Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Open accessAbstract
Background Substance-abusing individuals tend to display abnormal reward processing and a vulnerability to being impulsive. Detoxified alcoholics show differences in regional brain activation during a monetary incentive delay task. However, there is limited information on whether this uncharacteristic behavior represents a biological predisposition toward alcohol abuse, a consequence of chronic alcohol use, or both.Methods We investigated proposed neural correlates of substance disorder risk by examining reward system activity during a monetary incentive delay task with separate reward prospect, reward anticipation, and reward outcome phases in 30 individuals with and 19 without family histories of alcoholism. All subjects were healthy, lacked DSM-IV past or current alcohol or substance abuse histories, and were free of illegal substances as verified by a urine toxicology screening at the time of scanning. Additionally, we explored specific correlations between task-related nucleus accumbens (NAcc) activation and distinct factor analysis-derived domains of behavioral impulsivity.Results During reward anticipation, functional magnetic resonance imaging data confirmed blunted NAcc activation in family history positive subjects. In addition, we found atypical activation in additional reward-associated brain regions during additional task phases. We further found a significant negative correlation between NAcc activation during reward anticipation and an impulsivity construct.Conclusions Overall, results demonstrate that sensitivity of the reward circuit, including NAcc, is functionally different in alcoholism family history positive individuals in multiple regards.
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The pattern of reduced reward motivation may be evident even in the absence of the direct effects of repeated drug use on the brain, because it is found in family members of those with substance abuse.
“Notably, Andrews and colleagues [155] found this effect in family members of those with substance abuse, suggesting that this pattern may be evident even in the absence of the direct effects of repeated drug use on the brain.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [155]
Decreased NAc activation to monetary-reward outcome predicts family history of alcoholism.
“Andrews and colleagues [155] reported decreased NAc activation to monetary-reward outcome that predicted family history of alcoholism.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [155]
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- Authors
- Andrews, M. M., Meda, S. A., Thomas, A. D., Potenza, M. N., Krystal, J. H., Worhunsky, P., Stevens, M. C., O'Malley, S., Book, G. A., Reynolds, B., & Pearlson, G. D.
- Affiliations
- Hartford Hospital (US)
- Yale University (US)
- The Ohio State University (US)
- Corresponding author
- Pearlson, Godfrey D.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 69
- Issue
- 7
- Pages
- 675-683
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3677031
- OpenAlex
- W2015094921
- Cited by
- 181
- References
- 102
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 13 · 2020: 7 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 13 · 2015: 12 · 2014: 20 · 2013: 20 · 2012: 17
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01 AA017539, R01 DA020709, R01 DA020908, R01AA016599)
- National Institute on Alcohol Abuse and Alcoholism (5 P50 AA012870, K05 AA-14906-01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- reward processing, impulsivity, nucleus accumbens, reward anticipation, monetary incentive delay task, reward systems, substance use disorder risk, brain activation
- MeSH terms
- Adult, Alcoholism, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Middle Aged, Nucleus Accumbens, Oxygen, Reaction Time, Reward, Chi-Square Distribution, Young Adult
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