White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine
Open accessAbstract
Background Prenatal cocaine exposure (PCE) is associated with risk-taking behaviors, including increased initiation of substance use in adolescence. The neurobiological underpinnings of these behaviors in adolescents with PCE are not well understood. The goal of this study was to compare diffusion-weighted imaging data between adolescents with and without PCE using crossing-fiber models, which may provide more comprehensive estimates of white-matter microstructure within regions of multiple (e.g., primary and secondary) fiber orientations.Methods Thirty-nine PCE individuals and 17 comparably aged prenatally non-drug-exposed (NDE) youths were recruited from a longitudinal cohort followed since birth. White matter was examined using tensor-derived and crossing-fiber models. Whole-brain investigations were performed, as were analyses on seven white-matter regions, which included the splenium, body and genu of the corpus callosum, bilateral cingulum, and the right and left superior longitudinal fasciculus (SLF).Results Whole-brain analyses revealed no group differences. However, ROI analyses for anisotropy estimates derived from the crossing-fiber model revealed significant group differences for secondary fibers, with reduced anisotropy among PCE adolescents compared to prenatally non-exposed youth in the right cingulum and the left SLF, and increased anisotropy in the genu.Conclusions Our findings suggest that white-matter differences in PCE adolescents are subtle and localized primarily within secondary fiber orientations, perhaps arising from altered white-matter development.
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Cocaine abuse is associated with higher FA in some brain regions and lower FA in others.
“cocaine abuse is associated with higher FA in certain regions of the brain, and lower FA in other areas (Morie et al., 2017; Romero et al., 2010).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Morie et al., 2017
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- Smith SM Jenkinson M Johansen-Berg H Rueckert D Nichols TE Mackay CE Watkins KE Ciccarelli O Cader MZ Matthews PM Behrens TEJ 2006b Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data NeuroImage 31 1487 1505 16624579
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Hampton, W. H., Hanik, I. M., & Olson, I. R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.005 · Cited by 95 · see citing works
- Authors
- Morie, K. P., Yip, S. W., Zhai, Z. W., Xu, J., Hamilton, K. R., Sinha, R., Mayes, L. C., & Potenza, M. N.
- Affiliations
- Yale University (US)
- University of Maryland, College Park (US)
- Corresponding author
- Morie, Kristen P.
- ORCID
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 174
- Pages
- 23-29
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC5555052
- OpenAlex
- W2594061623
- Cited by
- 9
- References
- 50
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001863)
- National Institute on Alcohol Abuse and Alcoholism (RL1AA017539)
- National Institute of Mental Health (T32MH018268)
- National Institute on Drug Abuse (R01DA006025, P50DA016556, R01DA017863, K01DA039299, P50DA009241, K05DA020091, T32DA007238, T32DA022975)
- National Institute of Dental and Craniofacial Research (UL1DE019586)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- prenatal cocaine exposure, white matter microstructure, adolescents, corpus callosum, cingulum, superior longitudinal fasciculus, anisotropy, white matter development, risk-taking, substance use initiation
- MeSH terms
- Adolescent, Brain, Cocaine, Female, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Case-Control Studies, Anisotropy, Diffusion Tensor Imaging, Neuroimaging, White Matter
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