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Cited by 53Ovarian function and disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function

Altuntas, Yuksel, Bilir, Muammer, Ucak, Sema, Gundogdu, Sadi·2005·European Journal of Obstetrics & Gynecology and Reproductive Biology
DOI 10.1016/j.ejogrb.2004.07.038
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Abstract

Reactive hypoglycemia (RH), which is a postprandial hypoglycemic state, occurs within 2-5 h after food intake. It is classified as idiopathic, alimentary, or diabetic reactive hypoglycemia. We studied the incidence of reactive hypoglycemia and looked for any correlations between it and the presence of insulin sensitivity and/or beta cell function in young lean polycystic ovary syndrome (PCOS) patients. This study was designed as a cross-sectional study in 64 lean young women with PCOS (BMI < or = 25 kg/m2). Various indices of insulin sensitivity and beta cell function derived from the oral glucose tolerance test (OGTT) results were used. We found the rate of RH to be 50% in lean young women with PCOS. DHEA-S and PRL levels were found to be lower in subjects with RH (P < 0.05 and P > 0.05, respectively). Beta cell function indices such as the insulinogenic index (at 120 min), CIR (at 120 min) and HOMA beta cell index were found to be insignificantly higher in the RH group than the nonreactive hypoglycemia (NRH) group. The 4 h glucose level, but not the 3 h glucose level, was significantly correlated with insulin resistance indices, such as fasting insulin level, HOMA-IR, Quicky index, and FIRI in the RH group. Significantly decreased DHEA-S levels were an interesting finding. In conclusion, there is an urgent need to investigate RH in lean young women with PCOS. Our results indicate that more definite insulin resistance occurs in subjects with RH in the fourth hour of the OGTT than those with RH in the third hour. In addition, RH in the fourth hour together with a low DHEA-S level may be predictive of future diabetes in young women with PCOS even when they are not obese.

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Crossref · 10.1016/j.ejogrb.2004.07.038

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  • There is a decrease in insulin sensitivity in late reactive hypoglycaemia at 4 or 5 hours.

    “However, there is a decrease in insulin sensitivity in late reactive hypoglycaemia at 4 or 5 hours.”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [17]

  • Both IFG and IGT have insulin resistance and beta-cell defect.

    “Both IFG and IGT have both insulin resistance and beta-cell defect.”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [17]

  • Individuals with IFG have insulin sensitivity close to normal in muscle with severe hepatic insulin resistance in liver, whereas individuals with IGT have moderate insulin resistance in liver but severe insulin resistance in muscle.

    “Individuals with IFG have insulin sensitivity close to normal/normal in the muscle with severe hepatic insulin resistance in the liver whereas individuals with IGT have moderate insulin resistance in the liver, but severe insulin resistance in the muscle.[9, 15-19]”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [17]

  • These results indicate more exact insulin resistance in RH at 4 h or 5 h than in RH at 3 h.

    “These results indicate more exact insulin resistance in RH at 4 h or 5 h than in RH at 3 h.[17]”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [17]

  • Hypoglycemia may result from hyperinsulinism that may precede T2D.

    “Alternatively, hypoglycemia may result from hyperinsulinism that may precede T2D [8,9]”

    From Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study (2024) · cites this paper as [9]

Cites

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Research works printed but not linked: 2

  1. Marks, 1987, Glycaemic stability in healthy subjects: fluctuations in blood glucose concentration during the day, vol. 38, 19
  2. Drivsholm, 1999, Assessment of insulin-sensitivity and beta-cell function from an oral glucose tolerance test, Diabetologia, 42, 185

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Authors
Altuntas, Y., Bilir, M., Ucak, S., & Gundogdu, S.
Affiliations
Istanbul University-Cerrahpaşa (TR)
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2005-04
Volume
119
Issue
2
Pages
198-205
ISSN
  • 0028-2243 (ISSN-L)
  • 0301-2115
DOI
10.1016/j.ejogrb.2004.07.038
OpenAlex
W2036494076
Semantic Scholar
36ac9848dc2a6059984b41e1478cceeb6b3cb8f4
Cited by
53
References
44
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
reactive hypoglycemia, polycystic ovary syndrome, insulin sensitivity, insulin resistance, beta-cell function, dehydroepiandrosterone sulfate, prolactin, HOMA-IR, insulinogenic index, oral glucose tolerance test, diabetes risk prediction
MeSH terms
Adult, Blood Glucose, Cross-Sectional Studies, Fasting, Female, Food, Glucose Tolerance Test, Homeostasis, Humans, Hypoglycemia, Insulin, Insulin Resistance, Islets of Langerhans, Kinetics, Polycystic Ovary Syndrome, Prolactin, Dehydroepiandrosterone Sulfate

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