Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization

Weissberger, A J; Ho, K K

doi:10.1210/jcem.76.6.8501143

Cited by 185Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesHypothalamic control of reproductive hormones

Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization

Weissberger, A J, Ho, K K·1993·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.76.6.8501143

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Abstract

To determine whether testosterone modulates the somatotropic axis in adult males, we compared 24-h GH secretion (from 20-min sampling, using Cluster analysis) and insulin-like growth factor-I (IGF-I) levels of five hypogonadal men (aged 20-32 yr) with those of six normal men (aged 21-27 yr), and examined the effects of testosterone replacement (testosterone enanthate 250 mg im monthly). To elucidate whether the action of testosterone on the somatotropic axis is direct, or requires the aromatization of testosterone to estradiol, we also examined the effects of the nonsteroidal antiestrogen, tamoxifen (20 mg/day for 3 weeks), on 24-h GH secretion and IGF-I levels in the normal men and in four of the hypogonadal men during concurrent testosterone treatment. Compared to the normal men, the hypogonadal men had significantly reduced mean GH pulse amplitude (3.1 +/- 0.6 vs. 8.4 +/- 1.7 micrograms/L, P < 0.05), but not pulse frequency. Testosterone treatment resulted in a significant increase in 24-h mean serum GH (0.7 +/- 0.2 to 1.4 +/- 0.2 micrograms/L, P < 0.05), mean GH pulse amplitude (3.1 +/- 0.6 to 5.2 +/- 0.8 micrograms/L, P < 0.01) and serum IGF-I (0.9 +/- 0.1 to 1.1 +/- 0.1 U/mL, P < 0.05). In the normal men, tamoxifen significantly reduced 24-h mean serum GH (1.1 +/- 0.3 to 0.5 +/- 0.1 micrograms/L, P < 0.05), mean GH pulse amplitude (8.4 +/- 1.7 to 4.7 +/- 0.4 micrograms/L, P < 0.05), and serum IGF-I (1.0 +/- 0.1 to 0.7 +/- 0.1 U/mL, P < 0.001). In the hypogonadal men on…

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Testosterone positivity regulates GH release.
“As testosterone positivity regulates GH release (31)”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [31]
It is likely that reduced testosterone levels may account for lower GH levels following leuprolide treatment.
“As testosterone positivity regulates GH release (31), it is likely that reduced testosterone levels may account for lower GH levels following leuprolide treatment.”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [31]

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Authors: Weissberger, A. J., & Ho, K. K.
Affiliations: Garvan Institute of Medical Research (AU)
ORCID: Ho, K K
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1993-06
Volume: 76
Issue: 6
Pages: 1407-1412
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.76.6.8501143
OpenAlex: W2062033941
Cited by: 185
References: 32
Citations by year: 2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
FWCI: 4.51
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: somatotropic axis, testosterone, hypogonadism, growth hormone secretion, insulin-like growth factor I, aromatization, estradiol, tamoxifen, antiestrogens, testosterone replacement therapy, adult male
MeSH terms: Adult, Humans, Hypogonadism, Male, Osmolar Concentration, Reference Values, Growth Hormone, Tamoxifen, Testosterone

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Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization

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