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The effect of continuous glucose monitoring in well-controlled type 1 diabetes

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Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group·2009·Diabetes Care

Abstract

OBJECTIVE: The potential benefits of continuous glucose monitoring (CGM) in the management of adults and children with well-controlled type 1 diabetes have not been examined. RESEARCH DESIGN AND METHODS: A total of 129 adults and children with intensively treated type 1 diabetes (age range 8–69 years) and A1C <7.0% were randomly assigned to either continuous or standard glucose monitoring for 26 weeks. The main study outcomes were time with glucose level ≤70 mg/dl, A1C level, and severe hypoglycemic events. RESULTS: At 26 weeks, biochemical hypoglycemia (≤70 mg/dl) was less frequent in the CGM group than in the control group (median 54 vs. 91 min/day), but the difference was not statistically significant (P = 0.16). Median time with a glucose level ≤60 mg/dl was 18 versus 35 min/day, respectively (P = 0.05). Time out of range (≤70 or >180 mg/dl) was significantly lower in the CGM group than in the control group (377 vs. 491 min/day, P = 0.003). There was a significant treatment group difference favoring the CGM group in mean A1C at 26 weeks adjusted for baseline (P < 0.001). One or more severe hypoglycemic events occurred in 10 and 11% of the two groups, respectively (P = 1.0). Four outcome measures combining A1C and hypoglycemia data favored the CGM group in comparison with the control group (P < 0.001, 0.007, 0.005, and 0.003). CONCLUSIONS: Most outcomes, including those combining A1C and hypoglycemia, favored the CGM group. The weight of evidence suggests that CGM is beneficial for individuals with type 1 diabetes who have already achieved excellent control with A1C <7.0%.

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  • When stratified by CGM use, reductions in A1c were observed among children and young adults who wore the CGM for at least 6 days a week during the study period.

    “However, when further stratified by CGM use, reductions in A1c were observed among children and young adults who wore the CGM for at least 6 days a week during the study period96.”

    From Epidemiology of type 1 diabetes (2010) · cites this paper as [96]

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Authors
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Affiliations
Juvenile Diabetes Research Foundation (CA)
Corresponding author
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Venue
Diabetes Care
Published
2009-05-08
Volume
32
Issue
8
Pages
1378-1383
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
OpenAlex
W2102624023
Cited by
399
References
12
Citations by year
2026: 8 · 2025: 14 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 21 · 2020: 15 · 2019: 21 · 2018: 25 · 2017: 33 · 2016: 33 · 2015: 30 · 2014: 20 · 2013: 31 · 2012: 34
FWCI
28.07
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Diabetes Care (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
continuous glucose monitoring, type 1 diabetes, glycemic control, HbA1c, hypoglycemia, time in range, intensive insulin therapy, well-controlled diabetes, children and adults
MeSH terms
Adolescent, Adult, Aged, Blood Glucose, Child, Diabetes Mellitus, Type 1, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Middle Aged, Monitoring, Ambulatory, Young Adult

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