Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death
Abstract
AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca(2+) and Zn(2+). Ca(2+) permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca(2+) permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca(2+)-permeable AMPA receptors in neuronal function and survival.
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AMPARs that contain GluA2 are calcium-impermeable.
“This design renders AM-PARs that contain GluA2 calcium-impermeable (Liu and Zukin 2007).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Liu and Zukin 2007
There are forms of synaptic potentiation that are expressed by an exchange of GluA2-containing AMPARs in the synapse for GluA2-lacking AMPARs.
“In addition, there are also forms of synaptic potentiation that are expressed by an exchange of GluA2-containing AMPARs in the synapse for GluA2-lacking AMPARs (Liu and Zukin 2007).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Liu and Zukin 2007
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- Authors
- Liu, S. J., & Zukin, R. S.
- Affiliations
- Pennsylvania State University (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Liu, Siqiong June
- Zukin, R. Suzanne
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 30
- Issue
- 3
- Pages
- 126-134
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1990286087
- Cited by
- 530
- References
- 4
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 16 · 2023: 15 · 2022: 22 · 2021: 38 · 2020: 22 · 2019: 21 · 2018: 16 · 2017: 31 · 2016: 27 · 2015: 26 · 2014: 34 · 2013: 52 · 2012: 45
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS46742, R01NS046742)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- Ca2+-permeable AMPA receptors, GluR2 subunit, synaptic plasticity, neuronal cell death, calcium permeation, AMPA receptor subunit composition, RNA editing, receptor trafficking, dendritic protein synthesis, excitatory synapses, neurological disorders
- MeSH terms
- Animals, Calcium, Humans, Neuronal Plasticity, Neurons, Permeability, Synapses, Cell Death, Receptors, AMPA, Protein Subunits
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