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Cited by 230Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT)

Ishrat, Tauheed, Hoda, Md Nasrul, Khan, M. Badruzzaman, Yousuf, Seema, Ahmad, Muzamil, Khan, Mohd. Moshahid, Ahmad, Ajmal, Islam, Fakhrul·2009·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2009.02.002
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Abstract

Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. The aim of the present study was to examine the modulating impacts of CUR against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (ICV-STZ) infused rats. Rats were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with CUR (80 mg/kg) for three weeks. After two weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks and then sacrificed for biochemical and histopathological assays. ICV-STZ rats showed significant cognitive deficits, which were significantly improved by CUR supplementation. CUR supplementation significantly augmented increased 4-hydroxynonenal (4-HNE) and malonaldehyde (MDA), thiobarbituric reactive substances (TBARS), hydrogen peroxide (H2O2), protein carbonyl (PC) and oxidized glutathione (GSSG); decreased levels of reduced glutathione (GSH) and its dependent enzymes (Glutathione peroxidase [GPx] and glutathione reductase [GR]) in the hippocampus and cerebral cortex; and increased choline acetyltransferase (ChAT) activity in the hippocampus of ICV-STZ rats. The study suggests that CUR is effective in preventing cognitive deficits, and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).

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Metadata

Authors
Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., & Islam, F.
Affiliations
  • Emory University (US)
  • Jamia Hamdard (IN)
  • University of Pittsburgh (US)
Corresponding author
Islam, Fakhrul
ORCID
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2009-09
Volume
19
Issue
9
Pages
636-647
ISSN
0924-977X (ISSN-L)
DOI
10.1016/j.euroneuro.2009.02.002
OpenAlex
W2028376455
Cited by
230
References
71
Citations by year
2026: 3 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 22 · 2019: 15 · 2018: 22 · 2017: 19 · 2016: 17 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 19
FWCI
6.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Health and Family Welfare
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
curcumin, cognitive impairment, neurodegeneration, streptozotocin-induced neurotoxicity, oxidative stress, antioxidant activity, hippocampus, cerebral cortex, choline acetyltransferase, glutathione, lipid peroxidation, neuroprotection
MeSH terms
Alzheimer Disease, Animals, Brain, Cerebral Cortex, Choline O-Acetyltransferase, Cognition, Curcumin, Disease Models, Animal, Hippocampus, Injections, Intraventricular, Male, Nerve Degeneration, Streptozocin, Time Factors, Rats, Wistar, Reactive Oxygen Species, Neuroprotective Agents, Rats

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