The effect of continuous glucose monitoring in well-controlled type 1 diabetes
Open accessAbstract
OBJECTIVE: The potential benefits of continuous glucose monitoring (CGM) in the management of adults and children with well-controlled type 1 diabetes have not been examined. RESEARCH DESIGN AND METHODS: A total of 129 adults and children with intensively treated type 1 diabetes (age range 8–69 years) and A1C <7.0% were randomly assigned to either continuous or standard glucose monitoring for 26 weeks. The main study outcomes were time with glucose level ≤70 mg/dl, A1C level, and severe hypoglycemic events. RESULTS: At 26 weeks, biochemical hypoglycemia (≤70 mg/dl) was less frequent in the CGM group than in the control group (median 54 vs. 91 min/day), but the difference was not statistically significant (P = 0.16). Median time with a glucose level ≤60 mg/dl was 18 versus 35 min/day, respectively (P = 0.05). Time out of range (≤70 or >180 mg/dl) was significantly lower in the CGM group than in the control group (377 vs. 491 min/day, P = 0.003). There was a significant treatment group difference favoring the CGM group in mean A1C at 26 weeks adjusted for baseline (P < 0.001). One or more severe hypoglycemic events occurred in 10 and 11% of the two groups, respectively (P = 1.0). Four outcome measures combining A1C and hypoglycemia data favored the CGM group in comparison with the control group (P < 0.001, 0.007, 0.005, and 0.003). CONCLUSIONS: Most outcomes, including those combining A1C and hypoglycemia, favored the CGM group. The weight of evidence suggests that CGM is beneficial for individuals with type 1 diabetes who have already achieved excellent control with A1C <7.0%.
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When stratified by CGM use, reductions in A1c were observed among children and young adults who wore the CGM for at least 6 days a week during the study period.
“However, when further stratified by CGM use, reductions in A1c were observed among children and young adults who wore the CGM for at least 6 days a week during the study period96.”
From Epidemiology of type 1 diabetes (2010) · cites this paper as [96]
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Riveline, J., Schaepelynck, P., Chaillous, L., Renard, É., Sola‐Gazagnes, A., Penfornis, A., Tubiana‐Rufi, N., Sulmont, V., Catargi, B., Lukas, C., et al. (2012) · Diabetes Care · doi:10.2337/dc11-2021 · Cited by 96 · see citing works
Utility of different glycemic control metrics for optimizing management of diabetes
Kohnert, K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i1.17 · Cited by 95 · see citing works
Continuous glucose monitoring in type 1 diabetes
Mauras, N., Fox, L. A., ENGLERT, K. A., & Beck, R. W. (2012) · Endocrine · doi:10.1007/s12020-012-9765-1 · Cited by 89 · see citing works
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Wearable, robust, non-enzymatic continuous glucose monitoring system and its in vivo investigation
Yoon, H., Xuan, X., Jeong, S., & Park, J. Y. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.06.008 · Cited by 91 · see citing works
Psychosocial factors associated with use of continuous glucose monitoring
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Real-time continuous glucose monitoring system for treatment of diabetes: a systematic review
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Clinical Use of Continuous Glucose Monitoring in Adults with Type 1 Diabetes
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The Cost-Effectiveness of Real-Time Continuous Glucose Monitoring (RT-CGM) in Type 2 Diabetes
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Continuous Glucose Monitoring: Evidence and Consensus Statement for Clinical Use
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Continuous glucose monitoring in patients with type 1 diabetes using insulin injections
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- Authors
- Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
- Affiliations
- Juvenile Diabetes Research Foundation (CA)
- Corresponding author
- Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2009-05-08
- Volume
- 32
- Issue
- 8
- Pages
- 1378-1383
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2713649
- OpenAlex
- W2102624023
- Cited by
- 399
- References
- 12
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 21 · 2020: 15 · 2019: 21 · 2018: 25 · 2017: 33 · 2016: 33 · 2015: 30 · 2014: 20 · 2013: 31 · 2012: 34
- FWCI
- 28.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- continuous glucose monitoring, type 1 diabetes, glycemic control, HbA1c, hypoglycemia, time in range, intensive insulin therapy, well-controlled diabetes, children and adults
- MeSH terms
- Adolescent, Adult, Aged, Blood Glucose, Child, Diabetes Mellitus, Type 1, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Middle Aged, Monitoring, Ambulatory, Young Adult
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