Cited by 82Lipoproteins and Cardiovascular HealthMuscle Physiology and DisordersPharmacovigilance and Adverse Drug Reactions

Statin-associated myopathy and the quest for biomarkers: can we effectively predict statin-associated muscle symptoms?

Muntean, Danina M., Thompson, Paul D., Catapano, Alberico L., Stasiolek, Mariusz, Fabis, Jaroslaw, Muntner, Paul, Serban, Maria-Corina, Banach, Maciej·2017·Drug Discovery Today

Abstract

Over the past three decades, statins have become the cornerstone of prevention and treatment of atherosclerotic cardiovascular and metabolic diseases. Albeit generally well tolerated, these drugs can elicit a variety of muscle-associated symptoms that represent the most important reason for treatment discontinuation. Statin-associated myopathy has been systematically underestimated by randomized controlled trials as compared with the incidence observed in clinical practice and obtained from patient registries. There are several reasons for this discrepancy, among which the lack of reliable diagnostic tests and a validated questionnaire to assess muscle symptoms are recognized as unmet needs. Here, we review the cellular and molecular mechanisms underlying statin-associated myopathy and discuss the experimental and clinical data on various biomarkers to diagnose and predict muscle-related complaints.

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Crossref · 10.1016/j.drudis.2016.09.001

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  • These muscle effects might be relevant for SAMS patients, especially combined with potent LDL-lowering nutraceuticals.

    “All of these effects, along with the respective mechanistic bases (e.g., effect on muscle fibers and mitochondrial biogenesis), might be relevant for SAMS patients, especially in the combination with nutraceuticals with potent LDL-lowering action (178,179).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [178]

  • HMB, beta-alanine, and carnosine are known to improve muscle mass, function, hypertrophy, lean mass, aerobic performance, exercise capacity, and muscle protein synthesis, and to reduce muscle damage, protein breakdown, and fatigue.

    “Besides the nutraceuticals with LDL-lowering properties, it is worth mentioning those, such as b-hydroxy b-methylbutyric acid, b-alanine, and carnosine, that are known to improve muscle mass, muscle function, hypertrophy, lean body mass, aerobic performance and exercise capacity, and muscle protein synthesis, as well as to decrease muscle damage and muscle protein breakdown and fatigue (178,179).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [178]

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Authors
Muntean, D. M., Thompson, P. D., Catapano, A. L., Stasiolek, M., Fabis, J., Muntner, P., Serban, M.-C., & Banach, M.
Affiliations
  • Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
  • Hartford Hospital (US)
  • University of Milan (IT)
  • University of Alabama at Birmingham (US)
  • Medical University of Lodz (PL)
Corresponding author
Banach, Maciej
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2017-01
Volume
22
Issue
1
Pages
85-96
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2519430929
Cited by
82
References
135
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 8 · 2016: 2
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Lodz
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
statin-induced myopathy, statins, muscle symptoms, biomarkers, drug-induced myopathy, treatment discontinuation, atherosclerotic cardiovascular disease, metabolic disorders, diagnostic testing, molecular mechanisms, patient registry
MeSH terms
Animals, Drug Interactions, Humans, Muscular Diseases, Predictive Value of Tests, Risk Factors, Biomarkers, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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