A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Drug repurposing: progress, challenges and recommendations

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., et al. (2019) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.168 · Cited by 4,718

Drug repositioning: identifying and developing new uses for existing drugs

Ashburn, T. T., & Thor, K. B. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1468 · Cited by 3,237

A comprehensive map of molecular drug targets

Santos, R., Ursu, O., Gaulton, A., Bento, A. P., Donadi, R. S., Bologa, C. G., Karlsson, A., Al-Lazikani, B., Hersey, A., Oprea, T. I., et al. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.230 · Cited by 2,427

Alzheimer's disease

Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · cited 1×

The Genome Sequence of the SARS-Associated Coronavirus

Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A. R., Butterfield, Y. S. N., Khattra, J. S., Asano, J. K., Barber, S., Chan, S. Y., et al. (2003) · Science · doi:10.1126/science.1085953 · Cited by 2,027

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,718

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

Rothwell, P. M., Fowkes, F. G. R., Belch, J. F., Ogawa, H., Warlow, C. P., & Meade, T. W. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62110-1 · Cited by 1,497

Effects of chloroquine on viral infections: an old drug against today's diseases

Savarino, A., Boelaert, J. R., Cassone, A., Majori, G., & Cauda, R. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00806-5 · Cited by 1,272

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Aggarwal, V., Tuli, H. S., Varol, A., Thakral, F., Yerer, M. B., Sak, K., Varol, M., Jain, A., Khan, M. A., & Sethi, G. (2019) · Biomolecules · doi:10.3390/biom9110735 · Cited by 1,260

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242

Severe acute respiratory syndrome

Peiris, M. J. S., Guan, Y., & Yuen, K. (2004) · Nature Medicine · doi:10.1038/nm1143 · Cited by 1,157

Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD

Gart, E., Lima, E. S., Schuren, F. H. J., de Ruiter, C., Attema, J., Verschuren, L., Keijer, J., Salic, K., Morrison, M. C., & Kleemann, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010001 · Cited by 1,099

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Achan, J., Talisuna, A. O., Erhart, A., Yeka, A., Tibenderana, J., Baliraine, F. N., Rosenthal, P. J., & D’Alessandro, U. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-144 · Cited by 1,012

Antithyroid Drugs

Cooper, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmra042972 · Cited by 1,008

‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 936

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Pillaiyar, T., Manickam, M., & Namasivayam, V. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1256882 · Cited by 932

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone

Ismaya, W. T., Rozeboom, H. J., Weijn, A., Mes, J. J., Fusetti, F., Wichers, H. J., & Dijkstra, B. W. (2011) · Biochemistry · doi:10.1021/bi200395t · Cited by 872

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

Pillaiyar, T., Manickam, M., Namasivayam, V., Hayashi, Y., & Jung, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01461 · Cited by 773

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

de Wilde, A. H., Jochmans, D., Posthuma, C. C., Zevenhoven-Dobbe, J. C., van Nieuwkoop, S., Bestebroer, T. M., van den Hoogen, B. G., Neyts, J. H., & Snijder, E. J. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03011-14 · Cited by 731

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease<subtitle>A Randomized Controlled Trial</subtitle>

Green, R. C. (2009) · JAMA · doi:10.1001/jama.2009.1866 · Cited by 643

Drug repurposing: a promising tool to accelerate the drug discovery process

Parvathaneni, V., Kulkarni, N. S., Muth, A., & Gupta, V. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.014 · Cited by 597 · cited 1×

Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

Miyamoto, S., Miyake, N., Jarskog, L. F., Fleischhacker, W. W., & Lieberman, J. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.47 · Cited by 584

Acute myeloid leukaemia in adults

Ferrara, F., & Schiffer, C. A. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61727-9 · Cited by 573

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis

Noto, H., Goto, A., Tsujimoto, T., & Noda, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033411 · Cited by 566

World Alzheimer Report 2010: The global economic impact of dementia

Wimo, A. B., & Prince, M. J. (2010) · Cited by 559

Small molecules targeting severe acute respiratory syndrome human coronavirus

Wu, C., Jan, J., Ma, S.-H., Kuo, C., Juan, H., Cheng, Y. E., Hsu, H.-H., Huang, H., Wu, D., Brik, A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403596101 · Cited by 529

American Society of Health-System Pharmacists

Willett, K. C., & Morrill, A. M. (2016) · The SAGE Encyclopedia of Pharmacology and Society · doi:10.4135/9781483349985.n33 · Cited by 511

Regulation of the c-Abl and Bcr–Abl tyrosine kinases

Hantschel, O. D., & Superti‐Furga, G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1280 · Cited by 500

Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

Li, N.-C., Lee, A., Whitmer, R. A., Kivipelto, M., Lawler, E., Kazis, L. E., & Wolozin, B. (2010) · BMJ · doi:10.1136/bmj.b5465 · Cited by 486

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes

Millan, M. J., Maiofiss, L., Cussac, D., Audinot, V., Boutin, J. A., & Newman‐Tancredi, A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039867 · Cited by 485

Quinoline hybrids and their antiplasmodial and antimalarial activities

Hu, Y., Gao, C., Zhang, S., Xu, L., Xu, Z. G., Feng, L., Wu, X., & Zhao, F. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.061 · Cited by 382

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

Lee, M.-S., Hsu, C.-C., Wahlqvist, M. L., Tsai, H.-N., Chang, Y.-H., & Huang, Y.-C. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-20 · Cited by 380

Clathrin-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus into Target Cells Expressing ACE2 with the Cytoplasmic Tail Deleted

Inoue, Y., Tanaka, N., Tanaka, Y., Inoue, S., Morita, K., Zhuang, M., Hattori, T., & Sugamura, K. (2007) · Journal of Virology · doi:10.1128/jvi.00253-07 · Cited by 369

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

Carballo‐Carbajal, I., Laguna, A., Romero‐Giménez, J., Cuadros, T., Bové, J., Martínez‐Vicente, M., Parent, A., González-Sepúlveda, M., Peñuelas, N., Torra, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08858-y · Cited by 360

Cancer drug discovery by repurposing: teaching new tricks to old dogs

Gupta, S. C., Sung, B., Prasad, S., Webb, L. J., & Aggarwal, B. B. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.06.005 · Cited by 355

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models

Hebron, M. L., Lonskaya, I., & Moussa, C. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt192 · Cited by 337

Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

Wang, J., Ho, L., Chen, L., Zhao, Z., Zhao, W., Qian, X., Humala, N., Seror, I., Bartholomew, S. R., Rosendorff, C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31547 · Cited by 333

A review of computational drug repurposing

Park, K. (2019) · Translational and Clinical Pharmacology · doi:10.12793/tcp.2019.27.2.59 · Cited by 314

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

Takada, Y., Bhardwaj, A., Potdar, P. D., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 309

Inhibitors of Melanogenesis: An Updated Review

Pillaiyar, T., Namasivayam, V., Manickam, M., & Jung, S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00967 · Cited by 309

Triazole derivatives and their antiplasmodial and antimalarial activities

Chu, X., Wang, C., Wang, W., Liang, L., Liu, W., Gong, K., & Sun, K. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.047 · Cited by 297

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Ko, H. S., Lee, Y., Shin, J., Karuppagounder, S. S., Gadad, B. S., Koleske, A. J., Pletniková, O., Troncoso, J. C., Dawson, V. L., & Dawson, T. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006083107 · Cited by 291

Aspirin, salicylates, and cancer

Elwood, P. C., Gallagher, A. M., Duthie, G. G., Mur, L. A. J., & Morgan, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60243-9 · Cited by 280

Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays

Pohjala, L., Utt, A., Varjak, M., Lulla, A., Merits, A., Ahola, T., & Tammela, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028923 · Cited by 271

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

Pagan, F., Hebron, M., Valadez, E. H., Torres-Yaghi, Y., Huang, X., Mills, R. R., Wilmarth, B. M., Howard, H., Dunn, C., Carlson, A., et al. (2016) · Journal of Parkinson’s Disease · doi:10.3233/jpd-160867 · Cited by 265

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson’s disease

Karuppagounder, S. S., Brahmachari, S., Lee, Y., Dawson, V. L., Dawson, T. M., & Ko, H. S. (2014) · Scientific Reports · doi:10.1038/srep04874 · Cited by 264 · cited 1×

Trends in development and approval times for new therapeutics in the United States

Reichert, J. M. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1178 · Cited by 261

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

Ilijić, E., Guzmán, J. N., & Surmeier, D. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.007 · Cited by 260

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial

Low, J. G. H., Sung, C., Wijaya, L., Wei, Y., Rathore, A. P. S., Watanabe, S., Tan, B. H., Toh, L., Chua, L. T., Hou, Y., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70730-3 · Cited by 255

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

Madrid, P. B., Chopra, S., Manger, I. D., Gilfillan, L. G., Keepers, T. R., Shurtleff, A. C., Green, C. E., Iyer, L., Dilks, H. H., Davey, R. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060579 · Cited by 246

Nimodipine for primary degenerative, mixed and vascular dementia

Birks, J., & López-Arrieta, J. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000147 · Cited by 231

Current Status of Dengue Therapeutics Research and Development

Low, J. G. H., Ooi, E. E., & Vasudevan, S. G. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw423 · Cited by 215

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson’s disease

Imam, S. Z., Zhou, Q., Yamamoto, A., Valente, A. J., Ali, S. F., Bains, M., Roberts, J. L., Kahle, P. J., Clark, R. A., & Li, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1833-10.2011 · Cited by 214

Expression and 1,4-Dihydropyridine-Binding Properties of Brain L-Type Calcium Channel Isoforms

Sinnegger-Brauns, M. J., Huber, I. G., Koschak, A., Wild, C., Obermair, G. J., Einzinger, U., Hoda, J., Sartori, S. B., & Striessnig, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049981 · Cited by 214

Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial

Tam, D. T. H., Ngoc, T. V., Tien, N. L. B., Kieu, N. T. T., Thuy, T. T. T., Thanh, L. T., Tam, C. T., Truong, N. T., Dung, N. T., Qui, P. T., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis655 · Cited by 210

Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid

Fan, R., Xu, F., Previti, M. L., Davis, J., Grande, A. V., Robinson, J. K., & Nostrand, W. E. V. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4371-06.2007 · Cited by 200

Targeting apoptosis pathways by Celecoxib in cancer

Jendrossek, V. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.01.012 · Cited by 197

Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain

Corcoran, J. P. T., So, P. L., & Maden, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03563.x · Cited by 195

2008 FDA drug approvals

Hughes, B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2813 · Cited by 195

Evidence for defective retinoid transport and function in late onset Alzheimer's disease

Goodman, A. B., & Pardee, A. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437937100 · Cited by 184

The unravelling of the complex pattern of tyrosinase inhibition

Deri, B., Kanteev, M., Goldfeder, M., Lecina, D., Guallar, V., Adir, N., & Fishman, A. (2016) · Scientific Reports · doi:10.1038/srep34993 · Cited by 183

Cellular and molecular mechanisms controlling the migration of melanocytes and melanoma cells

Bonaventure, J., Domingues, M. J., & Larue, L. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12080 · Cited by 181

Simvastatin Inhibits the Activation of p21rasand Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

Ghosh, A., Roy, A., Matras, J., Brahmachari, S., Gendelman, H. E., & Pahan, K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4144-09.2009 · Cited by 175

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

Takeda, S., Sato, N., Takeuchi, D., Kurinami, H., Shinohara, M., Niisato, K., Kano, M., Ogihara, T., Rakugi, H., & Morishita, R. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138586 · Cited by 163

Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial

Whitehorn, J., Châu, N. V. V., Khanh, L. P., Kien, D. T. H., Quyen, N. T. H., Tran, N. T. T., Hang, N. T., Truong, N. T., Tai, L. T. H., Huong, N. T. C., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ949 · Cited by 163

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

Danielyan, L., Klein, R., Hanson, L. R., Buadze, M., Schwab, M. G., Gleiter, C. H., & Frey, W. H. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0944 · Cited by 158

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

Anekonda, T. S., Quinn, J. F., Harris, C., Frahler, K., Wadsworth, T. L., & Woltjer, R. L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.020 · Cited by 155

Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells

Li, N., Liu, B., Dluzen, D. E., & Jin, Y. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.12.015 · Cited by 147

Tyrosinase-Expressing Neuronal Cell Line as in Vitro Model of Parkinson’s Disease

Hasegawa, T. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11031082 · Cited by 146

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

Derbyshire, E. R., Prudêncio, M., Mota, M. M., & Clardy, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118370109 · Cited by 143

Melanins and Melanosomes

(2011) · Wiley eBooks · doi:10.1002/9783527636150 · Cited by 138

The amyloid cascade hypothesis

Korczyn, A. D. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.11.008 · Cited by 136

The Potential Effect of Metformin on Cancer: An Umbrella Review

Yu, H., Zhong, X. Z., Gao, P., Shi, J., Wu, Z., Guo, Z., Wang, Z., & Song, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00617 · Cited by 135

The Reaction of α-Synuclein with Tyrosinase

Tessari, I., Bisaglia, M., Valle, F., Samorı̀, B., Bergantino, E., Mammi, S., & Bubacco, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709014200 · Cited by 135

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

Mogi, M., Li, J., Tsukuda, K., Iwanami, J., Min, L., Sakata, A., Fujita, T., Iwai, M., & Horiuchi, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.032 · Cited by 134

The Nobel Chronicles

Raju, T. N. K. (2000) · The Lancet · doi:10.1016/s0140-6736(05)74775-9 · Cited by 133

How Thalidomide Works Against Cancer

Stewart, A. K. (2014) · Science · doi:10.1126/science.1249543 · Cited by 128

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

Greggio, E., Bergantino, E., Carter, D., Ahmad, R., Costin, G., Hearing, V. J., Clarimón, J., Singleton, A., Eerola, J., Hellström, O., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03019.x · Cited by 123

All-transretinoic acid as a novel therapeutic strategy for Alzheimer’s disease

Lee, H. P., Casadesús, G., Zhu, X., Lee, H., Perry, G. L., Smith, M. A., Gustaw‐Rothenberg, K., & Lerner, A. J. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.86 · Cited by 122

Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice

Selley, M. L. (2005) · Brain Research · doi:10.1016/j.brainres.2004.02.083 · Cited by 122

The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions

Polamreddy, P., & Gattu, N. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.022 · Cited by 121

Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent

Pantziarka, P., Sukhatme, V. V., Bouche, G., Melhuis, L., & Sukhatme, V. P. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.610 · Cited by 119

Loperamide

Regnard, C., Twycross, R., Mihalyo, M., & Wilcock, A. (2011) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.06.001 · Cited by 117

Gemcitabine: A Critical Nucleoside for Cancer Therapy

Gesto, D., Cerqueira, N. M. F. S. A., Fernandes, P. A., & Ramos, M. J. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799320682 · Cited by 116

Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier

Paris, D., Bachmeier, C., Patel, N., Quadros, A., Volmar, C.-H., Laporte, V., Ganey, J., Beaulieu-Abdelahad, D., Ait-Ghezala, G., Crawford, F., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00180 · Cited by 114

Repurposing approved drugs on the pathway to novel therapies

Schein, C. H. (2019) · Medicinal Research Reviews · doi:10.1002/med.21627 · Cited by 113

2014 FDA drug approvals

Mullard, A. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4545 · Cited by 113

Phase II safety, tolerability, and dose selection study of isradipine as a potential disease‐modifying intervention in early Parkinson's disease (STEADY‐PD)

Parkinson Study Group (2013) · Movement Disorders · doi:10.1002/mds.25639 · Cited by 113

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

Tong, H., Zhang, X., Meng, X., Lu, L., Mai, D., & Qu, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00165 · Cited by 112

Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1

Ahn, K. S., Sethi, G., & Aggarwal, B. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2507 · Cited by 107

An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis

Lynch, P. M., Burke, C. A., Phillips, R. K. S., Morris, J. S., Slack, R. S., Wang, X., Liu, J., Patterson, S. L., Sinicrope, F. A., Rodrı́guez-Bigas, M. A., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307235 · Cited by 104

Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease

Bortolanza, M., Nascimento, G. C., Socías, S. B., Ploper, D., Chehín, R. N., Raisman‐Vozari, R., & Bel, E. A. D. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1913-1 · Cited by 104

Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau Hyperphosphorylation

Parachikova, A. I., Vasilevko, V., Cribbs, D. H., LaFerla, F. M., & Green, K. N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100204 · Cited by 104

Treating Alzheimer's disease by targeting iron

Nikseresht, S., Bush, A. I., & Ayton, S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14567 · Cited by 98

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

Kumar, A., Sharma, N., Gupta, A. K., Kalonia, H., & Mishra, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.050 · Cited by 98

Prospects of Statins in Parkinson Disease

Roy, A., & Pahan, K. (2011) · The Neuroscientist · doi:10.1177/1073858410385006 · Cited by 96

Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70

Endo, H., Yano, M., Okumura, Y., & Kido, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.550 · Cited by 95

Simulating Henipavirus Multicycle Replication in a Screening Assay Leads to Identification of a Promising Candidate for Therapy

Porotto, M., Orefice, G., Yokoyama, C. C., Mungall, B. A., Realubit, R. B., Sganga, M. L., Aljofan, M., Whitt, M. A., Glickman, J. F., & Moscona, A. (2009) · Journal of Virology · doi:10.1128/jvi.00164-09 · Cited by 94

Towards Retinoid Therapy for Alzheimers Disease

Shudo, K., Fukasawa, H., Nakagomi, M., & Yamagata, N. (2009) · Current Alzheimer Research · doi:10.2174/156720509788486581 · Cited by 91

Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3−ILC1/NK cell transdifferentiation

Mazzurana, L., Forkel, M., Rao, A., Acker, A. V., Kokkinou, E., Ichiya, T., Almer, S. H., Höög, C., Friberg, D., & Mjösberg, J. (2019) · European Journal of Immunology · doi:10.1002/eji.201848075 · Cited by 91

Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K

Kim, M.-S., Kim, J., Lim, D. Y., Huang, Z., Chen, H., Langfald, A., Lubet, R. A., Grubbs, C. J., Dong, Z., & Bode, A. M. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0288 · Cited by 89

Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro

Shin, J. S., Jung, E., Kim, M., Baric, R. S., & Go, Y. Y. (2018) · Viruses · doi:10.3390/v10060283 · Cited by 86

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

Balducci, C., Santamaria, G., Vitola, P. L., Brandi, E., Grandi, F., Viscomi, A. R., Beeg, M., Gobbi, M., Salmona, M., Ottonello, S., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.002 · Cited by 83

Inhibitors of melanogenesis: a patent review (2009 – 2014)

Pillaiyar, T., Manickam, M., & Jung, S. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1039985 · Cited by 79

Identification of Antihypertensive Drugs Which Inhibit Amyloid-β Protein Oligomerization

Zhao, W., Wang, J., Ho, L., Ono, K., Teplow, D. B., & Pasinetti, G. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0925 · Cited by 78

Molecular Mechanisms and Bioavailability of Polyphenols in Prostate Cancer

Costea, T., Nagy, P., Ganea, C., Szöllõsi, J., & Mocanu, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051062 · Cited by 77

Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13

Fehniger, T. A., Byrd, J. C., Marcucci, G., Abboud, C. N., Kefauver, C. A., Payton, J. E., Vij, R., & Blum, W. G. (2008) · Blood · doi:10.1182/blood-2008-04-152678 · Cited by 77

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

Koronyo‐Hamaoui, M., Sheyn, J., Hayden, E. Y., Li, S., Fuchs, D.-T. S., Regis, G. C., Lopes, D. H. J., Black, K. L., Bernstein, K. E., Teplow, D. B., et al. (2019) · Brain · doi:10.1093/brain/awz364 · Cited by 75

The Renin-Angiotensin System and Antihypertensive Drugs in Alzheimer's Disease: Current Standing of the Angiotensin Hypothesis?

Kehoe, P., & Passmore, P. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111376 · Cited by 73

Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson’s Disease: Rationale for Clinical Trial, and Current Progress

Carroll, C., & Wyse, R. K. H. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-171203 · Cited by 73

Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

Soria-Castro, R., Schcolnik‐Cabrera, A., Rodríguez-López, G. M., Campillo-Navarro, M., Puebla‐Osorio, N., Estrada-Parra, S. A., Estrada‐García, I., Chacón‐Salinas, R., & Chávez-Blanco, A. D. (2019) · Journal of Immunology Research · doi:10.1155/2019/9678098 · Cited by 72

Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses

Kang, H., Kim, C., Kim, D., Song, J.-H., Choi, M., Choi, K., Kang, M.-G., Lee, K., Kim, H. S., Shin, J. S., et al. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.10.011 · Cited by 71

Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation

Hall, A. M., & Orlow, S. J. (2005) · Pigment Cell Research · doi:10.1111/j.1600-0749.2005.00213.x · Cited by 71

Evaluation of antileukaemic effects of rapamycin in patients with imatinib‐resistant chronic myeloid leukaemia

Sillaber, C., Mayerhofer, M., Böhm, A., Vales, A., Gruze, A., Aichberger, K. J., Esterbauer, H., Pfeilstöcker, M., Sperr, W. R., Pickl, W. F., et al. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01892.x · Cited by 71

Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats

Husson, M., Enderlin, V., Delacourte, A., Ghenimi, N., Alfos, S., Pallet, V., & Higueret, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.008 · Cited by 70

Statin uses and mortality in colorectal cancer patients: An updated systematic review and meta‐analysis

Li, Y., He, X., Ding, Y., Chen, H., & Sun, L. (2019) · Cancer Medicine · doi:10.1002/cam4.2151 · Cited by 70

Novel tyrosinase inhibitory peptide with free radical scavenging ability

Shen, Z., Wang, Y., Guo, Z. G., Tan, T., & Zhang, Y. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1661401 · Cited by 68

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

Noble, W. J., Garwood, C. J., & Hanger, D. P. (2009) · Prion · doi:10.4161/pri.3.2.8820 · Cited by 67

Towards the first targeted therapy for triple-negative breast cancer: Repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor

Ahmed, K., Koval, A., Xu, J., Bodmer, A., & Katanaev, V. L. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.02.018 · Cited by 67

Combination of Atorvastatin with Sulindac or Naproxen Profoundly Inhibits Colonic Adenocarcinomas by Suppressing the p65/β-Catenin/Cyclin D1 Signaling Pathway in Rats

Suh, N., Reddy, B. S., DeCastro, A., Paul, S., Lee, H. J., Smolarek, A. K., So, J. Y., Simi, B., Wang, C. X., Janakiram, N. B., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0222 · Cited by 66

Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell

Akrami, H., Aminzadeh, S., & Fallahi, H. (2014) · Tumor Biology · doi:10.1007/s13277-014-2952-3 · Cited by 66

Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice

García-Alloza, M., Prada, C. M., Lattarulo, C. R., Fine, S., Borrelli, L. A., Betensky, R. A., Greenberg, S. M., Frosch, M. P., & Bacskai, B. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06096.x · Cited by 65

Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature

Murteira, S., Ghezaiel, Z., Karray, S., & Lamure, M. P. (2013) · Journal of Market Access & Health Policy · doi:10.3402/jmahp.v1i0.21131 · Cited by 65

Tolerability of isradipine in early Parkinson's disease: A pilot dose escalation study

Simuni, T., Borushko, E., Avram, M. J., Miskevics, S. A., Martel, A., Zadikoff, C., Videnović, A., Weaver, F. M., Williams, K., & Surmeier, D. J. (2010) · Movement Disorders · doi:10.1002/mds.23308 · Cited by 65

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood–brain barrier

Bachmeier, C. J., Beaulieu‐Abdelahad, D., MULLAN, M. J., & Paris, D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.048 · Cited by 64

Drug repurposing approaches to fight Dengue virus infection and related diseases

Radi, M. (2017) · Frontiers in bioscience · doi:10.2741/4630 · Cited by 64

Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs

Barratt, M. J., & Frail, D. E. (2012) · Cited by 64

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

Cai, Z., Zhao, Y., Yao, S., & Zhao, B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70504-7 · Cited by 62

The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches

Hassan, M., Raza, H., Abbasi, M. A., Moustafa, A. A., & Seo, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.115 · Cited by 62

Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells

Pillaiyar, T., Hoang, T. A., LEE, K. ‐., Bang, S., Sharma, V. K., Yun, C., Roh, E., Hwang, B.-Y., Kim, Y. S., & Jung, S. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.02.067 · Cited by 62

Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease

Bourque, M., Morissette, M., & Paolo, T. D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.005 · Cited by 61

Non-Steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells

Valle, B. L., D’Souza, T., Becker, K. G., Wood, W. H., Zhang, Y., Wersto, R. P., & Morin, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061836 · Cited by 61

The role of the South Pacific in modulating Tropical Pacific variability

Chung, C. T. Y., Power, S. B., Sullivan, A., & Delage, F. P. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-52805-2 · Cited by 57

Confounding of the association between statins and Parkinson disease: systematic review and meta‐analysis

Bykov, K., Yoshida, K., Weisskopf, M. G., & Gagne, J. J. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4079 · Cited by 55

Mouse Hepatitis Virus Type 2 Enters Cells through a Clathrin-Mediated Endocytic Pathway Independent of Eps15

Pu, Y., & Zhang, X. (2008) · Journal of Virology · doi:10.1128/jvi.00837-08 · Cited by 53

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth

So, P.-L., Yip, P. K., Bunting, S. C. J., Wong, L., Mazarakis, N. D., Hall, S., McMahon, S. B., Maden, M., & Corcoran, J. P. T. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.027 · Cited by 51

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson’s disease

Tanabe, A., Yamamura, Y., Kasahara, J., Morigaki, R., Kaji, R., & Goto, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00050 · Cited by 50

Therapeutic Value of Voltage-Gated Sodium Channel Inhibitors in Breast, Colorectal, and Prostate Cancer: A Systematic Review

Martin, F., Ufodiama, C. E., Watt, I., Bland, M., & Brackenbury, W. J. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00273 · Cited by 47

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues

Vallone, A., D’Alessandro, S., Brogi, S., Brindisi, M., Chemi, G., Alfano, G., Lamponi, S., Lee, S. G., Jez, J. M., Koolen, K. M. J., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.03.024 · Cited by 47

Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors

Choi, J., & Jee, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226114 · Cited by 45

The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial

Brinkhuizen, T., Frencken, K. J. A., Nelemans, P. J., Hoff, M. L. S., Kelleners-Smeets, N. W. J., Hausen, A. Z., van der Horst, M. P. J., Rennspiess, D., Winnepenninckx, V. J. L., Steensel, M. A. M. V., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.01.050 · Cited by 45

A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug

Copenhaver, P. F., Anekonda, T. S., Musashe, D. T., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. L., & Quinn, J. F. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.006841 · Cited by 44

Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients?

Elwood, P. C., Pickering, J. E., Morgan, G., Galante, J., Weightman, A. L., Morris, D., Longley, M. J., Mason, M. D., Adams, R., Dolwani, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203957 · Cited by 43

Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase

Cecere, F., Iuliano, A., Albano, F., Zappelli, C., Castellano, I., Grimaldi, P., Masullo, M., Vendittis, E. D., & Ruocco, M. R. (2010) · BioMed Research International · doi:10.1155/2010/801726 · Cited by 42

Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines.

Melino, G., Draoui, M., Bernardini, S., Bellincampi, L., Reichert, U., & Cohen, P. (1996) · PubMed · Cited by 41

Clinical activity of mammalian target of rapamycin inhibitors in solid tumors

Alvarado, Y., Mita, M. M., Vemulapalli, S., Mahalingam, D., & Mita, A. C. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0178-5 · Cited by 41

Simvastatin prevents neuroinflammation by inhibiting N‐methyl‐D‐aspartic acid receptor 1 in 6‐hydroxydopamine‐treated PC12 cells

Yan, J., Sun, J., Huang, L., Fu, Q., & Du, G. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23329 · Cited by 41

New leads for drug repurposing against malaria

Pazhayam, N. M., Chhibber‐Goel, J., & Sharma, A. K. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.08.006 · Cited by 41

Exploring the Interaction of N/S Compounds with a Dicopper Center: Tyrosinase Inhibition and Model Studies

Buitrago, E., Vuillamy, A., Boumendjel, A., Yi, W., Gellon, G., Hardré, R., Philouze, C., Serratrice, G., Jamet, H., Réglier, M., et al. (2014) · Inorganic Chemistry · doi:10.1021/ic501829s · Cited by 41

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors

Vontzalidou, A., Zoidis, G., Chaita, E., Makropoulou, M., Aligiannis, N., Lambrinidis, G., Mikros, E., & Skaltsounis, A. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.07.029 · Cited by 40

Ibuprofen and hydrogel-released ibuprofen in the reduction of inflammation-induced migration in melanoma cells

Redpath, M., Marques, C. M. G., Dibden, C., Waddon, A. J., Lalla, R., & MacNeil, S. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09220.x · Cited by 40

Sequential RARβ and α signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways

Goncalves, M. B. C. V., Agudo‐Barriuso, M., Connor, S., McMahon, S. B., Minger, S. L., Maden, M., & Corcoran, J. P. T. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.018 · Cited by 39

Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment

Hanyu, H., Hirao, K., Shimizu, S., Iwamoto, T., Koizumi, K., & Abe, K. (2007) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e32804c58aa · Cited by 38

Inhibition of Influenza Virus Replication by Targeting Broad Host Cell Pathways

Marois, I., Cloutier, A., Meunier, I., Weingartl, H. M., Cantin, A. M., & Richter, M. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110631 · Cited by 38

Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase

Pillaiyar, T., LEE, K. ‐., Sharma, V. K., Joo, C., Cho, W., Roh, E., Kim, Y. S., & Jung, S. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.09.024 · Cited by 38

Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase

Choi, J., Park, S., & Jee, J. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.033 · Cited by 38

A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine

Catalano, R., Rocca, R., Juli, G., Costa, G., Maruca, A., Artese, A., Caracciolo, D., Tagliaferri, P., Alcaro, S., Tassone, P., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111715 · Cited by 38

Antiviral effects of quinine sulfate on HSV-1 HaCat cells infected: Analysis of the molecular mechanisms involved

Baroni, A., Paoletti, I., Ruocco, E., Ayala, F., Corrado, F., Wolf, R., Tufano, M. A., & Donnarumma, G. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.05.009 · Cited by 37

Repurposing drugs to target the malaria parasite unfolding protein response

Chen, Y., Murillo-Solano, C., Kirkpatrick, M. G., Antoshchenko, T., Park, H., & Pizarro, J. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-28608-2 · Cited by 37

Nilotinib – Differentiating the Hope from the Hype

Wyse, R. K. H., Brundin, P., & Sherer, T. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160904 · Cited by 36

Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case–control study

Broughton, T., Sington, J., & Beales, I. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-36 · Cited by 36

Clathrin Mediates Infectious Hepatitis C Virus Particle Egress

Benedicto, I., Gondar, V., Molina‐Jiménez, F., Garcı́a-Buey, L., López‐Cabrera, M., Gastaminza, P., & Majano, P. L. (2015) · Journal of Virology · doi:10.1128/jvi.03620-14 · Cited by 36

Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells

Arısan, E. D., Ergül, Z., Bozdağ, G., Rencüzoğulları, Ö., Gürkan, A. Ç., Yerlikaya, P. O., Coşkun, D., & Palavan-Ünsal, N. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4378-2 · Cited by 35

Drug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses

Amemiya, T., Gromiha, M. M., Horimoto, K., & Fukui, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-36636-1 · Cited by 35

Sodium valproate and 5-aza-2′-deoxycytidine differentially modulate DNA demethylation in G1 phase-arrested and proliferative HeLa cells

Rocha, M. A., Veronezi, G. M. B., Felisbino, M. B., Gatti, M. S. V., Tamashiro, W. M. D. S. C., & Mello, M. L. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-54848-x · Cited by 34

Interaction of Ethambutol with Human Organic Cation Transporters of the SLC22 Family Indicates Potential for Drug-Drug Interactions during Antituberculosis Therapy

Pan, X., Wang, L., Gründemann, D., & Sweet, D. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01255-13 · Cited by 30

Inhibition of l-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells

Poma, A. M., Bianchini, S., & Miranda, M. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(99)00142-4 · Cited by 29

Repositioning Aspirin to Treat Lung and Breast Cancers and Overcome Acquired Resistance to Targeted Therapy

Li, L., Hu, M., Wang, T., Chen, H., & Xu, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01503 · Cited by 28

Statin use and the risk of colorectal cancer in a population-based electronic health records study

Ibáñez‐Sanz, G., Guinó, E., Pontes, C., Quijada-Manuitt, M. Á., de la Peña, L., Aragón, M., Domínguez, M., Alonso, L. R., Blasco, A., García‐Rodríguez, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49877-5 · Cited by 27

The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole

Robert, M., Salvà, M., Segarra, R. M., Pavesi, M., Esbrí, R., Roberts, D. J., & Golor, G. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.010835 · Cited by 26

Middle East Respiratory Syndrome-Coronavirus (MERS-CoV): An Updated Overview and Pharmacotherapeutics

Pillaiyar, T. (2015) · Medicinal Chemistry · doi:10.4172/2161-0444.1000287 · Cited by 26

Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer’s disease

Ballard, C. G., Corbett, A., & Sharp, S. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.13 · Cited by 22

Repositioning of bromocriptine for treatment of acute myeloid leukemia

Lara-Castillo, M. C., Cornet-Masana, J. M., Etxabe, A., Banús‐Mulet, A., Torrente, M. Á., Nomdedéu, M., Díaz‐Beyá, M., Esteve, J., & Risueño, R. M. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1007-5 · Cited by 22

Repositioning Salirasib as a new antimalarial agent

Porta, E. O. J., Verdaguer, I. B., Perez, C., Banchio, C., de Azevedo, M. F., Katzin, A. M., & Labadié, G. R. (2019) · MedChemComm · doi:10.1039/c9md00298g · Cited by 22

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors

Choi, J., Lee, Y. M., & Jee, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010077 · Cited by 21

Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone

Falzon, D., Hill, G. R., Pal, S. N., Suwankesawong, W., & Jaramillo, E. (2014) · Bulletin of the World Health Organization · doi:10.2471/blt.14.142570 · Cited by 20

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds

Tian, J., Vandermosten, L., Peigneur, S., Moreels, L., Rozenski, J., Tytgat, J., Herdewijn, P. A., den Steen, P. E. V., & Jonghe, S. D. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.10.004 · Cited by 20

A combination of thalidomide and arsenic trioxide is effective and well tolerated in patients with myelodysplastic syndromes

Wei, W., Zhou, F., Zhang, Y., Guo, L., Shi, H., & Hou, J. (2012) · Leukemia Research · doi:10.1016/j.leukres.2011.12.023 · Cited by 19

The role of statins for primary prevention in non-elderly colorectal cancer patients.

Sehdev, A., Shih, Y. T., Huo, D., Vekhter, B. G., Lyttle, C. S., & Polite, B. N. (2014) · PubMed · Cited by 18

miR‑770‑5p modulates resistance to methotrexate in human colorectal adenocarcinoma cells by downregulating HIPK1

Zhang, D., Li, Y., & Sun, P. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8221 · Cited by 16

Recent Updates in Melanocyte Function: The Use of Promising Bioactive Compounds for the Treatment of Hypopigmentary Disorders

Ali, S., Naaz, I., Zaidi, K. U., & Ali, A. S. (2017) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666161223153953 · Cited by 16

Cinitapride Protects against Ethanol-lnduced Gastric Mucosal Injury in Rats: Role of 5-Hydroxytryptamine, Prostaglandins and Sulfhydryl Compounds

Romero, A. O. N.-D.-L.-L., pez, A. L. O., n, M. J. M. I., Casa, C. L., & Motilva, V. (2008) · Pharmacology · doi:10.1159/000139487 · Cited by 16

Update on the management of rosacea: a status report on the current role and new horizons with topical azelaic acid.

Rosso, J. Q. D., & Kircik, L. (2014) · PubMed · Cited by 14

Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin.

Eisenhardt, E. U., & Bickel, M. H. (1994) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08301-1 · Cited by 14

The role of statins for primary prevention in non-elderly colorectal cancer patients.

Sehdev, A., Shih, Y. T., Vekhter, B. G., Lyttle, C. S., & Polite, B. N. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.31.15_suppl.1513 · Cited by 13

Screening a library of approved drugs reveals that prednisolone synergizes with pitavastatin to induce ovarian cancer cell death

Abdullah, M. I., Abed, M. N., Khanim, F. L., & Richardson, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-46102-1 · Cited by 12

A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia

Cahill, K. E., Karimi, Y. H., Karrison, T. G., Jain, N., Green, M., Weiner, H., Fulton, N. C., Kadri, S., Godley, L. A., Artz, A. S., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000795 · Cited by 11

Thalidomide potentiates etoposide-induced apoptosis in murine neuroblastoma through suppression of NF-κB activation

Hiramatsu, T., Yoshizawa, J., Miyaguni, K., Sugihara, T., Harada, A., Kaji, S., Uchida, G., Kanamori, D., Baba, Y., Ashizuka, S., et al. (2018) · Pediatric Surgery International · doi:10.1007/s00383-018-4234-4 · Cited by 10

Cure of condyloma acuminata covering the glans penis using aminolevulinic acid/photodynamic therapy

Yin, G., Zhang, Y., Geng, M., Cai, B., & Zheng, Y. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101658 · Cited by 9

Evaluation of Antiplasmodial Potential of C2 and C8 Modified Quinolines: in vitro and in silico Study

Kumar, R., Sharma, R., Kumar, I., Upadhyay, P., Dhiman, A. K., Kumar, R., Kumar, R., Purohit, R., Sahal, D., & Sharma, U. K. (2018) · Medicinal Chemistry · doi:10.2174/1573406414666181015144413 · Cited by 9

Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera

Zhang, J., Akihisa, T., Kurita, M., Kikuchi, T., Zhu, W., Ye, F., Dong, Z., Liu, W., Feng, F., & Xu, J. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00167 · Cited by 8

The Relapse rate in patients with actinic keratosis treated with diclofenac sodium 3% gel

Agata, J., Dini, V., Oranges, T., Colombo, G., Bruno, G., Sergio, D. M., & Romanelli, M. (2019) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v6i2.06 · Cited by 3

Drug repurposing for cancer therapy

Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443

Utilizing graph machine learning within drug discovery and development

Gaudelet, T., Day, B., Jamasb, A. R., Soman, J., Regep, C., Liu, G., Hayter, J. B. R., Vickers, R., Roberts, C., Tang, J., et al. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab159 · Cited by 313

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Hung, S. W., Zhang, R., Tan, Z., Chung, J. P. W., Zhang, T., & Wang, C. C. (2021) · Medicinal Research Reviews · doi:10.1002/med.21802 · Cited by 175

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

Begley, C. G., Ashton, M. R., Baell, J. B., Bettess, M. D., Brown, M. P., Carter, B. A., Charman, W. N., Davis, C., Fisher, S., Frazer, I. H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd5524 · Cited by 164

Utilizing drug repurposing against COVID-19 – Efficacy, limitations, and challenges

Parvathaneni, V., & Gupta, V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118275 · Cited by 138

Drug Repurposing (DR): An Emerging Approach in Drug Discovery

Rudrapal, M., Khairnar, S. J., & Jadhav, A. G. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93193 · Cited by 210

Drug Repurposing in Dermatology: Molecular Biology and Omics Approach

Badria, F. A.-E., & Elgazar, A. A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93344 · Cited by 3

Drug Repurposing in Modern Pharmacology: A Strategic Review

Imran, D. M. (2025) · HYDERABAD JOURNAL OF SCIENCES

Repurposing Drugs for Skin Cancer

Khachigian, L. M. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867327666191220103901 · Cited by 8

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases

Hussain, M. S., Mir, P. A., Kumar, N., Mohi-ud-din, R., Wali, A. F., Mir, R. H., Talath, S., Sridhar, S. B., Shareef, J., Goud, M., et al. (2025) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/1070716 · Cited by 17