological Reports · doi:10.1007/s43440-026-00871-5

GRIA Gene Expression in Schizophrenia: A Participant-Level Meta-Analysis

Baumel, A., Yitzhaky, A., & Hertzberg, L. (2026) · ALPHA PSYCHIATRY · doi:10.31083/ap46200

Emerging Molecular Targets and Recent Advancements for the Management of Depression

Rana, S., Kumar, A. C. S., Kumar, B., Ser, H., & Jaitak, V. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06046-w

Distinct roles of AMPA receptor subunits as potential therapeutic targets in Alzheimer’s disease

Seo, J., Kim, K., & Park, M. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108394

Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett modelsPreprint

Landsberger, N., Rocco, G. D., de Donato, A., Indrigo, M. T., Varotto, V., Geusa, M., Taverna, S., Cifola, I., Pinatel, E., & Frasca, A. (2026) · Research Square · doi:10.21203/rs.3.rs-10618030/v1

Altered glutamatergic neurotransmission in the development and maintenance of PTSD

Ogłodek, E. A. (2026) · Polski Merkuriusz Lekarski · doi:10.36740/merkur202604120

Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides

Mariano, A., Rozov, A. V., Phillips, G., Singleton, S., Baptista-Hon, D., Valiullina, F., Sprengel, R., Langston, R. F., Martin, S. J., Hales, T. G., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2521987123

Discovery of a fluorinated benzoxathiazine AMPA receptor PAM that stabilizes the GluA2 dimer interface and displays antidepressant-like effects

wei, L., Yu, X., Zheng, Y., Zhou, M., Wang, Q., Zhang, Y., Chen, Q., Mu, X., Jiang, H., Ni, P., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119423

Discovery of GluA3 Preferring AMPA Receptor Positive Allosteric Modulator BRD3290

Greaves, C., Martenis, W. E., Nelson, S. D., Madison, J. M., Skepner, A., Báez-Nieto, D., Stalnaker, K. J., Lebois, E. P., Campbell, A. J., Pelham, K., et al. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00573

AMPA Receptor Positive Allosteric Modulators: Potential for the Treatment of Neuropsychiatric and Neurological Disorders

Reuillon, T. D., Ward, S. E., & Beswick, P. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160627114507 · Cited by 33 · see citing works

Modulating AMPA Receptors for the Treatment of CNS Disorders

Reuillon, T. D., Ward, S. E., & Beswick, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12654-x · Cited by 6 · see citing works

Therapeutic Potential of Positive AMPA Receptor Modulators in the Treatment of Neuropsychiatric Disorders

Marenco, S., & Weinberger, D. R. (2006) · CNS Drugs · doi:10.2165/00023210-200620030-00001 · Cited by 45 · see citing works

Therapeutic potential of positive allosteric modulators of AMPA receptors in brain disorders

Spinola, A., Italia, M., & Gardoni, F. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119960

AMPA Receptor Potentiators as Potential Rapid-Acting Antidepressants

Garro-Martínez, E., & Adell, A. (2021) · Contemporary Clinical Neuroscience · doi:10.1007/978-3-030-79790-4_6 · Cited by 1 · see citing works