L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease
Open accessAbstract
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility of modifying Alzheimer's pathology with the L-type voltage-gated calcium channel blockers verapamil, diltiazem, isradipine and nimodipine. All four compounds protected MC65 neuroblastoma cells from amyloid beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity. Isradipine was the most potent blocker, preventing APP CTF neurotoxicity at nanomolar concentrations. Intracellular beta amyloid expression was associated with increased expression of Cav 1.2 calcium channels and increased intracellular calcium influx from the extracellular space. Despite the cytoprotection afforded by calcium channel blockers, amyloid beta oligomer formation was not suppressed. The mechanism of cell death in MC65 cells is appeared to be caspase-3 independent. With the goal of determining if there is sufficient experimental support to move forward with animal trials of isradipine, we determined its bioavailability in the triple transgenic mouse model of AD. Subcutaneous implantation of carrier-bound isradipine (3 μg/g/day) for 60 days resulted in nanomolar concentrations in both the plasma and brain. Taken together, our in vitro results support the theory that calcium blockers exert protective effects downstream of the effects of beta amyloid. Isradipine's neuroprotective effect at concentrations that are clinically relevant and achievable in vitro and in vivo suggests that this particular calcium blocking agent may have therapeutic value in the treatment of Alzheimer's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Using L-type calcium channel blockers could mitigate the upregulation of L-type VGCCs and abnormal calcium influx induced by Aβ.
“Studies have shown that using L-type calcium channel blockers could mitigate the upregulation of L-type VGCCs and abnormal calcium influx induced by Aβ.320”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [320]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
Forette, F., Seux, M.-L., Staessen, J. A., Thijs, L., Birkenhäger, W. H., Babarskiene, M.-R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03086-4 · Cited by 1,441 · see citing works
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works
Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works
Arispe, N. J., Rojas, E., & Pollard, H. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.567 · Cited by 921 · see citing works
‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease
Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 905 · see citing works
Cell Death Independent of Caspases: A Review
Bröker, L. E., Kruyt, F. A. E., & Giaccone, G. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2223 · Cited by 899 · see citing works
Selkoe, D. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05554.x · Cited by 627 · see citing works
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
Selkoe, D. J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-8-200404200-00047 · Cited by 381 · see citing works
Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
Sondag, C. M., Dhawan, G., & Combs, C. K. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-1 · Cited by 295 · see citing works
Nimodipine for primary degenerative, mixed and vascular dementia
Birks, J., & López-Arrieta, J. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000147 · Cited by 231 · see citing works
Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice
Martínez‐Coria, H., Green, K. N., Billings, L. M., Kitazawa, M., Albrecht, M., Rammes, G., Parsons, C. G., Gupta, S., Banerjee, P., & LaFerla, F. M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090452 · Cited by 218 · see citing works
Expression and 1,4-Dihydropyridine-Binding Properties of Brain L-Type Calcium Channel Isoforms
Sinnegger-Brauns, M. J., Huber, I. G., Koschak, A., Wild, C., Obermair, G. J., Einzinger, U., Hoda, J., Sartori, S. B., & Striessnig, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049981 · Cited by 214 · see citing works
β-Amyloid impairs axonal BDNF retrograde trafficking
Poon, W. W., Blurton-Jones, M. M., Tu, C. H., Feinberg, L. M., Chabrier, M. A., Harris, J. W., Jeon, N. L., & Cotman, C. W. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.012 · Cited by 198 · see citing works
Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice
Quinn, J. F., Bussiere, J. R., Hammond, R., Montine, T. J., Henson, E., Jones, R. E., & Stackman, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.014 · Cited by 160 · see citing works
Self-citationPitt, J., Roth, W., Lacor, P., Smith, A. B., Blankenship, M., Velasco, P., De Felice, F., Breslin, P., & Klein, W. L. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.018 · Cited by 134 · see citing works
Tollefson, G. D. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90050-c · Cited by 121 · see citing works
Evaluation of Coenzyme Q as an Antioxidant Strategy for Alzheimer's Disease
Wadsworth, T. L., Bishop, J. A., Pappu, A. S., Woltjer, R. L., & Quinn, J. F. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14210 · Cited by 97 · see citing works
Self-citationPicone, P., Carrotta, R., Montana, G., Nobile, M. R., Biagio, P. L. S., & Carlo, M. D. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.056 · Cited by 97 · see citing works
Pollard, H. B., Rojas, E., & Arispe, N. J. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb23046.x · Cited by 95 · see citing works
Maezawa, I., Hong, H., Wu, H., Battina, S. K., Rana, S., Iwamoto, T., Radke, G. A., Pettersson, E., Martin, G. M., Hua, D. H., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03862.x · Cited by 88 · see citing works
Anekonda, T. S., & Adamus, G. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-122 · Cited by 88 · see citing works
Self-citationLin, C., Chen, T., Chiu, M., Way, T., & Lin, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.012 · Cited by 86 · see citing works
Sopher, B. L., Fukuchi, K.-I., Smith, A. C., Leppig, K. A., Furlong, C. E., & Martin, G. M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90092-2 · Cited by 84 · see citing works
Neurodegenerative mechanisms in alzheimer disease
Sopher, B. L., Fukuchi, K., Kavanagh, T. J., Furlong, C. E., & Martin, G. M. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02814999 · Cited by 75 · see citing works
Hong, H., Maezawa, I., Yao, N., Xu, B., Díaz-Avalos, R., Rana, S., Hua, D. H., Cheng, R. H., Lam, K. S., & Jin, L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.093 · Cited by 60 · see citing works
Alzheimer’s amyloid peptides mediate hypoxic up‐regulation of L‐type Ca 2+ channels
Scragg, J. L., Fearon, I. M., Boyle, J. P., Ball, S. G., Váradi, G., & Peers, C. (2004) · The FASEB Journal · doi:10.1096/fj.04-2659fje · Cited by 58 · see citing works
Woltjer, R. L., Nghiem, W., Maezawa, I., Milatović, D., Vaisar, T., Montine, K. S., & Montine, T. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03109.x · Cited by 58 · see citing works
Self-citationl-type calcium channels in the hippocampus and cerebellum of Alzheimer’s disease brain tissue
Coon, A. L., Wallace, D. R., Mactutus, C. F., & Booze, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00068-8 · Cited by 54 · see citing works
Woltjer, R. L., Cimino, P. J., Boutté, A. M., Schantz, A. M., Montine, K. S., Larson, E. B., Bird, T. D., Quinn, J. F., Zhang, J., & Montine, T. J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4263fje · Cited by 49 · see citing works
Self-citationNovel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death
Jin, L., Hua, D. H., Shie, F., Maezawa, I., Sopher, B. L., & Martin, G. M. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0011-9 · Cited by 46 · see citing works
Clinical findings with nimodipine in dementia: test of the calcium hypothesis.
Fritze, J., & Walden, J. (1995) · PubMed · Cited by 45 · see citing works
Barhwal, K. K., Hota, S. K., Baitharu, I., Prasad, D. N., Singh, S. B., & Ilavazhagan, G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.008 · Cited by 43 · see citing works
Woltjer, R. L., McMahan, W., Milatović, D., Kjerulf, J. D., Shie, F., Rung, L. G., Montine, K. S., & Montine, T. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.003 · Cited by 38 · see citing works
Self-citationPark, J., Park, Y., Rhim, S., Jhee, O., Kim, S., Yang, S.-C., Lee, M., Shaw, L. M. J., & Kang, J. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.11.021 · Cited by 23 · see citing works
Facchinetti, F., Fasolato, C., DELGIUDICE, E., Burgo, A., Furegato, S., Fusco, M., Basso, E., Seraglia, R., D'Arrigo, A. M., & Leon, A.-S. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.006 · Cited by 23 · see citing works
Homing in on Intracellular Aβ?
Golde, T. E., & Janus, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.013 · Cited by 23 · see citing works
Application of Coomassie brilliant blue staining to cultured hepatocytes
MOCHIZUKI, Y., & Furukawa, K. (1987) · Cell Biology International Reports · doi:10.1016/0309-1651(87)90003-8 · Cited by 20 · see citing works
Calcium channel blockers and Parkinson disease
Pfeiffer, R. F. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.31 · Cited by 18 · see citing works
Subcutaneous administration of nimodipine improves bioavailability in rabbits
Laslo, A. M., Eastwood, J. D., Urquhart, B. L., Lee, T., & Freeman, D. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.04.030 · Cited by 14 · see citing works
Sebastià, J., Pertusa, M., Vı́lchez, D., Planas, A. M., Verbeek, R., Rodrı́guez-Farré, E., Cristòfol, R. M., & Sanfeliu, C. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0492-8 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development
Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965 · see citing works
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138 · see citing works
Drug repositioning for Alzheimer's disease
Corbett, A., Pickett, J., Burns, A. S., Corcoran, J. P. T., Dunnett, S. B., Edison, P., Hagan, J. J., Holmes, C., Jones, E., Katona, C., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3869 · Cited by 302 · see citing works
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease
Ilijić, E., Guzmán, J. N., & Surmeier, D. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.007 · Cited by 260 · see citing works
Calcium signaling in Alzheimer's disease & therapies
Tong, B. C., Wu, A. J., Li, M., & Cheung, K. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.018 · Cited by 235 · see citing works
Antimicrobial Properties of Amyloid Peptides
Kagan, B. L., Jang, H., Capone, R. F., Arce, F. T., Ramachandran, S., Lal, R., & Nussinov, R. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200419b · Cited by 227 · see citing works
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
Ghosh, A., & Giese, K. P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0166-2 · Cited by 205 · see citing works
Parkinson's Disease Is Not Simply a Prion Disorder
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1787-16.2017 · Cited by 186 · see citing works
Di Benedetto, G., Burgaletto, C., Bellanca, C. M., Munafò, A., Bernardini, R., & Cantarella, G. (2022) · Cells · doi:10.3390/cells11172728 · Cited by 189 · see citing works
Zhang, H., Wu, L., Pchitskaya, E. I., Zakharova, O. A., Saito, T., Saido, T. C., & Борисович, Б. И. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1034-15.2015 · Cited by 181 · see citing works
Calcium channel blockers and dementia
Nimmrich, V., & Eckert, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12240 · Cited by 155 · see citing works
Pillaiyar, T., Meenakshisundaram, S., Manickam, M., & Sankaranarayanan, M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112275 · Cited by 140 · see citing works
Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress
Guzmán, J. N., Ilijić, E., Yang, B., Sánchez-Padilla, J., Wokosin, D. L., Galtieri, D. J., Kondapalli, J., Schumacker, P. T., & Surmeier, D. J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95898 · Cited by 136 · see citing works
Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine
Anekonda, T. S., & Quinn, J. F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.013 · Cited by 136 · see citing works
Self-citationVitamin D and the brain: Key questions for future research
Cui, X., Gooch, H. M., Groves, N. J., Sah, P., Burne, T. H. J., Eyles, D. W., & McGrath, J. J. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.004 · Cited by 117 · see citing works
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease
Александровна, П. Е., Pchitskaya, E. I., & Борисович, Б. И. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7506 · Cited by 102 · see citing works
Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease
Surmeier, D. J., Halliday, G. M., & Simuni, T. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.001 · Cited by 99 · see citing works
Salahuddin, P., Fatima, M. T., Abdelhameed, A. S., Nusrat, S., & Khan, R. H. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.02.065 · Cited by 95 · see citing works
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
Fang, J., Pieper, A. A., Nussinov, R., Lee, G., Bekris, L. M., Leverenz, J. B., Cummings, J. L., & Cheng, F. (2020) · Medicinal Research Reviews · doi:10.1002/med.21709 · Cited by 93 · see citing works
Novel Disease-Modifying Therapies for Alzheimer's Disease
Jiang, T., Yu, J., & Tan, L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120640 · Cited by 93 · see citing works
Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures
Chakroborty, S., & Stutzmann, G. E. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.012 · Cited by 91 · see citing works
A Review: Treatment of Alzheimer’s Disease Discovered in Repurposed Agents
Appleby, B. S., Nacopoulos, D. A., Milano, N. J., Zhong, K., & Cummings, J. L. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000345791 · Cited by 90 · see citing works
Türkeş, C., Demir, Y., & Beydemir, Ş. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1736631 · Cited by 84 · see citing works
Drug Repositioning Approaches for the Discovery of New Therapeutics for Alzheimer's Disease
Kim, T. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0325-7 · Cited by 82 · see citing works
Türkeş, C., Demir, Y., & Beydemir, Ş. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03009-x · Cited by 83 · see citing works
Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease
Baracaldo-Santamaría, D., Avendaño-Lopez, S. S., Ariza-Salamanca, D. F., Rodríguez-Giraldo, M., Calderón‐Ospina, C., González-Reyes, R. E., & Nava-Mesa, M. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109067 · Cited by 85 · see citing works
Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications
Appleby, B. S., & Cummings, J. L. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660162 · Cited by 78 · see citing works
Jiang, Y. Z., Xu, B., Chen, J., Sui, Y., Ren, L., Li, J., Zhang, H., Guo, L., & Sun, X. (2018) · Medical Science Monitor · doi:10.12659/msm.908765 · Cited by 76 · see citing works
Effect of calcium channel blockers on paraoxonase-1 (PON1) activity and oxidative stress
Türkeş, C., Söyüt, H., & Beydemir, Ş. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.08.007 · Cited by 74 · see citing works
Resveratrol and Calcium Signaling: Molecular Mechanisms and Clinical Relevance
McCalley, A. E., Kaja, S., Payne, A., & Koulen, P. (2014) · Molecules · doi:10.3390/molecules19067327 · Cited by 74 · see citing works
Calcium Ions in the Physiology and Pathology of the Central Nervous System
Pikor, D., Hurła, M., Słowikowski, B. K., Szymanowicz, O., Poszwa, J., Banaszek, N., Drelichowska, A., Jagodziński, P. P., Kozubski, W. P., & Dorszewska, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313133 · Cited by 75 · see citing works
Association between chronic kidney disease and Alzheimer’s disease: an update
Zhang, C., He, F.-F., Su, H., Zhang, C., & Meng, X. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00561-y · Cited by 70 · see citing works
Princen, K., Dooren, T. V., van Gorsel, M., Louros, N. N., Yang, X., Dumbacher, M., Bastiaens, I., Coupet, K., Dupont, S., Cuveliers, E., et al. (2024) · Science · doi:10.1126/science.add6260 · Cited by 71 · see citing works
Effects of Amyloid-β Peptides on Voltage-Gated L-Type CaV1.2 and CaV1.3 Ca2+ Channels
Kim, S., & Rhim, H. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0075-x · Cited by 70 · see citing works
Zhang, Q., Li, J., Liu, C., Song, C., Li, P., Yin, F., Xiao, Y., Li, J., Jiang, W., Zong, A., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.002 · Cited by 66 · see citing works
Colbourne, L., & Harrison, P. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01615-6 · Cited by 59 · see citing works
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease
Sushma, & Mondal, A. C. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103414 · Cited by 56 · see citing works
Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors
Barua, S., Kim, J. Y., Kim, J. Y., Kim, J. H., & Lee, J. E. (2019) · Neurochemical Research · doi:10.1007/s11064-018-02712-1 · Cited by 57 · see citing works
Rice, R. A., Berchtold, N. C., Cotman, C. W., & Green, K. N. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.090 · Cited by 57 · see citing works
Yang, T., Puckerin, A., & Colecraft, H. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037079 · Cited by 54 · see citing works
Baker, S. A., Leigh, W. A., Valle, G. D., Yturriaga, I. F. D., Ward, S. M., Cobine, C. A., Drumm, B. T., & Sanders, K. M. (2021) · eLife · doi:10.7554/elife.64099 · Cited by 54 · see citing works
Furazans in Medicinal Chemistry
Mancini, R. S., Barden, C., Weaver, D. F., & Reed, M. A. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01901 · Cited by 54 · see citing works
Melone, M. A. B., Dato, C., Paladino, S., Coppola, C., Trebini, C., Giordana, M. T., & Perrone, L. (2018) · Pharmaceutical Research · doi:10.1007/s11095-017-2276-2 · Cited by 52 · see citing works
RetractedAlzheimer's disease: which type of amyloid-preventing drug agents to employ?
Jang, H., Connelly, L. S., Arce, F. T., Ramachandran, S., Lal, R., Kagan, B. L., & Nussinov, R. (2013) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp00017f · Cited by 50 · see citing works
Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease
Corbett, A., Williams, G. H., & Ballard, C. G. (2013) · Pharmaceuticals · doi:10.3390/ph6101304 · Cited by 50 · see citing works
Chioua, M., Buzzi, E., Moraleda, I., Iriepa, I., Maj, M., Wnorowski, A., Giovannini, C., Tramarin, A., Portali, F., Ismaïli, L., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.06.044 · Cited by 49 · see citing works
Hou, S., Gu, R., & Wei, D. (2017) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.7b00452 · Cited by 48 · see citing works
Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease
Venuto, C. S., Yang, L., Javidnia, M., Oakes, D., Surmeier, D. J., & Simuni, T. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51300 · Cited by 48 · see citing works
Copenhaver, P. F., Anekonda, T. S., Musashe, D. T., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. L., & Quinn, J. F. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.006841 · Cited by 44 · see citing works
Self-citationCataldi, M. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030004 · Cited by 44 · see citing works
Membrane Pores in the Pathogenesis of Neurodegenerative Disease
Kagan, B. L. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00001-1 · Cited by 41 · see citing works
In vivo induction of membrane damage by β-amyloid peptide oligomers
Julien, C., Tomberlin, C., Roberts, C. M., Akram, A., Stein, G. H., Silverman, M. A., & Link, C. D. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0634-x · Cited by 39 · see citing works
Sun, Y., Yan, C., He, L., Xiang, S., Wang, P., Li, Z., Chen, Y., Zhao, J., Yuan, Y., Wang, W., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101899 · Cited by 40 · see citing works
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease
Ahmad, F., Karan, A., Sharma, R., Sharma, N. S., Sundar, V., Jayaraj, R. L., Mukherjee, S., & DeCoster, M. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102229 · Cited by 38 · see citing works
Pourbadie, H. G., Naderi, N., Khodagholi, F., Shaerzadeh, F., & Motamedi, F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.045 · Cited by 37 · see citing works
Griffioen, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713243 · Cited by 35 · see citing works
Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
Alves, V. S., Alves-Silva, H. S., Orts, D. J. B., Ribeiro-Silva, L., Arcisio-Miranda, M., & Oliveira, F. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.041 · Cited by 34 · see citing works
Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease
Александровна, П. Е., Chernyuk, D., & Борисович, Б. И. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200528162046 · Cited by 33 · see citing works
Čermáková, P., Fereshtehnejad, S., Johnell, K., Winblad, B. G., Eriksdotter, M., & Religa, D. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt264 · Cited by 32 · see citing works
Verapamil and Alzheimer’s Disease: Past, Present, and Future
Popović, N., Morales-Delgado, N., Mena, D. V., Alonso, A., Martínez, M. P., Bleda, M. C., & Popović, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00562 · Cited by 33 · see citing works
Ruciņš, M., Kaldre, D., Pajuste, K., Fernandes, M. A. S., Vicente, J. A. F., Klimavičiusa, L., Jaschenko, E., Kanepe, I., Shestakova, I., Plotniece, M., et al. (2013) · Comptes Rendus Chimie · doi:10.1016/j.crci.2013.07.003 · Cited by 32 · see citing works
Kaya, E. D., Söyüt, H., & Beydemir, Ş. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.05.019 · Cited by 32 · see citing works
Cheng, B., Li, Y., Ma, L., Wang, Z., Petersen, R. B., Zheng, L., Chen, Y., & Huang, K. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.02.013 · Cited by 31 · see citing works
Koran, M. E. I., Hohman, T. J., & Thornton‐Wells, T. A. (2013) · Human Genetics · doi:10.1007/s00439-013-1354-8 · Cited by 31 · see citing works
Ponne, S., Chinnadurai, R. K., & Boopathy, R. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0056 · Cited by 31 · see citing works
The Role of Cysteine Protease in Alzheimer Disease
Hasanbašić, S., Jahić, A., Karahmet, E., Sejranic, A., & Prnjavorac, A. (2016) · Materia Socio Medica · doi:10.5455/msm.2016.28.235-238 · Cited by 31 · see citing works
Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27 · see citing works
Chang, L., Zhang, Y., Liu, J., Song, Y., Lv, A., Li, Y., Zhou, W., Yan, Z., Almeida, O. F. X., & Wu, Y. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150942 · Cited by 27 · see citing works
Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders
Khatri, D. K., Kadbhane, A., Patel, M., Nene, S., Atmakuri, S., Srivastava, S., & Singh, S. B. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100022 · Cited by 24 · see citing works
Pall, M. L. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220202114510 · Cited by 25 · see citing works
Calcium channel blockers and Alzheimer's disease.
Tan, Y., Deng, Y., & Qing, H. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.02.010 · Cited by 25 · see citing works
Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease
Wang, M., Zhang, H., Liang, J., Huang, J., Wu, T., & Chen, N. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.007 · Cited by 25 · see citing works
Wang, D., Wang, J., Wang, D., Yu, X., Olatunji, O. J., Ouyang, Z., & Wei, Y. (2017) · Chemistry & Biodiversity · doi:10.1002/cbdv.201700385 · Cited by 24 · see citing works
Current and Future Nano-Carrier-Based Approaches in the Treatment of Alzheimer’s Disease
Kumar, A., Sudevan, S. T., Nair, A. S., Singh, A. K., Kumar, S., Jose, J., Behl, T., Mangalathillam, S., Mathew, B., & Kim, H. (2023) · Brain Sciences · doi:10.3390/brainsci13020213 · Cited by 24 · see citing works
Dubovsky, S. L. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1558206 · Cited by 24 · see citing works
Liu, L., Gao, H., Zaikin, A. A., & Chen, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.767892 · Cited by 23 · see citing works
Nicolas, J., Hendriksen, P. J. M., de Haan, L. H. J., Koning, R., Rietjens, I. M. C. M., & Bovee, T. F. H. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.11.010 · Cited by 22 · see citing works
Zhang, Z., Chen, R., An, W., Wang, C., Liao, G., Dong, X., Bi, A., Yin, Z., & Luo, L. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4133-5 · Cited by 21 · see citing works
Rodríguez-Massó, S. R., Erickson, M. A., Banks, W. A., Ulrich, H., & Martins, A. H. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.791709 · Cited by 21 · see citing works
Role of metal ions in the cognitive decline of Down syndrome
Malakooti, N., Pritchard, M. A., Adlard, P. A., & Finkelstein, D. I. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00136 · Cited by 21 · see citing works
Pourbadie, H. G., Naderi, N., Mehranfard, N., Janahmadi, M., Khodagholi, F., & Motamedi, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117555 · Cited by 21 · see citing works
Yu, H., Ding, Y.-H., Wei, Y.-B., Dyrba, M., Wang, D., Kang, X., Xu, W.-Z., Zhao, K., & Liu, Y. (2023) · Human Brain Mapping · doi:10.1002/hbm.26512 · Cited by 21 · see citing works
Role of STIM1 in neurodegeneration
Pascual-Caro, C., Espinosa-Bermejo, N., Pozo‐Guisado, E., & Martı́n-Romero, F. J. (2018) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v9.i2.16 · Cited by 19 · see citing works
Ji, Y., Hu, Y., Ren, J., Khanna, R., Yao, Y., Chen, Y., Li, Q., & Sun, L. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.03.005 · Cited by 19 · see citing works
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
Dumbacher, M., Dooren, T. V., Princen, K., Witte, K. D., Farinelli, M., Lievens, S., Tavernier, J. H., Dehaen, W., Wera, S., Winderickx, J., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0283-3 · Cited by 18 · see citing works
Xu, J., Song, W., Xu, Z., Danziger, M. M., Karavani, E., Zang, C., Chen, X., Li, Y., Paz, I. R., Gohel, D., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14373 · Cited by 17 · see citing works
Higham, J. P., Hidalgo, S., Buhl, E., & Hodge, J. J. L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00409 · Cited by 17 · see citing works
Egunlusi, A. O., Malan, S. F., Omoruyi, S. I., Ekpo, O. E., Palchykov, V. A., & Joubert, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112617 · Cited by 17 · see citing works
Rubi, L., Schandl, U., Lagler, M., Geier, P., Spies, D., Gupta, K. D., Boehm, S., & Kubista, H. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8234-1 · Cited by 17 · see citing works
Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease
Mittag, M., Mediavilla, L., Remy, S., Cuntz, H., & Jedlička, P. (2023) · The Journal of Physiology · doi:10.1113/jp283401 · Cited by 19 · see citing works
Lin, S.-Y., Hsu, W., Lin, C., & Chen, C. (2014) · Biomedicine · doi:10.7603/s40681-014-0025-y · Cited by 16 · see citing works
Hasreiter, J., Goldnagl, L., Böhm, S., & Kubista, H. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00329.2013 · Cited by 16 · see citing works
Pourbadie, H. G., Naderi, N., Janahmadi, M., Mehranfard, N., & Motamedi, F. (2016) · Synapse · doi:10.1002/syn.21915 · Cited by 16 · see citing works
Yang, Y., Yu, Z., Geng, J., Liu, M., Liu, N., Li, P., Hong, W., Yue, S., Jiang, H., Ge, H., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03438-1 · Cited by 15 · see citing works
Li, X., Rose, S. E., Montine, K. S., Keene, C. D., & Montine, T. J. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9380-1 · Cited by 15 · see citing works
Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance
Zhang, D. Y., Wang, J., Fleeman, R. M., Kuhn, M. K., Swulius, M. T., Proctor, E. A., & Dokholyan, N. V. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00221 · Cited by 14 · see citing works
Chen, W., Wang, Y., Wang, H., An, D., Sun, D., Li, P., Zhang, T., Lu, W., & Liu, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03322-x · Cited by 14 · see citing works
Singhal, K., & Sandhir, R. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23478 · Cited by 14 · see citing works
Calcium regulation and Alzheimer's disease
Rapaka, D., Bitra, V. R., Medapati, J. R., & Akula, A. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60666-6 · Cited by 14 · see citing works
Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons
Kurowski, P. N., Grzelka, K., & Szulczyk, P. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00093 · Cited by 13 · see citing works
- Authors
- Anekonda, T. S., Quinn, J. F., Harris, C., Frahler, K., Wadsworth, T. L., & Woltjer, R. L.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Anekonda, Thimmappa S.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 41
- Issue
- 1
- Pages
- 62-70
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC2982927
- OpenAlex
- W2051044968
- Cited by
- 155
- References
- 46
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 14 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 9
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Veterans Affairs (P30AG008017)
- Oregon Health and Science University
- National Institutes of Health
- National Eye Institute (5R21 EY 018708-02, T32 AT002688-05)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, isradipine, L-type calcium channels, calcium channel blockers, amyloid-beta, APP C-terminal fragments, intracellular calcium dysregulation, neuroprotection, Cav1.2 calcium channel, amyloid oligomerization, triple transgenic mouse model, drug bioavailability, verapamil, diltiazem, nimodipine
- MeSH terms
- Alzheimer Disease, Animals, Calcium Channel Blockers, Female, Humans, Mice, Transgenic, Neurons, Isradipine, Calcium Channels, L-Type, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review