Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure
Open accessAbstract
Prenatal exposure to maternal smoking has been linked to cognitive and auditory processing deficits in offspring. Preclinical studies have demonstrated that exposure to nicotine disrupts neurodevelopment during gestation and adolescence, possibly by disrupting the trophic effects of acetylcholine. Given recent clinical and preclinical work suggesting that neurocircuits that support auditory processing may be particularly vulnerable to developmental disruption by nicotine, we examined white matter microstructure in 67 adolescent smokers and nonsmokers with and without prenatal exposure to maternal smoking. The groups did not differ in age, educational attainment, IQ, years of parent education, or symptoms of inattention. Diffusion tensor anisotropy and anatomical magnetic resonance images were acquired, and auditory attention was assessed, in all subjects. Both prenatal exposure and adolescent exposure to tobacco smoke was associated with increased fractional anisotropy (FA) in anterior cortical white matter. Adolescent smoking was also associated with increased FA of regions of the internal capsule that contain auditory thalamocortical and corticofugal fibers. FA of the posterior limb of the left internal capsule was positively correlated with reaction time during performance of an auditory attention task in smokers but not in nonsmokers. Development of anterior cortical and internal capsule fibers may be particularly vulnerable to disruption in cholinergic signaling induced by nicotine in tobacco smoke. Nicotine-induced disruption of the development of auditory corticofugal fibers may interfere with the ability of these fibers to modulate ascending auditory signals, leading to greater noise and reduced efficiency of neurocircuitry that supports auditory processing.
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Higher FA is more commonly observed in younger nicotine users.
“with higher FA more commonly observed in younger nicotine users (Hudkins et al., 2012; Jacobsen et al., 2007).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Jacobsen et al., 2007
In adolescent smokers and nonsmokers matched on age, education, IQ, parental education, and inattention symptoms, prenatal and adolescent tobacco smoke exposure were both associated with increased fractional anisotropy in anterior cortical white matter.
“In a study of adolescent smokers and non-smokers who were similar with respect to age, education, IQ, parental education, and symptoms of inattention, prenatal and adolescent exposure to tobacco smoke were both associated with increased fractional anisotropy in anterior cortical white matter.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [258]
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- Authors
- Jacobsen, L. K., Picciotto, M. R., Heath, C. J., Frost, S. J., Tsou, K. A., Dwan, R. A., Jackowski, M. P., Constable, R. T., & Mencl, W. E.
- Affiliations
- Yale University (US)
- Haskins Laboratories (US)
- Universidade de São Paulo (BR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-05
- Volume
- 27
- Issue
- 49
- Pages
- 13491-13498
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673092
- OpenAlex
- W2008778314
- Cited by
- 147
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 17 · 2012: 7
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Research Online - ORO (The Open University) (submittedVersion)
- Funders
- National Institutes of Health (DA00436)
- U.S. Public Health Service
- National Institute on Alcohol Abuse and Alcoholism (P50AA015632, AA15632)
- National Institute of Mental Health (MH77681, R01MH077681)
- National Institute on Drug Abuse (DA017333, K02DA000436, R01DA017333, DA 14655, R01DA014655, DA 00436)
- National Institute of Biomedical Imaging and Bioengineering (R01EB006494)
- National Center for Research Resources (M01RR000125)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- prenatal tobacco exposure, adolescent smoking, nicotine, white matter microstructure, fractional anisotropy, internal capsule, auditory attention, corticofugal fibers, acetylcholine signaling, brain development, auditory processing
- MeSH terms
- Adolescent, Female, Humans, Male, Nerve Fibers, Myelinated, Nerve Net, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Adolescent Development
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