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Hypoglycemia in Type 1 Diabetes Mellitus
Open accessAbstract
Iatrogenic hypoglycemia, typically the result of the interplay of therapeutic hyperinsulinemia and compromised defenses resulting in hypoglycemia-associated autonomic failure (HAAF) in diabetes, is a problem for people with type 1 diabetes mellitus (T1DM). It causes recurrent morbidity is sometimes fatal, leads to recurrent hypoglycemia, and precludes euglycemia over a lifetime of T1DM. Risk factors include those that result in relative or absolute insulin excess and those indicative of HAAF in diabetes. Elimination of hypoglycemia from the lives of people with T1DM will likely be accomplished by new treatment methods that provide plasma glucose-regulated insulin replacement or secretion.
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“People with type 1 diabetes, particularly those with concomitant chronic kidney disease, are at higher risk of hypoglycemia, which should be avoided by careful insulin and carbohydrate matching (129).”
From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [129]
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Metadata
- Authors
- Cryer, P. E.
- Affiliations
- Barnes-Jewish Hospital (US)
- Corresponding author
- Cryer, Philip E.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 3
- Pages
- 641-654
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC2923455
- OpenAlex
- W2009090185
- Cited by
- 205
- References
- 68
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 11 · 2023: 12 · 2022: 12 · 2021: 21 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 16 · 2012: 11
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p60dk020579-35, UL1TR000448)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027085, P60-DK20579, R37-DK27085, T32 DK07120, P60-DK-020579, P30DK020579, T32DK007120)
- National Center for Research Resources (UL1-RR-24992, M01-RR00036, UL1RR024992, M01RR000036)
- NIH Clinical Center
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- hypoglycemia, type 1 diabetes, hypoglycemia-associated autonomic failure, iatrogenic hypoglycemia, hyperinsulinemia, insulin excess, hypoglycemia risk factors, insulin secretion
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 1, Humans, Hypoglycemia, Models, Biological, Risk Factors
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