The neurobiology of offensive aggression: Revealing a modular view

de Boer, S.F.; Olivier, B.; Veening, J.; Koolhaas, J.M.

doi:10.1016/j.physbeh.2015.04.040

Cited by 70Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorNeuroscience and Neuropharmacology Research

The neurobiology of offensive aggression: Revealing a modular view

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de Boer, S.F., Olivier, B., Veening, J., Koolhaas, J.M.·2015·Physiology & Behavior

DOI 10.1016/j.physbeh.2015.04.040

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Abstract

Experimental studies aimed at understanding the neurobiology of aggression started in the early 20th century, and by employing increasingly sophisticated tools of functional neuroanatomy (i.e., from electric/chemical lesion and stimulation techniques to neurochemical mapping and manipulations) have provided the important framework for the functional brain circuit organization of aggressive behaviors. Recently, newly emerging technologies for mapping,measuring and manipulating neural circuitry at the level of molecular and genetically defined neuronal subtypes promise to further delineate the precise neural microcircuits mediating the initiation and termination of aggressive behavior, and characterize its dynamic neuromolecular functioning. This paper will review some of the behavioral, neuroanatomical and neurochemical evidence in support of a modular view of the neurobiology of offensive aggressive behavior. Although aggressive behavior likely arises from a specific concerted activity within a distributed neural network across multiple brain regions, emerging opto- and pharmacogenetic neuronal manipulation studies make it clear that manipulation of molecularly-defined neurons within a single node of this global interconnected network seems to be both necessary and sufficient to evoke aggressive attacks. However, the evidence so far also indicates that in addition to behavior-specific neurons there are neuronal systems that should be considered as more general behavioral control modules. The answer to the question of behavioral specificity of brain structures at the level of individual neurons requires a change of the traditional experimental setup. Studies using c-fos expression mapping usually compare the activation patterns induced by for example aggression with a home cage control. However, to reveal the behavioral specificity of this neuronal activation pattern, a comparison with other social and non-social related behaviors such as mating, defensive burying or running might be more appropriate. In addition, the correlations between aggressive behavior and other behaviors in different environmental contexts might give an indication of these more general behavioral control functions. Elucidating how neural circuits that modulate social-aggressive behavior also mediate other complex emotional behaviors or states will lead to a better understanding of the molecular mechanisms by which social deficits are expressed in various neuropsychiatric disorders. This likely will lead to more efficacious pharmacological or circuit-based therapeutics to curb excessive/abnormal aggressive behavior and improve social function.

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An integrated analysis of genes and functional pathways for aggression in human and rodent models
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0068-7 · Cited by 98 · see citing works

Authors: de Boer, S. F., Olivier, B., Veening, J., & Koolhaas, J. M.
Affiliations: Utrecht University (NL)
Radboud University Nijmegen (NL)
University of Groningen (NL)
ORCID: Olivier, B.
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2015-07
Volume: 146
Pages: 111-127
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2015.04.040
OpenAlex: W2098804683
Cited by: 70
References: 211
Citations by year: 2026: 3 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 2
FWCI: 2.94
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: offensive aggression, neurobiology of aggression, social aggression, optogenetics, pharmacogenetics, neuronal cell types, behavioral specificity, neuromodulation, social dysfunction, neuropsychiatric disorders
MeSH terms: Aggression, Animals, Humans, Neural Pathways, Neurobiology, Social Behavior

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The neurobiology of offensive aggression: Revealing a modular view

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