Cited by 87Hemodynamic Monitoring and TherapySepsis Diagnosis and TreatmentCardiovascular Conditions and Treatments

Clinical monitoring of systemic hemodynamics in critically ill newborns

de Boode, Willem-Pieter·2010·Early Human Development

Abstract

Circulatory failure is a major cause of mortality and morbidity in critically ill newborn infants. Since objective measurement of systemic blood flow remains very challenging, neonatal hemodynamics is usually assessed by the interpretation of various clinical and biochemical parameters. An overview is given about the predictive value of the most used indicators of circulatory failure, which are blood pressure, heart rate, urine output, capillary refill time, serum lactate concentration, central-peripheral temperature difference, pH, standard base excess, central venous oxygen saturation and colour.

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Crossref · 10.1016/j.earlhumdev.2010.01.031

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  • Systemic blood flow and oxygenation are most frequently assessed indirectly using clinical and biochemical markers, which are essential in bedside monitoring, but their accuracy and predictive value in diagnosing circulatory failure is limited.

    “Systemic blood flow and oxygenation are most frequently assessed indirectly using clinical and biochemical markers, which are essential in bedside monitoring, but their accuracy and predictive value in diagnosing circulatory failure is limited [1].”
  • Intermittent clinical evaluation and continuous measurement of standard parameters such as heart rate, arterial oxygen saturation, and blood pressure are often inadequate for comprehensive hemodynamic evaluation given the dynamic nature of the cardiovascular system after surgery.

    “Intermittent clinical evaluation and continuous measurement of standard parameters, such as heart rate, arterial oxygen saturation, and blood pressure, are often inadequate for comprehensive hemodynamic evaluation given the dynamic nature of the cardiovascular system after surgery [1].”
  • Lactate levels typically increase only after oxygen delivery has fallen below a critical threshold and cellular oxygen extraction becomes insufficient to meet the metabolic demand.

    “Lactate levels typically increase only after oxygen delivery has fallen below a critical threshold and cellular oxygen extraction becomes insufficient to meet the metabolic demand [1].”

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Authors
de Boode, W.-P.
Venue
Early Human Development
Publisher
Elsevier BV
Published
2010-03
Volume
86
Issue
3
Pages
137-141
ISSN
0378-3782 (ISSN-L)
OpenAlex
W2112952354
Cited by
87
References
35
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 6
FWCI
6.10
Type
journal article
Language
en
Open access
closed
Locations
  • Early Human Development (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
Keywords
neonatal hemodynamics, circulatory failure, critically ill neonates, patient monitoring, blood pressure, heart rate, urine output, capillary refill time, serum lactate, central venous oxygen saturation, standard base excess
MeSH terms
Acid-Base Equilibrium, Blood Circulation, Blood Pressure, Body Temperature, Heart Rate, Hemodynamics, Humans, Infant, Newborn, Infant, Newborn, Diseases, Monitoring, Physiologic, Predictive Value of Tests, Urine, Critical Illness, Practice Guidelines as Topic, Lactic Acid

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