Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism

Cservenka, Anita; Casimo, Kaitlyn; Fair, Damien A.; Nagel, Bonnie J.

doi:10.1016/j.pscychresns.2013.12.004

Cited by 87Functional Brain Connectivity StudiesSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism

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Cservenka, Anita, Casimo, Kaitlyn, Fair, Damien A., Nagel, Bonnie J.·2014·Psychiatry Research: Neuroimaging

DOI 10.1016/j.pscychresns.2013.12.004PMC PMC3943736

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Abstract

Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FHP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents.

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Prior reports show NAcc connectivity to several brain networks either positively or negatively.
“The current report builds on prior reports showing NAcc connectivity to several brain networks either positively or negatively (see Fig. 2 and Costa Dias et al., 2012, Cservenka et al., 2014, Tomasi and Volkow, 2012).”
From Characterizing heterogeneity in children with and without ADHD based on reward system connectivity (2015) · cites this paper as Cservenka et al., 2014

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Plasma Orexin Levels Related to Altered Brain Activity During Abstinence in Patients with Alcohol Dependence
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Alcohol and the Cerebellum
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Neural response to threat and reward among young adults at risk for alcohol use disorder
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Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner
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Tangent space functional reconfigurations in individuals at risk for alcohol use disorder
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Resting state functional connectivity in adolescents with substance use disorder and their unaffected siblings
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Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens
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Elevated integration within the reward network underlies vulnerability to distress
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Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity
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Sex differences in reward network activation are linked to problematic substance use among high-risk adolescents
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Self-citation

Authors: Cservenka, A., Casimo, K., Fair, D. A., & Nagel, B. J.
Affiliations: Oregon Health & Science University (US)
University of Washington (US)
Corresponding author: Nagel, Bonnie J.
ORCID: Cservenka, Anita
Casimo, Kaitlyn
Fair, Damien A.
Nagel, Bonnie J.
Venue: Psychiatry Research: Neuroimaging
Publisher: Elsevier BV
Published: 2014-03
Volume: 221
Issue: 3
Pages: 210-219
ISSN: 0925-4927 (ISSN-L)
DOI: 10.1016/j.pscychresns.2013.12.004
PMC: PMC3943736
OpenAlex: W1999130928
Cited by: 86
References: 90
Citations by year: 2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 7 · 2015: 18 · 2014: 1
FWCI: 4.73
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Psychiatry Research Neuroimaging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA017664, U01AA021691, T32AA007468, P60AA010760)
National Institute of Mental Health (R00MH091238, R01MH096773)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: nucleus accumbens, resting-state functional connectivity, family history of alcoholism, inferior frontal gyrus, postcentral gyrus, orbitofrontal cortex, cerebellum, reward processing, executive function, risk indicators
MeSH terms: Adolescent, Alcoholism, Brain, Cerebellum, Child, Female, Frontal Lobe, Humans, Male, Nucleus Accumbens, Parietal Lobe, Research Design, Reward, Alcohol-Related Disorders

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Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism

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